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PR01157

Identifier
P2YPURNOCPTR  [View Relations]  [View Alignment]  
Accession
PR01157
No. of Motifs
5
Creation Date
14-MAR-1999  (UPDATE 07-DEC-2001)
Title
P2Y purinoceptor signature
Database References
PRINTS; PR90007 7TM; PR90006 GPCRCLAN; PR00237 GPCRRHODOPSN
PRINTS; PR01569 P2Y12PRNCPTR; PR01735 P2Y13PRNCPTR; PR00595 P2Y1PRNOCPTR
PRINTS; PR00594 P2Y2PRNOCPTR; PR01065 P2Y3PRNOCPTR; PR01066 P2Y4PRNOCPTR
PRINTS; PR01068 P2Y6PRNOCPTR
INTERPRO; IPR002286
GCRDB; GCR_1952; GCR_2065; GCR_2085; GCR_1008; GCR_0451; GCR_1412

GCRDB; GCR_0745
Literature References
1. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
 
2. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
G protein-coupled receptor fingerprints.
7TM, VOLUME 2, EDS. G.VRIEND AND B.BYWATER (1993).
 
3. BIRNBAUMER, L.
G proteins in signal transduction.
ANNU.REV.PHARMACOL.TOXICOL. 30 675-705 (1990).
 
4. CASEY, P.J. AND GILMAN, A.G.
G protein involvement in receptor-effector coupling.
J.BIOL.CHEM. 263(6) 2577-2580 (1988).
 
5. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Design of a discriminating fingerprint for G protein-coupled receptors.
PROTEIN ENG. 6(2) 167-176 (1993).
 
6. WATSON, S. AND ARKINSTALL, S.
Adenosine and adenine nucleotides.
IN THE G PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, 1994, PP.19-31.
 
7. COMMUNI, D., JANSSENS, R., SUAREZ-HUERTA, N., ROBAYE, B. AND BOEYNAEMS, J.
Advances in signalling by extracellular nucleotides: the role and 
transduction mechanisms of P2Y receptors.
CELL SIGNAL. 12 351-360 (2000).

Documentation
G protein-coupled receptors (GPCRs) constitute a vast protein family that 
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the 
sequence level, on the basis of which they can be separated into distinct 
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship, 
but between which there is no statistically significant similarity in 
sequence [1]. The currently known clan members include the rhodopsin-like 
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
 
The rhodopsin-like GPCRs themselves represent a widespread protein family 
that includes hormone, neurotransmitter and light receptors, all of
which transduce extracellular signals through interaction with guanine
nucleotide-binding (G) proteins. Although their activating ligands vary 
widely in structure and character, the amino acid sequences of the 
receptors are very similar and are believed to adopt a common structural 
framework comprising 7 transmembrane (TM) helices [3-5]. 
 
In addition to their roles in energy metabolism, extracellular nucleotides 
(such as ATP) can act as signalling molecules to induce a wide variety of 
biological effects. They are released into the extracellular fluid as a 
result of cell lysis, exocytosis of nucleotide-containing granules or by 
efflux through membrane transport proteins, and can function as autocrine 
and paracrine mediators [6,7]. Nucleotides play a role in synaptic 
transmission and in platelet-vessel wall interactions. In neurons of the 
central and peripheral nervous system, ATP is colocalised and cosecreted 
with more traditional neurotransmitters, such as catecholamines and 
acetylcholine, and has excitatory effects [6,7]. ATP is also found in high 
concentrations in the dense granules of platelets, together with ADP. These 
granules also contain lower levels of other nucleotides, such as adenine 
dinucleotides, GTP and UTP [7]. In addition, ADP is released from the 
vascular endothelium following injury and causes activation of platelets [6].
 
Receptors for adenine nucleotides are collectively termed P2 purinoceptors. 
They can be further subdivided into two structural classes: P2X receptors 
are ligand-gated ion channels, while P2Y receptors are G protein-coupled 
receptors. P2Y receptors have also been identified that are selective for 
uridine (rather than adenine) nucleotides [7]. 
 
