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PR00386

Identifier
P53SUPPRESSR  [View Relations]  [View Alignment]  
Accession
PR00386
No. of Motifs
6
Creation Date
05-MAY-1995  (UPDATE 07-JUN-1999)
Title
P53 tumour supressor signature
Database References

PROSITE; PS00348 P53
BLOCKS; BL00348
PFAM; PF00870 P53
INTERPRO; IPR002117
PDB; 1OLG; 1OLH
SCOP; 1OLG
Literature References
1. CLORE, G.M., ERNST, J., CLUBB, R., OMICHINSKI, J.G., KENNEDY, W.M.P.,
SAKAGUCHI, K., APPELLA, E. AND GRONENBORN, A.M.
Refined solution structure of the oligomerisation domain of the tumour
suppressor p53.
STRUCT.BIOL. 2(4) 321-333 (1995).
 
2. SOUSSI, T., DEFROMENTEL, C.C. AND MAY, P.
Structural aspects of the P53 protein in relation to gene evolution.
ONCOGENE 5(7) 945-952 (1990).
 
3. CLORE, G.M., OMICHINSKI, J.G., SAKAGUCHI, K., ZAMBRANO, N., SAKAMOTO, H.,
APPELLA, E. AND GRONENBORN, A.M.
High-resolution structure of the oligomerization domain of P53 by
multidimensional NMR. 
SCIENCE 265 346-355 (1996).

Documentation
The tumour suppressor P53 is involved in 50% of all human cancers [1-3].
The protein has been implicated in cell cycle regulation, particularly in
the monitoring of genomic DNA integrity prior to replication; for this
reason it has been dubbed `guardian of the genome'. P53 is a sequence-
specific DNA-binding protein and transcription factor; downstream targets
include the gene for p21, whose product inhibits cyclin-dependent kinase-4,
thereby blocking cell division.
 
The structure of P53 comprises 4 domains: an N-terminal transactivation
domain; a central DNA-binding domain; an oligomerisation domain; and a
C-terminal, basic, regulatory domain [1,3]. The structure of the oligo-
merisation domain consists of a dimer of dimers, each dimer consisting
of 2 anti-parallel alpha-helices and an anti-parallel beta-sheet. The sheets
lie on opposite sides of the tetramer and the helices form an unusual
4-helix bundle [1,3]. While the majority of P53 mutations found in human
cancers are located in the DNA-binding domain, some are also found in
the oligomerisation domain.
 
P53SUPPRESSR is a 6-element fingerprint that provides a signature for p53
tumour suppressor proteins. The fingerprint was derived from an initial
alignment of 9 sequences: the motifs were largely drawn from conserved
regions within the central DNA-binding domain - motif 1 spans loop L1, beta-
hairpin S2 S2' and connecting loop; motif 2 spans strand S4, loop L2 and
helix H1, and includes 2 of the zinc ligands (Cys176 and His179); motif 3
spans strands S7 and S8 and the connecting loop; motif 4, which contains the
remaining 2 zinc ligands (Cys238 and Cys242), spans loop L3 and strand S9,
and includes the region encoded by PROSITE pattern P53 (PS00348), which is
involved in binding the large T antigen of SV40 [2]; motif 5 spans strand
S10, helix H2 and the connecting loop; and motif 6 lies within the oligo-
merisation domain. Two iterations on OWL26.0 were required to reach
convergence, at which point a true set comprising 23 sequences was
identified. A single partial match was also found, a fragment lacking
the final 4 motifs. 
 
