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PR01279

Identifier
CRFRECEPTOR  [View Relations]  [View Alignment]  
Accession
PR01279
No. of Motifs
10
Creation Date
18-MAR-2000
Title
Corticotropin releasing factor receptor signature
Database References
PRINTS; PR90007 7TM; PR90006 GPCRCLAN; PR00249 GPCRSECRETIN
PRINTS; PR01280 CRFRECEPTOR1; PR01281 CRFRECEPTOR2
GCRDB; GCR_0679; GCR_0680; GCR_0846; GCR_1963; GCR_2555; GCR_2562
Literature References
1. ATTWOOD, T.K. AND FINDLAY, J.B.C.
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994). 
 
2. ISHIHARA T., NAKAMURA S., KAZIRO, Y., TAKAHASHI, T., TAKAHASHI, K.
AND NAGATA, S.
Molecular cloning and expression of a cDNA encoding the secretin receptor
EMBO J. 10 1635-1641 (1991).
 
3. LIN, H.Y., HARRIS, T.L., FLANNERY, M.S., ARUFFO, A., KAJI, E.H., 
GORN, A., KOLAKOWSKI, L.F., LODISH, H.F. AND GOLDRING, S.R.
Expression cloning of adenylate cyclase-coupled calcitonin receptor
SCIENCE 254 1022-1024 (1991).
 
4. JUEPPNER, H., ABOU-SAMRA, A.-B., FREEMAN, M., KONG, X.F., 
SCHIPANI, E., RICHARDS, J., KOLALOWSKI, L.F., HOCK, J., POTTS, J.T.,
KRONENBERG, H.M. AND SEGRE, G.E.
A G protein linked receptor for parathyroid hormone and parathyroid
hormone-related peptide.
SCIENCE 254 1024-1026 (1991).
 
5. ISHIHARA, T., SHIGEMOTO, R., MORI, K., TAKAHASHI, K. AND NAGATA, S.
Functional expression and tissue distribution of a novel receptor for
vasoactive intestinal polypeptide.
NEURON 8(4) 811-819 (1992).
 
6. CHEN, R., LEWIS, K.A., PERRIN, M.H. AND VALE, W.W.
Expression cloning of a human corticotropin-releasing-factor receptor.
PROC.NATL.ACAD.SCI.U.S.A. 90 8967-8971 (1993). 
7. VITA, N., LAURENT, P., LEFORT, S., CHALON, P., LELIAS, J.M., KAGHAD, M.,
LE FUR, G., CAPUT, D. AND FERRARA, P.
Primary structure and functional expression of mouse pituitary and human
brain corticotrophin releasing factor receptors.
FEBS LETT. 335 1-5 (1993). 

Documentation
 
G protein-coupled receptors (GPCRs) constitute a vast protein family that 
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the 
sequence level, on the basis of which they can be separated into distinct 
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship, 
but between which there is no statistically significant similarity in 
sequence [1]. The currently known clan members include the rhodopsin-like 
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
 
The secretin-like GPCRs include secretin [2], calcitonin [3], parathyroid
hormone/parathyroid hormone-related peptides [4] and vasoactive intestinal
peptide [5], all of which activate adenylyl cyclase and the phosphatidyl-
inositol-calcium pathway. The amino acid sequences of the receptors contain
high proportions of hydrophobic residues grouped into 7 domains, in a
manner reminiscent of the rhodopsins and other receptors believed to inter-
act with G proteins. However, while a similar 3D framework has been
proposed to account for this, there is no significant sequence similarity
between these families: the secretin-like receptors thus bear their own
unique `7TM' signature.
 
Corticotropin-releasing factor (CRF) is the principal neuroregulator of the
hypothalamic-pituitary-adrenocortical axis, playing an important role in
coordinating the endocrine, autonomic and behavioral responses to stress
and immune challenge [6]. The CRF receptor has been found in human cortex
tissue, pituitary, brainstem and testis [7]. The protein comprises 415 
amino acid residues with the characterstic 7TM architecture of the
secretin-like GPCR superfamily. Three isoforms (designated CRF-R1, CRF-R2
and CRF-R3) are produced as a result of alternative splicing of the same
gene: CRF-R1 appears to be the predominant form; CRF-R3 does not bind to
CRF with a high affinity [6].
 
