SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR01942

Identifier
NTKRECEPTOR3  [View Relations]  [View Alignment]  
Accession
PR01942
No. of Motifs
4
Creation Date
03-APR-2008
Title
Neurotrophic tyrosine kinase receptor type 3 signature
Database References
PRINTS; PR00109 TYRKINASE; PR01939 NTKRECEPTOR
PDB; 1WWC
SCOP; 1WWC
CATH; 1WWC
MIM; 191316
Literature References
1. BOTHWELL, M.
Functional interactions of neurotrophins and neurotrophin receptors.
ANNU.REV.NEUROSCI. 18 223-253 (1995).
 
2. HUANG, E. AND REICHARDT, L.
Neurotrophins: roles in neuronal development and function.
ANNU.REV.NEUROSCI. 24 677-736 (2001).
 
3. TESSAROLLO, L., TSOULFAS, P., MARTIN-ZANCA, D., GILBERT D., JENKINS N.,
COPELAND N. AND PARADA L.
TrkC, a receptor for neurotrophin-3, is widely expressed in the developing
nervous system and in non-neuronal tissues.
DEVELOPMENT 118 463-475 (1993).
 
4. MARTINEZ, A., ALCANTARA, S., BORRELL, V., DEL RIO, J., OTAL, R., CAMPOS,
N., BORONAT, A., BARBACID, M., SILOS-SANTIAGO, I. AND SORIANO, E.
TrkB and TrkC signaling are required for maturation and synaptogenesis of
hippocampal connections.
J.NEUROSCI. 18 7336-7350 (1998).
 
5. BRODSKI, C., SCHNURCH, H. AND DECHANT, G.
Neurotrophin-3 promotes the cholinergic differentiation of sympathetic 
neurons. 
PROC.NATL.ACAD.SCI.U.S.A. 97 9683-9688 (2000).
 
6. COSGAYA, J., CHAN, J. AND SHOOTER, E.
The neurotrophin receptor p75NTR as a positive modulator of myelination.
SCIENCE 98 1245-1248 (2002).

Documentation
Neurotrophins are a family of secreted proteins that regulate development, 
maintenance and function of vertebrate nervous systems. They act via two 
different classes of receptor: p75NTR (a member of the TNF receptor 
superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also 
known as tropomyosin-related kinases (Trks) [1]. 
 
NTRKs are multi-domain, transmembrane proteins - in addition to their
cytoplasmic kinase domains, members of the family possess a number of
extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand
binding induces them to dimerise, resulting in activation of their
cytoplasmic tyrosine kinase domains. The activated receptors couple to a
variety of intracellular signalling cascades, including the Ras,
phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP)
kinase, and phospholipase C (PLC)-gamma pathways [2].
 
NTRK3 (also termed TrkC) is a high-affinity receptor for neurotrophin-3
(NT-3). The receptor is widely expressed in the developing nervous system,
and is also found in many non-neuronal tissues [3]. In addition to roles in
synaptogenesis [4] and neuronal differentiation [5], NTRK3 is implicated in
peripheral nerve cell myelination, mediating the inhibitory effects of NT-3
on this process [6].
 
NTKRECEPTOR3 is a 4-element fingerprint that provides a signature for 
neurotrophic tyrosine kinase receptor type 3. The fingerprint was derived
from an initial alignment of 2 sequences: the motifs were drawn from 
conserved regions spanning the N-terminal extracellular domain, focusing on
those sections that characterise NTRK3 but distinguish it from other members
of the NTRK family - motif 1 lies in the signal sequence; and motifs 3 and 4
reside within the second Ig-like C2-type region, each encompassing a short
region of beta strand. Two iterations on SPTR55_38f were required to
reach convergence, at which point a true set comprising 11 sequences was
identified. A single partial match was also found, Q2PFX3_MACFA, a 
translated macaque cDNA that fails to match motifs 1 and 2.
Summary Information
  11 codes involving  4 elements
0 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
411111111
30000
20011
1234
True Positives
A4QPD0_MOUSE  NTRK3_MACFA   NTRK3_MOUSE   NTRK3_PANTR   
NTRK3_SAIBB Q68G04_RAT Q96CY4_HUMAN TRKC_CHICK
TRKC_HUMAN TRKC_PIG TRKC_RAT
True Positive Partials
Codes involving 2 elements
Q2PFX3_MACFA
Sequence Titles
A4QPD0_MOUSE Neurotrophic tyrosine kinase, receptor, type 3 - Mus musculus (Mouse). 
NTRK3_MACFA NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
NTRK3_MOUSE NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) - Mus musculus (Mouse).
NTRK3_PANTR NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) - Pan troglodytes (Chimpanzee).
NTRK3_SAIBB NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) - Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
Q68G04_RAT Ntrk3 protein - Rattus norvegicus (Rat).
Q96CY4_HUMAN Neurotrophic tyrosine kinase, receptor, type 3 (Neurotrophic tyrosine kinase, receptor, type 3, isoform CRA_e) - Homo sapiens (Human).
TRKC_CHICK NT-3 GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKC TYROSINE KINASE) (TRK-C) - GALLUS GALLUS (CHICKEN).
TRKC_HUMAN NT-3 GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKC TYROSINE KINASE) (GP145-TRKC) (TRK-C) - HOMO SAPIENS (HUMAN).
TRKC_PIG NT-3 GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKC TYROSINE KINASE) (GP145-TRKC) (TRK-C) - SUS SCROFA (PIG).
TRKC_RAT NT-3 GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKC TYROSINE KINASE) (GP145-TRKC) (TRK-C) - RATTUS NORVEGICUS (RAT).