An update on SPTR37_9f identified a true set of 36 sequences.
Summary Information
36 codes involving  6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
6363636363636
5000000
4000000
3000000
2000000
123456
True Positives
O15350        O15351        O36006        O57538        
O70366 O75080 O75195 O75922
O76078 O88897 O88898 O88899
O89097 O93379 P53_BOVIN P53_BRARE
P53_CANFA P53_CERAE P53_CHICK P53_CRIGR
P53_FELCA P53_HUMAN P53_MACFA P53_MACMU
P53_MESAU P53_MOUSE P53_ORYLA P53_PLAFE
P53_RABIT P53_RAT P53_SALIR P53_SHEEP
P53_XENLA Q16848 Q27937 Q92143
Sequence Titles
O15350      P53-LIKE TRANSCRIPTION FACTOR (P73 PROTEIN) - HOMO SAPIENS (HUMAN). 
O15351 P73 PROTEIN - HOMO SAPIENS (HUMAN).
O36006 CELLULAR TUMOR ANTIGEN P53 - MARMOTA MONAX (WOODCHUCK).
O57538 CELLULAR TUMOR ANTIGEN P53 - XIPHOPHORUS HELLERI.
O70366 CELLULAR TUMOR ANTIGEN P53 - MUS MUSCULUS (MOUSE).
O75080 P73H - HOMO SAPIENS (HUMAN).
O75195 P51B - HOMO SAPIENS (HUMAN).
O75922 DN P63 GAMMA - HOMO SAPIENS (HUMAN).
O76078 TA P63 GAMMA - HOMO SAPIENS (HUMAN).
O88897 TA*P63 GAMMA - MUS MUSCULUS (MOUSE).
O88898 TA*P63 ALPHA - MUS MUSCULUS (MOUSE).
O88899 DN P63 GAMMA - MUS MUSCULUS (MOUSE).
O89097 DN P63 ALPHA - MUS MUSCULUS (MOUSE).
O93379 CELLULAR TUMOR ANTIGEN P53 - ICTALURUS PUNCTATUS (CHANNEL CATFISH).
P53_BOVIN CELLULAR TUMOR ANTIGEN P53 - BOS TAURUS (BOVINE), AND BOS INDICUS (ZEBU).
P53_BRARE CELLULAR TUMOR ANTIGEN P53 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
P53_CANFA CELLULAR TUMOR ANTIGEN P53 - CANIS FAMILIARIS (DOG).
P53_CERAE CELLULAR TUMOR ANTIGEN P53 - CERCOPITHECUS AETHIOPS (GREEN MONKEY) (GRIVET).
P53_CHICK CELLULAR TUMOR ANTIGEN P53 - GALLUS GALLUS (CHICKEN).
P53_CRIGR CELLULAR TUMOR ANTIGEN P53 - CRICETULUS GRISEUS (CHINESE HAMSTER).
P53_FELCA CELLULAR TUMOR ANTIGEN P53 - FELIS SILVESTRIS CATUS (CAT).
P53_HUMAN CELLULAR TUMOR ANTIGEN P53 (PHOSPHOPROTEIN P53) - HOMO SAPIENS (HUMAN).
P53_MACFA CELLULAR TUMOR ANTIGEN P53 - MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY).
P53_MACMU CELLULAR TUMOR ANTIGEN P53 - MACACA MULATTA (RHESUS MACAQUE).
P53_MESAU CELLULAR TUMOR ANTIGEN P53 - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
P53_MOUSE CELLULAR TUMOR ANTIGEN P53 - MUS MUSCULUS (MOUSE).
P53_ORYLA CELLULAR TUMOR ANTIGEN P53 - ORYZIAS LATIPES (MEDAKA FISH).
P53_PLAFE CELLULAR TUMOR ANTIGEN P53 - PLATICHTHYS FLESUS (EUROPEAN FLOUNDER).
P53_RABIT CELLULAR TUMOR ANTIGEN P53 - ORYCTOLAGUS CUNICULUS (RABBIT).
P53_RAT CELLULAR TUMOR ANTIGEN P53 - RATTUS NORVEGICUS (RAT).
P53_SALIR CELLULAR TUMOR ANTIGEN P53 (TUMOR SUPPRESSING PROTEIN) - SALMO IRIDEUS (RAINBOW TROUT).
P53_SHEEP CELLULAR TUMOR ANTIGEN P53 - OVIS ARIES (SHEEP).
P53_XENLA CELLULAR TUMOR ANTIGEN P53 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q16848 CELLULAR TUMOR ANTIGEN P53 - HOMO SAPIENS (HUMAN).
Q27937 P53 TUMOR SUPPRESSOR HOMOLOG - LOLIGO FORBESI (NORTHERN EUROPEAN SQUID).
Q92143 CELLULAR TUMOR ANTIGEN P53 - XIPHOPHORUS MACULATUS (SOUTHERN PLATYFISH).
Scan History
OWL26_0    2  50   NSINGLE    
OWL28_1 1 50 NSINGLE
SPTR37_9f 2 37 NSINGLE
Initial Motifs
Motif 1  width=27
Element Seqn Id St Int Rpt
SGTAKSVTCTYSPDLNKMFCQLAKTCP P53_CERAE 116 116 -
SGTAKSVTCTYSPPLNKLFCQLAKTCP P53_FELCA 108 108 -
SGTAKSVTCTYSPALNKMFCQLAKTCP P53_HUMAN 116 116 -
SGTAKSVMCTYSISLNKLFCQLAKTCP P53_RAT 114 114 -
SGTAKSVMCTYSPPLNKLFCQLAKTCP P53_MOUSE 113 113 -
SGTAKSVTCTYSPSLNKLFCQLAKTCP P53_MESAU 119 119 -
NGTAKSVTCTYSPELNKLFCQLAKTCP P53_XENLA 90 90 -
SSTAKSVTCTYSPDLNKLFCQLAKTCP P53_SALIR 104 104 -
AGTAKSVTCTYSPVLNKVYCRLAKPCP P53_CHICK 101 101 -

