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PR00277

Identifier
INSULIN  [View Relations]  [View Alignment]  
Accession
PR00277
No. of Motifs
3
Creation Date
14-APR-1994  (UPDATE 17-APR-2009)
Title
Insulin signature
Database References
PRINTS; PR00276 INSULINFAMLY
PDB; 1A7F; 1AI0; 1AIY; 1APH; 1B9E; 1B9G; 1BEN; 1BPH

PDB; 1BQT; 1CPH
SCOP; 1A7F; 1AI0; 1AIY; 1APH; 1B9E; 1B9G; 1BEN; 1BPH

SCOP; 1BQT; 1CPH
CATH; 1A7F; 1AI0; 1AIY; 1APH; 1B9E; 1B9G; 1BEN; 1BPH

CATH; 1BQT; 1CPH
MIM; 147440; 176730; 608747
Literature References
1. BLUNDELL, T.L. AND HUMBEL, R.E. 
Hormone families: pancreatic hormones and homologous growth factors. 
NATURE 287 781-7 (1980). 
 
2. BELL, G.I., PICTET, R.L., RUTTER, W.J., CORDELL, B., TISCHER, E. AND
GOODMAN, H.M.
Sequence of the human insulin gene.
NATURE 284 26-32 (1980).
 
3. BELL, G.I., SWAIN, W.F., PICTET, R.L., CORDELL, B., GOODMAN, H.M. AND
RUTTER, W.J.
Nucleotide sequence of a cDNA clone encoding human preproinsulin.
NATURE 282 525-527 (1979).
 
4. GARIBAY-TUPAS, J.L., CSISZAR, K., FOX, M., POVEY, S. AND 
BRYANT-GREENWOOD, G.D. 
Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes
and their chromosomal localization on chromosome 9p24.1 by radiation hybrid
and breakpoint mapping. 
J.MOL.ENDOCRINOL. 23 355-365 (1999). 
 
5. GUNNERSEN, J.M., FU, P., ROCHE, P.J. AND TREGEAR, G.W. 
Expression of human relaxin genes: characterization of a novel 
alternatively-spliced human relaxin mRNA species. 
MOL.CELL.ENDOCRINOL. 118 85-94 (1996). 
 
6. KONDO, H., INO, M., SUZUKI, A., ISHIZAKI, H. AND IWAMI, M. 
Multiple gene copies for bombyxin, an insulin-related peptide of the 
silkmoth Bombyx mori: structural signs for gene rearrangement and 
duplication responsible for generation of multiple molecular forms of
bombyxin. 
J.MOL.BIOL. 259 926-937 (1996). 
 
7. COOKE, R.M., HARVEY, T.S. AND CAMPBELL, I.D. 
Solution structure of human insulin-like growth factor 1: a nuclear magnetic 
resonance and restrained molecular dynamics study. 
BIOCHEMISTRY 30 5484-5491 (1991). 
 
8. SATO, A., NISHIMURA, S., OHKUBO, T., KYOGOKU, Y., KOYAMA, S.,
KOBAYASHI, M., YASUDA, T. AND KOBAYASHI, Y. 
1H-NMR assignment and secondary structure of human insulin-like growth
factor-I (IGF-I) in solution. 
J.BIOCHEM. 111 529-536 (1992). 
 
9. BRANGE, J., DODSON, G.G., EDWARDS, D.J., HOLDEN, P.H. AND
WHITTINGHAM, J.L. 
A model of insulin fibrils derived from the X-ray crystal structure of a 
monomeric insulin (despentapeptide insulin). 
PROTEINS 27 507-516 (1997). 

Documentation
The insulin family of proteins groups together several evolutionarily
related active peptides [1]: these include insulin [2,3], relaxin [4,5],
insect prothoracicotropic hormone (bombyxin) [6], insulin-like growth
factors (IGF1 and IGF2) [7,8], mammalian Leydig cell-specific insulin-like
peptide (gene INSL3), early placenta insulin-like peptide (ELIP) (gene
INSL4), locust insulin-related peptide (LIRP), molluscan insulin-related
peptides (MIP), and Caenorhabditis elegans insulin-like peptides. The 3D
structures of a number of family members have been determined [7-9]. The
fold comprises two polypeptide chains (A and B) linked by two disulphide
bonds: all share a conserved arrangement of 4 cysteines in their A chain,
the first of which is linked by a disulphide bond to the third, while the
second and fourth are linked by interchain disulphide bonds to cysteines
in the B chain.
 
Insulin is found in many animals, and is involved in the regulation of
normal glucose homeostasis. It also has other specific physiological 
effects, such as increasing the permeability of cells to monosaccharides,
amino acids and fatty acids, and accelerating glycolysis and glycogen
synthesis in the liver [2]. Insulin exerts its effects by interaction with
a cell-surface receptor, which may also result in the promotion of cell
growth [2].
 
Insulin is synthesised as a prepropeptide from which an endoplasmic 
reticulum-targeting sequence is cleaved to yield proinsulin. The sequence
of prosinsulin contains 2 well-conserved regions (designated A and B), 
separated by an intervening connecting region (C), which is variable
between species [3]. The connecting region is cleaved, liberating the
active protein, which contains the A and B chains, held together by 2
disulphide bonds [3]. 
 
