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PR01357

Identifier
INTRLEUKN1AB  [View Relations]  [View Alignment]  
Accession
PR01357
No. of Motifs
6
Creation Date
14-MAY-2000
Title
Interleukin-1 alpha/beta precursor family signature
Database References
PRINTS; PR00262 IL1HBGF; PR00264 INTERLEUKIN1; PR01358 INTRLEUKIN1A
PRINTS; PR01359 INTRLEUKIN1B
PDB; 1ITA; 1I1B
SCOP; 1ITA; 1I1B
CATH; 1ITA; 1I1B
Literature References
1. OPPENHEIM, J.J., KOVACS, E.J., MATSUSHIMA, K. AND DURUM, S.K. 
There is more than one interleukin 1. 
IMMUNOL.TODAY 7 45-56 (1986).
 
2. ROTHWELL, N.J. AND LUHESHI, G.N.
Interleukin-1 in the brain: biology, pathology and therapeutic target.
TRENDS NEUROSCIENCE 23(12) 618-625 (2000).
 
3. PRIESTLE, J.P., SCHAR, H.-P. AND GRUTTER, M.G. 
Crystallographic refinement of interleukin 1 beta at 2.0 angstrom 
resolution. 
PROC.NATL.ACAD.SCI.U.S.A. 86 9667-9671 (1989). 
 
4. MURZIN, A.G., LESK, A.M. AND CHOTHIA, C. 
Patterns of structure and sequence in the Kunitz inhibitors, interleukins-1
beta and 1 alpha and fibroblast growth factors. 
J.MOL.BIOL. 223 531-543 (1992). 

Documentation
Interleukin-1 (IL-1) is a cytokine with a wide range of biological and
physiological effects, including fever, prostaglandin synthesis (in e.g.,
fibroblasts, muscle and endothelial cells), T-lymphocyte activation, and 
interleukin-2 production [1]. This family is a member of a superfamily that
also contains the heparin binding growth factors (HBGF), the Kunitz-type 
soybean trypsin inhibitors (STI) and histactophilin. All have very similar
structures, but although the interleukin-1 and HBGF families share some
sequence similarity (about 25%), they show none at all to the STIs.
 
Over a hundred cytokines have now been identified, including several
putative new members of the IL-1 family [2]. The IL-1 family consists of 2
main classes, designated alpha (IL1A) and beta (IL1B), as well as the more
recently discovered IL-1 receptor antagonist (IL1RA). Sequence similarity 
is high within the IL1A and IL1B subfamilies (about 60-70%) but low between
them (less than 30%). IL1As and IL1Bs are synthesised as larger precursors, 
which are processed to give mature carboxy fragments. IL1B requires this 
cleavage to become biologically active, but IL1A precursor is already 
active. Both IL1A and IL1B bind to the same IL1-specific receptor on the 
target cell, which is then internalised to initiate the relevant effects
(which appear to be similar or identical).
 
The crystal structures of IL1A and IL1B [3] have been solved, showing them 
to share the same 12-stranded beta-sheet structure as both the heparin
binding growth factors and the Kunitz-type soybean trypsin inhibitors [4].
The beta-sheets are arranged in 3 similar lobes around a central axis, 6
strands forming an anti-parallel beta-barrel. Several regions, especially 
the loop between strands 4 and 5, have been implicated in receptor binding.
 