P2YPURNOCPTR is a 5-element fingerprint that provides a signature for the 
P2Y purinoceptors. The fingerprint was derived from an initial alignment of
18 sequences: the motifs were drawn from conserved sections within either
loop or TM regions, focusing on those areas of the alignment that
characterise the P2Y receptors but distinguish them from the rest of the 
rhodopsin-like superfamily - motif 1 encodes part of TM domain 2, leading 
into the first external loop; motif 2 lies in the first external loop, 
leading into TM domain 3; motif 3 resides at the C-terminus of TM domain 3; 
motif 4 spans the C-terminus of TM domain 5, leading into the third 
cytoplasmic loop; and motif 5 resides in the C-terminal portion of TM domain
6. Two iterations on SPTR40_18f were required to reach convergence, at
which point a true set comprising 28 sequences was identified. Several 
partial matches were also found, all of which are closely related members
of the rhodopsin-like superfamily.
Summary Information
  28 codes involving  5 elements
0 codes involving 4 elements
4 codes involving 3 elements
19 codes involving 2 elements
Composite Feature Index
52828282828
400000
344004
25133314
12345
True Positives
O35811        O43190        O57466        O93361        
P2UR_HUMAN P2UR_MOUSE P2UR_RAT P2Y3_CHICK
P2Y4_HUMAN P2Y6_HUMAN P2Y6_RAT P2Y8_XENLA
P2YR_BOVIN P2YR_CHICK P2YR_HUMAN P2YR_MELGA
P2YR_MOUSE P2YR_RAT Q9BGT8 Q9BYU4
Q9CPV9 Q9CPZ4 Q9DE05 Q9EPX4
Q9ERK9 Q9H170 Q9H244 Q9JJS7
True Positive Partials
Codes involving 3 elements
Q99JA4 Q9JJ71 Q9JK47 Q9Y271
Codes involving 2 elements
CKR1_MACMU GP38_HUMAN GPRH_HUMAN GPRY_HUMAN
GPRY_MOUSE KI01_HUMAN KI01_RAT NY4R_HUMAN
O14626 O75819 P2Y5_CHICK PAR3_HUMAN
Q99MT7 Q9BXC2 Q9BY21 Q9D8I2
Q9ESG6 Q9UE21 TDA8_MOUSE
Sequence Titles
O35811      G-PROTEIN COUPLED RECEPTOR - Rattus norvegicus (Rat). 
O43190 PURINERGIC P2Y11 RECEPTOR - Homo sapiens (Human).
O57466 G PROTEIN COUPLED P2Y NUCLEOTIDE RECEPTOR - Meleagris gallopavo (Common turkey).
O93361 G PROTEIN-COUPLED RECEPTOR P2Y3 - MELEAGRIS GALLOPAVO (COMMON TURKEY).
P2UR_HUMAN P2U purinoceptor 1 (ATP receptor) (P2U1) (Purinergic receptor) - Homo sapiens (Human).
P2UR_MOUSE P2U purinoceptor 1 (ATP receptor) (P2U1) (Purinergic receptor) - Mus musculus (Mouse).
P2UR_RAT P2U purinoceptor 1 (ATP receptor) (P2U1) (Purinergic receptor) - Rattus norvegicus (Rat).
P2Y3_CHICK P2Y PURINOCEPTOR 3 (P2Y3) (NUCLEOSIDE DIPHOSPHATE RECEPTOR) - GALLUS GALLUS (CHICKEN).
P2Y4_HUMAN Uridine nucleotide receptor (UNR) (P2P) (P2Y4) - Homo sapiens (Human).
P2Y6_HUMAN P2Y PURINOCEPTOR 6 (P2Y6) - HOMO SAPIENS (HUMAN).
P2Y6_RAT P2Y PURINOCEPTOR 6 (P2Y6) - RATTUS NORVEGICUS (RAT).
P2Y8_XENLA P2Y purinoceptor 8 (P2Y8) - Xenopus laevis (African clawed frog).
P2YR_BOVIN P2Y PURINOCEPTOR 1 (ATP RECEPTOR) (P2Y1) (PURINERGIC RECEPTOR) - BOS TAURUS (BOVINE).
P2YR_CHICK P2Y PURINOCEPTOR 1 (ATP RECEPTOR) (P2Y1) (PURINERGIC RECEPTOR) - GALLUS GALLUS (CHICKEN).
P2YR_HUMAN P2Y PURINOCEPTOR 1 (ATP RECEPTOR) (P2Y1) (PURINERGIC RECEPTOR) - HOMO SAPIENS (HUMAN).
P2YR_MELGA P2Y PURINOCEPTOR 1 (ATP RECEPTOR) (P2Y1) (PURINERGIC RECEPTOR) (6H1 ORPHAN RECEPTOR) - MELEAGRIS GALLOPAVO (COMMON TURKEY).
P2YR_MOUSE P2Y PURINOCEPTOR 1 (ATP RECEPTOR) (P2Y1) (PURINERGIC RECEPTOR) - MUS MUSCULUS (MOUSE).
P2YR_RAT P2Y PURINOCEPTOR 1 (ATP RECEPTOR) (P2Y1) (PURINERGIC RECEPTOR) - RATTUS NORVEGICUS (RAT).
Q9BGT8 HYPOTHETICAL 39.5 KDA PROTEIN - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
Q9BYU4 P2Y11 RECEPTOR - Homo sapiens (Human).
Q9CPV9 4921504D23RIK PROTEIN (2900079B22RIK PROTEIN) - Mus musculus (Mouse).
Q9CPZ4 PURINERGIC RECEPTOR P2Y, G-PROTEIN COUPLED 2 - Mus musculus (Mouse).
Q9DE05 P2Y RECEPTOR - Raja erinacea (Little skate).
Q9EPX4 P2Y12 PLATELET ADP RECEPTOR - Rattus norvegicus (Rat).
Q9ERK9 P2Y6 RECEPTOR - Mus musculus (Mouse).
Q9H170 SSF1/P2Y11 CHIMERIC PROTEIN - Homo sapiens (Human).
Q9H244 P2Y12 PLATELET ADP RECEPTOR (G-PROTEIN COUPLED RECEPTOR SP1999) - Homo sapiens (Human).
Q9JJS7 P2Y4 RECEPTOR - Mus musculus (Mouse).

