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PR01939

Identifier
NTKRECEPTOR  [View Relations]  [View Alignment]  
Accession
PR01939
No. of Motifs
3
Creation Date
03-APR-2008
Title
Neurotrophic tyrosine kinase receptor family signature
Database References
PRINTS; PR00109 TYRKINASE; PR01940 NTKRECEPTOR1; PR01941 NTKRECEPTOR2
PRINTS; PR01942 NTKRECEPTOR3
PRODOM; PD861290; PD005226
Literature References
1. BOTHWELL, M.
Functional interactions of neurotrophins and neurotrophin receptors.
ANNU.REV.NEUROSCI. 18 223-253 (1995).
 
2. HUANG, E. AND REICHARDT, L.
Neurotrophins: roles in neuronal development and function.
ANNU.REV.NEUROSCI. 24 677-736 (2001).

Documentation
Neurotrophins are a family of secreted proteins that regulate development, 
maintenance and function of vertebrate nervous systems. They act via two 
different classes of receptor: p75NTR (a member of the TNF receptor 
superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also 
known as tropomyosin-related kinases (Trks) [1]. 
 
NTRKs are multi-domain, transmembrane proteins - in addition to their
cytoplasmic kinase domains, members of the family possess a number of
extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand
binding induces them to dimerise, resulting in activation of their
cytoplasmic tyrosine kinase domains. The activated receptors couple to a
variety of intracellular signalling cascades, including the Ras,
phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP)
kinase, and phospholipase C (PLC)-gamma pathways [2].
 
