Direct prePRINTS access:
|prePRINTS is an automatically generated supplement to the PRINTS database, aiming to provide increased protein family coverage.|
|The database is a compendium of protein "fingerprints", which are groups of conserved motifs used to characterise a protein family. The diagnostic power of a fingerprint is refined by iterative scanning of a SWISS-PROT/TrEMBL composite. Usually the motifs do not overlap, but are separated along a sequence, though they may be contiguous in 3D-space. Fingerprints can encode protein folds and functionalities more flexibly and powerfully than can single motifs, full diagnostic potency deriving from the mutual context provided by motif neighbours. (references)|
|prePRINTS is built from sequence alignments extracted from PRODOM. These alignments are extended and passed to a suite of motif detection methods. The resultant family- specific motif sets are then used to generate fingerprints which may be used for sequence diagnosis.|
|Each fingerprint is annotated automatically using PRECIS, a prototypic tool which creates protein reports extracted from concise information in SWISS-PROT. The mapping of SWISS-PROT information to PRECIS annotation is summarised here. Since automatically derived annotation tends to be of lower quality than that compiled by a human annotator, database entries are referred to as "preprints".|
|The database is managed by the object-relational PostgreSQL database management system. The prePRINTS schema is based on that used by PRINTS-S, the relational cousin of PRINTS.|
Contact us: or, for more info, visit Bioinformatics at Manchester, Faculty of Life Sciences, School of Computer Science, The University of Manchester.