Q99JA4 CYSTEINYL LEUKOTRIENE 1 RECEPTOR LONG ISOFORM (CYSTEINYL LEUKOTRIENE D4 RECEPTOR) - Mus musculus (Mouse).
Q9JJ71 CYSLT1 (CYSTEINYL LEUKOTRIENE 1 RECEPTOR SHORT ISOFORM) - Mus musculus (Mouse).
Q9JK47 LEUKOTRIENE D4 RECEPTOR - Mus musculus (Mouse).
Q9Y271 CYSTEINYL LEUKOTRIENE RECEPTOR - Homo sapiens (Human).

CKR1_MACMU C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) - Macaca mulatta (Rhesus macaque).
GP38_HUMAN Putative G protein-coupled receptor GPR38 - Homo sapiens (Human).
GPRH_HUMAN Putative G protein-coupled receptor GPR17 (R12) - Homo sapiens (Human).
GPRY_HUMAN Probable G protein-coupled receptor GPR34 - Homo sapiens (Human).
GPRY_MOUSE Probable G protein-coupled receptor GPR34 - Mus musculus (Mouse).
KI01_HUMAN Probable G protein-coupled receptor KIAA0001 - Homo sapiens (Human).
KI01_RAT Probable G protein-coupled receptor VTR 15-20 - Rattus norvegicus (Rat).
NY4R_HUMAN Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide receptor 1) (PP1) - Homo sapiens (Human).
O14626 PLATELET ACTIVATING RECEPTOR HOMOLOG - HOMO SAPIENS (HUMAN).
O75819 T CELL-DEATH ASSOCIATED PROTEIN - Homo sapiens (Human).
P2Y5_CHICK P2Y purinoceptor 5 (P2Y5) (Purinergic receptor 5) (6H1) - Gallus gallus (Chicken).
PAR3_HUMAN Proteinase-activated receptor 3 precursor (PAR-3) (Thrombin receptor- like 2) (Coagulation factor II receptor-like 2) - Homo sapiens (Human).
Q99MT7 G-PROTEIN COUPLED RECEPTOR GPR87 - Mus musculus (Mouse).
Q9BXC2 PUTATIVE G-PROTEIN-COUPLED RECEPTOR FKSG78 - Homo sapiens (Human).
Q9BY21 ORPHAN G PROTEIN-COUPLED RECEPTOR 87 - Homo sapiens (Human).
Q9D8I2 2010001L06RIK PROTEIN - Mus musculus (Mouse).
Q9ESG6 7 TRANSMEMBRANE G-PROTEIN COUPLED RECEPTOR - Mus musculus (Mouse).
Q9UE21 P2Y-LIKE G-PROTEIN COUPLED RECEPTOR - Homo sapiens (Human).
TDA8_MOUSE Probable G protein-coupled receptor TDAG8 - Mus musculus (Mouse).
Scan History
SPTR37_9f  2  134  NSINGLE    
