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PR01927

Identifier
INTRLEUKIN11  [View Relations]  [View Alignment]  
Accession
PR01927
No. of Motifs
3
Creation Date
23-JUL-2008
Title
Interleukin-11 signature
Database References
PRINTS; PR01944 INTLKN11FISH; PR01943 INTLKN11MAML
PFAM; PF07400 IL11
PRODOM; P20809
INTERPRO; IPR010873
MIM; 147681
Literature References
1. LENG, S. AND ELIAS, J.
Interleukin-11.
INT.J.BIOCHEM.CELL BIOL. 29 1059-1062 (1997).
 
2. TREPICCHIO, W. AND DORNER, A.
The therapeutic utility of Interleukin-11 in the treatment of inflammatory 
disease.
EXPERT OPIN.INVESTIG.DRUGS 7 1501-1504 (1998).

Documentation
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
 
Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates 
megakaryocytopoiesis, resulting in increased production of platelets, as 
well as activating osteoclasts, inhibiting epithelial cell proliferation 
and apoptosis, and inhibiting macrophage mediator production. These 
functions may be particularly important in mediating the hematopoietic, 
osseous and mucosal protective effects of IL-11 [1]. The cytokine also 
possesses anti-inflammatory activity, and has been proposed as a therapeutic
agent in the treatment of chronic inflammatory diseases, such as Crohn's 
disease and rheumatoid arthritis [2].
 
INTRLEUKIN11 is a 3-element fingerprint that provides a signature for 
interleukin-11. The fingerprint was derived from an initial alignment of 15
sequences: the motifs were drawn from conserved regions spanning virtually 
the full alignment length. A single iteration on SPTR55_38f was required to 
reach convergence, no further sequences being identified beyond the 
starting set.
Summary Information
15 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3151515
2000
123
True Positives
A3KPB8_MOUSE  A8CEL7_PAROL  A8K3F7_HUMAN  IL11_HUMAN    
IL11_MACFA IL11_MOUSE IL11_RAT Q494Q4_DANRE
Q494Q5_DANRE Q494Q7_TETNG Q494Q8_FUGRU Q494Q9_FUGRU
Q4H133_CYPCA Q5NKG1_ONCMY Q6UAM0_TETNG
Sequence Titles
A3KPB8_MOUSE Interleukin 11 - Mus musculus (Mouse).        
A8CEL7_PAROL Interleukin 11 type b - Paralichthys olivaceus (Japanese flounder).
A8K3F7_HUMAN cDNA FLJ78117, highly similar to Homo sapiens interleukin 11 (IL11), mRNA (Interleukin 11) - Homo sapiens (Human).
IL11_HUMAN Interleukin-11 precursor (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin) - Homo sapiens (Human).
IL11_MACFA Interleukin-11 precursor (IL-11) - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
IL11_MOUSE Interleukin-11 precursor (IL-11) - Mus musculus (Mouse).
IL11_RAT Interleukin-11 precursor (IL-11) - Rattus norvegicus (Rat).
Q494Q4_DANRE Interleukin-11b - Danio rerio (Zebrafish) (Brachydanio rerio).
Q494Q5_DANRE Interleukin-11a - Danio rerio (Zebrafish) (Brachydanio rerio).
Q494Q7_TETNG Interleukin-11a - Tetraodon nigroviridis (Green puffer).
Q494Q8_FUGRU Interleukin-11b - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
Q494Q9_FUGRU Interleukin-11a - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
Q4H133_CYPCA Interleukin-11 - Cyprinus carpio (Common carp).
Q5NKG1_ONCMY Interleukin-11 (Interleukin-11 precursor) - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Q6UAM0_TETNG Interleukin-11 - Tetraodon nigroviridis (Green puffer).
Scan History
SPTR55_38f 1  300  NSINGLE    
Initial Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
LDSLPTLAMSA A3KPB8_MOUSE 72 72 -
LDSLPTLAMSA IL11_MOUSE 72 72 -
LDSLPTLAMSA IL11_MACFA 72 72 -
LDSLPTLAMSA IL11_HUMAN 72 72 -
LDSLPTLAMSA A8K3F7_HUMAN 72 72 -
LDSLPTLAMSA IL11_RAT 72 72 -
LDSLPHLQHSA Q6UAM0_TETNG 73 73 -
FKSLPAISSRV Q4H133_CYPCA 70 70 -
FPSLPEMSNRS Q494Q7_TETNG 69 69 -
FKSLPLMNNRA Q5NKG1_ONCMY 72 72 -
FTSLPEMSNRS Q494Q9_FUGRU 69 69 -
FKSLPAISSRA Q494Q5_DANRE 70 70 -
LDTLPHLPHSA Q494Q8_FUGRU 73 73 -
LPDLPHMQHSA A8CEL7_PAROL 72 72 -
LSSLPSLNYSV Q494Q4_DANRE 68 68 -