INSULIN is a 3-element fingerprint that provides a signature for insulins.
The fingerprint was derived from an initial alignment of 28 sequences: the 
motifs were drawn from conserved regions spanning virtually the full
alignment length, focusing on those sections that characterise insulins but
distinguish them from closely related members of the insulin family. Three
iterations on SPTR55_38f were required to reach convergence, at which point 
a true set comprising 105 sequences was identified. Four partial matches
were also found, all of which are insulins that fail to make signficant 
matches with motifs 2 or 3.
Summary Information
 105 codes involving  3 elements
4 codes involving 2 elements
Composite Feature Index
3105105105
2431
123
True Positives
A0ELY2_9MURI  A0ELY3_APOSM  A0ELY4_MUSCR  A0ELY5_9MURI  
A0ELY6_9MURI A0ELY7_APOSM A0ELY8_MUSCR A0ELY9_9MURI
A0ELZ0_MERUN A0ELZ1_VOLKI A3RID6_ONCMY A3RID7_ONCMY
A4IGV9_XENTR A5PF52_DANRE A5PJB2_BOVIN A6XGL2_HUMAN
INS1_BATSP INS1_MOUSE INS1_RAT INS1_XENLA
INS2_BATSP INS2_MOUSE INS2_RAT INS2_THUTH
INS2_XENLA INS_ACIGU INS_ACOCA INS_ALLMI
INS_AMICA INS_ANAPL INS_ANGRO INS_ANSAN
INS_AOTTR INS_BALBO INS_BALPH INS_BOVIN
INS_CAIMO INS_CALMI INS_CAMDR INS_CANFA
INS_CAPHI INS_CAVPO INS_CERAE INS_CHIBR
INS_CHICK INS_CHIMO INS_CHRDO INS_CRILO
INS_CROAT INS_CYPCA INS_DIDMA INS_ELEMA
INS_FELCA INS_GADCA INS_GORGO INS_HORSE
INS_HUMAN INS_HYDCO INS_HYSCR INS_LAMFL
INS_LEPSP INS_LOPAM INS_LOPPI INS_MACFA
INS_MELGA INS_MYOCO INS_MYOSC INS_OCTDE
INS_ONCGO INS_ONCKE INS_ONCKI INS_ORENI
INS_ORNAN INS_PANBU INS_PANTR INS_PETMA
INS_PHYCA INS_PIAME INS_PIG INS_PLAFE
INS_POLSE INS_PONPY INS_PROGU INS_PSAOB
INS_RABIT INS_SAISC INS_SHEEP INS_SPETR
INS_SQUAC INS_STRCA INS_TRASC INS_VERMO
INS_ZAODH O73727 Q18NR0_SERDU Q2IDG8_MUSSP
Q2QAJ9_DANRE Q545I7_MOUSE Q5EEX1_MOUSE Q7LZM9_9SALA
Q7LZN0_POLSP Q7M0G1_CRISP Q90ZN4_9TELE Q9DDE5_DANRE
Q9I8Q7_RANPI
True Positive Partials
Codes involving 2 elements
A6NE30_HUMAN INS_KATPE Q18NR1_SERDU Q1WM24_HUMAN
Sequence Titles
A0ELY2_9MURI Preproinsulin 1 - Rattus losea (lesser rice-field rat). 
A0ELY3_APOSM Preproinsulin 1 - Apodemus semotus (Taiwan field mouse) (Formosan wood mouse).
A0ELY4_MUSCR Preproinsulin 1 - Mus caroli (Wild mouse) (Ricefield mouse).
A0ELY5_9MURI Preproinsulin 1 - Niviventer coxingi (Coxing's white-bellied rat).
A0ELY6_9MURI Preproinsulin 2 - Rattus losea (lesser rice-field rat).
A0ELY7_APOSM Preproinsulin 2 - Apodemus semotus (Taiwan field mouse) (Formosan wood mouse).
A0ELY8_MUSCR Preproinsulin 2 - Mus caroli (Wild mouse) (Ricefield mouse).
A0ELY9_9MURI Preproinsulin 2 - Niviventer coxingi (Coxing's white-bellied rat).
A0ELZ0_MERUN Preproinsulin - Meriones unguiculatus (Mongolian jird) (Mongolian gerbil).
A0ELZ1_VOLKI Preproinsulin - Volemys kikuchii (Taiwanese vole) (Microtus kikuchii).
A3RID6_ONCMY Preproinsulin 1 - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
A3RID7_ONCMY Preproinsulin 2 - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
A4IGV9_XENTR Ins protein - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
A5PF52_DANRE Preproinsulin - Danio rerio (Zebrafish) (Brachydanio rerio).
A5PJB2_BOVIN INS protein - Bos taurus (Bovine).
A6XGL2_HUMAN Insulin (Uncharacterized protein INS) - Homo sapiens (Human).
INS1_BATSP Insulin-1 - Batrachoididae sp. (Toadfish).
INS1_MOUSE Insulin-1 precursor [Contains: Insulin-1 B chain; Insulin-1 A chain] - Mus musculus (Mouse).
INS1_RAT Insulin-1 precursor [Contains: Insulin-1 B chain; Insulin-1 A chain] - Rattus norvegicus (Rat).
INS1_XENLA Insulin-1 precursor [Contains: Insulin-1 B chain; Insulin-1 A chain] - Xenopus laevis (African clawed frog).
INS2_BATSP Insulin 2 [Contains: Insulin B chain; Insulin A chain] - Batrachoididae sp. (Toadfish).
INS2_MOUSE Insulin-2 precursor [Contains: Insulin-2 B chain; Insulin-2 A chain] - Mus musculus (Mouse).
INS2_RAT Insulin-2 precursor [Contains: Insulin-2 B chain; Insulin-2 A chain] - Rattus norvegicus (Rat).
INS2_THUTH INSULIN 2 - THUNNUS THYNNUS (BLUEFIN TUNA).
INS2_XENLA Insulin-2 precursor [Contains: Insulin-2 B chain; Insulin-2 A chain] - Xenopus laevis (African clawed frog).
INS_ACIGU Insulin [Contains: Insulin B chain; Insulin A chain] - Acipenser guldenstadti (Caspian sturgeon) (Russian sturgeon).
INS_ACOCA Insulin [Contains: Insulin B chain; Insulin A chain] - Acomys cahirinus (Egyptian spiny mouse).
INS_ALLMI Insulin [Contains: Insulin B chain; Insulin A chain] - Alligator mississippiensis (American alligator).
INS_AMICA Insulin [Contains: Insulin B chain; Insulin A chain] - Amia calva (Bowfin).
INS_ANAPL Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Anas platyrhynchos (Domestic duck).
INS_ANGRO Insulin [Contains: Insulin B chain; Insulin A chain] - Anguilla rostrata (American eel).
INS_ANSAN Insulin [Contains: Insulin B chain; Insulin A chain] - Anser anser anser (Western graylag goose).
INS_AOTTR Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Aotus trivirgatus (Night monkey) (Douroucouli).
INS_BALBO Insulin [Contains: Insulin B chain; Insulin A chain] - Balaenoptera borealis (Sei whale) (Pollack whale).
INS_BALPH Insulin [Contains: Insulin B chain; Insulin A chain] - Balaenoptera physalus (Finback whale) (Common rorqual).
INS_BOVIN Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Bos taurus (Bovine).
INS_CAIMO Insulin [Contains: Insulin B chain; Insulin A chain] - Cairina moschata (Muscovy duck).
INS_CALMI Insulin [Contains: Insulin B chain; Insulin A chain] - Callorhynchus milii (Elephant fish) (Australian ghost shark).
INS_CAMDR Insulin [Contains: Insulin B chain; Insulin A chain] - Camelus dromedarius (Dromedary) (Arabian camel).
INS_CANFA Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Canis familiaris (Dog).
INS_CAPHI Insulin [Contains: Insulin B chain; Insulin A chain] - Capra hircus (Goat).
INS_CAVPO Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Cavia porcellus (Guinea pig).
INS_CERAE Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Cercopithecus aethiops (Green monkey) (Grivet).
INS_CHIBR Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Chinchilla brevicaudata (Chinchilla).
INS_CHICK Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Gallus gallus (Chicken).
