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PR00676

Identifier
MASPIN  [View Relations]  [View Alignment]  
Accession
PR00676
No. of Motifs
9
Creation Date
07-APR-1997  (UPDATE 07-JUN-1999)
Title
Maspin signature
Database References

PROSITE; PS00284 SERPIN
BLOCKS; BL00284
INTERPRO; IPR000240
Literature References
1. ZOU, Z., ANISOWICZ, A., HENDRIX, M.J., THOR, A., NEVEU, M., SHENG, S.,
RAFIDI, K., SEFTOR, E. AND SAGER, R.
Maspin, a serpin with tumor-suppressing activity in human mammary
epithelial cells.
SCIENCE 263 526-529 (1994).

Documentation
Maspin is a member of the serpin family of protease inhibitors [1]. The
protein is expressed in normal mammary epithelial cells but not in most
mammary carcinoma cell lines. Analysis of human breast cancer specimens
has revealed that loss of maspin expression occurs most frequently in
advanced cancers, supporting the hypothesis that maspin functions as a
tumour suppressor [1]. 
 
MASPIN is a 9-element fingerprint that provides a signature for maspins.
The fingerprint was derived from an initial alignment of 3 sequences: the
motifs were drawn from short conserved regions spanning virtually the
full alignment length. A single iteration on OWL29.2 was required to 
reach convergence, no further sequences being identified beyond the 
starting set.
 
An update on SPTR37_9f identified a true set of 3 sequences.
Summary Information
3 codes involving  9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
9333333333
8000000000
7000000000
6000000000
5000000000
4000000000
3000000000
2000000000
123456789
True Positives
MASP_HUMAN    MASP_MOUSE    MASP_RAT      
Sequence Titles
MASP_HUMAN  MASPIN PRECURSOR (PROTEASE INHIBITOR 5) - HOMO SAPIENS (HUMAN). 
MASP_MOUSE MASPIN PRECURSOR (PROTEASE INHIBITOR 5) - MUS MUSCULUS (MOUSE).
MASP_RAT MASPIN PRECURSOR (PROTEASE INHIBITOR 5) - RATTUS NORVEGICUS (RAT).
Scan History
OWL29_2    1  100  NSINGLE    
SPTR37_9f 2 4 NSINGLE
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
KQLCEKEPLGNVL MASP_HUMAN 17 17 -
KQLCEKEPAGNIL RNU58857 17 17 -
KQLCERDPAGNIL MMU54705 17 17 -

Motif 2 width=12
Element Seqn Id St Int Rpt
ICLSTSLSLAQV MMU54705 33 3 -
ICLSTSLSLAQV MASP_HUMAN 33 3 -
ICLSTSLSLAQV RNU58857 33 3 -

Motif 3 width=10
Element Seqn Id St Int Rpt
DTANEIGQVL MASP_HUMAN 49 4 -
DTANEIGQVL RNU58857 49 4 -
DTANEIGQVL MMU54705 49 4 -

Motif 4 width=16
Element Seqn Id St Int Rpt
KDKLEETKGQINSSIK RNU58857 122 63 -
KDKLEETKGQINSSIK MMU54705 122 63 -
KDKLEETKGQINNSIK MASP_HUMAN 122 63 -

Motif 5 width=15
Element Seqn Id St Int Rpt
HFEDILPENSISDQT RNU58857 143 5 -
HFEDILSENSISDQT MMU54705 143 5 -
HFENILADNSVNDQT MASP_HUMAN 143 5 -

Motif 6 width=14
Element Seqn Id St Int Rpt
KPVQMMNMEATFCM MASP_HUMAN 193 35 -
KPVQMMNLEATFCL RNU58857 193 35 -
KPVQMMNLEATFCL MMU54705 193 35 -

Motif 7 width=13
Element Seqn Id St Int Rpt
PSTMANAKVKLSL MMU54705 261 54 -
PSTMANAKVKLSL RNU58857 261 54 -
PSTMANAKVKLSI MASP_HUMAN 261 54 -

Motif 8 width=19
Element Seqn Id St Int Rpt
PKASLESLGLKSLFNESTS MMU54705 284 10 -
PKASLESLGLKSLFNESTS RNU58857 284 10 -
PKACLENLGLKHIFSEDTS MASP_HUMAN 284 10 -

Motif 9 width=19
Element Seqn Id St Int Rpt
DGGDSIEVPGSRILQHKDE RNU58857 329 26 -
DGGDSIEVPGARILQHKDE MASP_HUMAN 329 26 -
DGGESIEVPGSRILQHKDE MMU54705 329 26 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
KQLCEKEPAGNIL MASP_RAT 17 17 -
KQLCERDPAGNIL MASP_MOUSE 17 17 -
KQLCEKEPLGNVL MASP_HUMAN 17 17 -

Motif 2 width=12
Element Seqn Id St Int Rpt
ICLSTSLSLAQV MASP_RAT 33 3 -
ICLSTSLSLAQV MASP_MOUSE 33 3 -
ICLSTSLSLAQV MASP_HUMAN 33 3 -

Motif 3 width=10
Element Seqn Id St Int Rpt
DTANEIGQVL MASP_RAT 49 4 -
DTANEIGQVL MASP_MOUSE 49 4 -
DTANEIGQVL MASP_HUMAN 49 4 -

Motif 4 width=16
Element Seqn Id St Int Rpt
KDKLEETKGQINSSIK MASP_RAT 122 63 -
KDKLEETKGQINSSIK MASP_MOUSE 122 63 -
KDKLEETKGQINNSIK MASP_HUMAN 122 63 -

Motif 5 width=15
Element Seqn Id St Int Rpt
HFEDILPENSISDQT MASP_RAT 143 5 -
HFEDILSENSISDQT MASP_MOUSE 143 5 -
HFENILADNSVNDQT MASP_HUMAN 143 5 -

Motif 6 width=14
Element Seqn Id St Int Rpt
KPVQMMNLEATFCL MASP_RAT 193 35 -
KPVQMMNLEATFCL MASP_MOUSE 193 35 -
KPVQMMNMEATFCM MASP_HUMAN 193 35 -

Motif 7 width=13
Element Seqn Id St Int Rpt
PSTMANAKVKLSL MASP_RAT 261 54 -
PSTMANAKVKLSL MASP_MOUSE 261 54 -
PSTMANAKVKLSI MASP_HUMAN 261 54 -

Motif 8 width=19
Element Seqn Id St Int Rpt
PKASLESLGLKSLFNESTS MASP_RAT 284 10 -
PKASLESLGLKSLFNESTS MASP_MOUSE 284 10 -
PKACLENLGLKHIFSEDTS MASP_HUMAN 284 10 -

Motif 9 width=19
Element Seqn Id St Int Rpt
DGGDSIEVPGSRILQHKDE MASP_RAT 329 26 -
DGGESIEVPGSRILQHKDE MASP_MOUSE 329 26 -
DGGDSIEVPGARILQHKDE MASP_HUMAN 329 26 -