CRFRECEPTOR is a 10-element fingerprint that provides a signature for the 
corticotropin releasing factor receptors. The fingerprint was derived from
an initial alignment of 9 sequences: the motifs were drawn from conserved
regions spanning virtually the full alignment length, focusing on those
sections that characterise the CRF receptors but distinguish them from the
rest of the secretin-like GPCR superfamily - motifs 1-4 span the putative
extracellular domain; motif 5 encodes TM domain 1; motif 6 spans the second
cytoplasmic loop; motif 7 spans the second extracellular loop and the
N-terminus of TM domain 5; motif 8 resides in the third cytoplasmic loop;
motif 9 spans the C-terminus of TM domain 6 and the third extracellular 
loop; and motif 10 resides at the C-terminus. Two iterations on SPTR37_10f
were required to reach convergence, at which point a true set comprising 12
sequences was identified. A single partial match was found, DIHR_ACHDO, a
closely related diuretic hormone receptor that matches motifs 1 and 3.
Summary Information
  12 codes involving 10 elements
0 codes involving 9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
1012121212121212121212
90000000000
80000000000
70000000000
60000000000
50000000000
40000000000
30000000000
21010000000
12345678910
True Positives
CRF2_HUMAN    CRF2_MOUSE    CRF2_RAT      CRF2_XENLA    
CRFR_CHICK CRFR_HUMAN CRFR_MOUSE CRFR_RAT
CRFR_SHEEP CRFR_XENLA O43461 Q99431
True Positive Partials
Codes involving 2 elements
DIHR_ACHDO
Sequence Titles
CRF2_HUMAN  CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R) (CRF2) - HOMO SAPIENS (HUMAN). 
CRF2_MOUSE CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R) (CRF2) (CRF-RB) (CRH-R2) - MUS MUSCULUS (MOUSE).
CRF2_RAT CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R) (CRF2) - RATTUS NORVEGICUS (RAT).
CRF2_XENLA CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R) (CRF2) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
CRFR_CHICK CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R) (CRF1) - GALLUS GALLUS (CHICKEN).
CRFR_HUMAN CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R) (CRF1) - HOMO SAPIENS (HUMAN).
CRFR_MOUSE CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R) (CRF1) - MUS MUSCULUS (MOUSE).
CRFR_RAT CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R) (CRF1) - RATTUS NORVEGICUS (RAT).
CRFR_SHEEP CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R) (CRF1) - OVIS ARIES (SHEEP).
CRFR_XENLA CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R) (CRF1) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O43461 CORTICOTROPIN RELEASING HORMONE RECEPTOR TYPE 2 GAMMA ISOFORM - HOMO SAPIENS (HUMAN).
Q99431 CORTICOTROPIN RELEASING HORMONE RECEPTOR TYPE 2 BETA ISOFORM (CRF2 RECEPTOR, BETA ISOFORM) - HOMO SAPIENS (HUMAN).

DIHR_ACHDO DIURETIC HORMONE RECEPTOR PRECURSOR (DH-R) - ACHETA DOMESTICUS (HOUSE CRICKET).
Scan History
SPTR37_10f 2  100  NSINGLE    
Initial Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
PRSPAGQLVVRP CRFR_MOUSE 56 56 -
PRSAAGALVERP CRF2_HUMAN 52 52 -
PRSPAGQLVVRP CRFR_HUMAN 56 56 -
PRSPAGQLVVRP CRFR_RAT 56 56 -
PQSAPGALVERP CRF2_RAT 52 52 -
PQSAPGALVERP CRF2_MOUSE 72 72 -
PRSAVGQLVARP CRFR_CHICK 61 61 -
PRSLAGELVERP CRF2_XENLA 55 55 -
PSTAAGQMVARP CRFR_XENLA 56 56 -