SPTR40_18f 2 90 NSINGLE
Initial Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
YVLSLPTLIYYY P2Y4_HUMAN 84 84 -
YVLSLPTLVYYY Q9JJS7 80 80 -
YVLTLPALIFYY P2YR_CHICK 89 89 -
YAASLPLLVYYY P2UR_HUMAN 82 82 -
YAASLPLLVYYY P2UR_MOUSE 82 82 -
YAASLPLLVYYY P2UR_RAT 82 82 -
YVLSLPTLVYYY P2Y8_XENLA 92 92 -
YVLTLPALIFYY P2YR_HUMAN 100 100 -
YACSLPLLIYNY P2Y6_RAT 75 75 -
YVFSLPTLVYYY O57466 90 90 -
YACSLPLLIYNY P2Y6_HUMAN 75 75 -
YVLTLPALIFYY P2YR_MOUSE 100 100 -
YVCSLPLLIYNY P2Y3_CHICK 70 70 -
YVCSLPLLIYNY O93361 70 70 -
CALTLPPLAAYL Q9BYU4 78 78 -
MILTFPFKILSD Q9CPV9 79 79 -
MILTFPFKILSD Q9EPX4 79 79 -
MILTFPFKILSD Q9H244 73 73 -

Motif 2 width=18
Element Seqn Id St Int Rpt
CKFVRFLFYWNLYCSVLF P2Y4_HUMAN 108 12 -
CKFVRFLFYWNLYCSVLF Q9JJS7 104 12 -
CKLQRFIFHVNLYGSILF P2YR_CHICK 113 12 -
CKLVRFLFYTNLYCSILF P2UR_HUMAN 106 12 -
CKLVRFLFYTNLYCSILF P2UR_MOUSE 106 12 -
CKLVRFLFYTNLYCSILF P2UR_RAT 106 12 -
CKLVRFLFYANLYSSILF P2Y8_XENLA 116 12 -
CKLQRFIFHVNLYGSILF P2YR_HUMAN 124 12 -
CRLVRFLFYANLHGSILF P2Y6_RAT 99 12 -
CKIVRFLFYANLYSSILF O57466 114 12 -
CRLVRFLFYANLHGSILF P2Y6_HUMAN 99 12 -
CKLQRFIFHVNLYGSILF P2YR_MOUSE 124 12 -
CKFVRFQFYTNLHGSILF P2Y3_CHICK 94 12 -
CKFVRFQFYTNLHGSILF O93361 94 12 -
CRLERFLFTCNLLGSVIF Q9BYU4 102 12 -
CQVTSVTFYFTMYISISF Q9CPV9 103 12 -
CQVTSVTFYFTMYISISF Q9EPX4 103 12 -
CQVTSVIFYFTMYISISF Q9H244 97 12 -

Motif 3 width=11
Element Seqn Id St Int Rpt
HRYLGICHPLR P2Y4_HUMAN 132 6 -
HRYMGICHPLR Q9JJS7 128 6 -
HRYTGVVHPLK P2YR_CHICK 137 6 -
HRCLGVLRPLR P2UR_HUMAN 130 6 -
HRCLGVLRPLH P2UR_MOUSE 130 6 -
HRCLGVLRPLH P2UR_RAT 130 6 -
HRYRGVCHPIT P2Y8_XENLA 140 6 -
HRYSGVVYPLK P2YR_HUMAN 148 6 -
QRYLGICHPLA P2Y6_RAT 123 6 -
HRYMGICHPIR O57466 138 6 -
QRYLGICHPLA P2Y6_HUMAN 123 6 -
HRYSGVVYPLK P2YR_MOUSE 148 6 -
QRYMGICHPLA P2Y3_CHICK 118 6 -
QRYMGICHPLA O93361 118 6 -
NRYLGIVHPFF Q9BYU4 126 6 -
DRYLKTTRPFK Q9CPV9 127 6 -
DRYLKTTRPFK Q9EPX4 127 6 -
DRYQKTTRPFK Q9H244 121 6 -