INTRLEUKN1AB is a 6-element fingerprint that provides a signature for the
interleukin-1 alpha/beta precursor family. The fingerprint was derived from
an initial alignment of 24 sequences: the motifs were drawn from conserved
regions spanning virtually the full alignment length, focusing on those 
sections that characterise the IL-1AB family but distinguish them from the
rest of the IL-1 superfamily - motif 1 lies in the propeptide; motif 2 spans
beta-strands 1 and 2; motif 3 spans the C-terminal half of alpha-helix 1 and
strand 4; motif 4 encodes strands 5 and 6; motif 5 spans helix 2 and strand
8; and motif 6 encompasses strands 9 and 10. Two iterations on SPTR37_10f
were required to reach convergence, at which point a true set comprising 31
sequences was identified. Four partial matches were also found, all of which
are family members that fail to match one or more motifs.
Summary Information
  31 codes involving  6 elements
2 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
2 codes involving 2 elements
Composite Feature Index
6313131313131
5121222
4000000
3000000
2000202
123456
True Positives
IL1A_BOVIN    IL1A_CANFA    IL1A_CAPHI    IL1A_CERTO    
IL1A_FELCA IL1A_HORSE IL1A_HUMAN IL1A_MACFA
IL1A_MACMU IL1A_MOUSE IL1A_PIG IL1A_RABIT
IL1A_RAT IL1A_SHEEP IL1B_BOVIN IL1B_CAPHI
IL1B_CEREL IL1B_CERTO IL1B_FELCA IL1B_HORSE
IL1B_HUMAN IL1B_MACFA IL1B_MACMU IL1B_MACNE
IL1B_MOUSE IL1B_PIG IL1B_RABIT IL1B_RAT
IL1B_SHEEP O57398 Q29082
True Positive Partials
Codes involving 5 elements
Q62161 Q9YGD3
Codes involving 2 elements
IL1X_PIG O73909
Sequence Titles
IL1A_BOVIN  INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - BOS TAURUS (BOVINE). 
IL1A_CANFA INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - CANIS FAMILIARIS (DOG).
IL1A_CAPHI INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - CAPRA HIRCUS (GOAT).
IL1A_CERTO INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - CERCOCEBUS TORQUATUS ATYS (RED-CROWNED MANGABEY) (SOOTY MANGABEY).
IL1A_FELCA INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - FELIS SILVESTRIS CATUS (CAT).
IL1A_HORSE INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - EQUUS CABALLUS (HORSE).
IL1A_HUMAN INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) (HEMATOPOIETIN-1) - HOMO SAPIENS (HUMAN).
IL1A_MACFA INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) (HEMATOPOIETIN-1) - MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY).
IL1A_MACMU INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) (HEMATOPOIETIN-1) - MACACA MULATTA (RHESUS MACAQUE).
IL1A_MOUSE INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - MUS MUSCULUS (MOUSE).
IL1A_PIG INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - SUS SCROFA (PIG).
IL1A_RABIT INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - ORYCTOLAGUS CUNICULUS (RABBIT).
IL1A_RAT INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - RATTUS NORVEGICUS (RAT).
IL1A_SHEEP INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - OVIS ARIES (SHEEP).
IL1B_BOVIN INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - BOS TAURUS (BOVINE).
IL1B_CAPHI INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - CAPRA HIRCUS (GOAT).
IL1B_CEREL INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - CERVUS ELAPHUS (RED DEER).
IL1B_CERTO INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - CERCOCEBUS TORQUATUS ATYS (RED-CROWNED MANGABEY) (SOOTY MANGABEY).
IL1B_FELCA INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - FELIS SILVESTRIS CATUS (CAT).
IL1B_HORSE INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - EQUUS CABALLUS (HORSE).
IL1B_HUMAN INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) (CATABOLIN) - HOMO SAPIENS (HUMAN).
IL1B_MACFA INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY).
IL1B_MACMU INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - MACACA MULATTA (RHESUS MACAQUE).
IL1B_MACNE INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - MACACA NEMESTRINA (PIG-TAILED MACAQUE).
IL1B_MOUSE INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - MUS MUSCULUS (MOUSE).
IL1B_PIG INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - SUS SCROFA (PIG).
IL1B_RABIT INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) (LYMPHOCYTE PROLIFERATION POTENTIATING FACTOR) - ORYCTOLAGUS CUNICULUS (RABBIT).
IL1B_RAT INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - RATTUS NORVEGICUS (RAT).
IL1B_SHEEP INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - OVIS ARIES (SHEEP).
O57398 INTERLEUKIN-1 BETA - CYPRINUS CARPIO (COMMON CARP).
Q29082 INTERLEUKIN 1-BETA - SUS SCROFA (PIG).

Q62161 INTERLEUKIN-1 - MUS MUSCULUS (MOUSE).
Q9YGD3 INTERLEUKIN-1 BETA - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).