Motif 2 width=18
Element Seqn Id St Int Rpt
PAFFYGVRYNTTNNGYRE CRFR_MOUSE 69 1 -
PEYFNGVKYNTTRNAYRE CRF2_HUMAN 65 1 -
PAFFYGVRYNTTNNGYRE CRFR_HUMAN 69 1 -
PAFFYGVRYNTTNNGYRE CRFR_RAT 69 1 -
PEYFNGIKYNTTRNAYRE CRF2_RAT 65 1 -
PEYFNGIKYNTTRNAYRE CRF2_MOUSE 85 1 -
PEYFYGVRYNTTNNGYRE CRFR_CHICK 74 1 -
PDSFNGIRYNTTRNVYRE CRF2_XENLA 68 1 -
PEYFHGVQYNTTGNVYRE CRFR_XENLA 69 1 -

Motif 3 width=17
Element Seqn Id St Int Rpt
NGSWAARVNYSECQEIL CRFR_MOUSE 90 3 -
NGTWASKINYSQCEPIL CRF2_HUMAN 86 3 -
NGSWAARVNYSECQEIL CRFR_HUMAN 90 3 -
NGSWAARVNYSECQEIL CRFR_RAT 90 3 -
NGTWASRINYSHCEPIL CRF2_RAT 86 3 -
NGTWASRVNYSHCEPIL CRF2_MOUSE 106 3 -
NGSWAARVNYSQCQEIL CRFR_CHICK 95 3 -
NGTWASWMNYSQCVPIL CRF2_XENLA 89 3 -
NGSWAGRGDYAQCQEIL CRFR_XENLA 90 3 -

Motif 4 width=16
Element Seqn Id St Int Rpt
KKSKVHYHIAVIINYL CRFR_MOUSE 110 3 -
RKYDLHYRIALVVNYL CRF2_HUMAN 107 4 -
KKSKVHYHVAVIINYL CRFR_HUMAN 110 3 -
KKSKVHYHVAVIINYL CRFR_RAT 110 3 -
RKYDLHYRIALIINYL CRF2_RAT 107 4 -
RKYDLHYRIALIVNYL CRF2_MOUSE 127 4 -
KRSKLHYHIAVIINYL CRFR_CHICK 115 3 -
RKYALHYKIALIINYL CRF2_XENLA 109 3 -
KKTKVHYHIAIVINFL CRFR_XENLA 110 3 -

Motif 5 width=19
Element Seqn Id St Int Rpt
HCISLVALLVAFVLFLRLR CRFR_MOUSE 127 1 -
HCVSVAALVAAFLLFLALR CRF2_HUMAN 124 1 -
HCISLVALLVAFVLFLRLR CRFR_HUMAN 127 1 -
HCISLVALLVAFVLFLRLR CRFR_RAT 127 1 -
HCVSVVALVAAFLLFLVLR CRF2_RAT 124 1 -
HCVSVVALVAAFLLFLVLR CRF2_MOUSE 144 1 -
HCVSLGTLLVAFVLFMRLR CRFR_CHICK 132 1 -
HCISILALVIAFLLFLCLR CRF2_XENLA 126 1 -
HSISLCALLVAFILFLRLR CRFR_XENLA 127 1 -

Motif 6 width=13
Element Seqn Id St Int Rpt
TAIVLTYSTDRLR CRFR_MOUSE 215 69 -
TAIVMTYSTERLR CRF2_HUMAN 211 68 -
TAIVLTYSTDRLR CRFR_HUMAN 244 98 -
TAIVLTYSTDRLR CRFR_RAT 215 69 -
TAIVMTYSTEHLR CRF2_RAT 211 68 -
TAIVMTYSTEHLR CRF2_MOUSE 231 68 -
TAIVLTYSTDKLR CRFR_CHICK 220 69 -
TAIVMTYSTDKLR CRF2_XENLA 213 68 -
TAIVLTYSTDKLR CRFR_XENLA 215 69 -

Motif 7 width=16
Element Seqn Id St Int Rpt
WFGKRPGVYTDYIYQG CRFR_MOUSE 259 31 -
WFGKEPGDLVDYIYQG CRF2_HUMAN 255 31 -
WFGKRPGVYTDYIYQG CRFR_HUMAN 288 31 -
WFGKRPGVYTDYIYQG CRFR_RAT 259 31 -
WFGKEPGDLVDYIYQG CRF2_RAT 255 31 -
WFGKEAGDLVDYIYQG CRF2_MOUSE 275 31 -
WFGKRAGVYTDYIYQG CRFR_CHICK 264 31 -
WIGKEPGKYIDYIYQG CRF2_XENLA 257 31 -
WFGKKAGVYTDFIYQG CRFR_XENLA 259 31 -