Motif 4 width=12
Element Seqn Id St Int Rpt
CYGLMARRLYQP P2Y4_HUMAN 219 76 -
CYGLMARRLYRP Q9JJS7 215 76 -
CYGLIVKALIYK P2YR_CHICK 225 77 -
CYVLMARRLLKP P2UR_HUMAN 217 76 -
CYVLMARRLLKP P2UR_MOUSE 217 76 -
CYVLMARRLLKP P2UR_RAT 217 76 -
CYGLMTRELMKP P2Y8_XENLA 227 76 -
CYGLIVRALIYK P2YR_HUMAN 236 77 -
CYCRMARRLCRQ P2Y6_RAT 211 77 -
CYCLMAKRLCKR O57466 225 76 -
CYCLLACRLCRQ P2Y6_HUMAN 211 77 -
CYGLIVKALIYN P2YR_MOUSE 236 77 -
CYCSMARILCQK P2Y3_CHICK 206 77 -
CYCSMARILCQK O93361 206 77 -
AYGALGRAVLRS Q9BYU4 224 87 -
CYSLITKELYRS Q9CPV9 214 76 -
CYSLITKELYRS Q9EPX4 214 76 -
CYTLITKELYRS Q9H244 208 76 -

Motif 5 width=12
Element Seqn Id St Int Rpt
CFVPFHITRTIY P2Y4_HUMAN 257 26 -
CFVPFHITRTIY Q9JJS7 253 26 -
SYLPFHVMKTLN P2YR_CHICK 261 24 -
CFLPFHVTRTLY P2UR_HUMAN 257 28 -
CFLPFHVTRTLY P2UR_MOUSE 257 28 -
CFLPFHVTRTLY P2UR_RAT 256 27 -
CFMPFHITRTLY P2Y8_XENLA 268 29 -
SYIPFHVMKTMN P2YR_HUMAN 272 24 -
SFLPFHITKTAY P2Y6_RAT 251 28 -
CFVPFHITRTLY O57466 266 29 -
SFLPFHITKTAY P2Y6_HUMAN 251 28 -
SYIPFHVMKTMN P2YR_MOUSE 272 24 -
SFFPFHLTKTIY P2Y3_CHICK 246 28 -
SFFPFHLTKTIY O93361 246 28 -
SYVPYHIMRVLN Q9BYU4 260 24 -
CFVPFHFARIPY Q9CPV9 254 28 -
CFVPFHFARIPY Q9EPX4 254 28 -
CFVPFHFARIPY Q9H244 248 28 -
Final Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
YVLSLPTLVYYY O35811 80 80 -
YVLSLPTLIYYY P2Y4_HUMAN 84 84 -
YVLSLPTLVYYY Q9JJS7 80 80 -
YVLTLPALIFYY P2YR_CHICK 89 89 -
YVLTLPALIFYY P2YR_MELGA 89 89 -
YAASLPLLVYYY P2UR_HUMAN 82 82 -
YAASLPLLVYYY P2UR_MOUSE 82 82 -
YAASLPLLVYYY P2UR_RAT 82 82 -
YVLSLPTLVYYY P2Y8_XENLA 92 92 -
YAASLPLLVYYY Q9CPZ4 82 82 -
YVLTLPALIFYY P2YR_BOVIN 100 100 -
YVLTLPALIFYY P2YR_RAT 100 100 -
YVLTLPALIFYY P2YR_HUMAN 100 100 -
YACSLPLLIYNY P2Y6_RAT 75 75 -
YVFSLPTLVYYY O57466 90 90 -
YACSLPLLIYNY Q9ERK9 75 75 -
YACSLPLLIYNY P2Y6_HUMAN 75 75 -
YVLTLPALIFYY P2YR_MOUSE 100 100 -
YVCSLPLLIYNY P2Y3_CHICK 70 70 -
YVCSLPLLIYNY O93361 70 70 -
YVFSLPILIFYY Q9DE05 84 84 -
CALTLPPLAAYL O43190 75 75 -
CALTLPPLAAYL Q9BYU4 78 78 -
CALTLPPLAAYL Q9H170 498 498 -
MILTFPFKILSD Q9CPV9 79 79 -
MILTFPFKILSD Q9EPX4 79 79 -
MILTFPFKILSD Q9BGT8 73 73 -
MILTFPFKILSD Q9H244 73 73 -