NTKRECEPTOR is a 3-element fingerprint that provides a signature for the
neurotrophic tyrosine kinase receptor family. The fingerprint was derived
from an initial alignment of 5 sequences: the motifs were drawn from
conserved regions within the N-terminal extracellular domain - motif 1 spans
the first LRR region; and motifs 2 and 3 lie within the first and second
Ig-like C2-type domains, respectively. Two iterations on SPTR55_38f were
required to reach convergence, at which point a true set comprising 34
sequences was identified. A single partial match was also found,
A8WGA3_DANRE, a translated mRNA sequence from zebrafish that fails to match
motif 3.
Summary Information
  34 codes involving  3 elements
1 codes involving 2 elements
Composite Feature Index
3343434
2110
123
True Positives
A4QPD0_MOUSE  A6NF12_HUMAN  A8K3Z4_HUMAN  NTRK1_MOUSE   
NTRK3_MACFA NTRK3_MOUSE NTRK3_PANTR NTRK3_SAIBB
Q08D53_XENTR Q0VCN4_BOVIN Q3UHE3_MOUSE Q52V39_BRAFL
Q52V40_BRAFL Q548C2_HUMAN Q5PPW7_XENLA Q5VWE5_HUMAN
Q68G04_RAT Q7ZXJ8_XENLA Q8WXJ5_HUMAN Q8WXJ7_HUMAN
Q90699 Q96CY4_HUMAN Q9YH43_XENLA Q9YH44_XENLA
TRKA_HUMAN TRKA_RAT TRKB_CHICK TRKB_HUMAN
TRKB_MOUSE TRKB_RAT TRKC_CHICK TRKC_HUMAN
TRKC_PIG TRKC_RAT
True Positive Partials
Codes involving 2 elements
A8WGA3_DANRE
Sequence Titles
A4QPD0_MOUSE Neurotrophic tyrosine kinase, receptor, type 3 - Mus musculus (Mouse). 
A6NF12_HUMAN Tyrosine-protein kinase receptor (EC 2.7.10.1) - Homo sapiens (Human).
A8K3Z4_HUMAN cDNA FLJ75372, highly similar to Human trk proto-oncogene insert of pLM6 - Homo sapiens (Human).
NTRK1_MOUSE High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) - Mus musculus (Mouse).
NTRK3_MACFA NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
NTRK3_MOUSE NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) - Mus musculus (Mouse).
NTRK3_PANTR NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) - Pan troglodytes (Chimpanzee).
NTRK3_SAIBB NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) - Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
Q08D53_XENTR Tyrosine-protein kinase receptor (EC 2.7.10.1) - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Q0VCN4_BOVIN Neurotrophic tyrosine kinase, receptor, type 2 - Bos taurus (Bovine).
Q3UHE3_MOUSE CDNA, RIKEN full-length enriched library, clone:M5C1042H21 product:neurotrophic tyrosine kinase, receptor, type 2, full insert sequence - Mus musculus (Mouse).
Q52V39_BRAFL Tyrosine-protein kinase receptor (EC 2.7.10.1) - Branchiostoma floridae (Florida lancelet) (Amphioxus).
Q52V40_BRAFL Neurotrophic tyrosine kinase receptor precursor - Branchiostoma floridae (Florida lancelet) (Amphioxus).
Q548C2_HUMAN Neurotrophic tyrosine kinase receptor type 2 - Homo sapiens (Human).
Q5PPW7_XENLA Ntrk2 protein - Xenopus laevis (African clawed frog).
Q5VWE5_HUMAN Neurotrophic tyrosine kinase, receptor, type 2 (Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a) (cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA) - Homo sapiens (Human).
Q68G04_RAT Ntrk3 protein - Rattus norvegicus (Rat).
Q7ZXJ8_XENLA Trkb-B-prov protein - Xenopus laevis (African clawed frog).
Q8WXJ5_HUMAN Neurotrophin receptor tyrosine kinase type 2 truncated isoform - Homo sapiens (Human).
Q8WXJ7_HUMAN Tyrosine-protein kinase receptor (EC 2.7.10.1) - Homo sapiens (Human).
Q90699 TROPOMYOSIN RECEPTOR KINASE - GALLUS GALLUS (CHICKEN).
Q96CY4_HUMAN Neurotrophic tyrosine kinase, receptor, type 3 (Neurotrophic tyrosine kinase, receptor, type 3, isoform CRA_e) - Homo sapiens (Human).
Q9YH43_XENLA Tyrosine-protein kinase receptor (EC 2.7.10.1) - Xenopus laevis (African clawed frog).
Q9YH44_XENLA Tyrosine-protein kinase receptor (EC 2.7.10.1) - Xenopus laevis (African clawed frog).
TRKA_HUMAN HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (TRK1 TRANSFORMING TYROSINE KINASE PROTEIN) (P140-TRKA) (TRK-A) - HOMO SAPIENS (HUMAN).
TRKA_RAT HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (P140-TRKA) (SLOW NERVE GROWTH FACTOR RECEPTOR) (TRK-A) - RATTUS NORVEGICUS (RAT).
TRKB_CHICK BDNF/NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKB TYROSINE KINASE) (TRK-B) - GALLUS GALLUS (CHICKEN).
TRKB_HUMAN BDNF/NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKB TYROSINE KINASE) (GP145-TRKB) (TRK-B) - HOMO SAPIENS (HUMAN).
TRKB_MOUSE BDNF/NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKB TYROSINE KINASE) (GP145-TRKB/GP95-TRKB) (TRK-B) - MUS MUSCULUS (MOUSE).
TRKB_RAT BDNF/NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKB TYROSINE KINASE) (GP145-TRKB/GP95-TRKB) (TRK-B) - RATTUS NORVEGICUS (RAT).
TRKC_CHICK NT-3 GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKC TYROSINE KINASE) (TRK-C) - GALLUS GALLUS (CHICKEN).
TRKC_HUMAN NT-3 GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKC TYROSINE KINASE) (GP145-TRKC) (TRK-C) - HOMO SAPIENS (HUMAN).
TRKC_PIG NT-3 GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKC TYROSINE KINASE) (GP145-TRKC) (TRK-C) - SUS SCROFA (PIG).
TRKC_RAT NT-3 GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKC TYROSINE KINASE) (GP145-TRKC) (TRK-C) - RATTUS NORVEGICUS (RAT).

