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PR01103

Identifier
ADRENERGICR  [View Relations]  [View Alignment]  
Accession
PR01103
No. of Motifs
4
Creation Date
02-APR-1999
Title
Adrenergic receptor signature
Database References
PRINTS; PR90007 7TM; PR90006 GPCRCLAN; PR00237 GPCRRHODOPSN
PRINTS; PR00557 ADRENRGCA1AR; PR00556 ADRENRGCA1BR; PR00240 ADRENRGCA1DR
PRINTS; PR00558 ADRENRGCA2AR; PR00559 ADRENRGCA2BR; PR00560 ADRENRGCA2CR
PRINTS; PR00561 ADRENRGCB1AR; PR00562 ADRENRGCB2AR; PR00563 ADRENRGCB3AR

INTERPRO; IPR002233
GCRDB; GCR_0123; GCR_0395; GCR_0044; GCR_0046; GCR_0048; GCR_0049

GCRDB; GCR_0051
Literature References
1. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
 
2. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
G protein-coupled receptor fingerprints.
7TM, VOLUME 2, EDS. G.VRIEND AND B.BYWATER (1993).
 
3. BIRNBAUMER, L.
G proteins in signal transduction.
ANNU.REV.PHARMACOL.TOXICOL. 30 675-705 (1990).
 
4. CASEY, P.J. AND GILMAN, A.G.
G protein involvement in receptor-effector coupling.
J.BIOL.CHEM. 263(6) 2577-2580 (1988).
 
5. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Design of a discriminating fingerprint for G protein-coupled receptors.
PROTEIN ENG. 6(2) 167-176 (1993).
 
6. WATSON, S. AND ARKINSTALL, S.
Adrenaline and noradrenaline.
IN THE G PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, pp32-54.

Documentation
G protein-coupled receptors (GPCRs) constitute a vast protein family that 
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the 
sequence level, on the basis of which they can be separated into distinct 
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship, 
but between which there is no statistically significant similarity in 
sequence [1]. The currently known clan members include the rhodopsin-like 
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
 
The rhodopsin-like GPCRs themselves represent a widespread protein family 
that includes hormone, neurotransmitter and light receptors, all of
which transduce extracellular signals through interaction with guanine
nucleotide-binding (G) proteins. Although their activating ligands vary 
widely in structure and character, the amino acid sequences of the 
receptors are very similar and are believed to adopt a common structural 
framework comprising 7 transmembrane (TM) helices [3-5]. 
 
In the periphery, the adrenergic system plays an important role in
regulating the cardiovascular system [6]. Increased sympathetic discharge
to the heart increases the rate and force of contraction mediated through 
beta-1 receptors. Circulating adrenaline also acts on cardiac tissue, and, 
in addition, acts both on alpha-1 adrenoceptors in arterial smooth muscle, 
stimulating vasoconstriction, and on beta-2 adrenoceptors in vascular beds 
of skeletal muscle, stimulating vasodilation [6]. In the CNS, noradrenaline 
is thought to be involved in the regulation of mood, and various psycho-
active drugs alter noradrenergic function. Numerous drugs exert their 
actions via adrenoceptors: e.g., beta-2 selective agonists such as 
salbutamol are used in the acute treatment of asthma, while alpha agonists 
prolong the action of local anaesthetics, and act as nasal decongestants [6].
 
Adrenoceptors can be divided into three main classes based on sequence
similarity, receptor pharmacology and signalling mechanisms. Further 
subdivisions exist within each class [6]. A large number of agonists and 
antagonists distinguish between the different classes of adrenoceptor; by
contrast, relatively small differences in agonist and antagonist affinities
are demonstrated, especially within the alpha-1 and alpha-2 adrenoceptor
subtypes [6]. 
 
