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PR01931

Identifier
INTRLEUKIN16  [View Relations]  [View Alignment]  
Accession
PR01931
No. of Motifs
3
Creation Date
24-JUL-2008
Title
Interleukin-16 signature
Database References

PRODOM; PD615050; PD860252; PD904336; PD008552
PDB; 1I16; 1X6D
SCOP; 1I16; 1X6D
CATH; 1I16; 1X6D
MIM; 603035
Literature References
1. CRUIKSHANK, W., CENTER, D., NISAR, N., WU, M., NATKE, B., THEODORE, A.
AND KORNFELD, H.
Molecular and functional analysis of a lymphocyte chemoattractant factor: 
association of biologic function with CD4 expression.
PROC.NATL.ACAD.SCI.U.S.A. 91 5109-5113 (1994).
 
2. GLASS, W., SARISKY, R. AND VECCHIO, A.
Not-so-sweet sixteen: the role of IL-16 in infectious and immune-mediated 
inflammatory diseases.
J.INTERFERON CYTOKINE RES. 26 511-520 (2006).

Documentation
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
 
Interleukin-16 (IL-16, also known as lymphocyte chemoattractant factor) is
a proinflammatory cytokine that signals via CD4, inducing chemotactic and
immunomodulatory responses of CD4+ lymphocytes, monocytes and eosinophils
[1]. The cytokine has been implicated in the exacerbation of a number of 
infectious, immune-mediated and autoimmune inflammatory disorders, 
including atopic dermatitis, irritable bowel syndrome, systemic lupus 
erythematosus, neurodegenerative disorders, and viral infections [2].
 
INTRLEUKIN16 is a 3-element fingerprint that provides a signature for 
interleukin-16. The fingerprint was derived from an initial alignment of 5
sequences: the motifs were drawn from conserved regions spanning virtually 
the full alignment length, motifs 2 and 3 encompassing short regions of beta
strand. Two iterations on SPTR55_38f were required to reach convergence,
at which point a true set comprising 28 sequences was identified.
Summary Information
28 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3282828
2000
123
True Positives
A6NM20_HUMAN  A8MU65_HUMAN  IL16_AOTTR    IL16_BOVIN    
IL16_CERAE IL16_HUMAN IL16_MACFA IL16_MACMU
IL16_MOUSE IL16_PANTR IL16_SAISC Q2HYY2_TETNG
Q3UZ81_MOUSE Q58IE0_TETNG Q6VVE6_HUMAN Q6ZMQ7_HUMAN
Q6ZTT5_HUMAN Q6ZVH3_HUMAN Q70XC4_CHICK Q76EI9_PIG
Q76KI6_PIG Q76KI7_PIG Q804H4_CHICK Q804Z8_CHICK
Q8JID9_ANAPL Q8JIE0_ANAPL Q9QZP6_MOUSE Q9UME6_HUMAN
Sequence Titles
A6NM20_HUMAN Uncharacterized protein IL16 - Homo sapiens (Human). 
A8MU65_HUMAN Uncharacterized protein IL16 (Interleukin 16 (Lymphocyte chemoattractant factor), isoform CRA_d) - Homo sapiens (Human).
IL16_AOTTR Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Aotus trivirgatus (Night monkey) (Douroucouli).
IL16_BOVIN Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Bos taurus (Bovine).
IL16_CERAE Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Cercopithecus aethiops (Green monkey) (Grivet).
IL16_HUMAN Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Homo sapiens (Human).
IL16_MACFA Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
IL16_MACMU Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Macaca mulatta (Rhesus macaque).
IL16_MOUSE Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Mus musculus (Mouse).
IL16_PANTR Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Pan troglodytes (Chimpanzee).
IL16_SAISC Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Saimiri sciureus (Common squirrel monkey).
Q2HYY2_TETNG Interleukin-16 - Tetraodon nigroviridis (Green puffer).
Q3UZ81_MOUSE Adult male thymus cDNA, RIKEN full-length enriched library, clone:5830405J22 product:interleukin 16, full insert sequence - Mus musculus (Mouse).
Q58IE0_TETNG Interleukin 16 - Tetraodon nigroviridis (Green puffer).
Q6VVE6_HUMAN Neural interleukin 16 protein - Homo sapiens (Human).
Q6ZMQ7_HUMAN cDNA FLJ16759 fis, clone BRACE3046450, highly similar to Interleukin- 16 - Homo sapiens (Human).
Q6ZTT5_HUMAN cDNA FLJ44234 fis, clone THYMU3007137, highly similar to Interleukin- 16 - Homo sapiens (Human).
Q6ZVH3_HUMAN cDNA FLJ42574 fis, clone BRACE3008137, highly similar to Interleukin- 16 - Homo sapiens (Human).
Q70XC4_CHICK Interleukin-16 - Gallus gallus (Chicken).
Q76EI9_PIG Interleukin 16 - Sus scrofa (Pig).
Q76KI6_PIG Interleukin-16 - Sus scrofa (Pig).
Q76KI7_PIG Interleukin-16 - Sus scrofa (Pig).
Q804H4_CHICK Interleukin 16 - Gallus gallus (Chicken).
Q804Z8_CHICK Interleukin-16 - Gallus gallus (Chicken).
Q8JID9_ANAPL Interleukin-16 - Anas platyrhynchos (Domestic duck).
Q8JIE0_ANAPL Interleukin-16 - Anas platyrhynchos (Domestic duck).
Q9QZP6_MOUSE Neuronal IL-16 (Interleukin 16) - Mus musculus (Mouse).
Q9UME6_HUMAN Interleukin-16 - Homo sapiens (Human).
Scan History
SPTR55_38f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
PVAPKPAWFRQSLKGLR IL16_MOUSE 83 83 -
PVAPKPAWFRQSLKGLR IL16_HUMAN 83 83 -
PVAPKPVWFRQSLKGLR Q70XC4_CHICK 56 56 -
PVAPKPAWFRQSLKGLR Q8JIE0_ANAPL 56 56 -
PVAPKPPWFRQSLKKIQ Q2HYY2_TETNG 736 736 -