Motif 2 width=22
Element Seqn Id St Int Rpt
RAMAIYKQSQHMTEVVRRCPHH P53_CERAE 158 15 -
RAMAIYKKSEFMTEVVRRCPHH P53_FELCA 150 15 -
RAMAIYKQSQHMTEVVRRCPHH P53_HUMAN 158 15 -
RAMAIYKKSQHMTEVVRRCPHH P53_RAT 156 15 -
RAMAIYKKSQHMTEVVRRCPHH P53_MOUSE 155 15 -
RAMAIYKKLQYMTEVVRRCPHH P53_MESAU 161 15 -
RATAVYKKSEHVAEVVKRCPHH P53_XENLA 132 15 -
RALAIYKKLSDVADVVRRCPHH P53_SALIR 146 15 -
RAVAVYKKSEHVAEVVRRCPHH P53_CHICK 143 15 -

Motif 3 width=22
Element Seqn Id St Int Rpt
RHSVVVPYEPPEVGSDCTTIHY P53_CERAE 213 33 -
RHSVVVPYEPPEVGSDCTTIHY P53_FELCA 206 34 -
RHSVVVPYEPPEVGSDCTTIHY P53_HUMAN 213 33 -
RHSVVVPYEPPEVGSDYTTIHY P53_RAT 211 33 -
RHSVVVPYEPPEAGSEYTTIHY P53_MOUSE 210 33 -
RHSVVVPYEPPEVGSDCTTIHY P53_MESAU 216 33 -
RHSVCVPYEGPQVGTECTTVLY P53_XENLA 188 34 -
RHSVLVPYEPPQVGSECTTVLY P53_SALIR 202 34 -
RHSVVVPYEPPEVGSDCTTVLY P53_CHICK 199 34 -

Motif 4 width=23
Element Seqn Id St Int Rpt
YMCNSSCMGGMNRRPILTIITLE P53_CERAE 236 1 -
FMCNSSCMGGMNRRPIITIITLE P53_FELCA 229 1 -
YMCNSSCMGGMNRRPILTIITLE P53_HUMAN 236 1 -
YMCNSSCMGGMNRRPILTIITLE P53_RAT 234 1 -
YMCNSSCMGGMNRRPILTIITLE P53_MOUSE 233 1 -
YMCNSSCMGGMNRRPILTIITLE P53_MESAU 239 1 -
YMCNSSCMGGMNRRPILTIITLE P53_XENLA 211 1 -
FMCNSSCMGGMNRRPILTIITLE P53_SALIR 225 1 -
FMCNSSCMGGMNRRPILTILTLE P53_CHICK 222 1 -