ADRENERGICR is a 4-element fingerprint that provides a signature for the
adrenergic receptors. The fingerprint was derived from an initial alignment
of 29 sequences: the motifs were drawn from conserved sections spanning
virtually the full alignment length, focusing on those areas that 
characterise the adrenoceptors but distinguish them from the rest of the
rhodopsin-like superfamily - motif 1 lies in the first external loop; motif 
2 resides in the second cytoplasmic loop; motif 3 lies in the C-terminal
portion of TM domain 5, leading into the the third cytoplasmic loop; and 
motif 4 resides at the C-terminus. Four iterations on SPTR37_9f were required
to reach convergence, at which point a true set comprising 59 sequences was
identified. Several partial matches were also found, largely serotonin and 
dopamine receptors that match 2 motifs.
Summary Information
  59 codes involving  4 elements
0 codes involving 3 elements
10 codes involving 2 elements
Composite Feature Index
459595959
30000
22378
1234
True Positives
A1AA_BOVIN    A1AA_HUMAN    A1AA_ORYLA    A1AA_RABIT    
A1AA_RAT A1AB_HUMAN A1AB_MESAU A1AB_MOUSE
A1AB_RAT A1AD_HUMAN A1AD_MOUSE A1AD_RABIT
A1AD_RAT A2AA_CAVPO A2AA_HUMAN A2AA_MOUSE
A2AA_PIG A2AA_RAT A2AB_CAVPO A2AB_HUMAN
A2AB_MOUSE A2AB_RAT A2AC_CAVPO A2AC_DIDMA
A2AC_HUMAN A2AC_MOUSE A2AC_RAT A2AD_HUMAN
A2AR_CARAU A2AR_LABOS B1AR_CANFA B1AR_HUMAN
B1AR_MACMU B1AR_MELGA B1AR_MOUSE B1AR_PIG
B1AR_RAT B1AR_XENLA B2AR_BOVIN B2AR_CANFA
B2AR_HUMAN B2AR_MACMU B2AR_MESAU B2AR_MOUSE
B2AR_PIG B2AR_RAT B3AR_BOVIN B3AR_CANFA
B3AR_HUMAN B3AR_MACMU B3AR_MOUSE B3AR_RAT
B4AR_MELGA O54913 O60451 Q13675
Q13729 Q93126 Q93128
True Positive Partials
Codes involving 2 elements
5H1B_CAVPO 5H1B_SPAEH 5HTB_DROME D1DR_FUGRU
DADR_DIDMA DADR_HUMAN DADR_PIG DADR_XENLA
DOP2_DROME O77408
Sequence Titles
A1AA_BOVIN  ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) - BOS TAURUS (BOVINE). 
A1AA_HUMAN ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) - HOMO SAPIENS (HUMAN).
A1AA_ORYLA ALPHA-1A ADRENERGIC RECEPTOR (MAR1) - ORYZIAS LATIPES (MEDAKA FISH).
A1AA_RABIT ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) - ORYCTOLAGUS CUNICULUS (RABBIT).
A1AA_RAT ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) - RATTUS NORVEGICUS (RAT).
A1AB_HUMAN ALPHA-1B ADRENERGIC RECEPTOR (ALPHA 1B-ADRENOCEPTOR) - HOMO SAPIENS (HUMAN).
A1AB_MESAU ALPHA-1B ADRENERGIC RECEPTOR (ALPHA 1B-ADRENOCEPTOR) - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
A1AB_MOUSE ALPHA-1B ADRENERGIC RECEPTOR (ALPHA 1B-ADRENOCEPTOR) - MUS MUSCULUS (MOUSE).
A1AB_RAT ALPHA-1B ADRENERGIC RECEPTOR (ALPHA 1B-ADRENOCEPTOR) - RATTUS NORVEGICUS (RAT).
A1AD_HUMAN ALPHA-1D ADRENERGIC RECEPTOR (ALPHA 1D-ADRENOCEPTOR) (ALPHA-1A ADRENERGIC RECEPTOR) - HOMO SAPIENS (HUMAN).
A1AD_MOUSE ALPHA-1D ADRENERGIC RECEPTOR (ALPHA 1D-ADRENOCEPTOR) (ALPHA-1A ADRENERGIC RECEPTOR) - MUS MUSCULUS (MOUSE).
A1AD_RABIT ALPHA-1D ADRENERGIC RECEPTOR (ALPHA 1D-ADRENOCEPTOR) - ORYCTOLAGUS CUNICULUS (RABBIT).
A1AD_RAT ALPHA-1D ADRENERGIC RECEPTOR (ALPHA 1D-ADRENOCEPTOR) (ALPHA-1A ADRENERGIC RECEPTOR) (RA42) - RATTUS NORVEGICUS (RAT).
A2AA_CAVPO ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-2AAR) - CAVIA PORCELLUS (GUINEA PIG).
A2AA_HUMAN ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-2AAR SUBTYPE C10) - HOMO SAPIENS (HUMAN).
A2AA_MOUSE ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-2AAR) - MUS MUSCULUS (MOUSE).
A2AA_PIG ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-2AAR) - SUS SCROFA (PIG).
A2AA_RAT ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-2AAR) (CA2-47) (ALPHA-2D ADRENERGIC RECEPTOR) - RATTUS NORVEGICUS (RAT).
A2AB_CAVPO ALPHA-2B ADRENERGIC RECEPTOR (ALPHA-2B ADRENOCEPTOR) - CAVIA PORCELLUS (GUINEA PIG).
A2AB_HUMAN ALPHA-2B ADRENERGIC RECEPTOR (ALPHA-2B ADRENOCEPTOR) (SUBTYPE C2) - HOMO SAPIENS (HUMAN).
A2AB_MOUSE ALPHA-2B ADRENERGIC RECEPTOR (ALPHA-2B ADRENOCEPTOR) - MUS MUSCULUS (MOUSE).
A2AB_RAT ALPHA-2B ADRENERGIC RECEPTOR (ALPHA-2B ADRENOCEPTOR) - RATTUS NORVEGICUS (RAT).
A2AC_CAVPO ALPHA-2C ADRENERGIC RECEPTOR (ALPHA-2C ADRENOCEPTOR) - CAVIA PORCELLUS (GUINEA PIG).
A2AC_DIDMA ALPHA-2C ADRENERGIC RECEPTOR (ALPHA-2C ADRENOCEPTOR) - DIDELPHIS MARSUPIALIS VIRGINIANA (NORTH AMERICAN OPOSSUM).
A2AC_HUMAN ALPHA-2C-1 ADRENERGIC RECEPTOR (ALPHA-2C-1 ADRENOCEPTOR) (SUBTYPE C4) - HOMO SAPIENS (HUMAN).
A2AC_MOUSE ALPHA-2C ADRENERGIC RECEPTOR (ALPHA-2C ADRENOCEPTOR) (SUBTYPE C4) - MUS MUSCULUS (MOUSE).
A2AC_RAT ALPHA-2C ADRENERGIC RECEPTOR (ALPHA-2C ADRENOCEPTOR) (SUBTYPE C4) - RATTUS NORVEGICUS (RAT).
A2AD_HUMAN ALPHA-2C-2 ADRENERGIC RECEPTOR (ALPHA-2C-2 ADRENOCEPTOR) - HOMO SAPIENS (HUMAN).
A2AR_CARAU ALPHA-2 ADRENERGIC RECEPTOR (ALPHA-2 ADRENOCEPTOR) - CARASSIUS AURATUS (GOLDFISH).
A2AR_LABOS ALPHA-2 ADRENERGIC RECEPTOR (ALPHA-2 ADRENOCEPTOR) - LABRUS OSSIFAGUS (CUCKOO WRASSE).
B1AR_CANFA BETA-1 ADRENERGIC RECEPTOR - CANIS FAMILIARIS (DOG).
B1AR_HUMAN BETA-1 ADRENERGIC RECEPTOR - HOMO SAPIENS (HUMAN).
B1AR_MACMU BETA-1 ADRENERGIC RECEPTOR - MACACA MULATTA (RHESUS MACAQUE).
B1AR_MELGA BETA-1 ADRENERGIC RECEPTOR (BETA-T) - MELEAGRIS GALLOPAVO (COMMON TURKEY).
B1AR_MOUSE BETA-1 ADRENERGIC RECEPTOR - MUS MUSCULUS (MOUSE).
B1AR_PIG BETA-1 ADRENERGIC RECEPTOR - SUS SCROFA (PIG).
B1AR_RAT BETA-1 ADRENERGIC RECEPTOR - RATTUS NORVEGICUS (RAT).
B1AR_XENLA BETA-1 ADRENERGIC RECEPTOR (X-BETA1AR) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
B2AR_BOVIN BETA-2 ADRENERGIC RECEPTOR - BOS TAURUS (BOVINE).
B2AR_CANFA BETA-2 ADRENERGIC RECEPTOR - CANIS FAMILIARIS (DOG).
B2AR_HUMAN BETA-2 ADRENERGIC RECEPTOR - HOMO SAPIENS (HUMAN).
B2AR_MACMU BETA-2 ADRENERGIC RECEPTOR - MACACA MULATTA (RHESUS MACAQUE).
B2AR_MESAU BETA-2 ADRENERGIC RECEPTOR - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
B2AR_MOUSE BETA-2 ADRENERGIC RECEPTOR - MUS MUSCULUS (MOUSE).
B2AR_PIG BETA-2 ADRENERGIC RECEPTOR - SUS SCROFA (PIG).
B2AR_RAT BETA-2 ADRENERGIC RECEPTOR - RATTUS NORVEGICUS (RAT).
B3AR_BOVIN BETA-3 ADRENERGIC RECEPTOR - BOS TAURUS (BOVINE).
B3AR_CANFA BETA-3 ADRENERGIC RECEPTOR - CANIS FAMILIARIS (DOG).
B3AR_HUMAN BETA-3 ADRENERGIC RECEPTOR - HOMO SAPIENS (HUMAN).
B3AR_MACMU BETA-3 ADRENERGIC RECEPTOR - MACACA MULATTA (RHESUS MACAQUE).
B3AR_MOUSE BETA-3 ADRENERGIC RECEPTOR - MUS MUSCULUS (MOUSE).
B3AR_RAT BETA-3 ADRENERGIC RECEPTOR - RATTUS NORVEGICUS (RAT).
B4AR_MELGA BETA-4C ADRENERGIC RECEPTOR - MELEAGRIS GALLOPAVO (COMMON TURKEY).
O54913 ALPHA 1A-ADRENERGIC RECEPTOR - MUS MUSCULUS (MOUSE).
O60451 ALPHA 1A ADRENERGIC RECEPTOR ISOFORM 4 - HOMO SAPIENS (HUMAN).
Q13675 ALPHA 1C ADRENERGIC RECEPTOR ISOFORM 2 - HOMO SAPIENS (HUMAN).
Q13729 ALPHA 1C ADRENERGIC RECEPTOR ISOFORM 3 - HOMO SAPIENS (HUMAN).
Q93126 G PROTEIN-COUPLED RECEPTOR - BALANUS AMPHITRITE.
Q93128 G PROTEIN-COUPLED RECEPTOR - BALANUS AMPHITRITE.