IL1X_PIG INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN PRECURSOR (IL-1RA) (IL-1RN) (IRAP) - SUS SCROFA (PIG).
O73909 INTERLEUKIN-1BETA - GALLUS GALLUS (CHICKEN).
Scan History
SPTR37_10f 2  60   NSINGLE    
Initial Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
SHEHYNKGFRQAVSVVVAME IL1B_MACNE 53 53 -
SHEHYNEGFRQAVSVVVAME IL1B_MACFA 53 53 -
SHEHYNEGFRQAVSVVVAME IL1B_MACMU 53 53 -
SHEHYNKGFRQAVSVVVAME IL1B_CERTO 53 53 -
SCQPYNKSFRQVLSVVVALE IL1B_RABIT 53 53 -
SDHHYSKGFRQAASVVVAMD IL1B_HUMAN 53 53 -
SHQLYNKSFRQVVSVIVAME IL1B_SHEEP 53 53 -
SHQFYNKSFRQVVSVIVAME IL1B_BOVIN 53 53 -
SHQLWNKSIRQMVSVIVAVE IL1B_PIG 54 54 -
SQQHINKSFRQAVSLIVAVE IL1B_MOUSE 52 52 -
SHQLYNKSFRQVVSVIVAME IL1B_CEREL 53 53 -
SQQHLDKSFRKAVSLIVAVE IL1B_RAT 52 52 -
TSKTSRLSFKENVVMVTANG IL1A_SHEEP 59 59 -
TSKTSKLSFKENVVMVAASG IL1A_BOVIN 59 59 -
SHQPDNKSLRHAVSVIVAME IL1B_FELCA 53 53 -
ISKTSKLTFKQSMVVVSTNG IL1A_MACFA 59 59 -
ISKTSKLTFKQSMVVVSTNG IL1A_MACMU 59 59 -
TSKTSKLTFKESMVVVATNG IL1A_HUMAN 59 59 -
TSKTSRLNFKDSVVMAAANG IL1A_PIG 59 59 -
TSVSPNLTFQENVVAVTASG IL1A_RABIT 59 59 -
ISKTSKLSFKQSMVVVSTNG IL1A_CERTO 59 59 -
TSKMSTFTFKESRVVVSATS IL1A_RAT 59 59 -
TSKMSNFTFKESRVTVSATS IL1A_MOUSE 59 59 -
ELSSHPHSMRQVVNIIIAVE O57398 52 52 -

Motif 2 width=17
Element Seqn Id St Int Rpt
VRSLHCTLRDAQLKSLV IL1B_MACNE 119 46 -
VRSLHCTLRDAQLKSLV IL1B_MACFA 119 46 -
VRSLHCTLRDAQLKSLV IL1B_MACMU 119 46 -
VRSLHCTLRDAQLKSLV IL1B_CERTO 119 46 -
VRSLHCRLQDAQQKSLV IL1B_RABIT 118 45 -
VRSLNCTLRDSQQKSLV IL1B_HUMAN 119 46 -
VQSVKCKLQDREQKSLV IL1B_SHEEP 116 43 -
VQSIKCKLQDREQKSLV IL1B_BOVIN 116 43 -
VQSMECKLQDKDHKSLV IL1B_PIG 117 43 -
IRQLHYRLRDEQQKSLV IL1B_MOUSE 120 48 -
VQSVNCKLQDREQNSLV IL1B_CEREL 116 43 -
IRQLHCRLRDEQQKCLV IL1B_RAT 119 47 -
VIHQECILNDALNQSII IL1A_SHEEP 129 50 -
VIHQECILNDALNQSII IL1A_BOVIN 129 50 -
IQSQDYTFRDISQKSLV IL1B_FELCA 118 45 -
IIKHEFILNDTLNQTII IL1A_MACFA 129 50 -
IIKHEFILNDTLNQTII IL1A_MACMU 129 50 -
IIKYEFILNDALNQSII IL1A_HUMAN 129 50 -
VINHQCILNDARNQSII IL1A_PIG 129 50 -
IIKQEFTLNDALNQSLV IL1A_RABIT 129 50 -
IIKHESILNDTLNQTII IL1A_CERTO 129 50 -
IVKQEFIMNDSLNQNIY IL1A_RAT 131 52 -
LVRQKFVMNDSLNQTIY IL1A_MOUSE 131 52 -
SLTLQCTICDKYKKTMV O57398 116 44 -

