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PR01951

Identifier
LANCEUKARYTE  [View Relations]  [View Alignment]  
Accession
PR01951
No. of Motifs
7
Creation Date
27-JAN-2009
Title
Eukaryotic LanC-like protein family signature
Database References
PRINTS; PR01950 LANCSUPER
PDB; 2G02; 2G0D
SCOP; 2G02; 2G0D
CATH; 2G02; 2G0D
MIM; 604155
Literature References
1. MAYER, H., BAUER, H. AND PROHASKA, R. 
Organization and chromosomal localization of the human and mouse genes
coding for LanC-like protein 1 (LANCL1). 
CYTOGENET.CELL GENET. 93 100-104 (2001). 
 
2. BAUER, H., MAYER, H., MARCHLER-BAUER, A., SALZER, U. AND PROHASKA, R. 
Characterization of p40/GPR69A as a peripheral membrane protein related to
the lantibiotic synthetase component C. 
BIOCHEM.BIOPHYS.RES.COMMUN. 275 69-74 (2000). 
 
3. PARK, S. AND JAMES, C.D. 
Lanthionine synthetase components C-like 2 increases cellular sensitivity
to adriamycin by decreasing the expression of P-glycoprotein through a 
transcription-mediated mechanism. 
CANCER RES. 63 723-727 (2003). 
 
4. CHUNG, Y.J., STEEN, M.T. AND HANSEN, J.N. 
The subtilin gene of Bacillus subtilis ATCC 6633 is encoded in an operon 
that contains a homolog of the hemolysin B transport protein. 
J.BACTERIOL. 174 1417-1422 (1992). 
 
5. KLEIN, C., KALETTA, C., SCHNELL, N. AND ENTIAN, K.-D. 
Analysis of genes involved in biosynthesis of the lantibiotic subtilin. 
APPL.ENVIRON.MICROBIOL. 58 132-142 (1992). 
 
6. SCHNELL, N., ENGELKE, G., AUGUSTIN, J., ROSENSTEIN, R., UNGERMANN, V., 
GOETZ, F. AND ENTIAN, K.-D. 
Analysis of genes involved in the biosynthesis of lantibiotic epidermin. 
EUR.J. BIOCHEM. 204 57-68 (1992). 
 
7. ENGELKE, G., GUTOWSKI-ECKEL, Z., KIESAU, P., SIEGERS, K., HAMMELMANN, M. 
AND ENTIAN, K.-D. 
Regulation of nisin biosynthesis and immunity in Lactococcus lactis 6F3. 
APPL.ENVIRON.MICROBIOL. 60 814-825 (1994). 
 
8. KUIPERS, O.P., BEERTHUYZEN, M.M., SIEZEN, R.J. AND DE VOS, W.M. 
Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. 
Requirement of expression of the nisA and nisI genes for development of 
immunity. 
EUR.J.BIOCHEM. 216 281-291 (1993). 
 
9. ENGELKE, G., GUTOWSKI-ECKEL, Z., HAMMELMANN, M. AND ENTIAN, K.-D. 
Biosynthesis of the lantibiotic nisin: genomic organization and membrane 
localization of the NisB protein. 
APPL.ENVIRON.MICROBIOL. 58 3730-3743 (1992). 
 
10. LIU, X.G., YUE, Y.L., LI, B., NIE, Y.L., LI, W., WU, W.H. AND MA, L.G.
A G protein-coupled receptor is a plasma membrane receptor for the plant
hormone abscisic acid.
SCIENCE 315 1712-1716 (2007).
 
11. LI, B., YU, J.P.J., BRUNZELLE, J.S., MOLL, G.N., VAN DER DONK, W.A.,
AND NAIR, S.K.
Structure and Mechanism of the Lantibiotic Cyclase Involved in Nisin
Biosynthesis.
SCIENCE 311 1464-1467 (2006).
 
12. MAYER, H.., SALZER, U., BREUSS, J., ZIEGLER, S., MARCHLER-BAUER, A. 
AND PROHASKA, R. 
Isolation, molecular characterization, and tissue-specific expression of a
novel putative G protein-coupled receptor.
BIOCHIM.BIOPHYS.ACTA 1395 301-308 (1998).
 
13. ILLINGWORTH, C.J.R., PARKES, K.E., SNELL, R.R., MULLINEAUX, P.M. AND
REYNOLDS, C.A.
Criteria for confirming sequence periodicity identified by Fourier 
transform analysis: Application to GCR2, a candidate plant GPCR?   
BIOPHYSICAL CHEMISTRY 133 28-35 (2008).
 