INS_CHIMO Insulin [Contains: Insulin B chain; Insulin A chain] - Chimaera monstrosa (Rabbit fish).
INS_CHRDO Insulin [Contains: Insulin B chain; Insulin A chain] - Chrysemys dorbigni (Black-bellied slider turtle) (Trachemys dorbigni).
INS_CRILO Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Cricetulus longicaudatus (Long-tailed hamster) (Chinese hamster).
INS_CROAT Insulin [Contains: Insulin B chain; Insulin A chain] - Crotalus atrox (Western diamondback rattlesnake).
INS_CYPCA Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Cyprinus carpio (Common carp).
INS_DIDMA Insulin [Contains: Insulin B chain; Insulin A chain] - Didelphis marsupialis virginiana (North American opossum).
INS_ELEMA Insulin [Contains: Insulin B chain; Insulin A chain] - Elephas maximus (Indian elephant).
INS_FELCA Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Felis silvestris catus (Cat).
INS_GADCA Insulin [Contains: Insulin B chain; Insulin A chain] - Gadus callarias (Baltic cod).
INS_GORGO Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Gorilla gorilla gorilla (Lowland gorilla).
INS_HORSE Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Equus caballus (Horse).
INS_HUMAN Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Homo sapiens (Human).
INS_HYDCO Insulin [Contains: Insulin B chain; Insulin A chain] - Hydrolagus colliei (Spotted ratfish) (Pacific ratfish).
INS_HYSCR Insulin [Contains: Insulin B chain; Insulin A chain] - Hystrix cristata (Crested porcupine).
INS_LAMFL Insulin [Contains: Insulin B chain; Insulin A chain] - Lampetra fluviatilis (River lamprey).
INS_LEPSP Insulin [Contains: Insulin B chain; Insulin A chain] - Lepisosteus spatula (Alligator gar) (Atractosteus spatula).
INS_LOPAM Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Lophius americanus (American goosefish) (Anglerfish).
INS_LOPPI Insulin [Contains: Insulin B chain; Insulin A chain] - Lophius piscatorius (Allmouth goosefish) (Anglerfish).
INS_MACFA Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
INS_MELGA Insulin [Contains: Insulin B chain; Insulin A chain] - Meleagris gallopavo (Common turkey).
INS_MYOCO Insulin [Contains: Insulin B chain; Insulin A chain] - Myocastor coypus (Coypu) (Nutria).
INS_MYOSC Insulin [Contains: Insulin B chain; Insulin A chain] - Myoxocephalus scorpius (Shorthorn sculpin) (Daddy sculpin).
INS_OCTDE Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Octodon degus (Degu).
INS_ONCGO Insulin [Contains: Insulin B chain; Insulin A chain] - Oncorhynchus gorbuscha (Pink salmon) (Humpback salmon).
INS_ONCKE Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Oncorhynchus keta (Chum salmon).
INS_ONCKI Insulin [Contains: Insulin B chain; Insulin A chain] - Oncorhynchus kisutch (Coho salmon).
INS_ORENI Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
INS_ORNAN Insulin [Contains: Insulin B chain; Insulin A chain] - Ornithorhynchus anatinus (Duckbill platypus).
INS_PANBU Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Pantodon buchholtzi (Butterflyfish).
INS_PANTR Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Pan troglodytes (Chimpanzee).
INS_PETMA Insulin [Contains: Insulin B chain; Insulin A chain] - Petromyzon marinus (Sea lamprey).
INS_PHYCA Insulin [Contains: Insulin B chain; Insulin A chain] - Physeter catodon (Sperm whale) (Physeter macrocephalus).
INS_PIAME Insulin [Contains: Insulin B chain; Insulin A chain] - Piaractus mesopotamicus (Pacu).
INS_PIG Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Sus scrofa (Pig).
INS_PLAFE Insulin [Contains: Insulin B chain; Insulin A chain] - Platichthys flesus (European flounder).
INS_POLSE Insulin [Contains: Insulin B chain; Insulin A chain] - Polypterus senegalus (Senegal bichir).
INS_PONPY Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Pongo pygmaeus (Orangutan).
INS_PROGU Insulin [Contains: Insulin B chain; Insulin A chain] - Proechimys guairae (Casiragua).
INS_PSAOB Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Psammomys obesus (Fat sand rat).
INS_RABIT Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Oryctolagus cuniculus (Rabbit).
INS_SAISC Insulin [Contains: Insulin B chain; Insulin A chain] - Saimiri sciureus (Common squirrel monkey).
INS_SHEEP Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Ovis aries (Sheep).
INS_SPETR Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Spermophilus tridecemlineatus (Thirteen-lined ground squirrel).
INS_SQUAC Insulin [Contains: Insulin B chain; Insulin A chain] - Squalus acanthias (Spiny dogfish).
INS_STRCA Insulin [Contains: Insulin B chain; Insulin A chain] - Struthio camelus (Ostrich).
INS_TRASC Insulin [Contains: Insulin B chain; Insulin A chain] - Trachemys scripta (Red-eared slider turtle) (Pseudemys scripta).
INS_VERMO Insulin precursor [Contains: Insulin B chain; Insulin A chain] - Verasper moseri (Barfin flounder).
INS_ZAODH Insulin [Contains: Insulin B chain; Insulin A chain] - Zaocys dhumnades (Cantor).
O73727 PREPROINSULIN PRECURSOR - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
Q18NR0_SERDU Insulin - Seriola dumerili (Mediterranean greater amberjack).
Q2IDG8_MUSSP Insulin II - Mus spretus (Western wild mouse).
Q2QAJ9_DANRE Preproinsulin 2 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q545I7_MOUSE Adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010109C03 product:INSULIN 1 homolog (Insulin I) (Insulin 1) (Adult pancreas islet cells cDNA, RIKEN full-length enriched library, clone:C820020F18 product:insulin I, full insert sequence) (10 day old male pancreas cDNA, RIKEN full-length enriched library, clone:1810005L03 product:INSULIN 1, full insert sequence) - Mus musculus (Mouse).
Q5EEX1_MOUSE Proinsulin (Insulin II) (10 day old male pancreas cDNA, RIKEN full- length enriched library, clone:1810027C14 product:INSULIN 2, full insert sequence) - Mus musculus (Mouse).
Q7LZM9_9SALA Insulin - Amphiuma tridactylum (three-toed salamander).
Q7LZN0_POLSP Insulin I1 - Polyodon spathula (North American paddlefish).
Q7M0G1_CRISP Insulin - Cricetidae sp. (Hamster).
Q90ZN4_9TELE Preproinsulin - Catla catla (catla).
Q9DDE5_DANRE Insulin precursor - Danio rerio (Zebrafish) (Brachydanio rerio).
Q9I8Q7_RANPI Preproinsulin - Rana pipiens (Northern leopard frog).