Motif 3 width=17
Element Seqn Id St Int Rpt
LEQQVVFFMSFVQGEES IL1B_MACNE 152 16 -
LEQQVVFSMSFVQGEES IL1B_MACFA 152 16 -
LEQQVVFSMSFVQGEES IL1B_MACMU 152 16 -
VEQQVVFSMSFVQGEES IL1B_CERTO 152 16 -
LNQQVVFSMSFVQGEES IL1B_RABIT 151 16 -
MEQQVVFSMSFVQGEES IL1B_HUMAN 152 16 -
MSREVVFCMSFVQGEER IL1B_SHEEP 149 16 -
MNREVVFCMSFVQGEER IL1B_BOVIN 149 16 -
LKREVVFCMSFVQGDDS IL1B_PIG 150 16 -
INQQVIFSMSFVQGEPS IL1B_MOUSE 153 16 -
MSREVVFCMSFVQAEER IL1B_CEREL 149 16 -
ISQQVVFSMSFVQGETS IL1B_RAT 152 16 -
EEAVKFDMVAYVSEEDS IL1A_SHEEP 162 16 -
EEAVKFDMVAYVSEEDS IL1A_BOVIN 162 16 -
MNQQVVFRMSFVHGEEN IL1B_FELCA 151 16 -
DEAVKFDMGAYTSSKDD IL1A_MACFA 161 15 -
DEAVKFDMGAYTSSKDD IL1A_MACMU 161 15 -
DEAVKFDMGAYKSSKDD IL1A_HUMAN 161 15 -
DEAVKFDMAAYTSNDDS IL1A_PIG 162 16 -
GDAVKFDMGVYMTSEDS IL1A_RABIT 162 16 -
DEAVKFDMGAYTSSKDD IL1A_CERTO 161 15 -
QLEVKFDMYAYSSGGDD IL1A_RAT 164 16 -
QQEVKFDMYAYSSGGDD IL1A_MOUSE 164 16 -
QYKVQFSMSTFVSSATQ O57398 155 22 -

Motif 4 width=22
Element Seqn Id St Int Rpt
KIPVALGLKAKNLYLSCVLKDD IL1B_MACNE 171 2 -
KIPVALGLKAKNLYLSCVLKDD IL1B_MACFA 171 2 -
KIPVALGLKAKNLYLSCVLKDD IL1B_MACMU 171 2 -
KVPVALGLKAKNLYLSCVLKDD IL1B_CERTO 171 2 -
KIPVALGLRGKNLYLSCVMKDD IL1B_RABIT 170 2 -
KIPVALGLKEKNLYLSCVLKDD IL1B_HUMAN 171 2 -
KIPVALGIRDKNLYLSCVKKGD IL1B_SHEEP 168 2 -
KIPVALGIKDKNLYLSCVKKGD IL1B_BOVIN 168 2 -
KIPVTLGIKGKNLYLSCVMKDN IL1B_PIG 169 2 -
KIPVALGLKGKNLYLSCVMKDG IL1B_MOUSE 172 2 -
KIPVALGIRDKNQYLSCVKKGD IL1B_CEREL 168 2 -
KIPVALGLKGLNLYLSCVMKDG IL1B_RAT 171 2 -
QLPVTLRISKTQLFVSAQNEDE IL1A_SHEEP 179 0 -
QLPVTLRISKTQLFVSAQNEDE IL1A_BOVIN 179 0 -
KIPVVLCIKKNNLYLSCVMKDG IL1B_FELCA 170 2 -
KVPVILRISKTQLYVSAQDEDQ IL1A_MACFA 179 1 -
KVPVILRISKTQLYVSAQDEDQ IL1A_MACMU 179 1 -
KITVILRISKTQLYVTAQDEDQ IL1A_HUMAN 179 1 -
QLPVTLRISETRLFVSAQNEDE IL1A_PIG 179 0 -
ILPVTLRISQTPLFVSAQNEDE IL1A_RABIT 179 0 -
KVPVILRISKTQLYVSAQDEDQ IL1A_CERTO 179 1 -
KYPVTLKVSNTQLFVSAQGEDK IL1A_RAT 182 1 -
KYPVTLKISDSQLFVSAQGEDQ IL1A_MOUSE 182 1 -
AQPVCLGISNSNLYLACTQLDG O57398 174 2 -

Motif 5 width=14
Element Seqn Id St Int Rpt
MEKRFVFNKIEINN IL1B_MACNE 211 18 -
MEKRFVFNKIEINN IL1B_MACFA 211 18 -
MEKRFVFNKIEINN IL1B_MACMU 211 18 -
MEKRFVFNKIEINN IL1B_CERTO 211 18 -
MEKRFVFNKIEIKD IL1B_RABIT 210 18 -
MEKRFVFNKIEINN IL1B_HUMAN 211 18 -
MEKRFVFYKTEIKN IL1B_SHEEP 208 18 -
MEKRFVFYKTEIKN IL1B_BOVIN 208 18 -
MEKRFVFYKTEIKN IL1B_PIG 209 18 -
MEKRFVFNKIEVKS IL1B_MOUSE 212 18 -
MEKRFVFYKTEIKD IL1B_CEREL 208 18 -
MEKRFVFNKIEVKT IL1B_RAT 211 18 -
DETNLLFFWEKHGS IL1A_SHEEP 216 15 -
DETNLLFFWEKHGS IL1A_BOVIN 216 15 -
MEKRFVFNKTEIKG IL1B_FELCA 210 18 -
SETNFLFFWETHGT IL1A_MACFA 217 16 -
SETNFLFFWETHGT IL1A_MACMU 217 16 -
SETNLLFFWETHGT IL1A_HUMAN 217 16 -
DETSLLFFWEKHGN IL1A_PIG 216 15 -
SESDILFFWETQGN IL1A_RABIT 217 16 -
GETNSLSSWETRGT IL1A_CERTO 217 16 -
SETDLIFFWEKINS IL1A_RAT 220 16 -
SETDLIFFWKSINS IL1A_MOUSE 220 16 -
PNDSLLFFRKETGT O57398 217 21 -

