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PR01943

Identifier
INTLKN11MAML  [View Relations]  [View Alignment]  
Accession
PR01943
No. of Motifs
3
Creation Date
12-SEP-2008
Title
Mammalian interleukin-11 signature
Database References
PRINTS; PR01927 INTRLEUKIN11
Literature References
1. LENG, S. AND ELIAS, J.
Interleukin-11.
INT.J.BIOCHEM.CELL BIOL. 29 1059-1062 (1997).
 
2. TREPICCHIO, W. AND DORNER, A.
The therapeutic utility of Interleukin-11 in the treatment of inflammatory 
disease.
EXPERT OPIN.INVESTIG.DRUGS 7 1501-1504 (1998).
 
3. WANG, T., HOLLAND, J., BOLS, N. AND SECOMBES, C.
Cloning and expression of the first nonmammalian interleukin-11 gene in 
rainbow trout Oncorhynchus mykiss.
FEBS J. 272 1136-1147 (2005).
 
4. HUISING, M., KRUISWIJK, C., VAN SCHIJNDEL, J., SAVELKOUL, H., FLIK, G. 
AND VERBURG-VAN KEMENADE, B.
Multiple and highly divergent IL-11 genes in teleost fish.
IMMUNOGENETICS 57 432-443 (2005).

Documentation
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
 
Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates 
megakaryocytopoiesis, resulting in increased production of platelets, as 
well as activating osteoclasts, inhibiting epithelial cell proliferation 
and apoptosis, and inhibiting macrophage mediator production. These 
functions may be particularly important in mediating the hematopoietic, 
osseous and mucosal protective effects of IL-11 [1]. The cytokine also 
possesses anti-inflammatory activity, and has been proposed as a therapeutic
agent in the treatment of chronic inflammatory diseases, such as Crohn's 
disease and rheumatoid arthritis [2].
 
Although IL-11 was initially believed to be restricted to mammals,
subsequent studies demonstrated it to be expressed in fish [3,4]. Despite 
close similarity in gene structure and conservation of key amino acids 
between fish and mammalian IL-11, they share relatively low overall amino 
acid identity and may not necessarily be functionally analogous [4].
 
INTLKN11MAML is a 3-element fingerprint that provides a signature for
mammalian interleukin-11. The fingerprint was derived from an initial 
alignment of 6 sequences: the motifs were drawn from conserved regions  
spanning the N-terminal two thirds of the alignment. A single iteration on
SPTR55_38f was required to reach convergence, no further sequences being 
identified beyond the starting set.
Summary Information
6 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3666
2000
123
True Positives
A3KPB8_MOUSE  A8K3F7_HUMAN  IL11_HUMAN    IL11_MACFA    
IL11_MOUSE IL11_RAT
Sequence Titles
A3KPB8_MOUSE Interleukin 11 - Mus musculus (Mouse).        
A8K3F7_HUMAN cDNA FLJ78117, highly similar to Homo sapiens interleukin 11 (IL11), mRNA (Interleukin 11) - Homo sapiens (Human).
IL11_HUMAN Interleukin-11 precursor (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin) - Homo sapiens (Human).
IL11_MACFA Interleukin-11 precursor (IL-11) - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
IL11_MOUSE Interleukin-11 precursor (IL-11) - Mus musculus (Mouse).
IL11_RAT Interleukin-11 precursor (IL-11) - Rattus norvegicus (Rat).
Scan History
SPTR55_38f 1  300  NSINGLE    
Initial Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
SPRVSSDPRAD A3KPB8_MOUSE 28 28 -
SPRVSSDPRAD IL11_RAT 28 28 -
SPRVSSDPRAD IL11_MOUSE 28 28 -
PPRVSPDPRAE A8K3F7_HUMAN 28 28 -
PPRVSPDPRAE IL11_HUMAN 28 28 -
SPRASPDPRAE IL11_MACFA 28 28 -

Motif 2 width=15
Element Seqn Id St Int Rpt
TLAMSAGTLGSLQLP A3KPB8_MOUSE 77 38 -
TLAMSAGTLGSLQLP IL11_RAT 77 38 -
TLAMSAGTLGSLQLP IL11_MOUSE 77 38 -
TLAMSAGALGALQLP A8K3F7_HUMAN 77 38 -
TLAMSAGALGALQLP IL11_HUMAN 77 38 -
TLAMSAGALGALQLP IL11_MACFA 77 38 -

Motif 3 width=14
Element Seqn Id St Int Rpt
SLKTLEPELGALQA A3KPB8_MOUSE 118 26 -
SLKTLEPELGALQA IL11_RAT 118 26 -
SLKTLEPELGALQA IL11_MOUSE 118 26 -
SLKTLEPELGTLQA A8K3F7_HUMAN 118 26 -
SLKTLEPELGTLQA IL11_HUMAN 118 26 -
SLKTLEPELGTLQT IL11_MACFA 118 26 -
Final Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
SPRVSSDPRAD A3KPB8_MOUSE 28 28 -
SPRVSSDPRAD IL11_RAT 28 28 -
SPRVSSDPRAD IL11_MOUSE 28 28 -
PPRVSPDPRAE A8K3F7_HUMAN 28 28 -
PPRVSPDPRAE IL11_HUMAN 28 28 -
SPRASPDPRAE IL11_MACFA 28 28 -

Motif 2 width=15
Element Seqn Id St Int Rpt
TLAMSAGTLGSLQLP A3KPB8_MOUSE 77 38 -
TLAMSAGTLGSLQLP IL11_RAT 77 38 -
TLAMSAGTLGSLQLP IL11_MOUSE 77 38 -
TLAMSAGALGALQLP A8K3F7_HUMAN 77 38 -
TLAMSAGALGALQLP IL11_HUMAN 77 38 -
TLAMSAGALGALQLP IL11_MACFA 77 38 -

Motif 3 width=14
Element Seqn Id St Int Rpt
SLKTLEPELGALQA A3KPB8_MOUSE 118 26 -
SLKTLEPELGALQA IL11_RAT 118 26 -
SLKTLEPELGALQA IL11_MOUSE 118 26 -
SLKTLEPELGTLQA A8K3F7_HUMAN 118 26 -
SLKTLEPELGTLQA IL11_HUMAN 118 26 -
SLKTLEPELGTLQT IL11_MACFA 118 26 -