14. GAO, Y., ZENG, Q., GUO, J., CHENG, J., ELLIS, B.E. AND CHEN, J.G.
Genetic characterization reveals no role for the reported ABA receptor,
GCR2, in ABA control of seed germination and early seedling development 
in Arabidopsis.
PLANT J. 52 1001-1013 (2007).

Documentation
The LanC-like protein superfamily encompasses a highly divergent group of
peptide-modifying enzymes, including the eukaryotic and bacterial 
lanthionine synthetase C-like proteins (LanC) [1-3]; subtilin biosynthesis
protein SpaC from Bacillus subtilis [4,5]; epidermin biosynthesis protein
EpiC from Staphylococcus epidermidis [6]; nisin biosynthesis protein NisC 
from Lactoccocus lactis [7-9]; GCR2 from Arabidopsis thaliana [10]; and
many others.  
 
The 3D structure of the lantibiotic cyclase from L.lactis has been
determined by X-ray crystallography to 2.5A resolution [11]. The globular
structure is characterised by an all-alpha fold, in which an outer ring
of helices envelops an inner toroid composed of 7 shorter, hydrophobic 
helices. This 7-fold hydrophobic periodicity has led several authors to 
claim various members of the family, including eukaryotic LanC-1 and GCR2,
to be novel G protein-coupled receptors [10,12]; some of these claims have
since been corrected [2,13,14].
 
The eukaryotic lanthionine synthetase C-like proteins 1-3, are relatives of
the bacterial lanthionine synthetase components C (LanC) [1-3]. They are
ubiquitous in nature, being variously expressed in brain, spinal chord,
pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and
testis. LanC-like protein 2 is a bystander gene coamplified and over-
expressed with epidermal growth factor receptor (EGFR) in 20% of
glioblastomas; its exogenous expression in a sarcoma cell line decreases
the expression of ABCB1 (P-glycoprotein 1) and increases cellular
sensitivity to the anticancer drug adriamycin [3].
 