A8WGA3_DANRE Putative uncharacterized protein - Danio rerio (Zebrafish) (Brachydanio rerio).
Scan History
SPTR55_38f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=26
Element Seqn Id St Int Rpt
DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_PANTR 98 98 -
DMELYTGLQKLTIKNSGLRNIQPRAF NTRK3_MOUSE 98 98 -
DVEAYVGLRNLTIVDSGLKFVAHKAF TRKB_HUMAN 86 86 -
DLRGLGELRNLTIVKSGLRFVAPDAF TRKA_HUMAN 86 86 -
EVGFYVGLKNLTVVDSGLRFVSRQAF TRKB_CHICK 85 85 -

Motif 2 width=20
Element Seqn Id St Int Rpt
NVTSEDNGFTLTCIAENVVG NTRK3_PANTR 272 148 -
NVTSEDNGFTLTCIAENVVG NTRK3_MOUSE 272 148 -
NISSDDSGKQISCVAENLVG TRKB_HUMAN 254 142 -
NVTSDLNRKNVTCWAENDVG TRKA_HUMAN 253 141 -
NVSSMDSGLWISCVAENIVG TRKB_CHICK 253 142 -

Motif 3 width=18
Element Seqn Id St Int Rpt
GCLLFNKPTHYNNGNYTL NTRK3_PANTR 361 69 -
GCLLFNKPTHYNNGNYTL NTRK3_MOUSE 361 69 -
GCLQLDNPTHMNNGDYTL TRKB_HUMAN 344 70 -
GCLRLNQPTHVNNGNYTL TRKA_HUMAN 344 71 -
GCLQLDNPTHLNNGAYTL TRKB_CHICK 343 70 -
Final Motifs
Motif 1  width=26
Element Seqn Id St Int Rpt
DMELYTGLQKLTIKNSGLRSIQPRAF TRKC_HUMAN 98 98 -
DMELYTGLQKLTIKNSGLRSIQPRAF Q96CY4_HUMAN 98 98 -
DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_SAIBB 98 98 -
DMELYTGLQKLTIKNSGLRSIQPRAF TRKC_PIG 98 98 -
DMELYTGLQKLTIKNSGLRSIQPRAF NTRK3_PANTR 98 98 -
DMELYTGLQKLTIKNSGLRNIQPRAF A4QPD0_MOUSE 98 98 -
DMELYTGLQKLTIKNSGLRNIQPRAF Q68G04_RAT 98 98 -
DMELYTGLQKLTIKNSGLRNIQPRAF TRKC_RAT 98 98 -
DMELYTGLQKLTIKNSGLRNIQPRAF NTRK3_MOUSE 98 98 -
DMELYTGLQKLTIRNSGLRSIQPRAF NTRK3_MACFA 98 98 -
DVEAYVGLRNLTIVDSGLKFVAHKAF TRKB_HUMAN 86 86 -
DVEAYVGLRNLTIVDSGLKFVAHKAF Q8WXJ7_HUMAN 86 86 -
DVEAYVGLRNLTIVDSGLKFVAHKAF Q8WXJ5_HUMAN 86 86 -
DVEAYVGLRNLTIVDSGLKFVAHKAF Q5VWE5_HUMAN 86 86 -
DVEAYVGLRNLTIVDSGLKFVAHKAF Q548C2_HUMAN 86 86 -
DVEAYVGLRNLTIVDSGLKFVAYKAF TRKB_MOUSE 86 86 -
DVEAYVGLRNLTIVDSGLKFVAYKAF Q3UHE3_MOUSE 86 86 -
DVEAYVGLKNLTIVDSGLKFVAYKAF TRKB_RAT 86 86 -
DMELYTGLQRLTIRNSGLRNIQPRAF TRKC_CHICK 98 98 -
DLEAYVGLKNLTIVDSGLKSVAHKAF Q0VCN4_BOVIN 86 86 -
DLRGLGELRNLTIVKSGLRFVAPDAF A6NF12_HUMAN 56 56 -
DLRGLGELRNLTIVKSGLRFVAPDAF TRKA_HUMAN 86 86 -
DLRGLGELRNLTIVKSGLRFVAPDAF A8K3Z4_HUMAN 86 86 -
DVKIYTGLRNLTVVDSGLQIVSRQAF Q7ZXJ8_XENLA 85 85 -
DVKIYTGLRNLTVVDSGLQIVSRQAF Q9YH44_XENLA 85 85 -
DVKIYTGLRNLTVVDSGLQIVSRQAF Q9YH43_XENLA 85 85 -
DVKIYTGLRNLTVVDSGLQIVSRQAF Q08D53_XENTR 85 85 -
DLQGLGELRSLTIVKSGLRFVAPDAF NTRK1_MOUSE 86 86 -
DLQGLGELRSLTIVKSGLRFVAPDAF TRKA_RAT 86 86 -
EVGFYVGLKNLTVVDSGLRFVSRQAF TRKB_CHICK 85 85 -
DIKIYTGLRNLTVVDSGLQIVSRQAF Q5PPW7_XENLA 82 82 -
DTRMLWDLRHLTISNSGLQYISDDAF Q90699 76 76 -
QLGHYKGLIKLVIKNSNLSTIEDGAF Q52V39_BRAFL 81 81 -
QLGHYKGLIKLVIKNSNLSTIEDGAF Q52V40_BRAFL 81 81 -