Motif 6 width=16
Element Seqn Id St Int Rpt
KLEFESAQFPNWYIST IL1B_MACNE 225 0 -
KLEFESAQFPNWYIST IL1B_MACFA 225 0 -
KLEFESAQFPNWYIST IL1B_MACMU 225 0 -
KLECESAQFPNWYIST IL1B_CERTO 225 0 -
KLEFESAQFPNWYIST IL1B_RABIT 224 0 -
KLEFESAQFPNWYIST IL1B_HUMAN 225 0 -
TVEFESVLYPNWYIST IL1B_SHEEP 222 0 -
TVEFESVLYPNWYIST IL1B_BOVIN 222 0 -
RVEFESALYPNWYIST IL1B_PIG 223 0 -
KVEFESAEFPNWYIST IL1B_MOUSE 226 0 -
TVEFESVLYPNWYIST IL1B_CEREL 222 0 -
KVEFESAQFPNWYIST IL1B_RAT 225 0 -
MDYFKSVAHPKLFIAT IL1A_SHEEP 230 0 -
MDYFKSVAHPKLFIAT IL1A_BOVIN 230 0 -
NVEFESSQFPNWYIST IL1B_FELCA 224 0 -
KNYFISVAHPNLFIAT IL1A_MACFA 231 0 -
KNYFISVAHPNLFIAT IL1A_MACMU 231 0 -
KNYFTSVAHPNLFIAT IL1A_HUMAN 231 0 -
MDYFKSAAHPKLFIAT IL1A_PIG 230 0 -
KNYFKSAANPQLFIAT IL1A_RABIT 231 0 -
KNYFISVAHPNLFIAT IL1A_CERTO 231 0 -
KNYFTSAAFPELLIAT IL1A_RAT 234 0 -
KNYFTSAAYPELFIAT IL1A_MOUSE 234 0 -
YNTFESVKYPGWFIST O57398 232 1 -
Final Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
SHEHYNKGFRQAVSVVVAME IL1B_MACNE 53 53 -
SHEHYNEGFRQAVSVVVAME IL1B_MACFA 53 53 -
SHEHYNEGFRQAVSVVVAME IL1B_MACMU 53 53 -
SHEHYNKGFRQAVSVVVAME IL1B_CERTO 53 53 -
SCQPYNKSFRQVLSVVVALE IL1B_RABIT 53 53 -
SDHHYSKGFRQAASVVVAMD IL1B_HUMAN 53 53 -
SHQLYNKSFRQVVSVIVAME IL1B_SHEEP 53 53 -
SHQFYNKSFRQVVSVIVAME IL1B_BOVIN 53 53 -
SHQLYNKSFRQVVSVIVAME IL1B_CAPHI 53 53 -
SHQLWNKSIRQMVSVIVAVE IL1B_PIG 54 54 -
SQQHINKSFRQAVSLIVAVE IL1B_MOUSE 52 52 -
SHQLYNKSFRQVVSVIVAME IL1B_CEREL 53 53 -
SQQHLDKSFRKAVSLIVAVE IL1B_RAT 52 52 -
SHQLCNESSRPMVSVIVAKE Q29082 54 54 -
TSKTSRLSFKENVVMVTANG IL1A_CAPHI 59 59 -
TSKTSRLSFKENVVMVTANG IL1A_SHEEP 59 59 -
TSKTSKLSFKENVVMVAASG IL1A_BOVIN 59 59 -
SHHLYNKTFKHAMSIIVAVE IL1B_HORSE 53 53 -
SHQPDNKSLRHAVSVIVAME IL1B_FELCA 53 53 -
TSKTSKLNFKESVVLVAANG IL1A_HORSE 59 59 -
ISKTSKLTFKQSMVVVSTNG IL1A_MACFA 59 59 -
ISKTSKLTFKQSMVVVSTNG IL1A_MACMU 59 59 -
ISKTSQLTFKENVVVVAANG IL1A_CANFA 55 55 -
TSKTSKLTFKESMVVVATNG IL1A_HUMAN 59 59 -
TSKTPQLTLKKSVVMVAANG IL1A_FELCA 59 59 -
TSKTSRLNFKDSVVMAAANG IL1A_PIG 59 59 -
TSVSPNLTFQENVVAVTASG IL1A_RABIT 59 59 -
ISKTSKLSFKQSMVVVSTNG IL1A_CERTO 59 59 -
TSKMSTFTFKESRVVVSATS IL1A_RAT 59 59 -
TSKMSNFTFKESRVTVSATS IL1A_MOUSE 59 59 -
ELSSHPHSMRQVVNIIIAVE O57398 52 52 -