Motif 5 width=23
Element Seqn Id St Int Rpt
LLGRNSFEVRVCACPGRDRRTEE P53_CERAE 264 5 -
LLGRNSFEVRVCACPGRDRRTEE P53_FELCA 257 5 -
LLGRNSFEVRVCACPGRDRRTEE P53_HUMAN 264 5 -
LLGRDSFEVRVCACPGRDRRTEE P53_RAT 262 5 -
LLGRDSFEVRVCACPGRDRRTEE P53_MOUSE 261 5 -
LLGRNSFEVRICACPGRDRRTEE P53_MESAU 267 5 -
LLGRRCFEVRVCACPGRDRRTEE P53_XENLA 239 5 -
LLGRRSFEVRVCACPGRDRKTEE P53_SALIR 253 5 -
LLGRRCFEVRVCACPGRDRKIEE P53_CHICK 250 5 -

Motif 6 width=25
Element Seqn Id St Int Rpt
EYFTLQIRGRERFEMFRELNEALEL P53_CERAE 326 39 -
EYFTLQIRGRERFEMFRELNEALEL P53_FELCA 319 39 -
EYFTLQIRGRERFEMFRELNEALEL P53_HUMAN 326 39 -
EYFTLKIRGRERFEMFRELNEALEL P53_RAT 324 39 -
EYFTLKIRGRKRFEMFRELNEALEL P53_MOUSE 323 39 -
EYFTLKIRGQERFKMFQELNEALEL P53_MESAU 329 39 -
EIFTLRIKGRSRYEMIKKLNDALEL P53_XENLA 301 39 -
EIYTLQIRGKEKYEMLKKFNDSLEL P53_SALIR 326 50 -
EIFYLQVRGRRRYEMLKEINEALQL P53_CHICK 309 36 -
Final Motifs
Motif 1  width=27
Element Seqn Id St Int Rpt
SGTAKSVTCTYSPSLNKLFCQLAKTCP O36006 114 114 -
SGTAKSVTCTYSPCLNKLFCQLAKTCP P53_RABIT 113 113 -
SGTAKSVTCTYSPDLNKMFCQLAKTCP P53_CERAE 116 116 -
SGTAKSVTCTYSPDLNKMFCQLAKTCP P53_MACFA 116 116 -
SGTAKSVTCTYSPDLNKMFCQLAKTCP P53_MACMU 116 116 -
SGTAKSVTWTYSPLLNKLFCQLAKTCP P53_CANFA 103 103 -
SGTAKSVTCTYSPPLNKLFCQLAKTCP P53_FELCA 108 108 -
SGTAKSVTCTYSPALNKMFCQLAKTCP P53_HUMAN 116 116 -
SGTAKSVTCTYSPALNKMFCQLAKTCP Q16848 116 116 -
SGTAKSVMCTYSISLNKLFCQLAKTCP P53_RAT 114 114 -
SGTAKSVMCTYSPPLNKLFCQLAKTCP O70366 113 113 -
SGTAKSVMCTYSPPLNKLFCQLAKTCP P53_MOUSE 113 113 -
SGTAKSVTCTYSPSLNKLFCQLAKTCP P53_CRIGR 116 116 -
SGTAKSVTCTYSPSLNKLFCQLAKTCP P53_MESAU 119 119 -
SGTAKSVTCTYSPSLNKLFCQLAKTCP P53_SHEEP 104 104 -
SGTAKSVTCTYSPSLNKLFCQLAKTCP P53_BOVIN 108 108 -
SGTAKSVTCTYSPDLNKLFCQLAKTCP P53_BRARE 84 84 -
NGTAKSVTCTYSPELNKLFCQLAKTCP P53_XENLA 90 90 -
SSTAKSVTCTYSPDLNKLFCQLAKTCP P53_SALIR 104 104 -
AGTAKSVTCTYSPVLNKVYCRLAKPCP P53_CHICK 101 101 -
SSTAKSATWTYSTELKKLYCQIAKTCP O75080 90 90 -
SSTAKSATWTYSTELKKLYCQIAKTCP O75195 145 145 -
SSTAKSATWTYSTELKKLYCQIAKTCP O75922 90 90 -
SSTAKSATWTYSTELKKLYCQIAKTCP O76078 145 145 -
SSTAKSATWTYSTELKKLYCQIAKTCP O88897 184 184 -
SSTAKSATWTYSTELKKLYCQIAKTCP O88898 184 184 -
SSTAKSATWTYSTELKKLYCQIAKTCP O88899 90 90 -
SSTAKSATWTYSTELKKLYCQIAKTCP O89097 90 90 -
SSGTKSVTCTYSPDLNKLFCQLAKTCP O93379 91 91 -
SSTAKSATWTYSPLLKKLYCQIAKTCP O15350 134 134 -
SSTAKSATWTYSPLLKKLYCQIAKTCP O15351 134 134 -
SGTAKSVTSTYSVKLGKLFCQLAKTTP Q92143 82 82 -
SGTAKSVTSTYSVKLGKLFCQLAKTTP O57538 82 82 -
SGTAKSVTSTYSETLNKLYCQLAKTSP P53_ORYLA 100 100 -
SGTAKSVTSTFSELLKKLYCQLAKTSP P53_PLAFE 94 94 -
SKETKSTTWTYSEKLDKLYVRMATTCP Q27937 142 142 -