Motif 2 width=20
Element Seqn Id St Int Rpt
NVTSEDNGFTLTCIAENVVG TRKC_HUMAN 272 148 -
NVTSEDNGFTLTCIAENVVG Q96CY4_HUMAN 272 148 -
NVTSEDNGFTLTCIAENVVG NTRK3_SAIBB 272 148 -
NVTSEDNGFTLTCIAENVVG TRKC_PIG 272 148 -
NVTSEDNGFTLTCIAENVVG NTRK3_PANTR 272 148 -
NVTSEDNGFTLTCIAENVVG A4QPD0_MOUSE 272 148 -
NVTSEDNGFTLTCIAENVVG Q68G04_RAT 272 148 -
NVTSEDNGFTLTCIAENVVG TRKC_RAT 272 148 -
NVTSEDNGFTLTCIAENVVG NTRK3_MOUSE 272 148 -
NVTSEDNGFTLTCIAENVVG NTRK3_MACFA 272 148 -
NISSDDSGKQISCVAENLVG TRKB_HUMAN 254 142 -
NISSDDSGKQISCVAENLVG Q8WXJ7_HUMAN 254 142 -
NISSDDSGKQISCVAENLVG Q8WXJ5_HUMAN 254 142 -
NISSDDSGKQISCVAENLVG Q5VWE5_HUMAN 254 142 -
NISSDDSGKQISCVAENLVG Q548C2_HUMAN 254 142 -
NISSDDSGKQISCVAENLVG TRKB_MOUSE 254 142 -
NISSDDSGKQISCVAENLVG Q3UHE3_MOUSE 254 142 -
NISSDDSGKQISCVAENLVG TRKB_RAT 254 142 -
NVTSEDNGFLLTCIAENVVG TRKC_CHICK 272 148 -
NISSDDSGKQISCVAENLVG Q0VCN4_BOVIN 254 142 -
NVTSDLNRKNVTCWAENDVG A6NF12_HUMAN 223 141 -
NVTSDLNRKNVTCWAENDVG TRKA_HUMAN 253 141 -
NVTSDLNRKNVTCWAENDVG A8K3Z4_HUMAN 253 141 -
NVTSLDNKRIIVCVAENSVG Q7ZXJ8_XENLA 254 143 -
NVTSLDNKRIIVCVAENSVG Q9YH44_XENLA 254 143 -
NVTSLDNKRIIVCVAENSVG Q9YH43_XENLA 254 143 -
NVTSMDNKRVIVCVAENSVG Q08D53_XENTR 253 142 -
NVTSDLNKKNVTCWAENDVG NTRK1_MOUSE 255 143 -
NVTSDLNKKNVTCWAENDVG TRKA_RAT 255 143 -
NVSSMDSGLWISCVAENIVG TRKB_CHICK 253 142 -
NITSLDNKRVILCVAENSVG Q5PPW7_XENLA 251 143 -
NISSSLNHKDLTCRAENAVG Q90699 245 143 -
HNASEDDNGNWTCIAKNMVG Q52V39_BRAFL 252 145 -
HNASEDDNGNWTCIAKNMVG Q52V40_BRAFL 252 145 -