Motif 2 width=17
Element Seqn Id St Int Rpt
VRSLHCTLRDAQLKSLV IL1B_MACNE 119 46 -
VRSLHCTLRDAQLKSLV IL1B_MACFA 119 46 -
VRSLHCTLRDAQLKSLV IL1B_MACMU 119 46 -
VRSLHCTLRDAQLKSLV IL1B_CERTO 119 46 -
VRSLHCRLQDAQQKSLV IL1B_RABIT 118 45 -
VRSLNCTLRDSQQKSLV IL1B_HUMAN 119 46 -
VQSVKCKLQDREQKSLV IL1B_SHEEP 116 43 -
VQSIKCKLQDREQKSLV IL1B_BOVIN 116 43 -
VQSVKCKLQDREQKSLV IL1B_CAPHI 116 43 -
VQSMECKLQDKDHKSLV IL1B_PIG 117 43 -
IRQLHYRLRDEQQKSLV IL1B_MOUSE 120 48 -
VQSVNCKLQDREQNSLV IL1B_CEREL 116 43 -
IRQLHCRLRDEQQKCLV IL1B_RAT 119 47 -
VQSVDCKLQDKDEKALV Q29082 117 43 -
VIHQECILNDALNQSII IL1A_CAPHI 129 50 -
VIHQECILNDALNQSII IL1A_SHEEP 129 50 -
VIHQECILNDALNQSII IL1A_BOVIN 129 50 -
MHSVNCRLRDIYHKSLV IL1B_HORSE 118 45 -
IQSQDYTFRDISQKSLV IL1B_FELCA 118 45 -
IVNHQCTLNDALNQSVI IL1A_HORSE 129 50 -
IIKHEFILNDTLNQTII IL1A_MACFA 129 50 -
IIKHEFILNDTLNQTII IL1A_MACMU 129 50 -
IIKSQFILNDNLNQSIV IL1A_CANFA 125 50 -
IIKYEFILNDALNQSII IL1A_HUMAN 129 50 -
IIKSQFILNDNLSQSVI IL1A_FELCA 129 50 -
VINHQCILNDARNQSII IL1A_PIG 129 50 -
IIKQEFTLNDALNQSLV IL1A_RABIT 129 50 -
IIKHESILNDTLNQTII IL1A_CERTO 129 50 -
IVKQEFIMNDSLNQNIY IL1A_RAT 131 52 -
LVRQKFVMNDSLNQTIY IL1A_MOUSE 131 52 -
SLTLQCTICDKYKKTMV O57398 116 44 -