5H1B_CAVPO 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR) (5-HT1B RECEPTOR) - CAVIA PORCELLUS (GUINEA PIG).
5H1B_SPAEH 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR) - SPALAX LEUCODON EHRENBERGI (EHRENBERG'S MOLE RAT).
5HTB_DROME 5-HYDROXYTRYPTAMINE RECEPTOR 2B (5-HT RECEPTOR) (SEROTONIN RECEPTOR) - DROSOPHILA MELANOGASTER (FRUIT FLY).
D1DR_FUGRU D(1)-LIKE DOPAMINE RECEPTOR - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
DADR_DIDMA D(1A) DOPAMINE RECEPTOR - DIDELPHIS MARSUPIALIS VIRGINIANA (NORTH AMERICAN OPOSSUM).
DADR_HUMAN D(1A) DOPAMINE RECEPTOR - HOMO SAPIENS (HUMAN).
DADR_PIG D(1A) DOPAMINE RECEPTOR - SUS SCROFA (PIG).
DADR_XENLA D(1A) DOPAMINE RECEPTOR - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
DOP2_DROME DOPAMINE RECEPTOR 2 - DROSOPHILA MELANOGASTER (FRUIT FLY).
O77408 OCTOPAMINE RECEPTOR 1 (OA1) - LYMNAEA STAGNALIS (GREAT POND SNAIL).
Scan History
SPTR37_9f  4  99   NSINGLE    
Initial Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
PFSLANELLGYW A2AB_MOUSE 72 72 -
PFSATLEVLGYW A1AB_MESAU 100 100 -
PFSATLEVLGYW A1AB_RAT 100 100 -
PFSAALEVLGYW A1AB_HUMAN 100 100 -
PFSLANELLGYW A2AB_HUMAN 67 67 -
PFSLANEVMGYW A2AA_RAT 88 88 -
PFSLANEVMGYW A2AA_MOUSE 88 88 -
PFSLANEVMGYW A2AA_HUMAN 88 88 -
PFSAIFEILGYW A1AA_RAT 81 81 -
PFSLANELLGYW A2AB_RAT 72 72 -
PPGATLALTGHW B3AR_MOUSE 89 89 -
PPGATLALTGHW B3AR_RAT 89 89 -
PPGATLALTGHW B3AR_BOVIN 92 92 -
PFSLANELMAYW A2AD_HUMAN 106 106 -
PFSLANELMAYW A2AC_RAT 106 106 -
PFSLANELMAYW A2AC_MOUSE 106 106 -
PFGATIVVWGRW B1AR_MOUSE 113 113 -
PFSLANELMNYW A2AC_DIDMA 91 91 -
PFGATLVVRGTW B1AR_MELGA 96 96 -
PFGATIVVWGRW B1AR_MACMU 113 113 -
PFSLANELMAYW A2AC_HUMAN 106 106 -
PFGATIVVWGRW B1AR_HUMAN 113 113 -
PFGASHILMKMW B2AR_RAT 88 88 -
PFGASHILMKMW B2AR_MOUSE 88 88 -
PFGASHILMKMW B2AR_MESAU 88 88 -
PPAATLALTGHW B3AR_HUMAN 92 92 -
PFGAAHILMKMW B2AR_HUMAN 88 88 -
PFSLANEIMGYW A2AR_CARAU 82 82 -
PPGATILLSGHW B4AR_MELGA 78 78 -