Motif 2 width=17
Element Seqn Id St Int Rpt
DEATLKQLDSIHVTILH IL16_MOUSE 396 296 -
DEATLKQLDGIHVTILH IL16_HUMAN 400 300 -
DEATLKELDDIHVTILH Q70XC4_CHICK 378 305 -
DEATLKEFDDIHVTILH Q8JIE0_ANAPL 378 305 -
EDDTLKQLEDIHLVVLH Q2HYY2_TETNG 1057 304 -

Motif 3 width=25
Element Seqn Id St Int Rpt
GFSLAGGADLENKVITVHRVFPNGL IL16_MOUSE 420 7 -
GFSLAGGADLENKVITVHRVFPNGL IL16_HUMAN 424 7 -
GFSLAGGADLENKVITVHKVFPNGL Q70XC4_CHICK 402 7 -
GFSLAGGVDLENKVITVHKVFPNGL Q8JIE0_ANAPL 402 7 -
GFSIAGGSDLENKVLTVHKVFSSGL Q2HYY2_TETNG 1081 7 -
Final Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
PVAPKPAWFRQSLKGLR IL16_AOTTR 83 83 -
PVAPKPAWFRQSLKGLR Q9QZP6_MOUSE 781 781 -
PVAPKPAWFRQSLKGLR Q76KI7_PIG 83 83 -
PVAPKPAWFRQSLKGLR Q76KI6_PIG 83 83 -
PVAPKPAWFRQSLKGLR Q76EI9_PIG 83 83 -
PVAPKPAWFRQSLKGLR IL16_SAISC 83 83 -
PVAPKPAWFRQSLKGLR IL16_PANTR 83 83 -
PVAPKPAWFRQSLKGLR IL16_MOUSE 83 83 -
PVAPKPAWFRQSLKGLR IL16_BOVIN 83 83 -
PVAPKPAWFRQSLKGLR A6NM20_HUMAN 784 784 -
PVAPKPAWFRQSLKGLR Q9UME6_HUMAN 83 83 -
PVAPKPAWFRQSLKGLR Q6ZVH3_HUMAN 616 616 -
PVAPKPAWFRQSLKGLR Q6ZTT5_HUMAN 278 278 -
PVAPKPAWFRQSLKGLR Q6ZMQ7_HUMAN 784 784 -
PVAPKPAWFRQSLKGLR Q6VVE6_HUMAN 784 784 -
PVAPKPAWFRQSLKGLR IL16_HUMAN 83 83 -
PVAPKPAWFRQSLKGLR A8MU65_HUMAN 738 738 -
PVAPKPAWFRQSLKGLR IL16_CERAE 83 83 -
PVAPKPAWFRQSLKGLR IL16_MACMU 83 83 -
PVAPKPAWFRQSLKGLR IL16_MACFA 83 83 -
PVAPKPAWFRQSLKGLR Q3UZ81_MOUSE 83 83 -
PVAPKPVWFRQSLKGLR Q70XC4_CHICK 56 56 -
PVAPKPVWFRQSLKGLR Q804Z8_CHICK 56 56 -
PVAPKPVWFRQSLKGLR Q804H4_CHICK 56 56 -
PVAPKPAWFRQSLKGLR Q8JID9_ANAPL 56 56 -
PVAPKPAWFRQSLKGLR Q8JIE0_ANAPL 56 56 -
PVAPKPPWFRQSLKKIQ Q2HYY2_TETNG 736 736 -
PVAPKPPWFRQSLKKIQ Q58IE0_TETNG 37 37 -