Motif 3 width=17
Element Seqn Id St Int Rpt
LEQQVVFFMSFVQGEES IL1B_MACNE 152 16 -
LEQQVVFSMSFVQGEES IL1B_MACFA 152 16 -
LEQQVVFSMSFVQGEES IL1B_MACMU 152 16 -
VEQQVVFSMSFVQGEES IL1B_CERTO 152 16 -
LNQQVVFSMSFVQGEES IL1B_RABIT 151 16 -
MEQQVVFSMSFVQGEES IL1B_HUMAN 152 16 -
MSREVVFCMSFVQGEER IL1B_SHEEP 149 16 -
MNREVVFCMSFVQGEER IL1B_BOVIN 149 16 -
MSREVVFCMSFVQGEER IL1B_CAPHI 149 16 -
LKREVVFCMSFVQGDDS IL1B_PIG 150 16 -
INQQVIFSMSFVQGEPS IL1B_MOUSE 153 16 -
MSREVVFCMSFVQAEER IL1B_CEREL 149 16 -
ISQQVVFSMSFVQGETS IL1B_RAT 152 16 -
LKREVVFCMSFVQGDDS Q29082 150 16 -
EEAVKFDMVAYVSEEDS IL1A_CAPHI 162 16 -
EEAVKFDMVAYVSEEDS IL1A_SHEEP 162 16 -
EEAVKFDMVAYVSEEDS IL1A_BOVIN 162 16 -
TNQQVVFCMSFVQGEEE IL1B_HORSE 151 16 -
MNQQVVFRMSFVHGEEN IL1B_FELCA 151 16 -
DDAVKFDMGAYTSEEDS IL1A_HORSE 162 16 -
DEAVKFDMGAYTSSKDD IL1A_MACFA 161 15 -
DEAVKFDMGAYTSSKDD IL1A_MACMU 161 15 -
DDAVKFDMGAYTSEDSK IL1A_CANFA 158 16 -
DEAVKFDMGAYKSSKDD IL1A_HUMAN 161 15 -
DDAVKFDMGAYTSKEDS IL1A_FELCA 162 16 -
DEAVKFDMAAYTSNDDS IL1A_PIG 162 16 -
GDAVKFDMGVYMTSEDS IL1A_RABIT 162 16 -
DEAVKFDMGAYTSSKDD IL1A_CERTO 161 15 -
QLEVKFDMYAYSSGGDD IL1A_RAT 164 16 -
QQEVKFDMYAYSSGGDD IL1A_MOUSE 164 16 -
QYKVQFSMSTFVSSATQ O57398 155 22 -

Motif 4 width=22
Element Seqn Id St Int Rpt
KIPVALGLKAKNLYLSCVLKDD IL1B_MACNE 171 2 -
KIPVALGLKAKNLYLSCVLKDD IL1B_MACFA 171 2 -
KIPVALGLKAKNLYLSCVLKDD IL1B_MACMU 171 2 -
KVPVALGLKAKNLYLSCVLKDD IL1B_CERTO 171 2 -
KIPVALGLRGKNLYLSCVMKDD IL1B_RABIT 170 2 -
KIPVALGLKEKNLYLSCVLKDD IL1B_HUMAN 171 2 -
KIPVALGIRDKNLYLSCVKKGD IL1B_SHEEP 168 2 -
KIPVALGIKDKNLYLSCVKKGD IL1B_BOVIN 168 2 -
KIPVALGIRDKNLYLSWVKKGD IL1B_CAPHI 168 2 -
KIPVTLGIKGKNLYLSCVMKDN IL1B_PIG 169 2 -
KIPVALGLKGKNLYLSCVMKDG IL1B_MOUSE 172 2 -
KIPVALGIRDKNQYLSCVKKGD IL1B_CEREL 168 2 -
KIPVALGLKGLNLYLSCVMKDG IL1B_RAT 171 2 -
KIPVTLGIKGKNLYLSCVMKDD Q29082 169 2 -
QLPVTLRISKTQLFVSAQNEDE IL1A_CAPHI 179 0 -
QLPVTLRISKTQLFVSAQNEDE IL1A_SHEEP 179 0 -
QLPVTLRISKTQLFVSAQNEDE IL1A_BOVIN 179 0 -
KIPVALGLKEKNLYLSCGMKDG IL1B_HORSE 170 2 -
KIPVVLCIKKNNLYLSCVMKDG IL1B_FELCA 170 2 -
QLPVTLRISKTRLFVSAQNEDE IL1A_HORSE 179 0 -
KVPVILRISKTQLYVSAQDEDQ IL1A_MACFA 179 1 -
KVPVILRISKTQLYVSAQDEDQ IL1A_MACMU 179 1 -
KLPVTLRISKTRLFVSAQNEDE IL1A_CANFA 174 -1 -
KITVILRISKTQLYVTAQDEDQ IL1A_HUMAN 179 1 -
KLPVTLRISKTRLFVSAQNEDE IL1A_FELCA 179 0 -
QLPVTLRISETRLFVSAQNEDE IL1A_PIG 179 0 -
ILPVTLRISQTPLFVSAQNEDE IL1A_RABIT 179 0 -
KVPVILRISKTQLYVSAQDEDQ IL1A_CERTO 179 1 -
KYPVTLKVSNTQLFVSAQGEDK IL1A_RAT 182 1 -
KYPVTLKISDSQLFVSAQGEDQ IL1A_MOUSE 182 1 -
AQPVCLGISNSNLYLACTQLDG O57398 174 2 -