Motif 2 width=9
Element Seqn Id St Int Rpt
YNSKRTPRR A2AB_MOUSE 125 41 -
YPTLVTRRK A1AB_MESAU 153 41 -
YPTLVTRRK A1AB_RAT 153 41 -
YPTLVTRRK A1AB_HUMAN 153 41 -
YNSKRTPRR A2AB_HUMAN 120 41 -
YNLKRTPRR A2AA_RAT 141 41 -
YNLKRTPRR A2AA_MOUSE 141 41 -
YNLKRTPRR A2AA_HUMAN 141 41 -
YPTIVTQRR A1AA_RAT 134 41 -
YNSKRTPCR A2AB_RAT 125 41 -
YGTLVTKRR B3AR_MOUSE 142 41 -
YGTLVTKRR B3AR_RAT 142 41 -
YGALVTKRR B3AR_BOVIN 145 41 -
YNLKRTPRR A2AD_HUMAN 159 41 -
YNLKRTPRR A2AC_RAT 159 41 -
YNLKRTPRR A2AC_MOUSE 159 41 -
YQSLLTRAR B1AR_MOUSE 166 41 -
YNLKRTPRR A2AC_DIDMA 144 41 -
YQSLMTRAR B1AR_MELGA 149 41 -
YQSLLTRAR B1AR_MACMU 166 41 -
YNLKRTPRR A2AC_HUMAN 159 41 -
YQSLLTRAR B1AR_HUMAN 166 41 -
YQSLLTKNK B2AR_RAT 141 41 -
YQSLLTKNK B2AR_MOUSE 141 41 -
YQSLLTKNK B2AR_MESAU 141 41 -
YGALVTKRC B3AR_HUMAN 145 41 -
YQSLLTKNK B2AR_HUMAN 141 41 -
YNLKRTPKR A2AR_CARAU 135 41 -
YEALVTKGR B4AR_MELGA 131 41 -