Motif 2 width=18
Element Seqn Id St Int Rpt
CKFVRFLFYWNLYCSVLF O35811 104 12 -
CKFVRFLFYWNLYCSVLF P2Y4_HUMAN 108 12 -
CKFVRFLFYWNLYCSVLF Q9JJS7 104 12 -
CKLQRFIFHVNLYGSILF P2YR_CHICK 113 12 -
CKLQRFIFHVNLYGSILF P2YR_MELGA 113 12 -
CKLVRFLFYTNLYCSILF P2UR_HUMAN 106 12 -
CKLVRFLFYTNLYCSILF P2UR_MOUSE 106 12 -
CKLVRFLFYTNLYCSILF P2UR_RAT 106 12 -
CKLVRFLFYANLYSSILF P2Y8_XENLA 116 12 -
CKLVRFLFYTNLYCSILF Q9CPZ4 106 12 -
CKLQRFIFHVNLYGSILF P2YR_BOVIN 124 12 -
CKLQRFIFHVNLYGSILF P2YR_RAT 124 12 -
CKLQRFIFHVNLYGSILF P2YR_HUMAN 124 12 -
CRLVRFLFYANLHGSILF P2Y6_RAT 99 12 -
CKIVRFLFYANLYSSILF O57466 114 12 -
CRFVRFLFYANLHGSILF Q9ERK9 99 12 -
CRLVRFLFYANLHGSILF P2Y6_HUMAN 99 12 -
CKLQRFIFHVNLYGSILF P2YR_MOUSE 124 12 -
CKFVRFQFYTNLHGSILF P2Y3_CHICK 94 12 -
CKFVRFQFYTNLHGSILF O93361 94 12 -
CKLXRFIFHVNLYGSILF Q9DE05 108 12 -
CRLERFLFTCNLLGSVIF O43190 99 12 -
CRLERFLFTCNLLGSVIF Q9BYU4 102 12 -
CRLERFLFTCNLLGSVIF Q9H170 522 12 -
CQVTSVTFYFTMYISISF Q9CPV9 103 12 -
CQVTSVTFYFTMYISISF Q9EPX4 103 12 -
CQVTSVIFYFTMYISISF Q9BGT8 97 12 -
CQVTSVIFYFTMYISISF Q9H244 97 12 -

Motif 3 width=11
Element Seqn Id St Int Rpt
HRYLGICHPLR O35811 128 6 -
HRYLGICHPLR P2Y4_HUMAN 132 6 -
HRYMGICHPLR Q9JJS7 128 6 -
HRYTGVVHPLK P2YR_CHICK 137 6 -
HRYTGVVHPLK P2YR_MELGA 137 6 -
HRCLGVLRPLR P2UR_HUMAN 130 6 -
HRCLGVLRPLH P2UR_MOUSE 130 6 -
HRCLGVLRPLH P2UR_RAT 130 6 -
HRYRGVCHPIT P2Y8_XENLA 140 6 -
HRCLGVLRPLH Q9CPZ4 130 6 -
HRYSGVVYPLK P2YR_BOVIN 148 6 -
HRYSGVVYPLK P2YR_RAT 148 6 -
HRYSGVVYPLK P2YR_HUMAN 148 6 -
QRYLGICHPLA P2Y6_RAT 123 6 -
HRYMGICHPIR O57466 138 6 -
QRYLGICHPLA Q9ERK9 123 6 -
QRYLGICHPLA P2Y6_HUMAN 123 6 -
HRYSGVVYPLK P2YR_MOUSE 148 6 -
QRYMGICHPLA P2Y3_CHICK 118 6 -
QRYMGICHPLA O93361 118 6 -
HRYTGVVHPMK Q9DE05 132 6 -
NRYLGIVHPFF O43190 123 6 -
NRYLGIVHPFF Q9BYU4 126 6 -
NRYLGIVHPFF Q9H170 546 6 -
DRYLKTTRPFK Q9CPV9 127 6 -
DRYLKTTRPFK Q9EPX4 127 6 -
DRYQKTTRPFK Q9BGT8 121 6 -
DRYQKTTRPFK Q9H244 121 6 -