Motif 2 width=22
Element Seqn Id St Int Rpt
RAMAIYKKSQHMTEVVRRCPHH O36006 156 15 -
RAMAIYKKSQHMTEVVRRCPHH P53_RABIT 155 15 -
RAMAIYKQSQHMTEVVRRCPHH P53_CERAE 158 15 -
RAMAIYKQSQHMTEVVRRCPHH P53_MACFA 158 15 -
RAMAIYKQSQHMTEVVRRCPHH P53_MACMU 158 15 -
RAMAIYKKSEFVTEVVRRCPHH P53_CANFA 145 15 -
RAMAIYKKSEFMTEVVRRCPHH P53_FELCA 150 15 -
RAMAIYKQSQHMTEVVRRCPHH P53_HUMAN 158 15 -
RAMAIYKQSQHMTEVVRRCPHH Q16848 158 15 -
RAMAIYKKSQHMTEVVRRCPHH P53_RAT 156 15 -
RAMAIYKKSQHMTEVVRRCPHH O70366 155 15 -
RAMAIYKKSQHMTEVVRRCPHH P53_MOUSE 155 15 -
RAMAIYKKLQYMTEVVRRCPHH P53_CRIGR 158 15 -
RAMAIYKKLQYMTEVVRRCPHH P53_MESAU 161 15 -
RAMAIYKKLEHMTEVVRRSPHH P53_SHEEP 146 15 -
RAMAIYKKLEHMTEVVRRCPHH P53_BOVIN 150 15 -
RATAIYKKSEHVAEVVRRCPHH P53_BRARE 126 15 -
RATAVYKKSEHVAEVVKRCPHH P53_XENLA 132 15 -
RALAIYKKLSDVADVVRRCPHH P53_SALIR 146 15 -
RAVAVYKKSEHVAEVVRRCPHH P53_CHICK 143 15 -
RAMPVYKKAEHVTEVVKRCPNH O75080 132 15 -
RAMPVYKKAEHVTEVVKRCPNH O75195 187 15 -
RAMPVYKKAEHVTEVVKRCPNH O75922 132 15 -
RAMPVYKKAEHVTEVVKRCPNH O76078 187 15 -
RAMPVYKKAEHVTEVVKRCPNH O88897 226 15 -
RAMPVYKKAEHVTEVVKRCPNH O88898 226 15 -
RAMPVYKKAEHVTEVVKRCPNH O88899 132 15 -
RAMPVYKKAEHVTEVVKRCPNH O89097 132 15 -
RATAVYKRSEHVAEVVRRCPHH O93379 133 15 -
RAMPVYKKAEHVTDVVKRCPNH O15350 176 15 -
RAMPVYKKAEHVTDVVKRCPNH O15351 176 15 -
RATAVYKKTEHVGEVVKRCPHH Q92143 124 15 -
RATSVYKKTEHVGEVVKRCPHH O57538 124 15 -
RATAVYKKTEHVADVVRRCPHH P53_ORYLA 142 15 -
RATAVYKKTEHVADVVRRCPHH P53_PLAFE 136 15 -
RAMPIYMKPEHVQEVVKRCPNH Q27937 184 15 -