Motif 3 width=8
Element Seqn Id St Int Rpt
YLRIYVIA A2AB_MOUSE 197 63 -
YCRVYIVA A1AB_MESAU 223 61 -
YCRVYIVA A1AB_RAT 223 61 -
YCRVYIVA A1AB_HUMAN 223 61 -
YLRIYLIA A2AB_HUMAN 192 63 -
YVRIYQIA A2AA_RAT 216 66 -
YVRIYQIA A2AA_MOUSE 216 66 -
YVRIYQIA A2AA_HUMAN 216 66 -
YCRVYVVA A1AA_RAT 204 61 -
YLRIYVIA A2AB_RAT 197 63 -
YARVFVVA B3AR_MOUSE 221 70 -
YARVFVVA B3AR_RAT 221 70 -
YARVFVVA B3AR_BOVIN 224 70 -
YARIYRVA A2AD_HUMAN 230 62 -
YARIYRVA A2AC_RAT 230 62 -
YARIYRVA A2AC_MOUSE 230 62 -
YLRVFREA B1AR_MOUSE 244 69 -
YVRIYRVA A2AC_DIDMA 215 62 -
YLRVYREA B1AR_MELGA 227 69 -
YLRVFREA B1AR_MACMU 244 69 -
YARIYRVA A2AC_HUMAN 230 62 -
YLRVFREA B1AR_HUMAN 244 69 -
YSRVFQVA B2AR_RAT 219 69 -
YSRVFQVA B2AR_MOUSE 219 69 -
YSRVFQVA B2AR_MESAU 219 69 -
YARVFVVA B3AR_HUMAN 224 70 -
YSRVFQEA B2AR_HUMAN 219 69 -
YCKIYRVA A2AR_CARAU 201 57 -
YVRVFAVA B4AR_MELGA 210 70 -