LANCEUKARYTE is a 7-element fingerprint that provides a signature for the
eukaryotic LanC-like protein family. The fingerprint was derived from an
initial alignment of 10 sequences: the motifs were drawn from conserved 
regions spanning virtually the full alignment length, focusing on those
sections that characterise the eukaryotic LanC proteins but distinguish 
them from closely related members of the LanC-like protein superfamily.
Four iterations on SPTR55_38f were required to reach convergence, at which
point a true set comprising 24 sequences was identified. Numerous partial 
matches were also found, all of which are members of the LanC-like 
superfamily that fail to make significant matches with one or more motifs.
Summary Information
  24 codes involving  7 elements
1 codes involving 6 elements
5 codes involving 5 elements
12 codes involving 4 elements
8 codes involving 3 elements
2 codes involving 2 elements
Composite Feature Index
724242424242424
60111111
53153544
45012611122
30071367
21020001
1234567
True Positives
A2RUX2_DANRE  A4IIE7_XENTR  A6QPG6_BOVIN  A7S296_NEMVE  
LANC1_DANRE LANC1_HUMAN LANC1_MOUSE LANC1_RAT
LANC2_HUMAN LANC2_MOUSE LANC3_DROME LANC3_DROPS
LANC3_HUMAN LANC3_MOUSE Q17NS4_AEDAE Q1LZH8_BOVIN
Q28BK5_XENTR Q28ES9_XENTR Q4RG04_TETNG Q53TN2_HUMAN
Q5RD57_PONPY Q68FQ9_RAT Q6NSL4_HUMAN Q7ZSZ1_XENLA
True Positive Partials
Codes involving 6 elements
Q4R850_MACFA
Codes involving 5 elements
A5AP09_VITVI A5HIY4_POPTR A7P1J1_VITVI A7PWY6_VITVI
Q5ZKQ0_CHICK
Codes involving 4 elements
A2XVS3_ORYSI A3C653_ORYSJ A7S2P7_NEMVE A9RX77_PHYPA
Q00RJ6_ORYSA Q16N67_AEDAE Q337G9_ORYSJ Q337H0_ORYSJ
Q7X7D6_ORYSJ Q8VZQ6_ARATH Q8W3F0_ORYSJ Q9SKU0_ARATH
Codes involving 3 elements
A2Z8Z7_ORYSI A5BN66_VITVI A7R2I8_VITVI A7T8A4_NEMVE
A8PZA9_BRUMA A9TEG3_PHYPA Q9C929_ARATH Q9LKK8_SOLCH
Codes involving 2 elements
A9NV23_PICSI Q5DGK1_SCHJA
Sequence Titles
A2RUX2_DANRE Zgc:158293 protein - Danio rerio (Zebrafish) (Brachydanio rerio). 
A4IIE7_XENTR LOC734145 protein - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
A6QPG6_BOVIN MGC148337 protein - Bos taurus (Bovine).
A7S296_NEMVE Predicted protein - Nematostella vectensis (Starlet sea anemone).
LANC1_DANRE LanC-like protein 1 - Danio rerio (Zebrafish) (Brachydanio rerio).
LANC1_HUMAN LanC-like protein 1 (40 kDa erythrocyte membrane protein) (p40) - Homo sapiens (Human).
LANC1_MOUSE LanC-like protein 1 (40 kDa erythrocyte membrane protein) (p40) - Mus musculus (Mouse).
LANC1_RAT LanC-like protein 1 (40 kDa erythrocyte membrane protein) (p40) - Rattus norvegicus (Rat).
LANC2_HUMAN LanC-like protein 2 (Testis-specific adriamycin sensitivity protein) - Homo sapiens (Human).
LANC2_MOUSE LanC-like protein 2 (Testis-specific adriamycin sensitivity protein) - Mus musculus (Mouse).
LANC3_DROME LanC-like protein 3 homolog - Drosophila melanogaster (Fruit fly).
LANC3_DROPS LanC-like protein 3 homolog - Drosophila pseudoobscura (Fruit fly).
LANC3_HUMAN LanC-like protein 3 - Homo sapiens (Human).
LANC3_MOUSE LanC-like protein 3 - Mus musculus (Mouse).
Q17NS4_AEDAE Putative uncharacterized protein - Aedes aegypti (Yellowfever mosquito).
Q1LZH8_BOVIN LanC lantibiotic synthetase component C-like 1 (Bacterial) - Bos taurus (Bovine).
Q28BK5_XENTR LanC lantibiotic synthetase component C-like 2 (Bacterial) - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Q28ES9_XENTR LanC lantibiotic synthetase component C-like 1 (Bacterial) (Putative uncharacterized protein LOC548800) - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Q4RG04_TETNG Chromosome undetermined SCAF15108, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer).
Q53TN2_HUMAN Putative uncharacterized protein LANCL1 (LanC lantibiotic synthetase component C-like 1 (Bacterial), isoform CRA_a) - Homo sapiens (Human).
Q5RD57_PONPY Putative uncharacterized protein DKFZp459I0726 - Pongo pygmaeus (Orangutan).
Q68FQ9_RAT LanC (Bacterial lantibiotic synthetase component C)-like 2 (Predicted) - Rattus norvegicus (Rat).
Q6NSL4_HUMAN LanC lantibiotic synthetase component C-like 2 (Bacterial) - Homo sapiens (Human).
Q7ZSZ1_XENLA MGC52973 protein - Xenopus laevis (African clawed frog).

Q4R850_MACFA Testis cDNA clone: QtsA-13449, similar to human LanC lantibiotic synthetase component C-like2; testis-specific adriamycin sensitivity protein; LanC(bacterial lantibiotic synthetase component C)-like 2; Gprotein-coupled receptor 69B (LOC392673), - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).

A5AP09_VITVI Putative uncharacterized protein - Vitis vinifera (Grape).
A5HIY4_POPTR Abscisic acid ABA receptor - Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa).
A7P1J1_VITVI Chromosome chr19 scaffold_4, whole genome shotgun sequence - Vitis vinifera (Grape).
A7PWY6_VITVI Chromosome chr12 scaffold_36, whole genome shotgun sequence - Vitis vinifera (Grape).
Q5ZKQ0_CHICK Putative uncharacterized protein - Gallus gallus (Chicken).