Motif 3 width=22
Element Seqn Id St Int Rpt
RHSVVVPYEPPEVGSECTTIHY O36006 211 33 -
RHSVVVPYEPPEVGSDCTTIHY P53_RABIT 210 33 -
RHSVVVPYEPPEVGSDCTTIHY P53_CERAE 213 33 -
RHSVVVPYEPPEVGSDCTTIHY P53_MACFA 213 33 -
RHSVVVPYEPPEVGSDCTTIHY P53_MACMU 213 33 -
RHSVVVPYEPPEVGSDYTTIHY P53_CANFA 201 34 -
RHSVVVPYEPPEVGSDCTTIHY P53_FELCA 206 34 -
RHSVVVPYEPPEVGSDCTTIHY P53_HUMAN 213 33 -
RHSVVVPYEPPEVGSDCTTIHY Q16848 213 33 -
RHSVVVPYEPPEVGSDYTTIHY P53_RAT 211 33 -
RHSVVVPYEPPEAGSEYTTIHY O70366 210 33 -
RHSVVVPYEPPEAGSEYTTIHY P53_MOUSE 210 33 -
RHSVVVPYEPPEVGSDCTTIHY P53_CRIGR 213 33 -
RHSVVVPYEPPEVGSDCTTIHY P53_MESAU 216 33 -
RHSVVVPYESPEIESECTTIHY P53_SHEEP 202 34 -
RHSVVVPYESPEIDSECTTIHY P53_BOVIN 206 34 -
RHSVFVPYEAPQLGAEWTTVLL P53_BRARE 181 33 -
RHSVCVPYEGPQVGTECTTVLY P53_XENLA 188 34 -
RHSVLVPYEPPQVGSECTTVLY P53_SALIR 202 34 -
RHSVVVPYEPPEVGSDCTTVLY P53_CHICK 199 34 -
RQSVLVPYEPPQVGTEFTTVLY O75080 189 35 -
RQSVLVPYEPPQVGTEFTTVLY O75195 244 35 -
RQSVLVPYEPPQVGTEFTTVLY O75922 189 35 -
RQSVLVPYEPPQVGTEFTTVLY O76078 244 35 -
RQSVLVPYEPPQVGTEFTTVLY O88897 283 35 -
RQSVLVPYEPPQVGTEFTTVLY O88898 283 35 -
RQSVLVPYEPPQVGTEFTTVLY O88899 189 35 -
RQSVLVPYEPPQVGTEFTTVLY O89097 189 35 -
AHSVVVPYEPPQVGSQSTTVLY O93379 189 34 -
RQSVVVPYEPPQVGTEFTTILY O15350 233 35 -
RQSVVVPYEPPQVGTEFTTILY O15351 233 35 -
RHSVTVPYERPQLGSEMTTILL Q92143 176 30 -
RHSVTVPYERPQLGSEMTTILL O57538 176 30 -
RQSVTVPYEPPQPGSEMTTILL P53_ORYLA 194 30 -
RQSVTVPYEPPQLGSETTAILL P53_PLAFE 188 30 -
RQSVLIPHEMPQAGSEWVVNLY Q27937 239 33 -

