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PR01832

Identifier
VEGFRECEPTOR  [View Relations]  [View Alignment]  
Accession
PR01832
No. of Motifs
6
Creation Date
13-MAR-2003
Title
Vascular endothelial growth factor receptor signature
Database References
PRINTS; PR01833 VEGFRECEPTR1; PR01834 VEGFRECEPTR2; PR01835 VEGFRECEPTR3

PDB; 1QSV; 1VR2
SCOP; 1QSV; 1VR2
CATH; 1QSV; 1VR2
Literature References
1. CONNOLLY, D.T., HEUVELMAN, D.M., NELSON, R., OLANDER, J.V., EPPLEY, B.L.,
DELFINO, J.J., SIEGEL, N.R., LEIMGRUBER, R.M. AND FEDER, J.
Tumor vascular permeability factor stimulates endothelial cell growth and
angiogenesis.
J.CLIN.INVEST. 84 1470-1478 (1989).
 
2. AIELLO, L.P., AVERY, R.L., ARRIGG, P.G., KEYT, B.A., JAMPEL, H.D.,
SHAH, S.T., PASQUALE, L.R.,THIEME, H., IWAMOTO, M.A. AND  PARK, J.E.
Vascular endothelial growth factor in ocular fluid of patients with diabetic
retinopathy and other retinal disorders.
N.ENGL.J.MED. 331 1480-1487 (1994).
 
3. MUSTONEN, T. AND ALITALO, K.
Endothelial receptor tyrosine kinases involved in angiogenesis.
J.CELL.BIOL. 129 895-898 (1995).

Documentation
Vascular endothelial growth factor (VEGF) is a potent and specific
endothelial cell mitogen [1]. Through binding with its receptor, VEGFR, VEGF
has critical roles in the growth and maintenance of vascular endothelial
cells and in the development of new blood- and lymphatic-vessels in
physiological and pathological states [2]. The vessel systems are important 
for the supply of oxygen and nutrients to all tissues of the body, as well
as for the drainage of excess fluids with waste metabolites from peripheral
tissues. VEGF receptors have a characteristic structure, with 7 Ig-like
domains in the extracellular domain and a cytoplasmic tyrosine kinase domain
with a long kinase insert region.
 
The VEGF receptor family consists of three members, VEGFR-1 (Flt-1), VEGFR-2
(KDR/Flk-1) and VEGFR-3 (Flt-4), all of which belong to the receptor type
tyrosine kinase superfamily [3]. Among these receptors, VEGFR-1 binds
strongest to VEGF, VEGF-2 binds more weakly, and VEGFR-3 shows essentially
no binding, although it does bind to other members of the VEGF family.
 