A2XVS3_ORYSI Putative uncharacterized protein - Oryza sativa subsp. indica (Rice).
A3C653_ORYSJ Putative uncharacterized protein - Oryza sativa subsp. japonica (Rice).
A7S2P7_NEMVE Predicted protein - Nematostella vectensis (Starlet sea anemone).
A9RX77_PHYPA Predicted protein - Physcomitrella patens subsp. patens.
Q00RJ6_ORYSA OSIGBa0155K17.4 protein - Oryza sativa (Rice).
Q16N67_AEDAE Putative uncharacterized protein - Aedes aegypti (Yellowfever mosquito).
Q337G9_ORYSJ Lanthionine synthetase C-like protein, expressed - Oryza sativa subsp. japonica (Rice).
Q337H0_ORYSJ Lanthionine synthetase C-like protein, expressed - Oryza sativa subsp. japonica (Rice).
Q7X7D6_ORYSJ OSJNBa0074L08.13 protein (Putative uncharacterized protein) (OSJNBa0081C01.1 protein) - Oryza sativa subsp. japonica (Rice).
Q8VZQ6_ARATH Putative uncharacterized protein At2g20770 - Arabidopsis thaliana (Mouse-ear cress).
Q8W3F0_ORYSJ Putative lanthionine synthetase - Oryza sativa subsp. japonica (Rice).
Q9SKU0_ARATH Putative uncharacterized protein At2g20770 - Arabidopsis thaliana (Mouse-ear cress).

A2Z8Z7_ORYSI Putative uncharacterized protein - Oryza sativa subsp. indica (Rice).
A5BN66_VITVI Putative uncharacterized protein - Vitis vinifera (Grape).
A7R2I8_VITVI Chromosome undetermined scaffold_431, whole genome shotgun sequence (Chromosome undetermined scaffold_2392, whole genome shotgun sequence) - Vitis vinifera (Grape).
A7T8A4_NEMVE Predicted protein - Nematostella vectensis (Starlet sea anemone).
A8PZA9_BRUMA Lanthionine synthetase C-like protein - Brugia malayi (Filarial nematode worm).
A9TEG3_PHYPA Predicted protein - Physcomitrella patens subsp. patens.
Q9C929_ARATH Putative G protein-coupled receptor; 80093-78432 - Arabidopsis thaliana (Mouse-ear cress).
Q9LKK8_SOLCH Putative 7-transmembrane G-protein-coupled receptor - Solanum chacoense (Chaco potato).

A9NV23_PICSI Putative uncharacterized protein - Picea sitchensis (Sitka spruce).
Q5DGK1_SCHJA SJCHGC06492 protein - Schistosoma japonicum (Blood fluke).
Scan History
SPTR55_38f 4  100  NSINGLE    
Initial Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
EERSFPNPFPDYEA LANC2_MOUSE 19 19 -
EERAFVNPFPDYEA LANC2_HUMAN 20 20 -
AQRAFPNPYADYNK LANC1_HUMAN 2 2 -
AQRAFPNPYADYNK LANC1_RAT 2 2 -
AQRAFPNPYADYNK LANC1_MOUSE 2 2 -
EQRALKNPYPDYTG LANC1_DANRE 3 3 -
ERRYLKNPFPDFAG LANC3_DROME 2 2 -
TKRCFANRFDDYQG LANC3_HUMAN 3 3 -
ERRYLKNPFQDFIG LANC3_DROPS 2 2 -
TKRCFANRFDDYQG LANC3_MOUSE 3 3 -

Motif 2 width=16
Element Seqn Id St Int Rpt
IKEVVSAIIESGKSLS LANC2_MOUSE 224 191 -
IKEVVNAIIESGKTLS LANC2_HUMAN 224 190 -
IQQICETILTSGENLA LANC1_HUMAN 179 163 -
IQQICETILTSGEKLS LANC1_RAT 179 163 -
IQQICENILTSGENLS LANC1_MOUSE 179 163 -
IQQICDAILESGQILS LANC1_DANRE 185 168 -
LVSICQLIVTSGREYS LANC3_DROME 189 173 -
IKSICQAILDSGKQYA LANC3_HUMAN 198 181 -
LISICQLIVTSGREYS LANC3_DROPS 190 174 -
IKAICQAILDSGKQYA LANC3_MOUSE 198 181 -

Motif 3 width=13
Element Seqn Id St Int Rpt
CPLLYQWHRKQYV LANC2_MOUSE 248 8 -
CPLLYQWHRKQYV LANC2_HUMAN 248 8 -
SPLMYEWYQEYYV LANC1_HUMAN 203 8 -
SPLMYEWYQEYYV LANC1_RAT 203 8 -
SPLMYEWYQEYYV LANC1_MOUSE 203 8 -
SPLMYEWYQEEYV LANC1_DANRE 209 8 -
CPLMYQYHGTEYL LANC3_DROME 211 6 -
FPLMYSYYGTEYL LANC3_HUMAN 220 6 -
LPLMFQYHGTEYL LANC3_DROPS 212 6 -
FPLMYSYYGTEYL LANC3_MOUSE 220 6 -

