SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR01908

Identifier
ADSPHPHTASE  [View Relations]  [View Alignment]  
Accession
PR01908
No. of Motifs
4
Creation Date
11-MAY-2006
Title
Atypical dual specificity phosphatase family signature
Database References
PRINTS; PR00700 PRTYPHPHTASE; PR01764 MAPKPHPHTASE; PR01909 ADSPHPHTASEA
PRINTS; PR01910 ADSPHPHTASEB
INTERPRO; IPR000340
PDB; 1J4X; 1VHR
SCOP; 1J4X; 1VHR
CATH; 1J4X; 1VHR
Literature References
1. ISHIBASHI, T., BOTTARO, D.P., CHAN, A., MIKI, T. AND AARONSON, S.A. 
Expression cloning of a human dual-specificity phosphatase. 
PROC.NATL.ACAD.SCI.U.S.A. 89 12170-12174 (1992). 
 
2. YUVANIYAMA, J., DENU, J.M., DIXON, J.E. AND SAPER, M.A. 
Crystal structure of the dual specificity protein phosphatase VHR. 
SCIENCE 272 1328-1331 (1996). 
 
3. TODD, J.L., TANNER, K.G. AND DENU, J.M. 
Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates 
for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in 
down-regulating the ERK pathway.
J.BIOL.CHEM. 274(19) 13271-80 (1999).
 
4. TODD, J.L., RIGAS, J.D., RAFTY, L.A. AND DENU, J.M. 
Dual-specificity protein tyrosine phosphatase VHR down-regulates c-Jun 
N-terminal kinase (JNK).
ONCOGENE 21(16) 2573-83 (2002).
 
5. VASUDEVAN, S.A., SKOKO, J., WANG, K., BURLINGAME, S.M., PATEL, P.N., 
LAZO, J.S., NUCHTERN, J.G. AND YANG, J. 
MKP-8, a novel MAPK phosphatase that inhibits p38 kinase.
BIOCHEM.BIOPHYS.RES.COMMUN. 330(2) 511-8 (2005).
 
6. RAHMOUNI, S., CERIGNOLI, F., ALONSO, A., TSUTJI, T., HENKENS, R., 
ZHU, C., LOUIS-DIT-SULLY, C., MOUTSCHEN, M., JIANG, W. AND MUSTELIN, T. 
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and
senescence.
NAT.CELL BIOL. 8(5) 524-31 (2006). 

Documentation
Dual Specificity Phosphatases (DUSPs) are members of the superfamily of 
Protein Tyrosine Phosphatases (PTPs). They remove the phosphate group from
both phospho-tyrosine and phospho-serine/threonine residues. Many of these
proteins have been related to the MAP kinase signalling pathway and hence they
are also termed MAP kinase phosphatases (MKPs). A group of DUSPs share a high
degree of similarity with the MKP subgroup, but lack the N-terminal regulatory
domain, which provides the substrate specificity towards the MAP kinases.
These proteins form a heterogeneous group and have in common the presence of
a single catalytic PTP domain. They are small-sized and have been named Low
Molecular Weight-DUSPs (LMW-DUSPs) or Atypical-DUSPs. VHR was the first
characterised member of this subfamily; its crystal structure is known [1,2].
 
The functions of many of the members of this group remain unknown, although 
some have been related to regulation of MAP kinase pathways [3-5]. VHR has
also been related to the control of cell-senescence [6]. On the basis of
sequence similarity, this family can be subdivided into two groups, for 
convenience termed A and B. 
 
ADSPHPHTASE is a 4-element fingerprint that provides a signature for the
atypical dual specificity phosphatase family. The fingerprint was derived from
an initial alignment of 16 sequences: the motifs were drawn from conserved
regions spanning the N-terminal portion of the alignment, avoiding the catalytic
PTP domain, which is conserved in the PTP superfamily. Four iterations on
SPTR49_32f were required to reach convergence, at which point a true set
comprising 47 sequences was identified. Several partial matches were also
found, representing orthologous DUSPs from different organisms.
Summary Information
  47 codes involving  4 elements
3 codes involving 3 elements
4 codes involving 2 elements
Composite Feature Index
447474747
31233
21331
1234
True Positives
DUS13_HUMAN   DUS13_MOUSE   DUS14_HUMAN   DUS14_MOUSE   
DUS18_BOVIN DUS18_HUMAN DUS18_MOUSE DUS18_PONPY
DUS18_RAT DUS21_HUMAN DUS3_HUMAN DUS3_MOUSE
DUS3_PONPY Q25DK0_MACFA Q25N50_MACFA Q29RA3_BRARE
Q32KN1_BOVIN Q3TLZ7_MOUSE Q497R2_MOUSE Q4R3T3_MACFA
Q4RQC9_TETNG Q4RQD0_TETNG Q4S3F5_TETNG Q4S3F6_TETNG
Q5FVI9_RAT Q5R6H6_PONPY Q5SV91_MOUSE Q5U0J1_HUMAN
Q5XIN2_RAT Q5XJN5_BRARE Q68J44_HUMAN Q6B8I0_MOUSE
Q6B8I1_HUMAN Q6FI36_HUMAN Q6GM01_XENLA Q6IAR0_HUMAN
Q7TNW3_MOUSE Q7TPY1_MOUSE Q8BK84_MOUSE Q8SXF8_DROME
Q96J67_HUMAN Q9BV47_HUMAN Q9D700_MOUSE Q9D9D8_MOUSE
Q9DA25_MOUSE Q9VWN2_DROME Q9Y346_HUMAN
True Positive Partials
Codes involving 3 elements
Q2T9T7_BOVIN Q5PQ70_XENLA Q8IYJ9_HUMAN
Codes involving 2 elements
Q3UQN8_MOUSE Q3V2Y9_MOUSE Q5VZP5_HUMAN Q7PNB0_ANOGA
Sequence Titles
DUS13_HUMAN Du