VEGFRECEPTOR is a 6-element fingerprint that provides a signature for the 
vascular endothelial growth factor receptors. The fingerprint was derived
from an initial alignment of 12 sequences: the motifs were drawn from
conserved regions within the extracellular domain, motifs 1, 3, 4, 5 and 6 
residing within the 1st, 2nd, 3rd, 4th and 5th Ig-like domains, respectively
- motif 3 spans beta-strands 5 and 6. Two iterations on SPTR40_20f were
required to reach convergence, at which point a true set comprising 18 
sequences was identified.
Summary Information
18 codes involving  6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
6181818181818
5000000
4000000
3000000
2000000
123456
True Positives
O08775        O55095        P79701        Q12954        
Q8UUW9 Q8VCD0 Q91ZT0 Q91ZT1
Q9DAV2 Q9JJ08 VEGR_RAT VGR1_HUMAN
VGR1_MOUSE VGR2_COTJA VGR2_HUMAN VGR2_MOUSE
VGR3_HUMAN VGR3_MOUSE
Sequence Titles
O08775      VEGF RECEPTOR-2/FLK-1 - RATTUS NORVEGICUS (RAT). 
O55095 SFLT-1 (FLT-1 PROTEIN) - Mus musculus (Mouse).
P79701 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR - Coturnix coturnix (common quail).
Q12954 SOLUBLE VASCULAR ENDOTHELIAL CELL GROWTH FACTOR RECEPTOR - Homo sapiens (Human).
Q8UUW9 RECEPTOR TYROSINE KINASE FLK-1/VEGFR-2 - Brachydanio rerio (Zebrafish) (Zebra danio).
Q8VCD0 KINASE INSERT DOMAIN PROTEIN RECEPTOR - Mus musculus (Mouse).
Q91ZT0 RECEPTOR TYROSINE KINASE VEGFR-3KT - Rattus norvegicus (Rat).
Q91ZT1 RECEPTOR TYROSINE KINASE VEGFR-3 - Rattus norvegicus (Rat).
Q9DAV2 FMS-LIKE TYROSINE KINASE 1 - Mus musculus (Mouse).
Q9JJ08 SOLUBLE FLT-1 - Rattus norvegicus (Rat).
VEGR_RAT VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 PRECURSOR (EC 2.7.1.112) (VEGFR-1) (TYROSINE-PROTEIN KINASE RECEPTOR FLT) (FLT-1) - RATTUS NORVEGICUS (RAT).
VGR1_HUMAN Vascular endothelial growth factor receptor 1 precursor (EC 2.7.1.112) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Tyrosine- protein kinase FRT) - Homo sapiens (Human).
VGR1_MOUSE Vascular endothelial growth factor receptor 1 precursor (EC 2.7.1.112) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2) - Mus musculus (Mouse).
VGR2_COTJA Vascular endothelial growth factor receptor 2 precursor (EC 2.7.1.112) (VEGFR-2) (Endothelial kinase receptor EK1) (Quek 1) (Quek1) - Coturnix coturnix japonica (Japanese quail).
VGR2_HUMAN Vascular endothelial growth factor receptor 2 precursor (EC 2.7.1.112) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) - Homo sapiens (Human).
VGR2_MOUSE Vascular endothelial growth factor receptor 2 precursor (EC 2.7.1.112) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) - Mus musculus (Mouse).
VGR3_HUMAN Vascular endothelial growth factor receptor 3 precursor (EC 2.7.1.112) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) - Homo sapiens (Human).
VGR3_MOUSE Vascular endothelial growth factor receptor 3 precursor (EC 2.7.1.112) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) - Mus musculus (Mouse).
Scan History
SPTR40_20f 2  40   NSINGLE    
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
CSTLTLDTAQANHTGLYTC O55095 90 90 -
CSTLTLDTAQANHTGLYTC VGR1_MOUSE 90 90 -
CSTLTLNMAQANHTGLYSC Q9JJ08 89 89 -
CSTLTLNMAQANHTGLYSC VEGR_RAT 89 89 -
CSTLTLNTAQANHTGFYSC Q12954 89 89 -
CSTLTLNTAQANHTGFYSC VGR1_HUMAN 89 89 -
CKTLTIPKVIGNDTGAYKC VGR2_HUMAN 85 85 -
CKVLLLAQTHANNTGSYHC VGR3_MOUSE 93 93 -
CKVLLLHEVHANDTGSYVC VGR3_HUMAN 93 93 -
CKTLTLLRVIGNDTGDYRC VGR2_COTJA 82 82 -
CKVLVLTESQANDTGYYHC P79701 102 102 -
CSKLVIHNLRHNDTGIYSC Q8UUW9 86 86 -

Motif 2 width=12
Element Seqn Id St Int Rpt
YIFVSDAGSPFI O55095 126 17 -
YIFVSDAGSPFI VGR1_MOUSE 126 17 -
YIFVSDAGSPFI Q9JJ08 125 17 -
YIFVSDAGSPFI VEGR_RAT 125 17 -
YIFISDTGRPFV Q12954 125 17 -
YIFISDTGRPFV VGR1_HUMAN 125 17 -
YVYVQDYRSPFI VGR2_HUMAN 115 11 -
YVFVRDFKHPFI VGR3_MOUSE 129 17 -
YVFVRDFEQPFI VGR3_HUMAN 129 17 -
YVYVQDYRSPFV VGR2_COTJA 112 11 -
YIFVRDFEQPFI P79701 138 17 -
YVFVKDPHHPFV Q8UUW9 117 12 -