Motif 4 width=10
Element Seqn Id St Int Rpt
DFRRAFRRIL A2AB_MOUSE 437 232 -
EFKRAFMRIL A1AB_MESAU 354 123 -
EFKRAFMRIL A1AB_RAT 354 123 -
EFKRAFVRIL A1AB_HUMAN 354 123 -
DFRRAFRRIL A2AB_HUMAN 432 232 -
DFRRAFKKIL A2AA_RAT 432 208 -
DFRRAFKKIL A2AA_MOUSE 432 208 -
DFRRAFKKIL A2AA_HUMAN 432 208 -
EFKKAFQNVL A1AA_RAT 332 120 -
DFRRAFRRIL A2AB_RAT 435 230 -
DFRDAFRRLL B3AR_MOUSE 348 119 -
DFRDAFRRLL B3AR_RAT 348 119 -
DFRSAFRRLL B3AR_BOVIN 351 119 -
DFRRSFKHIL A2AD_HUMAN 439 201 -
DFRRSFKHIL A2AC_RAT 439 201 -
DFRRSFKHIL A2AC_MOUSE 439 201 -
DFRKAFQRLL B1AR_MOUSE 371 119 -
DFRRSFKHIL A2AC_DIDMA 450 227 -
DFRKAFKRLL B1AR_MELGA 348 113 -
DFRNAFQRLL B1AR_MACMU 385 133 -
DFRPSFKHIL A2AC_HUMAN 442 204 -
DFRKAFQGLL B1AR_HUMAN 382 130 -
DFRIAFQELL B2AR_RAT 331 104 -
DFRIAFQELL B2AR_MOUSE 331 104 -
DFRIAFQELL B2AR_MESAU 331 104 -
DFRSAFRRLL B3AR_HUMAN 351 119 -
DFRIAFQELL B2AR_HUMAN 331 104 -
DFRKAFKKIC A2AR_CARAU 389 180 -
DFRSAFRKLL B4AR_MELGA 319 101 -
Final Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
PFSLANELLGYW A2AB_MOUSE 72 72 -
PFSATLEVLGYW A1AB_MESAU 100 100 -
PFSATLEVLGYW A1AB_RAT 100 100 -
PFSATLEVLGYW A1AB_MOUSE 99 99 -
PFSAALEVLGYW A1AB_HUMAN 100 100 -
PFSAIFEVLGYW A1AA_HUMAN 81 81 -
PFSAIFEVLGYW Q13729 81 81 -
PFSAIFEVLGYW Q13675 81 81 -
PFSAIFEVLGYW O60451 81 81 -
PFSLANELLGYW A2AB_CAVPO 67 67 -
PFSLANELLGYW A2AB_HUMAN 67 67 -
PFSLANEVMGYW A2AA_CAVPO 88 88 -
PFSLANEVMGYW A2AA_RAT 88 88 -
PFSLANEVMGYW A2AA_PIG 88 88 -
PFSLANEVMGYW A2AA_MOUSE 88 88 -
PFSLANEVMGYW A2AA_HUMAN 88 88 -
PFSAIFEILGYW A1AA_RABIT 81 81 -
PFSAIFEILGYW O54913 81 81 -
PFSAIFEILGYW A1AA_RAT 81 81 -
PFSLANELMGYW A2AR_LABOS 87 87 -
PFSLANELLGYW A2AB_RAT 72 72 -
PFSATMEVLGFW A1AD_HUMAN 151 151 -
PFSATMEVLGFW A1AD_RAT 145 145 -
PFSATMEVLGFW A1AD_RABIT 156 156 -
PFSATMEVLGFW A1AD_MOUSE 145 145 -
PPGATLALTGHW B3AR_MOUSE 89 89 -
PPGATLALTGHW B3AR_RAT 89 89 -
PPGATLALTGHW B3AR_BOVIN 92 92 -
PFSLANELMAYW A2AC_CAVPO 102 102 -
PFSLANELMAYW A2AD_HUMAN 106 106 -
PFSLANELMAYW A2AC_RAT 106 106 -
PFSLANELMAYW A2AC_MOUSE 106 106 -
PFGATIVVWGRW B1AR_MOUSE 113 113 -
PFGATIVVWGRW B1AR_RAT 113 113 -
PFSLANELMNYW A2AC_DIDMA 91 91 -
PFGATLVVRGTW B1AR_MELGA 96 96 -
PFSAIFEILDRW A1AA_ORYLA 81 81 -
PFSAIFEILGYW A1AA_BOVIN 81 81 -
PPAATLVLTGHW B3AR_MACMU 92 92 -
PPGATLALTGRW B3AR_CANFA 92 92 -
PFGATIVVWGRW B1AR_MACMU 113 113 -
PFGATIVMRGRW B1AR_CANFA 113 113 -
PFSLANELMAYW A2AC_HUMAN 106 106 -
PFGATIVVWGRW B1AR_HUMAN 113 113 -
PFGATIVVWGRW B1AR_PIG 113 113 -
PFGASHILMKMW B2AR_CANFA 88 88 -
PFGASHILMKMW B2AR_RAT 88 88 -
PFGASHILMKMW B2AR_MOUSE 88 88 -
PFGASHILMKMW B2AR_MESAU 88 88 -
PPAATLALTGHW B3AR_HUMAN 92 92 -
PFGAAHILMKMW B2AR_HUMAN 88 88 -
PFGAAHILMKMW B2AR_MACMU 88 88 -
PLGATLVVSGRW B1AR_XENLA 90 90 -
PFGACHILMKMW B2AR_BOVIN 88 88 -
PFGASHILMKMW B2AR_PIG 88 88 -
PFSLANEIMGYW A2AR_CARAU 82 82 -
PPGATILLSGHW B4AR_MELGA 78 78 -
PFSATLEVLDVW Q93126 88 88 -
PFSATLEVLDVW Q93128 88 88 -

