SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR01502

Identifier
UXTPROTEIN  [View Relations]  [View Alignment]  
Accession
PR01502
No. of Motifs
6
Creation Date
30-NOV-2000
Title
Ubiquitously expressed transcript protein signature
Database References
Literature References
1. SCHROER, A., SCHNEIDER, S., ROPERS, H-H. AND NOTHWANG, H.G.
Cloning and characterization of UXT, a novel gene in human Xp11, which is
widely and abundantly expressed in tumour tissue.
GENOMICS 56 340-343 (1999).

Documentation
The human Xp11 region is extremely gene rich and of great interest
biologically due to the large number of disease loci found there. Disease-
related genes found in this regions are involved in Norrie disease,
retinitis pigmentosa, synovial sarcoma, syndromic and nonsyndromic mental
retardation, Renpennning syndrome, Prieto syndrome and Sutherland-Hann
syndrome. A number of oncogenes are also found here.
 
A novel gene was identified in the Xp11 region via exon-trapping
experiments. Northern analysis revealed no apparent splice variants, and
significant expression in all tissues tested. The gene was thus named
ubiquitously expressed transcript (UXT). UXT does not share significant 
sequence similarity with any known genes. However, a search of dbEST 
indicated widespread expression in tumour tissue [1].
 
UXTPROTEIN is a 6-element fingerprint that provides a signature for the
ubiquitously expressed transcript protein. The fingerprint was derived from
an initial alignment of 3 sequences: the motifs were drawn from conserved
regions spanning virtually the full alignment length. A single iteration on
SPTR39_14f was required to reach convergence, no further sequences being
identified beyond the starting set.
Summary Information
3 codes involving  6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
6333333
5000000
4000000
3000000
2000000
123456
True Positives
Q9Y6E5        UXT_HUMAN     UXT_MOUSE     
Sequence Titles
Q9Y6E5      HSPC024-ISO - Homo sapiens (Human).           
UXT_HUMAN UXT PROTEIN (UBIQUITOUSLY EXPRESSED TRANSCRIPT PROTEIN) (HSPC024) - Homo sapiens (Human).
UXT_MOUSE UXT PROTEIN (UBIQUITOUSLY EXPRESSED TRANSCRIPT PROTEIN) - Mus musculus (Mouse).
Scan History
SPTR39_14f 1  80   NSINGLE    
Initial Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
RYETFISDVLQRDLRKVLDHR Q9Y6E5 31 31 -
RYETFISDVLQRDLRKVLDHR UXT_HUMAN 19 19 -
RYETFISDVLQRDLQKVLDHR UXT_MOUSE 19 19 -

Motif 2 width=13
Element Seqn Id St Int Rpt
YLQLRNVIERLQE Q9Y6E5 61 9 -
YLQLRNVIERLQE UXT_HUMAN 49 9 -
YLQLRNVIERLQE UXT_MOUSE 49 9 -

Motif 3 width=14
Element Seqn Id St Int Rpt
SELYMQVDLGCNFF Q9Y6E5 77 3 -
SELYMQVDLGCNFF UXT_HUMAN 65 3 -
SELYMQVDLGCNFF UXT_MOUSE 65 3 -

Motif 4 width=11
Element Seqn Id St Int Rpt
EALKFIDRKSS Q9Y6E5 117 26 -
EALKFIDRKSS UXT_HUMAN 105 26 -
EALKFIDRKSS UXT_MOUSE 105 26 -

Motif 5 width=12
Element Seqn Id St Int Rpt
TKDSMNIKAHIH Q9Y6E5 137 9 -
TKDSMNIKAHIH UXT_HUMAN 125 9 -
TKDSMNIKAHIH UXT_MOUSE 125 9 -

Motif 6 width=14
Element Seqn Id St Int Rpt
EGLRELQGLQNFPE Q9Y6E5 152 3 -
EGLRELQGLQNFPE UXT_HUMAN 140 3 -
EGLRELQGLQNFPE UXT_MOUSE 140 3 -
Final Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
RYETFISDVLQRDLRKVLDHR Q9Y6E5 31 31 -
RYETFISDVLQRDLRKVLDHR UXT_HUMAN 19 19 -
RYETFISDVLQRDLQKVLDHR UXT_MOUSE 19 19 -

Motif 2 width=13
Element Seqn Id St Int Rpt
YLQLRNVIERLQE Q9Y6E5 61 9 -
YLQLRNVIERLQE UXT_HUMAN 49 9 -
YLQLRNVIERLQE UXT_MOUSE 49 9 -

Motif 3 width=14
Element Seqn Id St Int Rpt
SELYMQVDLGCNFF Q9Y6E5 77 3 -
SELYMQVDLGCNFF UXT_HUMAN 65 3 -
SELYMQVDLGCNFF UXT_MOUSE 65 3 -

Motif 4 width=11
Element Seqn Id St Int Rpt
EALKFIDRKSS Q9Y6E5 117 26 -
EALKFIDRKSS UXT_HUMAN 105 26 -
EALKFIDRKSS UXT_MOUSE 105 26 -

Motif 5 width=12
Element Seqn Id St Int Rpt
TKDSMNIKAHIH Q9Y6E5 137 9 -
TKDSMNIKAHIH UXT_HUMAN 125 9 -
TKDSMNIKAHIH UXT_MOUSE 125 9 -

Motif 6 width=14
Element Seqn Id St Int Rpt
EGLRELQGLQNFPE Q9Y6E5 152 3 -
EGLRELQGLQNFPE UXT_HUMAN 140 3 -
EGLRELQGLQNFPE UXT_MOUSE 140 3 -