Motif 2 width=10
Element Seqn Id St Int Rpt
YLRHVQWLRR A3KPB8_MOUSE 104 21 -
YLRHVQWLRR IL11_MOUSE 104 21 -
YLRHVQWLRR IL11_MACFA 104 21 -
YLRHVQWLRR IL11_HUMAN 104 21 -
YLRHVQWLRR A8K3F7_HUMAN 104 21 -
YFRHVQWLRR IL11_RAT 104 21 -
FRQHVDWLKR Q6UAM0_TETNG 105 21 -
FEHHFEWLNR Q4H133_CYPCA 102 21 -
YEHHFEWLNR Q494Q7_TETNG 102 22 -
FEHHFAWLSR Q5NKG1_ONCMY 104 21 -
YEHHFEWLNR Q494Q9_FUGRU 102 22 -
FQHHFEWLNN Q494Q5_DANRE 102 21 -
FRQHIDWLKL Q494Q8_FUGRU 105 21 -
FRLHVDWLKT A8CEL7_PAROL 105 22 -
FKFHLDWVQR Q494Q4_DANRE 100 21 -

Motif 3 width=11
Element Seqn Id St Int Rpt
HLTLDWAVRGL A3KPB8_MOUSE 182 68 -
HLTLDWAVRGL IL11_MOUSE 182 68 -
HLTLDWAVRGL IL11_MACFA 182 68 -
HLTLDWAVRGL IL11_HUMAN 182 68 -
HLTLDWAVRGL A8K3F7_HUMAN 182 68 -
HLTLDWAVRGL IL11_RAT 182 68 -
TVFCDWTKRVL Q6UAM0_TETNG 180 65 -
RLFCDWASRVF Q4H133_CYPCA 179 67 -
KLFCDWAYRAF Q494Q7_TETNG 179 67 -
RLFCDWAQRVF Q5NKG1_ONCMY 181 67 -
KLFCDWAYRAF Q494Q9_FUGRU 179 67 -
SLFCDWAARVL Q494Q5_DANRE 178 66 -
KIFCHWSKRVL Q494Q8_FUGRU 180 65 -
KVFCNWSKRVL A8CEL7_PAROL 180 65 -
LIFCDYYTRAL Q494Q4_DANRE 172 62 -
Final Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
LDSLPTLAMSA A3KPB8_MOUSE 72 72 -
LDSLPTLAMSA IL11_MOUSE 72 72 -
LDSLPTLAMSA IL11_MACFA 72 72 -
LDSLPTLAMSA IL11_HUMAN 72 72 -
LDSLPTLAMSA A8K3F7_HUMAN 72 72 -
LDSLPTLAMSA IL11_RAT 72 72 -
LDSLPHLQHSA Q6UAM0_TETNG 73 73 -
FKSLPAISSRV Q4H133_CYPCA 70 70 -
FPSLPEMSNRS Q494Q7_TETNG 69 69 -
FKSLPLMNNRA Q5NKG1_ONCMY 72 72 -
FTSLPEMSNRS Q494Q9_FUGRU 69 69 -
FKSLPAISSRA Q494Q5_DANRE 70 70 -
LDTLPHLPHSA Q494Q8_FUGRU 73 73 -
LPDLPHMQHSA A8CEL7_PAROL 72 72 -
LSSLPSLNYSV Q494Q4_DANRE 68 68 -

Motif 2 width=10
Element Seqn Id St Int Rpt
YLRHVQWLRR A3KPB8_MOUSE 104 21 -
YLRHVQWLRR IL11_MOUSE 104 21 -
YLRHVQWLRR IL11_MACFA 104 21 -
YLRHVQWLRR IL11_HUMAN 104 21 -
YLRHVQWLRR A8K3F7_HUMAN 104 21 -
YFRHVQWLRR IL11_RAT 104 21 -
FRQHVDWLKR Q6UAM0_TETNG 105 21 -
FEHHFEWLNR Q4H133_CYPCA 102 21 -
YEHHFEWLNR Q494Q7_TETNG 102 22 -
FEHHFAWLSR Q5NKG1_ONCMY 104 21 -
YEHHFEWLNR Q494Q9_FUGRU 102 22 -
FQHHFEWLNN Q494Q5_DANRE 102 21 -
FRQHIDWLKL Q494Q8_FUGRU 105 21 -
FRLHVDWLKT A8CEL7_PAROL 105 22 -
FKFHLDWVQR Q494Q4_DANRE 100 21 -

Motif 3 width=11
Element Seqn Id St Int Rpt
HLTLDWAVRGL A3KPB8_MOUSE 182 68 -
HLTLDWAVRGL IL11_MOUSE 182 68 -
HLTLDWAVRGL IL11_MACFA 182 68 -
HLTLDWAVRGL IL11_HUMAN 182 68 -
HLTLDWAVRGL A8K3F7_HUMAN 182 68 -
HLTLDWAVRGL IL11_RAT 182 68 -
TVFCDWTKRVL Q6UAM0_TETNG 180 65 -
RLFCDWASRVF Q4H133_CYPCA 179 67 -
KLFCDWAYRAF Q494Q7_TETNG 179 67 -
RLFCDWAQRVF Q5NKG1_ONCMY 181 67 -
KLFCDWAYRAF Q494Q9_FUGRU 179 67 -
SLFCDWAARVL Q494Q5_DANRE 178 66 -
KIFCHWSKRVL Q494Q8_FUGRU 180 65 -
KVFCNWSKRVL A8CEL7_PAROL 180 65 -
LIFCDYYTRAL Q494Q4_DANRE 172 62 -