Motif 2 width=9
Element Seqn Id St Int Rpt
YNSKRTPRR A2AB_MOUSE 125 41 -
YPTLVTRRK A1AB_MESAU 153 41 -
YPTLVTRRK A1AB_RAT 153 41 -
YPTLVTRRK A1AB_MOUSE 152 41 -
YPTLVTRRK A1AB_HUMAN 153 41 -
YPTIVTQRR A1AA_HUMAN 134 41 -
YPTIVTQRR Q13729 134 41 -
YPTIVTQRR Q13675 134 41 -
YPTIVTQRR O60451 134 41 -
YNSKRTPRR A2AB_CAVPO 120 41 -
YNSKRTPRR A2AB_HUMAN 120 41 -
YNLKRTPRR A2AA_CAVPO 141 41 -
YNLKRTPRR A2AA_RAT 141 41 -
YNLKRTPRR A2AA_PIG 141 41 -
YNLKRTPRR A2AA_MOUSE 141 41 -
YNLKRTPRR A2AA_HUMAN 141 41 -
YPTIVTQRR A1AA_RABIT 134 41 -
YPTIVTQRR O54913 134 41 -
YPTIVTQRR A1AA_RAT 134 41 -
YNLKRTPKR A2AR_LABOS 140 41 -
YNSKRTPCR A2AB_RAT 125 41 -
YPAIMTERK A1AD_HUMAN 204 41 -
YPAIMTERK A1AD_RAT 198 41 -
YPAIMTERK A1AD_RABIT 209 41 -
YPAIMTERK A1AD_MOUSE 198 41 -
YGTLVTKRR B3AR_MOUSE 142 41 -
YGTLVTKRR B3AR_RAT 142 41 -
YGALVTKRR B3AR_BOVIN 145 41 -
YNLKRTPRR A2AC_CAVPO 155 41 -
YNLKRTPRR A2AD_HUMAN 159 41 -
YNLKRTPRR A2AC_RAT 159 41 -
YNLKRTPRR A2AC_MOUSE 159 41 -
YQSLLTRAR B1AR_MOUSE 166 41 -
YQSLLTRAR B1AR_RAT 166 41 -
YNLKRTPRR A2AC_DIDMA 144 41 -
YQSLMTRAR B1AR_MELGA 149 41 -
YPAIMTKRR A1AA_ORYLA 134 41 -
YPTIVTQKR A1AA_BOVIN 134 41 -
YGALVTKRR B3AR_MACMU 145 41 -
YGALVTKRR B3AR_CANFA 145 41 -
YQSLLTRAR B1AR_MACMU 166 41 -
YQSLLTRAR B1AR_CANFA 166 41 -
YNLKRTPRR A2AC_HUMAN 159 41 -
YQSLLTRAR B1AR_HUMAN 166 41 -
YQSLLTRAA B1AR_PIG 166 41 -
YQSLLTKNK B2AR_CANFA 141 41 -
YQSLLTKNK B2AR_RAT 141 41 -
YQSLLTKNK B2AR_MOUSE 141 41 -
YQSLLTKNK B2AR_MESAU 141 41 -
YGALVTKRC B3AR_HUMAN 145 41 -
YQSLLTKNK B2AR_HUMAN 141 41 -
YQSLLTKNK B2AR_MACMU 141 41 -
YQSLLTKGR B1AR_XENLA 143 41 -
YQCLLTKNK B2AR_BOVIN 141 41 -
YQCLLTKNK B2AR_PIG 141 41 -
YNLKRTPKR A2AR_CARAU 135 41 -
YEALVTKGR B4AR_MELGA 131 41 -
YPSLMSTRR Q93126 141 41 -
YPSLMSTRR Q93128 141 41 -

Motif 3 width=8
Element Seqn Id St Int Rpt
YLRIYVIA A2AB_MOUSE 197 63 -
YCRVYIVA A1AB_MESAU 223 61 -
YCRVYIVA A1AB_RAT 223 61 -
YCRVYIVA A1AB_MOUSE 222 61 -
YCRVYIVA A1AB_HUMAN 223 61 -
YCRVYVVA A1AA_HUMAN 204 61 -
YCRVYVVA Q13729 204 61 -
YCRVYVVA Q13675 204 61 -
YCRVYVVA O60451 204 61 -
YLRIYLIA A2AB_CAVPO 191 62 -
YLRIYLIA A2AB_HUMAN 192 63 -
YVRIYQIA A2AA_CAVPO 215 65 -
YVRIYQIA A2AA_RAT 216 66 -
YVRIYQIA A2AA_PIG 216 66 -
YVRIYQIA A2AA_MOUSE 216 66 -
YVRIYQIA A2AA_HUMAN 216 66 -
YCRVYVVA A1AA_RABIT 204 61 -
YCRVYVVA O54913 204 61 -
YCRVYVVA A1AA_RAT 204 61 -
YIRIYQVA A2AR_LABOS 211 62 -
YLRIYVIA A2AB_RAT 197 63 -
YCRVYVVA A1AD_HUMAN 274 61 -
YCRVYVVA A1AD_RAT 268 61 -
YCRVYVVA A1AD_RABIT 279 61 -
YCRVYVVA A1AD_MOUSE 268 61 -
YARVFVVA B3AR_MOUSE 221 70 -
YARVFVVA B3AR_RAT 221 70 -
YARVFVVA B3AR_BOVIN 224 70 -
YARIYRVA A2AC_CAVPO 226 62 -
YARIYRVA A2AD_HUMAN 230 62 -
YARIYRVA A2AC_RAT 230 62 -
YARIYRVA A2AC_MOUSE 230 62 -
YLRVFREA B1AR_MOUSE 244 69 -
YLRVFREA B1AR_RAT 244 69 -
YVRIYRVA A2AC_DIDMA 215 62 -
YLRVYREA B1AR_MELGA 227 69 -
YCRVYVVA A1AA_ORYLA 204 61 -
YCRVYVVA A1AA_BOVIN 204 61 -
YARVFVVA B3AR_MACMU 224 70 -
YARVFLVA B3AR_CANFA 224 70 -
YLRVFREA B1AR_MACMU 244 69 -
YLRVFREA B1AR_CANFA 244 69 -
YARIYRVA A2AC_HUMAN 230 62 -
YLRVFREA B1AR_HUMAN 244 69 -
YLRVFREA B1AR_PIG 243 68 -
YSRVFQVA B2AR_CANFA 219 69 -
YSRVFQVA B2AR_RAT 219 69 -
YSRVFQVA B2AR_MOUSE 219 69 -
YSRVFQVA B2AR_MESAU 219 69 -
YARVFVVA B3AR_HUMAN 224 70 -
YSRVFQEA B2AR_HUMAN 219 69 -
YSRVFQEA B2AR_MACMU 219 69 -
YIRVFKEA B1AR_XENLA 222 70 -
YSRVFQVA B2AR_BOVIN 219 69 -
YSRVFQVA B2AR_PIG 219 69 -
YCKIYRVA A2AR_CARAU 201 57 -
YVRVFAVA B4AR_MELGA 210 70 -
YGRIYRTA Q93126 220 70 -
YGRIYRTA Q93128 220 70 -