Motif 3 width=11
Element Seqn Id St Int Rpt
ITWDSRRGFII O55095 185 47 -
ITWDSRRGFII VGR1_MOUSE 185 47 -
IAWDSRRGFII Q9JJ08 184 47 -
IAWDSRRGFII VEGR_RAT 184 47 -
IIWDSRKGFII Q12954 184 47 -
IIWDSRKGFII VGR1_HUMAN 184 47 -
ISWDSKKGFTI VGR2_HUMAN 177 50 -
VLWDDRRGMRV VGR3_MOUSE 183 42 -
VVWDDRRGMLV VGR3_HUMAN 183 42 -
ISWDNKKGFTI VGR2_COTJA 172 48 -
IFWDNKKGMQV P79701 192 42 -
VQWDPKKGFTV Q8UUW9 176 47 -

Motif 4 width=13
Element Seqn Id St Int Rpt
LLHGQTLVLNCTA O55095 243 47 -
LLHGQTLVLNCTA VGR1_MOUSE 243 47 -
FLRGQTLVLNCTV Q9JJ08 242 47 -
FLRGQTLVLNCTV VEGR_RAT 242 47 -
LLRGHTLVLNCTA Q12954 242 47 -
LLRGHTLVLNCTA VGR1_HUMAN 242 47 -
LSVGEKLVLNCTA VGR2_HUMAN 236 48 -
LLVGEKLVLNCTV VGR3_MOUSE 242 48 -
LLVGEKLVLNCTV VGR3_HUMAN 242 48 -
LAVGEKLVLNCTV VGR2_COTJA 231 48 -
LLVGEKLVLNCTV P79701 251 48 -
VLVGDTLILNCSA Q8UUW9 233 46 -

Motif 5 width=18
Element Seqn Id St Int Rpt
LIIKDVTTEDAGDYTILL O55095 391 135 -
LIIKDVTTEDAGDYTILL VGR1_MOUSE 391 135 -
LIIKDVTAEDAGDYTILL Q9JJ08 390 135 -
LIIKDVTAEDAGDYTILL VEGR_RAT 390 135 -
LIIKDVTEEDAGNYTILL Q12954 390 135 -
LIIKDVTEEDAGNYTILL VGR1_HUMAN 390 135 -
LTIMEVSERDTGNYTVIL VGR2_HUMAN 383 134 -
LVLKEVTEASAGVYTLAL VGR3_MOUSE 384 129 -
LVLKEVTEASTGTYTLAL VGR3_HUMAN 384 129 -
LVITEATEKDAGNYTVVL VGR2_COTJA 374 130 -
MQIKDVAEHHAGTYTLVL P79701 392 128 -
LTIKQVRQKDAGIFTIAL Q8UUW9 381 135 -