Motif 4 width=16
Element Seqn Id St Int Rpt
RHKKFRSGNYPSSLSN LANC2_MOUSE 297 36 -
RHKKFRSGNYPSSLSN LANC2_HUMAN 297 36 -
CQLKFPSGNYPPCIGD LANC1_HUMAN 252 36 -
CQLKFPSGNYPSCLDD LANC1_RAT 252 36 -
CRLKFPSGNYPPCLDD LANC1_MOUSE 252 36 -
CQLKFPSGNYAPCVGD LANC1_DANRE 258 36 -
LELQDSDGNFPVALED LANC3_DROME 265 41 -
LMEQEQNCNWPPELGE LANC3_HUMAN 267 34 -
LVLQDAEGNFPVALED LANC3_DROPS 266 41 -
LMEQEQNCNWPPELGE LANC3_MOUSE 267 34 -

Motif 5 width=22
Element Seqn Id St Int Rpt
AYQVFKEEKYLKEAMECSDVIW LANC2_MOUSE 334 21 -
AYKVFKEEKYLKEAMECSDVIW LANC2_HUMAN 334 21 -
AYKVFREEKYLCDAYQCADVIW LANC1_HUMAN 289 21 -
AYKVFKEEHYLCDAQQCADVIW LANC1_RAT 289 21 -
AYKVFKEERYLCDAQQCADVIW LANC1_MOUSE 289 21 -
AFKVFGVRQYLEDALQCGEVIW LANC1_DANRE 295 21 -
AYLIFKEEKYLASLRRCADMVW LANC3_DROME 306 25 -
AYLVSKKPQYLDTCIRCGELTW LANC3_HUMAN 307 24 -
AYLIFKEEKYLTSLRRSADLVW LANC3_DROPS 307 25 -
AYLISKKPQYLDTCIRCGELTW LANC3_MOUSE 307 24 -

Motif 6 width=19
Element Seqn Id St Int Rpt
LYRLTQDKKYLYRACKFAE LANC2_MOUSE 380 24 -
LYRLTQDKKYLYRACKFAE LANC2_HUMAN 380 24 -
LYNLTQDMKYLYRACKFAE LANC1_HUMAN 335 24 -
LYNLTQDAKYLYRACKFAE LANC1_RAT 335 24 -
LYNLTQDLKYLYRACKFAE LANC1_MOUSE 335 24 -
LYKITQDPKHLYRACMFAD LANC1_DANRE 341 24 -
LFRLTNEMRYLYRAHKFME LANC3_DROME 352 24 -
LYRLTGNSKYIYRAQRFAQ LANC3_HUMAN 353 24 -
LFRLTNEMKYLYRAHKFME LANC3_DROPS 353 24 -
LYRLTGNSKYIYRAQRFAQ LANC3_MOUSE 353 24 -

Motif 7 width=15
Element Seqn Id St Int Rpt
DILVPETARFPAFEL LANC2_MOUSE 430 31 -
DVLGPETSRFPAFEL LANC2_HUMAN 430 31 -
DLLVPTKARFPAFEL LANC1_HUMAN 385 31 -
DLLVPTKAKFPAFEL LANC1_RAT 385 31 -
DLLVPTKAKFPAFEL LANC1_MOUSE 385 31 -
DLLQPARAKFPCFEV LANC1_DANRE 391 31 -
DLLEPEQAYFPFMDV LANC3_DROME 403 32 -
DLLQPNQAEFPLFSV LANC3_HUMAN 404 32 -
DILEPEQAYFPFMDV LANC3_DROPS 404 32 -
DLLQPNQAEFPLFSV LANC3_MOUSE 404 32 -
Final Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
EERSFPNPFPDYEA LANC2_MOUSE 19 19 -
EERAFVNPFPDYEA LANC2_HUMAN 20 20 -
EERAFVNPFPDYEA Q6NSL4_HUMAN 20 20 -
AQRAFPNPYADYNK LANC1_HUMAN 2 2 -
AQRAFPNPYADYNK Q53TN2_HUMAN 2 2 -
AQRAFPNPYADYNK LANC1_RAT 2 2 -
AQRAFPNPYADYNK LANC1_MOUSE 2 2 -
EERSFPNPFLDYEV Q68FQ9_RAT 19 19 -
AQRAFPNPYADYNK Q5RD57_PONPY 2 2 -
EERAFLNPFPDYRP A4IIE7_XENTR 20 20 -
EERAFLNPFPDYRP Q28BK5_XENTR 2 2 -
EDRAFPNPFPDYEA A6QPG6_BOVIN 2 2 -
AQRAFPNPYADYNK Q1LZH8_BOVIN 2 2 -
EERCFSNPFPDYEP A2RUX2_DANRE 20 20 -
EQRCLQNPYPDYSQ Q28ES9_XENTR 2 2 -
EQRCFQNPYPDYNH Q7ZSZ1_XENLA 2 2 -
EQRALKNPYPDYTG LANC1_DANRE 3 3 -
EERSFPNPYPDWEP Q4RG04_TETNG 20 20 -
ERREFENKFSDYDG A7S296_NEMVE 4 4 -
GGRFFQNPFQDYVG Q17NS4_AEDAE 5 5 -
ERRYLKNPFPDFAG LANC3_DROME 2 2 -
TKRCFANRFDDYQG LANC3_HUMAN 3 3 -
ERRYLKNPFQDFIG LANC3_DROPS 2 2 -
TKRCFANRFDDYQG LANC3_MOUSE 3 3 -