Motif 4 width=10
Element Seqn Id St Int Rpt
DFRRAFRRIL A2AB_MOUSE 437 232 -
EFKRAFMRIL A1AB_MESAU 354 123 -
EFKRAFMRIL A1AB_RAT 354 123 -
EFKRAFMRIL A1AB_MOUSE 353 123 -
EFKRAFVRIL A1AB_HUMAN 354 123 -
EFKKAFQNVL A1AA_HUMAN 332 120 -
EFKKAFQNVL Q13729 332 120 -
EFKKAFQNVL Q13675 332 120 -
EFKKAFQNVL O60451 332 120 -
DFRRAFRRIL A2AB_CAVPO 430 231 -
DFRRAFRRIL A2AB_HUMAN 432 232 -
DFRRAFKKIL A2AA_CAVPO 432 209 -
DFRRAFKKIL A2AA_RAT 432 208 -
DFRRAFKKIL A2AA_PIG 432 208 -
DFRRAFKKIL A2AA_MOUSE 432 208 -
DFRRAFKKIL A2AA_HUMAN 432 208 -
EFKKAFQNVL A1AA_RABIT 332 120 -
EFKKAFQNVL O54913 332 120 -
EFKKAFQNVL A1AA_RAT 332 120 -
DFRRAFQKIL A2AR_LABOS 415 196 -
DFRRAFRRIL A2AB_RAT 435 230 -
EFKRAFLRLL A1AD_HUMAN 408 126 -
EFKRAFLRLL A1AD_RAT 402 126 -
EFKRAFLRLL A1AD_RABIT 413 126 -
EFKRAFLRLL A1AD_MOUSE 402 126 -
DFRDAFRRLL B3AR_MOUSE 348 119 -
DFRDAFRRLL B3AR_RAT 348 119 -
DFRSAFRRLL B3AR_BOVIN 351 119 -
DFRRSFKHIL A2AC_CAVPO 436 202 -
DFRRSFKHIL A2AD_HUMAN 439 201 -
DFRRSFKHIL A2AC_RAT 439 201 -
DFRRSFKHIL A2AC_MOUSE 439 201 -
DFRKAFQRLL B1AR_MOUSE 371 119 -
DFRKAFQRLL B1AR_RAT 371 119 -
DFRRSFKHIL A2AC_DIDMA 450 227 -
DFRKAFKRLL B1AR_MELGA 348 113 -
EFKKAFQSLL A1AA_ORYLA 330 118 -
EFKKAFQNVL A1AA_BOVIN 332 120 -
DFRSAFRRLL B3AR_MACMU 351 119 -
DFRSAFRRLL B3AR_CANFA 351 119 -
DFRNAFQRLL B1AR_MACMU 385 133 -
DFRRAFQRLL B1AR_CANFA 379 127 -
DFRPSFKHIL A2AC_HUMAN 442 204 -
DFRKAFQGLL B1AR_HUMAN 382 130 -
DFRKAFQRLL B1AR_PIG 372 121 -
DFRIAFQELL B2AR_CANFA 331 104 -
DFRIAFQELL B2AR_RAT 331 104 -
DFRIAFQELL B2AR_MOUSE 331 104 -
DFRIAFQELL B2AR_MESAU 331 104 -
DFRSAFRRLL B3AR_HUMAN 351 119 -
DFRIAFQELL B2AR_HUMAN 331 104 -
DFRIAFQELL B2AR_MACMU 331 104 -
DFRKAFKRLL B1AR_XENLA 330 100 -
DFRIAFQELL B2AR_BOVIN 331 104 -
DFRMAFQELL B2AR_PIG 331 104 -
DFRKAFKKIC A2AR_CARAU 389 180 -
DFRSAFRKLL B4AR_MELGA 319 101 -
DFRFAFSSIL Q93126 433 205 -
DFRFAFSSIL Q93128 433 205 -