A6NE30_HUMAN Uncharacterized protein INS - Homo sapiens (Human).
INS_KATPE Insulin [Contains: Insulin B chain; Insulin A chain] - Katsuwonus pelamis (Skipjack tuna) (Bonito).
Q18NR1_SERDU Insulin - Seriola dumerili (Mediterranean greater amberjack).
Q1WM24_HUMAN INSIGF long transcript variant (INSIGF short transcript variant) - Homo sapiens (Human).
Scan History
SPTR55_38f 3  600  NSINGLE    
Initial Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
FVKQHLCGSHLV INS2_RAT 25 25 -
FVKQHLCGSHLV INS2_MOUSE 25 25 -
AANQHLCGSHLV INS_CAIMO 1 1 -
AANQHLCGSHLV INS_ANSAN 1 1 -
AANQHLCGSHLV INS_ACIGU 1 1 -
FVNQHLCGSHLV INS_FELCA 25 25 -
FVKQHLCGPHLV INS1_RAT 25 25 -
FVKQHLCGPHLV INS1_MOUSE 25 25 -
LANQHLCGSHLV INS2_XENLA 24 24 -
FVNQHLCGPHLV INS_AOTTR 25 25 -
AANQRLCGSHLV INS_ALLMI 1 1 -
LVNQHLCGSHLV INS1_XENLA 24 24 -
ASTQHLCGSHLV INS_ANGRO 1 1 -
APPQHLCGSHLV INS_GADCA 2 2 -
APPQHLCGSHLV INS1_BATSP 2 2 -
APPQHLCGSHLV INS2_BATSP 2 2 -
AASQHLCGSHLV INS_AMICA 1 1 -
VPTQRLCGSHLV INS_CALMI 1 1 -
FVSRHLCGSNLV INS_CAVPO 25 25 -
FVNQHLCGSHLV INS_HUMAN 25 25 -
FVNQHLCGSHLV INS_GORGO 25 25 -
FVNQHLCGSHLV INS_CERAE 25 25 -
FVNQHLCGSHLV INS_CAPHI 1 1 -
FVNQHLCGSHLV INS_CANFA 25 25 -
FVNQHLCGSHLV INS_BOVIN 25 25 -
FVNQHLCGSHLV INS_BALPH 1 1 -
FVNQHLCGSHLV INS_BALBO 1 1 -
FANQHLCGSHLV INS_CAMDR 1 1 -