Motif 4 width=23
Element Seqn Id St Int Rpt
YMCNSSCMGGMNRRPILTIITLE O36006 234 1 -
YMCNSSCMGGMNRRPILTIITLE P53_RABIT 233 1 -
YMCNSSCMGGMNRRPILTIITLE P53_CERAE 236 1 -
YMCNSSCMGGMNRRPILTIITLE P53_MACFA 236 1 -
YMCNSSCMGGMNRRPILTIITLE P53_MACMU 236 1 -
YMCNSSCMGGMNRRPILTIITLE P53_CANFA 224 1 -
FMCNSSCMGGMNRRPIITIITLE P53_FELCA 229 1 -
YMCNSSCMGGMNRRPILTIITLE P53_HUMAN 236 1 -
YMCNSSCMGGMNRRPILTIITLE Q16848 236 1 -
YMCNSSCMGGMNRRPILTIITLE P53_RAT 234 1 -
YMCNSSCMGGMNRRPILTIITLE O70366 233 1 -
YMCNSSCMGGMNRRPILTIITLE P53_MOUSE 233 1 -
YMCNSSCMGGMNRRPILTIITLE P53_CRIGR 236 1 -
YMCNSSCMGGMNRRPILTIITLE P53_MESAU 239 1 -
FMCNSSCMGGMNRRPILTIITLE P53_SHEEP 225 1 -
FMCNSSCMGGMNRRPILTIITLE P53_BOVIN 229 1 -
YMCNSSCMGGMNRRPILTIITLE P53_BRARE 204 1 -
YMCNSSCMGGMNRRPILTIITLE P53_XENLA 211 1 -
FMCNSSCMGGMNRRPILTIITLE P53_SALIR 225 1 -
FMCNSSCMGGMNRRPILTILTLE P53_CHICK 222 1 -
FMCNSSCVGGMNRRPILIIVTLE O75080 212 1 -
FMCNSSCVGGMNRRPILIIVTLE O75195 267 1 -
FMCNSSCVGGMNRRPILIIVTLE O75922 212 1 -
FMCNSSCVGGMNRRPILIIVTLE O76078 267 1 -
FMCNSSCVGGMNRRPILIIVTLE O88897 306 1 -
FMCNSSCVGGMNRRPILIIVTLE O88898 306 1 -
FMCNSSCVGGMNRRPILIIVTLE O88899 212 1 -
FMCNSSCVGGMNRRPILIIVTLE O89097 212 1 -
YMCNSSCMGGMNRRPILTIITLE O93379 212 1 -
FMCNSSCVGGMNRRPILIIITLE O15350 256 1 -
FMCNSSCVGGMNRRPILIIITLE O15351 256 1 -
FMCNSSCMGGMNRRPILTILTLE Q92143 199 1 -
FMCNSSCMGGMNRRPILTILTLE O57538 199 1 -
YMCNSSCMGGMNRRPILTILTLE P53_ORYLA 217 1 -
FMCNSSCMGGMNRRQILTILTLE P53_PLAFE 211 1 -
FMCLGSCVGGPNRRPIQLVFTLE Q27937 262 1 -

Motif 5 width=23
Element Seqn Id St Int Rpt
LLGRNSFEVRVCACPGRDRRTEE O36006 262 5 -
LLGRNSFEVRVCACPGRDRRTEE P53_RABIT 261 5 -
LLGRNSFEVRVCACPGRDRRTEE P53_CERAE 264 5 -
LLGRNSFEVRVCACPGRDRRTEE P53_MACFA 264 5 -
LLGRNSFEVRVCACPGRDRRTEE P53_MACMU 264 5 -
VLGRNSFEVRVCACPGRDRRTEE P53_CANFA 252 5 -
LLGRNSFEVRVCACPGRDRRTEE P53_FELCA 257 5 -
LLGRNSFEVRVCACPGRDRRTEE P53_HUMAN 264 5 -
LLGRNSFEVRVCACPGRDRRTEE Q16848 264 5 -
LLGRDSFEVRVCACPGRDRRTEE P53_RAT 262 5 -
LLGRDSFEVRVCACPGRDRRTEE O70366 261 5 -
LLGRDSFEVRVCACPGRDRRTEE P53_MOUSE 261 5 -
LLGRNSFEVRICACPGRDRRTEE P53_CRIGR 264 5 -
LLGRNSFEVRICACPGRDRRTEE P53_MESAU 267 5 -
LLGRSSFEVRVCACPGRDRRTEE P53_SHEEP 253 5 -
LLGRNSFEVRVCACPGRDRRTEE P53_BOVIN 257 5 -
LLGRRSFEVRVCACPGRDRKTEE P53_BRARE 232 5 -
LLGRRCFEVRVCACPGRDRRTEE P53_XENLA 239 5 -
LLGRRSFEVRVCACPGRDRKTEE P53_SALIR 253 5 -
LLGRRCFEVRVCACPGRDRKIEE P53_CHICK 250 5 -
VLGRRCFEARICACPGRDRKADE O75080 240 5 -
VLGRRCFEARICACPGRDRKADE O75195 295 5 -
VLGRRCFEARICACPGRDRKADE O75922 240 5 -
VLGRRCFEARICACPGRDRKADE O76078 295 5 -
VLGRRCFEARICACPGRDRKADE O88897 334 5 -
VLGRRCFEARICACPGRDRKADE O88898 334 5 -
VLGRRCFEARICACPGRDRKADE O88899 240 5 -
VLGRRCFEARICACPGRDRKADE O89097 240 5 -
LLGRRTFEVRVCACPGRDRKTEE O93379 240 5 -
VLGRRSFEGRICACPGRDRKADE O15350 284 5 -
VLGRRSFEGRICACPGRDRKADE O15351 284 5 -
VLGRRCFEVRVCACPGRDRKTEE Q92143 227 5 -
VLGRRCFEVRVCACPGRDRKTEE O57538 227 5 -
VLGRRCFEVRICACPGRDRKTEE P53_ORYLA 244 4 -
VLGRRCFEVRVCACPGRDRKTDE P53_PLAFE 239 5 -
VLGRRAVEVRICACPGRDRKADE Q27937 289 4 -