Motif 5 width=14
Element Seqn Id St Int Rpt
MEKRFVFNKIEINN IL1B_MACNE 211 18 -
MEKRFVFNKIEINN IL1B_MACFA 211 18 -
MEKRFVFNKIEINN IL1B_MACMU 211 18 -
MEKRFVFNKIEINN IL1B_CERTO 211 18 -
MEKRFVFNKIEIKD IL1B_RABIT 210 18 -
MEKRFVFNKIEINN IL1B_HUMAN 211 18 -
MEKRFVFYKTEIKN IL1B_SHEEP 208 18 -
MEKRFVFYKTEIKN IL1B_BOVIN 208 18 -
MEKRFVFYKTEIKN IL1B_CAPHI 208 18 -
MEKRFVFYKTEIKN IL1B_PIG 209 18 -
MEKRFVFNKIEVKS IL1B_MOUSE 212 18 -
MEKRFVFYKTEIKD IL1B_CEREL 208 18 -
MEKRFVFNKIEVKT IL1B_RAT 211 18 -
MEKRFVFYKTEIKN Q29082 209 18 -
DETNLLFFWEKHGS IL1A_CAPHI 216 15 -
DETNLLFFWEKHGS IL1A_SHEEP 216 15 -
DETNLLFFWEKHGS IL1A_BOVIN 216 15 -
MEKRFVFNKMEIKG IL1B_HORSE 210 18 -
MEKRFVFNKTEIKG IL1B_FELCA 210 18 -
DETNLLFFWERHGS IL1A_HORSE 216 15 -
SETNFLFFWETHGT IL1A_MACFA 217 16 -
SETNFLFFWETHGT IL1A_MACMU 217 16 -
DETNLLFFWERHGS IL1A_CANFA 211 15 -
SETNLLFFWETHGT IL1A_HUMAN 217 16 -
DETNLLFFWERHGS IL1A_FELCA 216 15 -
DETSLLFFWEKHGN IL1A_PIG 216 15 -
SESDILFFWETQGN IL1A_RABIT 217 16 -
GETNSLSSWETRGT IL1A_CERTO 217 16 -
SETDLIFFWEKINS IL1A_RAT 220 16 -
SETDLIFFWKSINS IL1A_MOUSE 220 16 -
PNDSLLFFRKETGT O57398 217 21 -

Motif 6 width=16
Element Seqn Id St Int Rpt
KLEFESAQFPNWYIST IL1B_MACNE 225 0 -
KLEFESAQFPNWYIST IL1B_MACFA 225 0 -
KLEFESAQFPNWYIST IL1B_MACMU 225 0 -
KLECESAQFPNWYIST IL1B_CERTO 225 0 -
KLEFESAQFPNWYIST IL1B_RABIT 224 0 -
KLEFESAQFPNWYIST IL1B_HUMAN 225 0 -
TVEFESVLYPNWYIST IL1B_SHEEP 222 0 -
TVEFESVLYPNWYIST IL1B_BOVIN 222 0 -
TVEFESVLYPNWYIST IL1B_CAPHI 222 0 -
RVEFESALYPNWYIST IL1B_PIG 223 0 -
KVEFESAEFPNWYIST IL1B_MOUSE 226 0 -
TVEFESVLYPNWYIST IL1B_CEREL 222 0 -
KVEFESAQFPNWYIST IL1B_RAT 225 0 -
RVEFESALYPNWYIST Q29082 223 0 -
MDYFKSVAHPKLFIAT IL1A_CAPHI 230 0 -
MDYFKSVAHPKLFIAT IL1A_SHEEP 230 0 -
MDYFKSVAHPKLFIAT IL1A_BOVIN 230 0 -
NVEFESAMYPNWYIST IL1B_HORSE 224 0 -
NVEFESSQFPNWYIST IL1B_FELCA 224 0 -
KNYFKSVAHPKLFIAT IL1A_HORSE 230 0 -
KNYFISVAHPNLFIAT IL1A_MACFA 231 0 -
KNYFISVAHPNLFIAT IL1A_MACMU 231 0 -
KHYFKSVAQPKLFIAT IL1A_CANFA 225 0 -
KNYFTSVAHPNLFIAT IL1A_HUMAN 231 0 -
KNYFKSVAHPKLFIAT IL1A_FELCA 230 0 -
MDYFKSAAHPKLFIAT IL1A_PIG 230 0 -
KNYFKSAANPQLFIAT IL1A_RABIT 231 0 -
KNYFISVAHPNLFIAT IL1A_CERTO 231 0 -
KNYFTSAAFPELLIAT IL1A_RAT 234 0 -
KNYFTSAAYPELFIAT IL1A_MOUSE 234 0 -
YNTFESVKYPGWFIST O57398 232 1 -