Motif 3 width=18
Element Seqn Id St Int Rpt
GCLLFNKPTHYNNGNYTL TRKC_HUMAN 361 69 -
GCLLFNKPTHYNNGNYTL Q96CY4_HUMAN 361 69 -
GCLLFNKPTHYNNGNYTL NTRK3_SAIBB 361 69 -
GCLLFNKPTHYNNGNYTL TRKC_PIG 361 69 -
GCLLFNKPTHYNNGNYTL NTRK3_PANTR 361 69 -
GCLLFNKPTHYNNGNYTL A4QPD0_MOUSE 361 69 -
GCLLFNKPTHYNNGNYTL Q68G04_RAT 361 69 -
GCLLFNKPTHYNNGNYTL TRKC_RAT 361 69 -
GCLLFNKPTHYNNGNYTL NTRK3_MOUSE 361 69 -
GCLLFNKPTHYNNGNYTL NTRK3_MACFA 361 69 -
GCLQLDNPTHMNNGDYTL TRKB_HUMAN 344 70 -
GCLQLDNPTHMNNGDYTL Q8WXJ7_HUMAN 344 70 -
GCLQLDNPTHMNNGDYTL Q8WXJ5_HUMAN 344 70 -
GCLQLDNPTHMNNGDYTL Q5VWE5_HUMAN 344 70 -
GCLQLDNPTHMNNGDYTL Q548C2_HUMAN 344 70 -
GCLQLDNPTHMNNGDYTL TRKB_MOUSE 344 70 -
GCLQLDNPTHMNNGDYTL Q3UHE3_MOUSE 344 70 -
GCLQLDNPTHMNNGDYTL TRKB_RAT 344 70 -
GCLLFNKPTHYNNGNYTI TRKC_CHICK 361 69 -
GCLQLDNPTHMNNGDYKL Q0VCN4_BOVIN 344 70 -
GCLRLNQPTHVNNGNYTL A6NF12_HUMAN 314 71 -
GCLRLNQPTHVNNGNYTL TRKA_HUMAN 344 71 -
GCLRLNQPTHVNNGNYTL A8K3Z4_HUMAN 344 71 -
GCLQLDSPTHLNNGFYTL Q7ZXJ8_XENLA 346 72 -
GCLQLDSPTHLNNGFYTL Q9YH44_XENLA 346 72 -
GCLQLDSPTHLNNGFYTL Q9YH43_XENLA 346 72 -
GCLQLDSPTHLNNGFYTL Q08D53_XENTR 345 72 -
GCLRLNQPTHVNNGNYTL NTRK1_MOUSE 347 72 -
GCLRLNQPTHVNNGNYTL TRKA_RAT 347 72 -
GCLQLDNPTHLNNGAYTL TRKB_CHICK 343 70 -
GCLQLDSPTHLNNGFYTL Q5PPW7_XENLA 343 72 -
GCLQLNRPTHVNNGNYTL Q90699 337 72 -
GCLKFEVPSHVDNGNYTL Q52V39_BRAFL 343 71 -
GCLKFEVPSHVDNGNYTL Q52V40_BRAFL 343 71 -