Motif 2 width=16
Element Seqn Id St Int Rpt
IKEVVSAIIESGKSLS LANC2_MOUSE 224 191 -
IKEVVNAIIESGKTLS LANC2_HUMAN 224 190 -
IKEVVNAIIESGKTLS Q6NSL4_HUMAN 224 190 -
IQQICETILTSGENLA LANC1_HUMAN 179 163 -
IQQICETILTSGENLA Q53TN2_HUMAN 179 163 -
IQQICETILTSGEKLS LANC1_RAT 179 163 -
IQQICENILTSGENLS LANC1_MOUSE 179 163 -
IKEVVTAIIESGKRLS Q68FQ9_RAT 224 191 -
IQQICDTILTSGENLA Q5RD57_PONPY 179 163 -
IKEVVDAIIESGKNLS A4IIE7_XENTR 222 188 -
IKEVVDAIIESGKNLS Q28BK5_XENTR 204 188 -
IKEVVNAIIESGKALS A6QPG6_BOVIN 201 185 -
IQQICETVLTSGEDLA Q1LZH8_BOVIN 179 163 -
IAKVVTAIVESGKNLS A2RUX2_DANRE 215 181 -
IQQVCNTVLESGDRLS Q28ES9_XENTR 182 166 -
IQQVCSTVLESGERLA Q7ZSZ1_XENLA 182 166 -
IQQICDAILESGQILS LANC1_DANRE 185 168 -
LSKVVTAIVESGKSFS Q4RG04_TETNG 209 175 -
IDQICSAVVSSGLNLA A7S296_NEMVE 189 171 -
LNTICGVIIESGKRYS Q17NS4_AEDAE 186 167 -
LVSICQLIVTSGREYS LANC3_DROME 189 173 -
IKSICQAILDSGKQYA LANC3_HUMAN 198 181 -
LISICQLIVTSGREYS LANC3_DROPS 190 174 -
IKAICQAILDSGKQYA LANC3_MOUSE 198 181 -

Motif 3 width=13
Element Seqn Id St Int Rpt
CPLLYQWHRKQYV LANC2_MOUSE 248 8 -
CPLLYQWHRKQYV LANC2_HUMAN 248 8 -
CPLLYQWHRKQYV Q6NSL4_HUMAN 248 8 -
SPLMYEWYQEYYV LANC1_HUMAN 203 8 -
SPLMYEWYQEYYV Q53TN2_HUMAN 203 8 -
SPLMYEWYQEYYV LANC1_RAT 203 8 -
SPLMYEWYQEYYV LANC1_MOUSE 203 8 -
CPLLYQWHRKQYV Q68FQ9_RAT 248 8 -
SPLMYEWYQEYYV Q5RD57_PONPY 203 8 -
CPLLYQWHKKQYV A4IIE7_XENTR 246 8 -
CPLLYQWHKKQYV Q28BK5_XENTR 228 8 -
CPLLYQWHRKQYV A6QPG6_BOVIN 225 8 -
TPLMYEWYQEYYV Q1LZH8_BOVIN 203 8 -
CPLLYEWHKKQYV A2RUX2_DANRE 239 8 -
SPLMYEWYREYYV Q28ES9_XENTR 206 8 -
SPLMHEWYREYYV Q7ZSZ1_XENLA 206 8 -
SPLMYEWYQEEYV LANC1_DANRE 209 8 -
CPLLYQWHQKQYL Q4RG04_TETNG 233 8 -
SPLMYAWHGKHYL A7S296_NEMVE 211 6 -
IPLMYHCWGDEYL Q17NS4_AEDAE 208 6 -
CPLMYQYHGTEYL LANC3_DROME 211 6 -
FPLMYSYYGTEYL LANC3_HUMAN 220 6 -
LPLMFQYHGTEYL LANC3_DROPS 212 6 -
FPLMYSYYGTEYL LANC3_MOUSE 220 6 -