Motif 2 width=7
Element Seqn Id St Int Rpt
DALYLVC INS_ALLMI 13 0 -
EALYLVC INS2_MOUSE 37 0 -
EALYLVC INS_CAIMO 13 0 -
EALYLVC INS_ANSAN 13 0 -
EALYLVC INS_ACIGU 13 0 -
EALYLVC INS_FELCA 37 0 -
EALYLVC INS1_RAT 37 0 -
EALYLVC INS1_MOUSE 37 0 -
EALYLVC INS2_XENLA 36 0 -
EALYLVC INS_AOTTR 37 0 -
EALYLVC INS2_RAT 37 0 -
EALYLVC INS1_XENLA 36 0 -
EALYLVC INS_ANGRO 13 0 -
DALYLVC INS_GADCA 14 0 -
DALYLVC INS1_BATSP 14 0 -
DALYLVC INS2_BATSP 14 0 -
EALFLVC INS_AMICA 13 0 -
DALYFVC INS_CALMI 13 0 -
ETLYSVC INS_CAVPO 37 0 -
EALYLVC INS_HUMAN 37 0 -
EALYLVC INS_GORGO 37 0 -
EALYLVC INS_CERAE 37 0 -
EALYLVC INS_CAPHI 13 0 -
EALYLVC INS_CANFA 37 0 -
EALYLVC INS_BOVIN 37 0 -
EALYLVC INS_BALPH 13 0 -
EALYLVC INS_BALBO 13 0 -
EALYLVC INS_CAMDR 13 0 -