Motif 8 width=10
Element Seqn Id St Int Rpt
RASTTSETIQ CRFR_MOUSE 299 24 -
RASTTSETIQ CRF2_HUMAN 295 24 -
RASTTSETIQ CRFR_HUMAN 328 24 -
RASTTSETIQ CRFR_RAT 299 24 -
RASTTSETIQ CRF2_RAT 295 24 -
RASTTSETIQ CRF2_MOUSE 315 24 -
RASTTSETIQ CRFR_CHICK 304 24 -
RASTTSETIQ CRF2_XENLA 297 24 -
RASTTSETIQ CRFR_XENLA 299 24 -

Motif 9 width=22
Element Seqn Id St Int Rpt
FFVNPGEDEVSRVVFIYFNSFL CRFR_MOUSE 330 21 -
FFVNPGEDDLSQIMFIYFNSFL CRF2_HUMAN 326 21 -
FFVNPGEDEVSRVVFIYFNSFL CRFR_HUMAN 359 21 -
FFVNPGEDEVSRVVFIYFNSFL CRFR_RAT 330 21 -
FFVNPGEDDLSQIVFIYFNSFL CRF2_RAT 326 21 -
FFVNPGEDDLSQIVFIYFNSFL CRF2_MOUSE 346 21 -
FFVNPGEDEISRIVFIYFNSFL CRFR_CHICK 335 21 -
FFVNPGEDDVSQIVFIYFNSFL CRF2_XENLA 328 21 -
FFVTPGEDEISRIVFIYFNSFL CRFR_XENLA 330 21 -

Motif 10 width=19
Element Seqn Id St Int Rpt
RAMSIPTSPTRVSFHSIKQ CRFR_MOUSE 393 41 -
RAMSIPTSPTRISFHSIKQ CRF2_HUMAN 389 41 -
RAMSIPTSPTRVSFHSIKQ CRFR_HUMAN 422 41 -
RAMSIPTSPTRVSFHSIKQ CRFR_RAT 393 41 -
RAMSIPTSPTRISFHSIKQ CRF2_RAT 389 41 -
RAMSIPTSPTRISFHSIKQ CRF2_MOUSE 409 41 -
RAMSIPTSPTRVSFHSIKQ CRFR_CHICK 398 41 -
RAMSIPTSPTRISFHSIKQ CRF2_XENLA 391 41 -
RAMSIPTSPTRISFHSIKQ CRFR_XENLA 393 41 -
Final Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
PRSPAGQLVVRP CRFR_MOUSE 56 56 -
PRSAAGALVERP CRF2_HUMAN 52 52 -
PRSAAGALVERP O43461 38 38 -
PRSAAGALVERP Q99431 79 79 -
PRSPAGQLVVRP CRFR_HUMAN 56 56 -
PRSPAGQLVVRP CRFR_RAT 56 56 -
PQSAPGALVERP CRF2_RAT 52 52 -
PQSAPGALVERP CRF2_MOUSE 72 72 -
PRSAVGQLVARP CRFR_CHICK 61 61 -
PQSPAGQLVVRP CRFR_SHEEP 56 56 -
PRSLAGELVERP CRF2_XENLA 55 55 -
PSTAAGQMVARP CRFR_XENLA 56 56 -

Motif 2 width=18
Element Seqn Id St Int Rpt
PAFFYGVRYNTTNNGYRE CRFR_MOUSE 69 1 -
PEYFNGVKYNTTRNAYRE CRF2_HUMAN 65 1 -
PEYFNGVKYNTTRNAYRE O43461 51 1 -
PEYFNGVKYNTTRNAYRE Q99431 92 1 -
PAFFYGVRYNTTNNGYRE CRFR_HUMAN 69 1 -
PAFFYGVRYNTTNNGYRE CRFR_RAT 69 1 -
PEYFNGIKYNTTRNAYRE CRF2_RAT 65 1 -
PEYFNGIKYNTTRNAYRE CRF2_MOUSE 85 1 -
PEYFYGVRYNTTNNGYRE CRFR_CHICK 74 1 -
LVFFYGVRYNTTSNGYRV CRFR_SHEEP 69 1 -
PDSFNGIRYNTTRNVYRE CRF2_XENLA 68 1 -
PEYFHGVQYNTTGNVYRE CRFR_XENLA 69 1 -