Motif 4 width=16
Element Seqn Id St Int Rpt
RHKKFRSGNYPSSLSN LANC2_MOUSE 297 36 -
RHKKFRSGNYPSSLSN LANC2_HUMAN 297 36 -
RHKKFRSGNYPSSLSN Q6NSL4_HUMAN 297 36 -
CQLKFPSGNYPPCIGD LANC1_HUMAN 252 36 -
CQLKFPSGNYPPCIGD Q53TN2_HUMAN 252 36 -
CQLKFPSGNYPSCLDD LANC1_RAT 252 36 -
CRLKFPSGNYPPCLDD LANC1_MOUSE 252 36 -
RHKKFRSGNYPSSLSN Q68FQ9_RAT 297 36 -
CQLKFPSGNYPPCIGD Q5RD57_PONPY 252 36 -
RHKKFRSGNYPSSLSN A4IIE7_XENTR 295 36 -
RHKKFRSGNYPSSLSN Q28BK5_XENTR 277 36 -
RHKRFRSGNYPSSLSN A6QPG6_BOVIN 274 36 -
CQLKFPSGNYPPCVDD Q1LZH8_BOVIN 252 36 -
RHKKFRSGNYPSSLSN A2RUX2_DANRE 288 36 -
SRLKFPSGNFPACIGD Q28ES9_XENTR 255 36 -
RCLKFPTGNFPPCIGD Q7ZSZ1_XENLA 255 36 -
CQLKFPSGNYAPCVGD LANC1_DANRE 258 36 -
RRKRFRSGNFPSSLSN Q4RG04_TETNG 282 36 -
LSLQFPSGNFPSSLGN A7S296_NEMVE 260 36 -
LSLQDAEGNFPVTLQD Q17NS4_AEDAE 258 37 -
LELQDSDGNFPVALED LANC3_DROME 265 41 -
LMEQEQNCNWPPELGE LANC3_HUMAN 267 34 -
LVLQDAEGNFPVALED LANC3_DROPS 266 41 -
LMEQEQNCNWPPELGE LANC3_MOUSE 267 34 -

Motif 5 width=22
Element Seqn Id St Int Rpt
AYQVFKEEKYLKEAMECSDVIW LANC2_MOUSE 334 21 -
AYKVFKEEKYLKEAMECSDVIW LANC2_HUMAN 334 21 -
AYKVFKEEKYLKEAMECSDVIW Q6NSL4_HUMAN 334 21 -
AYKVFREEKYLCDAYQCADVIW LANC1_HUMAN 289 21 -
AYKVFREEKYLCDAYQCADVIW Q53TN2_HUMAN 289 21 -
AYKVFKEEHYLCDAQQCADVIW LANC1_RAT 289 21 -
AYKVFKEERYLCDAQQCADVIW LANC1_MOUSE 289 21 -
AYQVFKEEKYLKEAMECSDVIW Q68FQ9_RAT 334 21 -
AYKVFREEKYLCDAYQCADVIW Q5RD57_PONPY 289 21 -
AHKVFKEDKYLKDAVECSEVIW A4IIE7_XENTR 332 21 -
AHKVFKEDKYLKDAVECSEVIW Q28BK5_XENTR 314 21 -
AHKVFKEEKYLKDAVECSDVIW A6QPG6_BOVIN 311 21 -
AYKVFKEERYLNDAYQCADVIW Q1LZH8_BOVIN 289 21 -
AHTVFRDEKYLRDALECGELIW A2RUX2_DANRE 325 21 -
AYKVFGEQQYLVDALQCAEVAW Q28ES9_XENTR 292 21 -
AYKVFGEPQYLVDALQCAEVAW Q7ZSZ1_XENLA 292 21 -
AFKVFGVRQYLEDALQCGEVIW LANC1_DANRE 295 21 -
AHQVFKEDKYLKEATECAEVIW Q4RG04_TETNG 319 21 -
AHKVFGKEKYLNAAQRCGEVIW A7S296_NEMVE 297 21 -
AYIVFKDQKYLQSCVRCADLVW Q17NS4_AEDAE 300 26 -
AYLIFKEEKYLASLRRCADMVW LANC3_DROME 306 25 -
AYLVSKKPQYLDTCIRCGELTW LANC3_HUMAN 307 24 -
AYLIFKEEKYLTSLRRSADLVW LANC3_DROPS 307 25 -
AYLISKKPQYLDTCIRCGELTW LANC3_MOUSE 307 24 -