Motif 4 width=12
Element Seqn Id St Int Rpt
CYGLMARRLYRP O35811 215 76 -
CYGLMARRLYQP P2Y4_HUMAN 219 76 -
CYGLMARRLYRP Q9JJS7 215 76 -
CYGLIVKALIYK P2YR_CHICK 225 77 -
CYGLIVKALIYK P2YR_MELGA 225 77 -
CYVLMARRLLKP P2UR_HUMAN 217 76 -
CYVLMARRLLKP P2UR_MOUSE 217 76 -
CYVLMARRLLKP P2UR_RAT 217 76 -
CYGLMTRELMKP P2Y8_XENLA 227 76 -
CYVLMARRLLKP Q9CPZ4 217 76 -
CYGLIVRALIYK P2YR_BOVIN 236 77 -
CYGLIVRALIYK P2YR_RAT 236 77 -
CYGLIVRALIYK P2YR_HUMAN 236 77 -
CYCRMARRLCRQ P2Y6_RAT 211 77 -
CYCLMAKRLCKR O57466 225 76 -
CYCRMARRLCRQ Q9ERK9 211 77 -
CYCLLACRLCRQ P2Y6_HUMAN 211 77 -
CYGLIVKALIYN P2YR_MOUSE 236 77 -
CYCSMARILCQK P2Y3_CHICK 206 77 -
CYCSMARILCQK O93361 206 77 -
CYGFIVKALISN Q9DE05 220 77 -
AYGALGRAVLRS O43190 221 87 -
AYGALGRAVLRS Q9BYU4 224 87 -
AYGALGRAVLRS Q9H170 644 87 -
CYSLITKELYRS Q9CPV9 214 76 -
CYSLITKELYRS Q9EPX4 214 76 -
CYTLITKELYRS Q9BGT8 208 76 -
CYTLITKELYRS Q9H244 208 76 -

Motif 5 width=12
Element Seqn Id St Int Rpt
CFVPFHITRTIY O35811 253 26 -
CFVPFHITRTIY P2Y4_HUMAN 257 26 -
CFVPFHITRTIY Q9JJS7 253 26 -
SYLPFHVMKTLN P2YR_CHICK 261 24 -
SYLPFHVMKTLN P2YR_MELGA 261 24 -
CFLPFHVTRTLY P2UR_HUMAN 257 28 -
CFLPFHVTRTLY P2UR_MOUSE 257 28 -
CFLPFHVTRTLY P2UR_RAT 256 27 -
CFMPFHITRTLY P2Y8_XENLA 268 29 -
CFLPFHLTRTLY Q9CPZ4 257 28 -
SYIPFHVMKTMN P2YR_BOVIN 272 24 -
SYIPFHVMKTMN P2YR_RAT 272 24 -
SYIPFHVMKTMN P2YR_HUMAN 272 24 -
SFLPFHITKTAY P2Y6_RAT 251 28 -
CFVPFHITRTLY O57466 266 29 -
SFLPFHITKTAY Q9ERK9 251 28 -
SFLPFHITKTAY P2Y6_HUMAN 251 28 -
SYIPFHVMKTMN P2YR_MOUSE 272 24 -
SFFPFHLTKTIY P2Y3_CHICK 246 28 -
SFFPFHLTKTIY O93361 246 28 -
SYLPFHVMKNLN Q9DE05 255 23 -
SYVPYHIMRVLN O43190 257 24 -
SYVPYHIMRVLN Q9BYU4 260 24 -
SYVPYHIMRVLN Q9H170 680 24 -
CFVPFHFARIPY Q9CPV9 254 28 -
CFVPFHFARIPY Q9EPX4 254 28 -
CFVPFHFARIPY Q9BGT8 248 28 -
CFVPFHFARIPY Q9H244 248 28 -