Motif 3 width=17
Element Seqn Id St Int Rpt
NGSWAARVNYSECQEIL CRFR_MOUSE 90 3 -
NGTWASKINYSQCEPIL CRF2_HUMAN 86 3 -
NGTWASKINYSQCEPIL O43461 72 3 -
NGTWASKINYSQCEPIL Q99431 113 3 -
NGSWAARVNYSECQEIL CRFR_HUMAN 90 3 -
NGSWAARVNYSECQEIL CRFR_RAT 90 3 -
NGTWASRINYSHCEPIL CRF2_RAT 86 3 -
NGTWASRVNYSHCEPIL CRF2_MOUSE 106 3 -
NGSWAARVNYSQCQEIL CRFR_CHICK 95 3 -
NGTWAARVNHSECQEIL CRFR_SHEEP 90 3 -
NGTWASWMNYSQCVPIL CRF2_XENLA 89 3 -
NGSWAGRGDYAQCQEIL CRFR_XENLA 90 3 -

Motif 4 width=16
Element Seqn Id St Int Rpt
KKSKVHYHIAVIINYL CRFR_MOUSE 110 3 -
RKYDLHYRIALVVNYL CRF2_HUMAN 107 4 -
RKYDLHYRIALVVNYL O43461 93 4 -
RKYDLHYRIALVVNYL Q99431 134 4 -
KKSKVHYHVAVIINYL CRFR_HUMAN 110 3 -
KKSKVHYHVAVIINYL CRFR_RAT 110 3 -
RKYDLHYRIALIINYL CRF2_RAT 107 4 -
RKYDLHYRIALIVNYL CRF2_MOUSE 127 4 -
KRSKLHYHIAVIINYL CRFR_CHICK 115 3 -
EKSKAHYHIAVIINYL CRFR_SHEEP 110 3 -
RKYALHYKIALIINYL CRF2_XENLA 109 3 -
KKTKVHYHIAIVINFL CRFR_XENLA 110 3 -

Motif 5 width=19
Element Seqn Id St Int Rpt
HCISLVALLVAFVLFLRLR CRFR_MOUSE 127 1 -
HCVSVAALVAAFLLFLALR CRF2_HUMAN 124 1 -
HCVSVAALVAAFLLFLALR O43461 110 1 -
HCVSVAALVAAFLLFLALR Q99431 151 1 -
HCISLVALLVAFVLFLRLR CRFR_HUMAN 127 1 -
HCISLVALLVAFVLFLRLR CRFR_RAT 127 1 -
HCVSVVALVAAFLLFLVLR CRF2_RAT 124 1 -
HCVSVVALVAAFLLFLVLR CRF2_MOUSE 144 1 -
HCVSLGTLLVAFVLFMRLR CRFR_CHICK 132 1 -
HCISLAALLVAFVLFLRLR CRFR_SHEEP 127 1 -
HCISILALVIAFLLFLCLR CRF2_XENLA 126 1 -
HSISLCALLVAFILFLRLR CRFR_XENLA 127 1 -

Motif 6 width=13
Element Seqn Id St Int Rpt
TAIVLTYSTDRLR CRFR_MOUSE 215 69 -
TAIVMTYSTERLR CRF2_HUMAN 211 68 -
TAIVMTYSTERLR O43461 197 68 -
TAIVMTYSTERLR Q99431 238 68 -
TAIVLTYSTDRLR CRFR_HUMAN 244 98 -
TAIVLTYSTDRLR CRFR_RAT 215 69 -
TAIVMTYSTEHLR CRF2_RAT 211 68 -
TAIVMTYSTEHLR CRF2_MOUSE 231 68 -
TAIVLTYSTDKLR CRFR_CHICK 220 69 -
TAVVLTYSTDRLR CRFR_SHEEP 215 69 -
TAIVMTYSTDKLR CRF2_XENLA 213 68 -
TAIVLTYSTDKLR CRFR_XENLA 215 69 -