Motif 6 width=19
Element Seqn Id St Int Rpt
LYRLTQDKKYLYRACKFAE LANC2_MOUSE 380 24 -
LYRLTQDKKYLYRACKFAE LANC2_HUMAN 380 24 -
LYRLTQDKKYLYRACKFAE Q6NSL4_HUMAN 380 24 -
LYNLTQDMKYLYRACKFAE LANC1_HUMAN 335 24 -
LYNLTQDMKYLYRACKFAE Q53TN2_HUMAN 335 24 -
LYNLTQDAKYLYRACKFAE LANC1_RAT 335 24 -
LYNLTQDLKYLYRACKFAE LANC1_MOUSE 335 24 -
LYQLTQDKKYLYRACKFAE Q68FQ9_RAT 380 24 -
LYNLAQDMKYLYRACKFAE Q5RD57_PONPY 335 24 -
LYNHTQDKKYLYRACRFAE A4IIE7_XENTR 378 24 -
LYNHTQDKKYLYRACRFAE Q28BK5_XENTR 360 24 -
LYHITQDKKYLYRACKFAE A6QPG6_BOVIN 357 24 -
LYSLTQDAKYLYRACKFAE Q1LZH8_BOVIN 335 24 -
LYRCTRDRKHLHRACKFAE A2RUX2_DANRE 371 24 -
LYNLTKDVKFLYRACKFAE Q28ES9_XENTR 338 24 -
LYNQTQDVKFLYRACKFAE Q7ZSZ1_XENLA 338 24 -
LYKITQDPKHLYRACMFAD LANC1_DANRE 341 24 -
LYKLTQEKKHLYRSCKFAE Q4RG04_TETNG 365 24 -
LYKATNESKYLYRAIKFAD A7S296_NEMVE 343 24 -
LYRLTADPKYLYRAIKFME Q17NS4_AEDAE 346 24 -
LFRLTNEMRYLYRAHKFME LANC3_DROME 352 24 -
LYRLTGNSKYIYRAQRFAQ LANC3_HUMAN 353 24 -
LFRLTNEMKYLYRAHKFME LANC3_DROPS 353 24 -
LYRLTGNSKYIYRAQRFAQ LANC3_MOUSE 353 24 -

Motif 7 width=15
Element Seqn Id St Int Rpt
DILVPETARFPAFEL LANC2_MOUSE 430 31 -
DVLGPETSRFPAFEL LANC2_HUMAN 430 31 -
DVLGPETSRFPAFEL Q6NSL4_HUMAN 430 31 -
DLLVPTKARFPAFEL LANC1_HUMAN 385 31 -
DLLVPTKARFPAFEL Q53TN2_HUMAN 385 31 -
DLLVPTKAKFPAFEL LANC1_RAT 385 31 -
DLLVPTKAKFPAFEL LANC1_MOUSE 385 31 -
DMLVPETARFPAFEL Q68FQ9_RAT 430 31 -
DLLVPTKARFPAFEL Q5RD57_PONPY 385 31 -
DMLTPETSRFPAFEL A4IIE7_XENTR 428 31 -
DMLTPETSRFPAFEL Q28BK5_XENTR 410 31 -
DILAPEASRFPAFEL A6QPG6_BOVIN 407 31 -
DLLVPTKARFPAFEL Q1LZH8_BOVIN 385 31 -
DVLQPEVSCFPAFQL A2RUX2_DANRE 421 31 -
DLLEPTKAKFPSFEM Q28ES9_XENTR 388 31 -
DLLEPTKAKFPSFEM Q7ZSZ1_XENLA 388 31 -
DLLQPARAKFPCFEV LANC1_DANRE 391 31 -
ELADPQASCFPAFEL Q4RG04_TETNG 415 31 -
DLIEPRSSLLPGFEL A7S296_NEMVE 393 31 -
DLLRPERASFPFMDV Q17NS4_AEDAE 397 32 -
DLLEPEQAYFPFMDV LANC3_DROME 403 32 -
DLLQPNQAEFPLFSV LANC3_HUMAN 404 32 -
DILEPEQAYFPFMDV LANC3_DROPS 404 32 -
DLLQPNQAEFPLFSV LANC3_MOUSE 404 32 -