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PR01926

Identifier
INTERLEUKIN9  [View Relations]  [View Alignment]  
Accession
PR01926
No. of Motifs
3
Creation Date
24-JUL-2008
Title
Interleukin-9 signature
Database References

PRODOM; PD033324
INTERPRO; IPR003630
MIM; 146931
Literature References
1. LAUDER, A., JOLIN, H., SMITH, P., VAN DEN BERG, J., JONES, A.,
WISDEN, W., SMITH, K., DASVARMA, A., FALLON, P. AND MCKENZIE, A.
Lymphomagenesis, hydronephrosis, and autoantibodies result from
dysregulation of IL-9 and are differentially dependent on Th2 cytokines.
J.IMMUNOL. 173 113-122 (2004).
 
2. KNOOPS, L. AND RENAULD, J.
IL-9 and its Receptor: From Signal Transduction to Tumorigenesis.
GROWTH FACTORS 22 207-215 (2004).
 
3. TOWNSEND, M., FALLON, P., MATTHEWS, D., SMITH, P., JOLIN, H. AND 
MCKENZIE, A.
IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary 
mastocytosis and goblet cell hyperplasia but not T cell development. 
IMMUNITY 13 573-583 (2000).

Documentation
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
 
Interleukin-9 (IL-9) is expressed primarily by activated T cells [1]. The 
growth factor and anti-apoptotic activities of IL-9 on multiple transformed
cells suggest a potential role for the cytokine in tumourigenesis [2]. IL-9
has also been proposed as a candidate gene for asthma [3].
 
INTERLEUKIN9 is a 3-element fingerprint that provides a signature for 
interleukin-9. The fingerprint was derived from an initial alignment of 4
sequences: the motifs were drawn from conserved regions spanning the
C-terminal two thirds of the alignment. Two iterations on SPTR55_38f were
required to reach convergence, at which point a true set comprising 7 
sequences was identified. 
Summary Information
7 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3777
2000
123
True Positives
IL9_HUMAN     IL9_MOUSE     Q38JW2_XENTR  Q38JW3_XENTR  
Q6NZ74_HUMAN Q6NZ75_HUMAN Q7TNZ3_SIGHI
Sequence Titles
IL9_HUMAN   Interleukin-9 precursor (IL-9) (T-cell growth factor P40) (P40 cytokine) - Homo sapiens (Human). 
IL9_MOUSE Interleukin-9 precursor (IL-9) (T-cell growth factor P40) (P40 cytokine) - Mus musculus (Mouse).
Q38JW2_XENTR Interleukin-9 - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Q38JW3_XENTR Interleukin-9 - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Q6NZ74_HUMAN Interleukin 9 - Homo sapiens (Human).
Q6NZ75_HUMAN Interleukin 9 - Homo sapiens (Human).
Q7TNZ3_SIGHI Interleukin 9 - Sigmodon hispidus (Hispid cotton rat).
Scan History
SPTR55_38f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
TSCLCLGIPSD IL9_HUMAN 52 52 -
TSCLCLSVPTD IL9_MOUSE 52 52 -
NMCGCLDIPQN Q38JW2_XENTR 51 51 -
NMCGCLDIPQN Q38JW3_XENTR 48 48 -

Motif 2 width=10
Element Seqn Id St Int Rpt
TRPCFSERLS IL9_HUMAN 65 2 -
TTPCYREGLL IL9_MOUSE 65 2 -
SLSCFNSGLQ Q38JW2_XENTR 64 2 -
SLSCFNSGLQ Q38JW3_XENTR 61 2 -

Motif 3 width=10
Element Seqn Id St Int Rpt
GNALTFLKSL IL9_HUMAN 119 44 -
GNTLSFLKSL IL9_MOUSE 119 44 -
GNWYSFLEEL Q38JW2_XENTR 116 42 -
GNWYSFLEEL Q38JW3_XENTR 113 42 -
Final Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
TSCLCLGIPSD IL9_HUMAN 52 52 -
TSCLCLGIPSD Q6NZ75_HUMAN 52 52 -
TSCPCLGIPSD Q6NZ74_HUMAN 52 52 -
TSCLCLPIPSD Q7TNZ3_SIGHI 55 55 -
TSCLCLSVPTD IL9_MOUSE 52 52 -
NMCGCLDIPQN Q38JW2_XENTR 51 51 -
NMCGCLDIPQN Q38JW3_XENTR 48 48 -

Motif 2 width=10
Element Seqn Id St Int Rpt
TRPCFSERLS IL9_HUMAN 65 2 -
TRPCFSERLS Q6NZ75_HUMAN 65 2 -
TRPCFSERLS Q6NZ74_HUMAN 65 2 -
TVPCFREGLS Q7TNZ3_SIGHI 68 2 -
TTPCYREGLL IL9_MOUSE 65 2 -
SLSCFNSGLQ Q38JW2_XENTR 64 2 -
SLSCFNSGLQ Q38JW3_XENTR 61 2 -

Motif 3 width=10
Element Seqn Id St Int Rpt
GNALTFLKSL IL9_HUMAN 119 44 -
GNALTFLKSL Q6NZ75_HUMAN 119 44 -
GNALTFLKSL Q6NZ74_HUMAN 119 44 -
GNTLSFLKNL Q7TNZ3_SIGHI 122 44 -
GNTLSFLKSL IL9_MOUSE 119 44 -
GNWYSFLEEL Q38JW2_XENTR 116 42 -
GNWYSFLEEL Q38JW3_XENTR 113 42 -