Q2PFX3_MACFA Tyrosine-protein kinase receptor (EC 2.7.10.1) - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
Scan History
SPTR55_38f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
MDVSLCPAKCSFW NTRK3_PANTR 1 1 -
MDVSLCPAKCSFW NTRK3_MOUSE 1 1 -

Motif 2 width=15
Element Seqn Id St Int Rpt
NGNASINITDISRNI NTRK3_PANTR 66 52 -
NGNASINITDISRNI NTRK3_MOUSE 66 52 -

Motif 3 width=15
Element Seqn Id St Int Rpt
PRVVSLEEPELRLEH NTRK3_PANTR 305 224 -
PRVVSLVEPEVRLEH NTRK3_MOUSE 305 224 -

Motif 4 width=15
Element Seqn Id St Int Rpt
KIIHVEYYQEGEISE NTRK3_PANTR 346 26 -
KIIHMDYYQEGEVSE NTRK3_MOUSE 346 26 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
MDVSLCPAKCSFW A4QPD0_MOUSE 1 1 -
MDVSLCPAKCSFW Q96CY4_HUMAN 1 1 -
MDVSLCPAKCSFW Q68G04_RAT 1 1 -
MDVSLCPAKCSFW NTRK3_SAIBB 1 1 -
MDVSLCPAKCSFW TRKC_RAT 1 1 -
MDVSLCPAKCSFW NTRK3_PANTR 1 1 -
MDVSLCPAKCSFW NTRK3_MOUSE 1 1 -
MDVSLCPAKCSFW NTRK3_MACFA 1 1 -
MDVSLCPAKCSFW TRKC_HUMAN 1 1 -
MDVSLCPAKCSFW TRKC_PIG 1 1 -
MDVSLCPTKCTFW TRKC_CHICK 1 1 -

Motif 2 width=15
Element Seqn Id St Int Rpt
NGNASINITDISRNI A4QPD0_MOUSE 66 52 -
NGNASINITDISRNI Q96CY4_HUMAN 66 52 -
NGNASINITDISRNI Q68G04_RAT 66 52 -
NGNASINITDISRNI NTRK3_SAIBB 66 52 -
NGNASINITDISRNI TRKC_RAT 66 52 -
NGNASINITDISRNI NTRK3_PANTR 66 52 -
NGNASINITDISRNI NTRK3_MOUSE 66 52 -
NGNASINITDISRNI NTRK3_MACFA 66 52 -
NGNASINITDISRNI TRKC_HUMAN 66 52 -
NGNASINITDISRNI TRKC_PIG 66 52 -
NGNTSINITDISRNI TRKC_CHICK 66 52 -

Motif 3 width=15
Element Seqn Id St Int Rpt
PRVVSLVEPEVRLEH A4QPD0_MOUSE 305 224 -
PRVVSLEEPELRLEH Q96CY4_HUMAN 305 224 -
PRVVSLVEPEVRLEH Q68G04_RAT 305 224 -
PRVVSLEEPELRLEH NTRK3_SAIBB 305 224 -
PRVVSLVEPEVRLEH TRKC_RAT 305 224 -
PRVVSLEEPELRLEH NTRK3_PANTR 305 224 -
PRVVSLVEPEVRLEH NTRK3_MOUSE 305 224 -
PRVVSLEEPELRLEH NTRK3_MACFA 305 224 -
PRVVSLEEPELRLEH TRKC_HUMAN 305 224 -
PRVVSLEEPELRLEH TRKC_PIG 305 224 -
PRILTLEEPVLHLEH TRKC_CHICK 305 224 -

Motif 4 width=15
Element Seqn Id St Int Rpt
KIIHMDYYQEGEVSE A4QPD0_MOUSE 346 26 -
KIIHVEYYQEGEISE Q96CY4_HUMAN 346 26 -
KIIHMDYYQEGEVSE Q68G04_RAT 346 26 -
KIIHVEYYQEGEISE NTRK3_SAIBB 346 26 -
KIIHMDYYQEGEVSE TRKC_RAT 346 26 -
KIIHVEYYQEGEISE NTRK3_PANTR 346 26 -
KIIHMDYYQEGEVSE NTRK3_MOUSE 346 26 -
KIIHVEYYQEGEISE NTRK3_MACFA 346 26 -
KIIHVEYYQEGEISE TRKC_HUMAN 346 26 -
KITHVEYYQEGEVSE TRKC_PIG 346 26 -
EIIHMEFYQQGEVSE TRKC_CHICK 346 26 -