Motif 2 width=17
Element Seqn Id St Int Rpt
DEATLKQLDSIHVTILH IL16_AOTTR 401 301 -
DEATLKQLDSIHVTILH Q9QZP6_MOUSE 1094 296 -
DEATLKQLDSIHVTILH Q76KI7_PIG 405 305 -
DEATLKQLDSIHVTILH Q76KI6_PIG 405 305 -
DEATLKQLDSIHVTILH Q76EI9_PIG 405 305 -
DEATLKQLDSIHVTILH IL16_SAISC 396 296 -
DEATLKQLDSIHVTILH IL16_PANTR 400 300 -
DEATLKQLDSIHVTILH IL16_MOUSE 396 296 -
DEATLKQLDSIHVTILH IL16_BOVIN 397 297 -
DEATLKQLDGIHVTILH A6NM20_HUMAN 1101 300 -
DEATLKQLDGIHVTILH Q9UME6_HUMAN 400 300 -
DEATLKQLDGIHVTILH Q6ZVH3_HUMAN 933 300 -
DEATLKQLDGIHVTILH Q6ZTT5_HUMAN 594 299 -
DEATLKQLDGIHVTILH Q6ZMQ7_HUMAN 1101 300 -
DEATLKQLDGIHVTILH Q6VVE6_HUMAN 1101 300 -
DEATLKQLDGIHVTILH IL16_HUMAN 400 300 -
DEATLKQLDGIHVTILH A8MU65_HUMAN 1055 300 -
DEATLKQLDSIHVTILH IL16_CERAE 400 300 -
DEATLKQLDSIHVTILH IL16_MACMU 399 299 -
DEATLKQLDSIHVTILH IL16_MACFA 399 299 -
DEATLKQLDSIHVTILH Q3UZ81_MOUSE 396 296 -
DEATLKELDDIHVTILH Q70XC4_CHICK 378 305 -
DEATLKELDDIHVTILH Q804Z8_CHICK 378 305 -
DEATLKELDDIHVTILH Q804H4_CHICK 378 305 -
DEATLKEFDDIHVTILH Q8JID9_ANAPL 378 305 -
DEATLKEFDDIHVTILH Q8JIE0_ANAPL 378 305 -
EDDTLKQLEDIHLVVLH Q2HYY2_TETNG 1057 304 -
EDDTLKQLEDIHLVVLH Q58IE0_TETNG 358 304 -

Motif 3 width=25
Element Seqn Id St Int Rpt
GFSLAGGADLENKVITVHRVFPNGL IL16_AOTTR 425 7 -
GFSLAGGADLENKVITVHRVFPNGL Q9QZP6_MOUSE 1118 7 -
GFSLAGGADLENKVITVHRVFPNGL Q76KI7_PIG 429 7 -
GFSLAGGADLENKVITVHRVFPNGL Q76KI6_PIG 429 7 -
GFSLAGGADLENKVITVHRVFPNGL Q76EI9_PIG 429 7 -
GFSLAGGADLENKVITVHRVFPNGL IL16_SAISC 420 7 -
GFSLAGGADLENKVITVHRVFPNGL IL16_PANTR 424 7 -
GFSLAGGADLENKVITVHRVFPNGL IL16_MOUSE 420 7 -
GFSLAGGADLENKVITVHRVFPNGL IL16_BOVIN 421 7 -
GFSLAGGADLENKVITVHRVFPNGL A6NM20_HUMAN 1125 7 -
GFSLAGGADLENKVITVHRVFPNGL Q9UME6_HUMAN 424 7 -
GFSLAGGADLENKVITVHRVFPNGL Q6ZVH3_HUMAN 957 7 -
GFSLAGGADLENKVITVHRVFPNGL Q6ZTT5_HUMAN 618 7 -
GFSLAGGADLENKVITVHRVFPNGL Q6ZMQ7_HUMAN 1125 7 -
GFSLAGGADLENKVITVHRVFPNGL Q6VVE6_HUMAN 1125 7 -
GFSLAGGADLENKVITVHRVFPNGL IL16_HUMAN 424 7 -
GFSLAGGADLENKVITVHRVFPNGL A8MU65_HUMAN 1079 7 -
GFSLAGGADLENKVITVHKVFPNGL IL16_CERAE 424 7 -
GFSLAGGADLENKVITVHKVFPNGL IL16_MACMU 423 7 -
GFSLAGGADLENKVITVHKVFPNGL IL16_MACFA 423 7 -
GFSLAGGADLENKVITVHRVFTNGL Q3UZ81_MOUSE 420 7 -
GFSLAGGADLENKVITVHKVFPNGL Q70XC4_CHICK 402 7 -
GFSLAGGADLENKVITVHKVFPNGL Q804Z8_CHICK 402 7 -
GFSLAGGADLENKVITVHKVFPNGL Q804H4_CHICK 402 7 -
GFSLAGGVDLENKVITVHKVFPNGL Q8JID9_ANAPL 402 7 -
GFSLAGGVDLENKVITVHKVFPNGL Q8JIE0_ANAPL 402 7 -
GFSIAGGSDLENKVLTVHKVFSSGL Q2HYY2_TETNG 1081 7 -
GFSIAGGSDLENKVLTVHKVFSSGL Q58IE0_TETNG 382 7 -