Motif 3 width=10
Element Seqn Id St Int Rpt
SLYQLENYCN INS_HUMAN 101 57 -
SLYQLENYCN INS_GORGO 101 57 -
SLYQLENYCN INS_CERAE 101 57 -
SLYQLENYCN INS_CAPHI 42 22 -
SLYQLENYCN INS_CANFA 101 57 -
SLYQLENYCN INS_BOVIN 96 52 -
SLYQLENYCN INS_BALPH 42 22 -
SLYQLENYCN INS_BALBO 42 22 -
SLYQLENYCN INS_CAMDR 42 22 -
SLYQLENYCN INS2_RAT 101 57 -
SLYQLENYCN INS2_MOUSE 101 57 -
SLYQLENYCN INS_CAIMO 42 22 -
SLYQLENYCN INS_ANSAN 42 22 -
SLYDLENYCN INS_ACIGU 43 23 -
SLYQLEHYCN INS_FELCA 101 57 -
SLYQLENYCN INS1_RAT 101 57 -
SLYQLENYCN INS1_MOUSE 99 55 -
SLFQLENYCN INS2_XENLA 97 54 -
SLYQLQNYCN INS_AOTTR 99 55 -
SLYQLENYCN INS_ALLMI 42 22 -
SLFQLESYCN INS1_XENLA 97 54 -
SIFDLQNYCN INS_ANGRO 42 22 -
DIFDLQNYCN INS_GADCA 42 21 -
DIFDLQSYCN INS1_BATSP 42 21 -
DKFDLQSYCN INS2_BATSP 41 20 -
TIYEMEKYCN INS_AMICA 43 23 -
SLVNLEGYCN INS_CALMI 80 60 -
TRHQLQSYCN INS_CAVPO 101 57 -
Final Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
FVKQHLCGSHLV Q5EEX1_MOUSE 25 25 -
FVKQHLCGSHLV Q2IDG8_MUSSP 25 25 -
FVKQHLCGSHLV INS2_RAT 25 25 -
FVKQHLCGSHLV INS2_MOUSE 25 25 -
FVKQHLCGSHLV A0ELY9_9MURI 25 25 -
FVKQHLCGSHLV A0ELY8_MUSCR 25 25 -
FVKQHLCGSHLV A0ELY7_APOSM 25 25 -
AANQHLCGSHLV INS_ANAPL 1 1 -
AANQHLCGSHLV INS_TRASC 1 1 -
AANQHLCGSHLV INS_STRCA 1 1 -
AANQHLCGSHLV INS_MELGA 1 1 -
AANQHLCGSHLV INS_CHRDO 1 1 -
AANQHLCGSHLV INS_CHICK 25 25 -
AANQHLCGSHLV INS_CAIMO 1 1 -
AANQHLCGSHLV INS_ANSAN 1 1 -
FVBQHLCGSHLV INS_ACOCA 1 1 -
FVNQHLCGSHLV INS_HYSCR 1 1 -
AANQHLCGSHLV INS_ACIGU 1 1 -
FVNQHLCGSHLV INS_FELCA 25 25 -
FPNQHLCGSHLV INS_ORNAN 1 1 -
AANQHLCGSHLV Q7LZN0_POLSP 1 1 -
FVKQHLCGPHLV A0ELY2_9MURI 25 25 -
FVKQHLCGPHLV Q545I7_MOUSE 25 25 -
FVKQHLCGPHLV INS1_RAT 25 25 -
FVKQHLCGPHLV INS1_MOUSE 25 25 -
FVKQHLCGPHLV A0ELY5_9MURI 25 25 -
FVKQHLCGPHLV A0ELY4_MUSCR 25 25 -
FVKQHLCGPHLV A0ELY3_APOSM 25 25 -
LANQHLCGSHLV INS2_XENLA 24 24 -
FVNQHLCGPHLV INS_AOTTR 25 25 -
FVNQHLCGPHLV INS_SAISC 1 1 -
LVNQHLCGSHLV INS_DIDMA 1 1 -
AANQRLCGSHLV INS_ALLMI 1 1 -
LVNQHLCGSHLV INS1_XENLA 24 24 -
LANQHLCGSHLV A4IGV9_XENTR 24 24 -
FVNKHLCGSHLV INS_CHIBR 1 1 -
AANQHLCGSHLV INS_LEPSP 1 1 -
AANRHLCGSHLV INS_POLSE 1 1 -
ASTQHLCGSHLV INS_ANGRO 1 1 -
FDNQYLCGSHLV Q9I8Q7_RANPI 24 24 -
GAPQHLCGSHLV INS_PIAME 3 3 -
GAPQHLCGSHLV INS_CYPCA 24 24 -
GAPQHLCGSHLV Q90ZN4_9TELE 24 24 -
LPSQHLCGSHLV INS_SQUAC 1 1 -
ITNQYLCGSHLV Q7LZM9_9SALA 1 1 -
GTPQHLCGSHLV A5PF52_DANRE 24 24 -
GTPQHLCGSHLV Q9DDE5_DANRE 24 24 -
GTPQHLCGSHLV O73727 24 24 -
APNQRLCGSHLV INS_CROAT 1 1 -
AAAQHLCGSHLV A3RID6_ONCMY 23 23 -
APPQHLCGSHLV Q18NR0_SERDU 26 26 -
APPQHLCGSHLV INS2_THUTH 2 2 -
AAAQHLCGSHLV INS_ONCKI 1 1 -
AAAQHLCGSHLV INS_ONCKE 23 23 -
AAAQHLCGSHLV INS_ONCGO 1 1 -
AAAQHLCGSHLV A3RID7_ONCMY 23 23 -
APAQHLCGSHLV INS_LOPAM 26 26 -
APAQHLCGSHLV INS_LOPPI 2 2 -
APPQHLCGSHLV INS_GADCA 2 2 -
ADPQHLCGSHLV INS_MYOSC 1 1 -
GGPQHLCGSHLV INS_ORENI 26 26 -
APNQRLCGSHLV INS_ZAODH 1 1 -
APPQHLCGSHLV INS1_BATSP 2 2 -
LPPQHLCGAHLV INS_VERMO 26 26 -
VPPQHLCGAHLV INS_PLAFE 2 2 -
AGGTHLCGSHLV INS_LAMFL 6 6 -
AGGTHLCGSHLV INS_PETMA 6 6 -
APPQHLCGSHLV INS2_BATSP 2 2 -
ASSQHLCGSHLV INS_PANBU 24 24 -
AASQHLCGSHLV INS_AMICA 1 1 -
VPTQRLCGSHLV INS_CHIMO 1 1 -
VPTQRLCGSHLV INS_HYDCO 1 1 -
VPTQRLCGSHLV INS_CALMI 1 1 -
SPSQHLCGSSLV Q2QAJ9_DANRE 23 23 -
YSSQHLCGSNLV INS_OCTDE 25 25 -
FVSRHLCGSNLV INS_CAVPO 25 25 -
YVSQRLCGSQLV INS_MYOCO 1 1 -
YVGQRLCGSQLV INS_PROGU 1 1 -
FVNQHLCGSHLV A0ELZ0_MERUN 25 25 -
FVNQHLCGSHLV Q7M0G1_CRISP 1 1 -
FVNQHLCGSHLV INS_SPETR 25 25 -
FVNQHLCGSHLV INS_SHEEP 25 25 -
FVNQHLCGSHLV INS_RABIT 25 25 -
FVNQHLCGSHLV INS_PSAOB 25 25 -
FVNQHLCGSHLV INS_PONPY 25 25 -
FVNQHLCGSHLV INS_PIG 25 25 -
FVNQHLCGSHLV INS_PHYCA 1 1 -
FVNQHLCGSHLV INS_PANTR 25 25 -
FVNQHLCGSHLV INS_MACFA 25 25 -
FVNQHLCGSHLV INS_HUMAN 25 25 -
FVNQHLCGSHLV INS_HORSE 1 1 -
FVNQHLCGSHLV INS_GORGO 25 25 -
FVNQHLCGSHLV INS_ELEMA 1 1 -
FVNQHLCGSHLV INS_CRILO 25 25 -
FVNQHLCGSHLV INS_CERAE 25 25 -
FVNQHLCGSHLV INS_CAPHI 1 1 -
FVNQHLCGSHLV INS_CANFA 25 25 -
FVNQHLCGSHLV INS_BOVIN 25 25 -
FVNQHLCGSHLV INS_BALPH 1 1 -
FVNQHLCGSHLV INS_BALBO 1 1 -
FVNQHLCGSHLV A6XGL2_HUMAN 25 25 -
FVNQHLCGSHLV A5PJB2_BOVIN 25 25 -
FVNQHLCGSHLV A0ELZ1_VOLKI 25 25 -
FANQHLCGSHLV INS_CAMDR 1 1 -
FVKQHLCGSHLV A0ELY6_9MURI 25 25 -