Motif 6 width=25
Element Seqn Id St Int Rpt
EYFTLKIRGRARFEMFQELNEALEL O36006 324 39 -
EYFILKIRGRERFEMFRELNEALEL P53_RABIT 324 40 -
EYFTLQIRGRERFEMFRELNEALEL P53_CERAE 326 39 -
EYFTLQIRGRERFEMFRELNEALEL P53_MACFA 326 39 -
EYFTLQIRGRERFEMFRELNEALEL P53_MACMU 326 39 -
EYFTLQIRGRERYEMFRNLNEALEL P53_CANFA 314 39 -
EYFTLQIRGRERFEMFRELNEALEL P53_FELCA 319 39 -
EYFTLQIRGRERFEMFRELNEALEL P53_HUMAN 326 39 -
EYFTLQIRGRERFEMFRELNEALEL Q16848 326 39 -
EYFTLKIRGRERFEMFRELNEALEL P53_RAT 324 39 -
EYFTLKIRGRKRFEMFRELNEALEL O70366 323 39 -
EYFTLKIRGRKRFEMFRELNEALEL P53_MOUSE 323 39 -
EYFTLKIRGHERFKMFQELNEALEL P53_CRIGR 326 39 -
EYFTLKIRGQERFKMFQELNEALEL P53_MESAU 329 39 -
EYFTLQIRGRKRFEMFRELNEALEL P53_SHEEP 315 39 -
EYFTLQIRGFKRYEMFRELNDALEL P53_BOVIN 319 39 -
EIFTLQVRGRERYEILKKLNDSLEL P53_BRARE 302 47 -
EIFTLRIKGRSRYEMIKKLNDALEL P53_XENLA 301 39 -
EIYTLQIRGKEKYEMLKKFNDSLEL P53_SALIR 326 50 -
EIFYLQVRGRRRYEMLKEINEALQL P53_CHICK 309 36 -
ELLYLPVRGRETYEMLLKIKESLEL O75080 305 42 -
ELLYLPVRGRETYEMLLKIKESLEL O75195 360 42 -
ELLYLPVRGRETYEMLLKIKESLEL O75922 305 42 -
ELLYLPVRGRETYEMLLKIKESLEL O76078 360 42 -
ELLYLPVRGRETYEMLLKIKESLEL O88897 395 38 -
ELLYLPVRGRETYEMLLKIKESLEL O88898 399 42 -
ELLYLPVRGRETYEMLLKIKESLEL O88899 301 38 -
ELLYLPVRGRETYEMLLKIKESLEL O89097 305 42 -
EIYTLQVRGKERYEFLKKINDGLEL O93379 304 41 -
DTYYLQVRGRENFEILMKLKESLEL O15350 353 46 -
DTYYLQVRGRENFEILMKLKESLEL O15351 353 46 -
EIYTLSIRGRNRYLWFKSLNDGLEL Q92143 289 39 -
EIYTLSIRGRNRYLWFKSLNDGLEL O57538 289 39 -
EVFHFEVYGRERYEFLKKINDGLEL P53_ORYLA 302 35 -
EVFTVLVKGRERYEIIKKINEAFEG P53_PLAFE 306 44 -
ECFTLKVRGRENYEILCKLRDIMEL Q27937 351 39 -