Motif 6 width=15
Element Seqn Id St Int Rpt
SRQVLTCTVYGIPRP O55095 449 40 -
SRQVLTCTVYGIPRP VGR1_MOUSE 449 40 -
SRQVLTCTVYGIPQP Q9JJ08 448 40 -
SRQVLTCTVYGIPQP VEGR_RAT 448 40 -
SRQILTCTAYGIPQP Q12954 448 40 -
SRQILTCTAYGIPQP VGR1_HUMAN 448 40 -
TTQTLTCTVYAIPPP VGR2_HUMAN 439 38 -
SRQTLTCTAYGVPQP VGR3_MOUSE 439 37 -
SRQALTCTAYGVPLP VGR3_HUMAN 439 37 -
STQALTCTIYAVPPP VGR2_COTJA 430 38 -
SPQALTCTVYGIPAP P79701 447 37 -
QRHKLTCTAFGIPMP Q8UUW9 438 39 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
CSTLTLDTAQANHTGLYTC O55095 90 90 -
CSTLTLDTAQANHTGLYTC Q9DAV2 90 90 -
CSTLTLDTAQANHTGLYTC VGR1_MOUSE 90 90 -
CSTLTLNMAQANHTGLYSC Q9JJ08 89 89 -
CSTLTLNMAQANHTGLYSC VEGR_RAT 89 89 -
CSTLTLNTAQANHTGFYSC Q12954 89 89 -
CSTLTLNTAQANHTGFYSC VGR1_HUMAN 89 89 -
CKTLTIPKVIGNDTGAYKC VGR2_HUMAN 85 85 -
CKVLSLAQTHANNTGSYYC Q91ZT0 93 93 -
CKVLSLAQTHANNTGSYYC Q91ZT1 93 93 -
CKVLLLAQTHANNTGSYHC VGR3_MOUSE 93 93 -
CKTLTIPRVVGNDTGAYKC Q8VCD0 87 87 -
CKTLTIPRVVGNDTGAYKC VGR2_MOUSE 87 87 -
CKTLTVPRVVGNDTGAYKC O08775 85 85 -
CKVLLLHEVHANDTGSYVC VGR3_HUMAN 93 93 -
CKTLTLLRVIGNDTGDYRC VGR2_COTJA 82 82 -
CKVLVLTESQANDTGYYHC P79701 102 102 -
CSKLVIHNLRHNDTGIYSC Q8UUW9 86 86 -

Motif 2 width=12
Element Seqn Id St Int Rpt
YIFVSDAGSPFI O55095 126 17 -
YIFVSDAGSPFI Q9DAV2 126 17 -
YIFVSDAGSPFI VGR1_MOUSE 126 17 -
YIFVSDAGSPFI Q9JJ08 125 17 -
YIFVSDAGSPFI VEGR_RAT 125 17 -
YIFISDTGRPFV Q12954 125 17 -
YIFISDTGRPFV VGR1_HUMAN 125 17 -
YVYVQDYRSPFI VGR2_HUMAN 115 11 -
YVFVRDFEQPFI Q91ZT0 129 17 -
YVFVRDFEQPFI Q91ZT1 129 17 -
YVFVRDFKHPFI VGR3_MOUSE 129 17 -
YVYVRDYRSPFI Q8VCD0 117 11 -
YVYVRDYRSPFI VGR2_MOUSE 117 11 -
YVYVQDHRSPFI O08775 115 11 -
YVFVRDFEQPFI VGR3_HUMAN 129 17 -
YVYVQDYRSPFV VGR2_COTJA 112 11 -
YIFVRDFEQPFI P79701 138 17 -
YVFVKDPHHPFV Q8UUW9 117 12 -

Motif 3 width=11
Element Seqn Id St Int Rpt
ITWDSRRGFII O55095 185 47 -
ITWDSRRGFII Q9DAV2 185 47 -
ITWDSRRGFII VGR1_MOUSE 185 47 -
IAWDSRRGFII Q9JJ08 184 47 -
IAWDSRRGFII VEGR_RAT 184 47 -
IIWDSRKGFII Q12954 184 47 -
IIWDSRKGFII VGR1_HUMAN 184 47 -
ISWDSKKGFTI VGR2_HUMAN 177 50 -
VLWDDRRGMRV Q91ZT0 183 42 -
VLWDDRRGMRV Q91ZT1 183 42 -
VLWDDRRGMRV VGR3_MOUSE 183 42 -
ISWDSEIGFTL Q8VCD0 179 50 -
ISWDSEIGFTL VGR2_MOUSE 179 50 -
ISWDSEKGFTI O08775 177 50 -
VVWDDRRGMLV VGR3_HUMAN 183 42 -
ISWDNKKGFTI VGR2_COTJA 172 48 -
IFWDNKKGMQV P79701 192 42 -
VQWDPKKGFTV Q8UUW9 176 47 -