Motif 2 width=7
Element Seqn Id St Int Rpt
EALYMVC Q9I8Q7_RANPI 36 0 -
EALYLVC Q2IDG8_MUSSP 37 0 -
EALYLVC INS2_RAT 37 0 -
EALYLVC INS2_MOUSE 37 0 -
EALYLVC A0ELY9_9MURI 37 0 -
EALYLVC A0ELY8_MUSCR 37 0 -
EALYLVC A0ELY7_APOSM 37 0 -
EALYLVC INS_ANAPL 13 0 -
EALYLVC INS_TRASC 13 0 -
EALYLVC INS_STRCA 13 0 -
EALYLVC INS_MELGA 13 0 -
EALYLVC INS_CHRDO 13 0 -
EALYLVC INS_CHICK 37 0 -
EALYLVC INS_CAIMO 13 0 -
EALYLVC INS_ANSAN 13 0 -
EALYLVC INS_ACOCA 13 0 -
EALYLVC INS_HYSCR 13 0 -
EALYLVC INS_ACIGU 13 0 -
EALYLVC INS_FELCA 37 0 -
EALYLVC INS_ORNAN 13 0 -
EALYLVC Q7LZN0_POLSP 13 0 -
EALYLVC A0ELY2_9MURI 37 0 -
EALYLVC Q545I7_MOUSE 37 0 -
EALYLVC INS1_RAT 37 0 -
EALYLVC INS1_MOUSE 37 0 -
EALYLVC A0ELY5_9MURI 37 0 -
EALYLVC A0ELY4_MUSCR 37 0 -
EALYLVC A0ELY3_APOSM 37 0 -
EALYLVC INS2_XENLA 36 0 -
EALYLVC INS_AOTTR 37 0 -
EALYLVC INS_SAISC 13 0 -
EALYLVC INS_DIDMA 13 0 -
DALYLVC INS_ALLMI 13 0 -
EALYLVC INS1_XENLA 36 0 -
EALYLVC A4IGV9_XENTR 36 0 -
DALYLVC INS_CHIBR 13 0 -
EALYLVC INS_LEPSP 13 0 -
EALYLVC INS_POLSE 13 0 -
EALYLVC INS_ANGRO 13 0 -
EALYLVC Q5EEX1_MOUSE 37 0 -
DALYLVC INS_PIAME 15 0 -
DALYLVC INS_CYPCA 36 0 -
DALYLVC Q90ZN4_9TELE 36 0 -
EALYFVC INS_SQUAC 13 0 -
EALFLVC Q7LZM9_9SALA 13 0 -
DALYLVC A5PF52_DANRE 36 0 -
DALYLVC Q9DDE5_DANRE 36 0 -
DALYLVC O73727 36 0 -
EALFLIC INS_CROAT 13 0 -
DALYLVC A3RID6_ONCMY 35 0 -
DALYLVC Q18NR0_SERDU 38 0 -
DALYLVC INS2_THUTH 14 0 -
DALYLVC INS_ONCKI 13 0 -
DALYLVC INS_ONCKE 35 0 -
DALYLVC INS_ONCGO 13 0 -
DALYLVC A3RID7_ONCMY 35 0 -
DALYLVC INS_LOPAM 38 0 -
DALYLVC INS_LOPPI 14 0 -
DALYLVC INS_GADCA 14 0 -
DALYLVC INS_MYOSC 13 0 -
DALYLVC INS_ORENI 38 0 -
EALFLIC INS_ZAODH 13 0 -
DALYLVC INS1_BATSP 14 0 -
DALYLVC INS_VERMO 38 0 -
DALYLVC INS_PLAFE 14 0 -
EALYVVC INS_LAMFL 18 0 -
EALYVVC INS_PETMA 18 0 -
DALYLVC INS2_BATSP 14 0 -
DALYMVC INS_PANBU 36 0 -
EALFLVC INS_AMICA 13 0 -
DALYFVC INS_CHIMO 13 0 -
DALYFVC INS_HYDCO 13 0 -
DALYFVC INS_CALMI 13 0 -
DALYLVC Q2QAJ9_DANRE 35 0 -
EALYMTC INS_OCTDE 37 0 -
ETLYSVC INS_CAVPO 37 0 -
DTLYSVC INS_MYOCO 13 0 -
DTLYSVC INS_PROGU 13 0 -
EALYLVC A0ELZ0_MERUN 37 0 -
EALYLVC Q7M0G1_CRISP 13 0 -
EALYLVC INS_SPETR 37 0 -
EALYLVC INS_SHEEP 37 0 -
EALYLVC INS_RABIT 37 0 -
EALYLVC INS_PSAOB 37 0 -
EALYLVC INS_PONPY 37 0 -
EALYLVC INS_PIG 37 0 -
EALYLVC INS_PHYCA 13 0 -
EALYLVC INS_PANTR 37 0 -
EALYLVC INS_MACFA 37 0 -
EALYLVC INS_HUMAN 37 0 -
EALYLVC INS_HORSE 13 0 -
EALYLVC INS_GORGO 37 0 -
EALYLVC INS_ELEMA 13 0 -
EALYLVC INS_CRILO 37 0 -
EALYLVC INS_CERAE 37 0 -
EALYLVC INS_CAPHI 13 0 -
EALYLVC INS_CANFA 37 0 -
EALYLVC INS_BOVIN 37 0 -
EALYLVC INS_BALPH 13 0 -
EALYLVC INS_BALBO 13 0 -
EALYLVC A6XGL2_HUMAN 37 0 -
EALYLVC A5PJB2_BOVIN 37 0 -
EALYLVC A0ELZ1_VOLKI 37 0 -
EALYLVC INS_CAMDR 13 0 -
EALYLVC A0ELY6_9MURI 37 0 -