Motif 7 width=16
Element Seqn Id St Int Rpt
WFGKRPGVYTDYIYQG CRFR_MOUSE 259 31 -
WFGKEPGDLVDYIYQG CRF2_HUMAN 255 31 -
WFGKEPGDLVDYIYQG O43461 241 31 -
WFGKEPGDLVDYIYQG Q99431 282 31 -
WFGKRPGVYTDYIYQG CRFR_HUMAN 288 31 -
WFGKRPGVYTDYIYQG CRFR_RAT 259 31 -
WFGKEPGDLVDYIYQG CRF2_RAT 255 31 -
WFGKEAGDLVDYIYQG CRF2_MOUSE 275 31 -
WFGKRAGVYTDYIYQG CRFR_CHICK 264 31 -
WFGKRPGVYTDYIYQG CRFR_SHEEP 259 31 -
WIGKEPGKYIDYIYQG CRF2_XENLA 257 31 -
WFGKKAGVYTDFIYQG CRFR_XENLA 259 31 -

Motif 8 width=10
Element Seqn Id St Int Rpt
RASTTSETIQ CRFR_MOUSE 299 24 -
RASTTSETIQ CRF2_HUMAN 295 24 -
RASTTSETIQ O43461 281 24 -
RASTTSETIQ Q99431 322 24 -
RASTTSETIQ CRFR_HUMAN 328 24 -
RASTTSETIQ CRFR_RAT 299 24 -
RASTTSETIQ CRF2_RAT 295 24 -
RASTTSETIQ CRF2_MOUSE 315 24 -
RASTTSETIQ CRFR_CHICK 304 24 -
RASTTSETIQ CRFR_SHEEP 299 24 -
RASTTSETIQ CRF2_XENLA 297 24 -
RASTTSETIQ CRFR_XENLA 299 24 -

Motif 9 width=22
Element Seqn Id St Int Rpt
FFVNPGEDEVSRVVFIYFNSFL CRFR_MOUSE 330 21 -
FFVNPGEDDLSQIMFIYFNSFL CRF2_HUMAN 326 21 -
FFVNPGEDDLSQIMFIYFNSFL O43461 312 21 -
FFVNPGEDDLSQIMFIYFNSFL Q99431 353 21 -
FFVNPGEDEVSRVVFIYFNSFL CRFR_HUMAN 359 21 -
FFVNPGEDEVSRVVFIYFNSFL CRFR_RAT 330 21 -
FFVNPGEDDLSQIVFIYFNSFL CRF2_RAT 326 21 -
FFVNPGEDDLSQIVFIYFNSFL CRF2_MOUSE 346 21 -
FFVNPGEDEISRIVFIYFNSFL CRFR_CHICK 335 21 -
FFVNPGEDEVSRVVFIYFNSFL CRFR_SHEEP 330 21 -
FFVNPGEDDVSQIVFIYFNSFL CRF2_XENLA 328 21 -
FFVTPGEDEISRIVFIYFNSFL CRFR_XENLA 330 21 -

Motif 10 width=19
Element Seqn Id St Int Rpt
RAMSIPTSPTRVSFHSIKQ CRFR_MOUSE 393 41 -
RAMSIPTSPTRISFHSIKQ CRF2_HUMAN 389 41 -
RAMSIPTSPTRISFHSIKQ O43461 375 41 -
RAMSIPTSPTRISFHSIKQ Q99431 416 41 -
RAMSIPTSPTRVSFHSIKQ CRFR_HUMAN 422 41 -
RAMSIPTSPTRVSFHSIKQ CRFR_RAT 393 41 -
RAMSIPTSPTRISFHSIKQ CRF2_RAT 389 41 -
RAMSIPTSPTRISFHSIKQ CRF2_MOUSE 409 41 -
RAMSIPTSPTRVSFHSIKQ CRFR_CHICK 398 41 -
RAMSIPTSPTRVSFHSIKQ CRFR_SHEEP 393 41 -
RAMSIPTSPTRISFHSIKQ CRF2_XENLA 391 41 -
RAMSIPTSPTRISFHSIKQ CRFR_XENLA 393 41 -