Motif 4 width=13
Element Seqn Id St Int Rpt
LLHGQTLVLNCTA O55095 243 47 -
LLHGQTLVLNCTA Q9DAV2 243 47 -
LLHGQTLVLNCTA VGR1_MOUSE 243 47 -
FLRGQTLVLNCTV Q9JJ08 242 47 -
FLRGQTLVLNCTV VEGR_RAT 242 47 -
LLRGHTLVLNCTA Q12954 242 47 -
LLRGHTLVLNCTA VGR1_HUMAN 242 47 -
LSVGEKLVLNCTA VGR2_HUMAN 236 48 -
LLVGEKLVLNCTV Q91ZT0 242 48 -
LLVGEKLVLNCTV Q91ZT1 242 48 -
LLVGEKLVLNCTV VGR3_MOUSE 242 48 -
LSAGEKLVLNCTA Q8VCD0 238 48 -
LSAGEKLVLNCTA VGR2_MOUSE 238 48 -
LSAGEKLVLNCTA O08775 236 48 -
LLVGEKLVLNCTV VGR3_HUMAN 242 48 -
LAVGEKLVLNCTV VGR2_COTJA 231 48 -
LLVGEKLVLNCTV P79701 251 48 -
VLVGDTLILNCSA Q8UUW9 233 46 -

Motif 5 width=18
Element Seqn Id St Int Rpt
LIIKDVTTEDAGDYTILL O55095 391 135 -
LIIKDVTTEDAGDYTILL Q9DAV2 391 135 -
LIIKDVTTEDAGDYTILL VGR1_MOUSE 391 135 -
LIIKDVTAEDAGDYTILL Q9JJ08 390 135 -
LIIKDVTAEDAGDYTILL VEGR_RAT 390 135 -
LIIKDVTEEDAGNYTILL Q12954 390 135 -
LIIKDVTEEDAGNYTILL VGR1_HUMAN 390 135 -
LTIMEVSERDTGNYTVIL VGR2_HUMAN 383 134 -
LVLKEVTEASAGVYTLAL Q91ZT0 384 129 -
LVLKEVTEASAGVYTLAL Q91ZT1 384 129 -
LVLKEVTEASAGVYTLAL VGR3_MOUSE 384 129 -
LTIMEVTERDAGNYTVIL Q8VCD0 385 134 -
LTIMEVTERDAGNYTVIL VGR2_MOUSE 385 134 -
LTIMEVSERDAGNYTVIL O08775 383 134 -
LVLKEVTEASTGTYTLAL VGR3_HUMAN 384 129 -
LVITEATEKDAGNYTVVL VGR2_COTJA 374 130 -
MQIKDVAEHHAGTYTLVL P79701 392 128 -
LTIKQVRQKDAGIFTIAL Q8UUW9 381 135 -

Motif 6 width=15
Element Seqn Id St Int Rpt
SRQVLTCTVYGIPRP O55095 449 40 -
SRQVLTCTVYGIPRP Q9DAV2 449 40 -
SRQVLTCTVYGIPRP VGR1_MOUSE 449 40 -
SRQVLTCTVYGIPQP Q9JJ08 448 40 -
SRQVLTCTVYGIPQP VEGR_RAT 448 40 -
SRQILTCTAYGIPQP Q12954 448 40 -
SRQILTCTAYGIPQP VGR1_HUMAN 448 40 -
TTQTLTCTVYAIPPP VGR2_HUMAN 439 38 -
SRQTLTCTTYGVPQP Q91ZT0 439 37 -
SRQTLTCTTYGVPQP Q91ZT1 439 37 -
SRQTLTCTAYGVPQP VGR3_MOUSE 439 37 -
TMQTLTCTVYANPPL Q8VCD0 441 38 -
TMQTLTCTVYANPPL VGR2_MOUSE 441 38 -
TMQTLTCTVYANPPL O08775 439 38 -
SRQALTCTAYGVPLP VGR3_HUMAN 439 37 -
STQALTCTIYAVPPP VGR2_COTJA 430 38 -
SPQALTCTVYGIPAP P79701 447 37 -
QRHKLTCTAFGIPMP Q8UUW9 438 39 -