Motif 3 width=10
Element Seqn Id St Int Rpt
SLYQLENYCN A0ELZ0_MERUN 101 57 -
SLYQLENYCN Q7M0G1_CRISP 42 22 -
SLYQLENYCN INS_SPETR 101 57 -
SLYQLENYCN INS_SHEEP 96 52 -
SLYQLENYCN INS_RABIT 101 57 -
SLYQLENYCN INS_PSAOB 101 57 -
SLYQLENYCN INS_PONPY 101 57 -
SLYQLENYCN INS_PIG 99 55 -
SLYQLENYCN INS_PHYCA 42 22 -
SLYQLENYCN INS_PANTR 101 57 -
SLYQLENYCN INS_MACFA 101 57 -
SLYQLENYCN INS_HUMAN 101 57 -
SLYQLENYCN INS_HORSE 77 57 -
SLYQLENYCN INS_GORGO 101 57 -
SLYQLENYCN INS_ELEMA 42 22 -
SLYQLENYCN INS_CRILO 101 57 -
SLYQLENYCN INS_CERAE 101 57 -
SLYQLENYCN INS_CAPHI 42 22 -
SLYQLENYCN INS_CANFA 101 57 -
SLYQLENYCN INS_BOVIN 96 52 -
SLYQLENYCN INS_BALPH 42 22 -
SLYQLENYCN INS_BALBO 42 22 -
SLYQLENYCN A6XGL2_HUMAN 89 45 -
SLYQLENYCN A5PJB2_BOVIN 96 52 -
SLYQLENYCN A0ELZ1_VOLKI 101 57 -
SLYQLENYCN INS_CAMDR 42 22 -
SLYQLENYCN A0ELY6_9MURI 101 57 -
SLYQLENYCN Q5EEX1_MOUSE 101 57 -
SLYQLENYCN Q2IDG8_MUSSP 101 57 -
SLYQLENYCN INS2_RAT 101 57 -
SLYQLENYCN INS2_MOUSE 101 57 -
SLYQLENYCN A0ELY9_9MURI 101 57 -
SLYQLENYCN A0ELY8_MUSCR 101 57 -
SLYQLENYCN A0ELY7_APOSM 101 57 -
SLYQLENYCN INS_ANAPL 72 52 -
SLYQLENYCN INS_TRASC 42 22 -
SLYQLENYCN INS_STRCA 42 22 -
SLYQLENYCN INS_MELGA 42 22 -
SLYQLENYCN INS_CHRDO 42 22 -
SLYQLENYCN INS_CHICK 98 54 -
SLYQLENYCN INS_CAIMO 42 22 -
SLYQLENYCN INS_ANSAN 42 22 -
SLYQLENYCN INS_ACOCA 42 22 -
SLYQLQNYCN INS_HYSCR 42 22 -
SLYDLENYCN INS_ACIGU 43 23 -
SLYQLEHYCN INS_FELCA 101 57 -
SMYQLENYCN INS_ORNAN 42 22 -
SLYHLENYCN Q7LZN0_POLSP 43 23 -
SLYQLENYCN A0ELY2_9MURI 101 57 -
SLYQLENYCN Q545I7_MOUSE 99 55 -
SLYQLENYCN INS1_RAT 101 57 -
SLYQLENYCN INS1_MOUSE 99 55 -
SLYQLENYCN A0ELY5_9MURI 101 57 -
SLYQLENYCN A0ELY4_MUSCR 99 55 -
SLYQLENYCN A0ELY3_APOSM 101 57 -
SLFQLENYCN INS2_XENLA 97 54 -
SLYQLQNYCN INS_AOTTR 99 55 -
SLYQLQNYCN INS_SAISC 42 22 -
SLYQLETYCN INS_DIDMA 42 22 -
SLYQLENYCN INS_ALLMI 42 22 -
SLFQLESYCN INS1_XENLA 97 54 -
SLFQLESYCN A4IGV9_XENTR 97 54 -
TLYQLENYCN INS_CHIBR 77 57 -
TIYELENYCN INS_LEPSP 43 23 -
SLYDPENYCN INS_POLSE 43 23 -
SIFDLQNYCN INS_ANGRO 42 22 -
SLYDLENYCN Q9I8Q7_RANPI 97 54 -
SIFDLQNYCN INS_PIAME 43 21 -
SIFELQNYCN INS_CYPCA 99 56 -
SIFELQNYCN Q90ZN4_9TELE 99 56 -
SLYDLEGYCN INS_SQUAC 44 24 -
SLNQLENYCN Q7LZM9_9SALA 43 23 -
SIFELQNYCN A5PF52_DANRE 99 56 -
SIFELQNYCN Q9DDE5_DANRE 99 56 -
SIFELQNYCN O73727 99 56 -
SLYQLENYCN INS_CROAT 42 22 -
NIFDLQNYCN A3RID6_ONCMY 96 54 -
NIFDLQNYCN Q18NR0_SERDU 107 62 -
NIFDLQNYCN INS2_THUTH 42 21 -
NIFDLQNYCN INS_ONCKI 41 21 -
NIFDLQNYCN INS_ONCKE 96 54 -
NIFDLQNYCN INS_ONCGO 41 21 -
NIFDLQNYCN A3RID7_ONCMY 98 56 -
NIFDLQNYCN INS_LOPAM 107 62 -
NIFDLQNYCN INS_LOPPI 42 21 -
DIFDLQNYCN INS_GADCA 42 21 -
NIRVLENYCN INS_MYOSC 41 21 -
TIFDLQNYCN INS_ORENI 104 59 -
SLYELENYCN INS_ZAODH 42 22 -
DIFDLQSYCN INS1_BATSP 42 21 -
NIFDLQNYCN INS_VERMO 106 61 -
NIFDLQNYCN INS_PLAFE 42 21 -
SIYDMENYCN INS_LAMFL 48 23 -
SIYDMENYCN INS_PETMA 48 23 -
DKFDLQSYCN INS2_BATSP 41 20 -
NIFDLQNYCN INS_PANBU 101 58 -
TIYEMEKYCN INS_AMICA 43 23 -
SLANLEGYCN INS_CHIMO 50 30 -
SLANLEGYCN INS_HYDCO 50 30 -
SLVNLEGYCN INS_CALMI 80 60 -
TIYHLEDYCS Q2QAJ9_DANRE 98 56 -
TFNQLQNYCN INS_OCTDE 98 54 -
TRHQLQSYCN INS_CAVPO 101 57 -
SRNQLMSYCN INS_MYOCO 41 21 -
SRNQLLTYCN INS_PROGU 41 21 -