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PR01234

Identifier
TNECROSISFCT  [View Relations]  [View Alignment]  
Accession
PR01234
No. of Motifs
5
Creation Date
20-OCT-1999
Title
Tumour necrosis factor family signature
Database References
PRINTS; PR01235 TNFALPHA; PR01236 TNFBETA; PR01237 TNFC

PROSITE; PS00251 TNF_1; PS50049 TNF_2
BLOCKS; BL00251
PFAM; PF00229 TNF
INTERPRO; IPR000478
PDB; 1TNF
SCOP; 1TNF
CATH; 1TNF
Literature References
1. FRANSEN, L., MULLER, R., MARMENOUT, A., TAVERNIER, J., VAN DER
HEYDEN, J., KAWASHIMA, E., CHOLLET, A., TIZARD, R., VAN HEUVERSWYN, H.
AND VAN VLIET, A.
Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic
expression.
NUCLEIC ACIDS RES. 13 4417-4429 (1985).
 
2. KRIEGLER, M., PEREZ, C., DEFAY, K., ALBERT, I. AND LU, S.D. 
A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane
protein: ramifications for the complex physiology of TNF.
CELL 53 45-53 (1988). 
 
3. SHERRY, B., JUE, D.M., ZENTELLA, A. AND CERAMI, A.
Characterization of high molecular weight glycosylated forms of murine 
tumor necrosis factor.
BIOCHEM.BIOPHYS.RES.COMMUN. 173 1072-1078 (1990). 
 
4. CSEH, K. AND BEUTLER, B.
Alternative cleavage of the cachectin/tumor necrosis factor propeptide 
results in a larger, inactive form of secreted protein.
J.BIOL.CHEM. 264 16256-16260 (1989). 
 
5. JONES, E.Y., STUART, D.I. AND WALKER, N.P.
Structure of tumour necrosis factor.
NATURE 338 225-228 (1989). 
 
6. VAN OSTADE X., TAVERNIER J., PRANGE T. AND FIERS W.
Localization of the active site of human tumour necrosis factor (hTNF) by
mutational analysis.
EMBO J. 10 827-836 (1991). 

Documentation
Tumor necrosis factor (TNF) (or cachectin) is a monocyte-derived cytotoxin
that has been implicated in tumour regression, septic shock and cachexia
[1,2]. The protein is synthesised as a prohormone with an unusually long 
and atypical signal sequence, which is absent from the mature secreted
cytokine [3]. A short hydrophobic stretch of amino acids serves to anchor 
the prohormone in lipid bilayers [4]. Both the mature protein and a 
partially-processed form of the hormone are secreted after cleavage of the
propeptide [4]. 
 
The structure of TNF has been determined to 2.9A using X-ray crystallography
[5]. The protein is trimeric, each subunit consisting of an anti-parallel
beta-sandwich. The subunits trimerise via a novel edge-to-face packing of
beta-sheets [5]. Comparison of the subunit fold with that of other proteins
reveals similarity to the `jelly-roll' structural motif characteristic of
viral coat proteins [5]. It is believed that each TNF molecule has three 
receptor-interaction sites (between the three subunits), thus allowing
signal transmission by receptor clustering [6]. 
 
TNECROSISFCT is a 5-element fingerprint that provides a signature for
tumour necrosis factors. The fingerprint was derived from an initial
alignment of 21 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length - motif 1 includes beta-strand
1; motif 2 spans strands 2 and 3; motif 3 encodes strands 6 and 7; motif 4
spans strands 9 and 10; and motif 5 encodes strand 11. Two iterations on 
SPTR37_10f were required to reach convergence, at which point a true set
comprising 30 sequences was identified.
Summary Information
30 codes involving  5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
53030303030
400000
300000
200000
12345
True Positives
O18779        O35853        O77764        Q28320        
TNFA_BOVIN TNFA_CANFA TNFA_CAVPO TNFA_FELCA
TNFA_HORSE TNFA_HUMAN TNFA_MACFA TNFA_MACMU
TNFA_MARMO TNFA_MOUSE TNFA_PAPHU TNFA_PAPSP
TNFA_PERLE TNFA_PIG TNFA_RABIT TNFA_RAT
TNFA_SHEEP TNFA_TRIVU TNFB_BOVIN TNFB_HUMAN
TNFB_MOUSE TNFB_PIG TNFB_RABIT TNFB_RAT
TNFC_HUMAN TNFC_MOUSE
Sequence Titles
O18779      TUMOR NECROSIS FACTOR ALPHA - BOS TAURUS (BOVINE). 
O35853 TUMOR NECROSIS FACTOR ALPHA - MUS MUSCULUS (MOUSE).
O77764 TUMOUR NECROSIS FACTOR ALPHA - MACROPUS EUGENII (TAMMAR WALLABY).
Q28320 TNF-ALPHA - CAPRA HIRCUS (GOAT).
TNFA_BOVIN TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - BOS TAURUS (BOVINE).
TNFA_CANFA TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - CANIS FAMILIARIS (DOG)
TNFA_CAVPO TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - CAVIA PORCELLUS (GUINE
TNFA_FELCA TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - FELIS SILVESTRIS CATUS
TNFA_HORSE TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - EQUUS CABALLUS (HORSE)
TNFA_HUMAN TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - HOMO SAPIENS (HUMAN).
TNFA_MACFA TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - MACACA FASCICULARIS (C
TNFA_MACMU TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - MACACA MULATTA (RHESUS
TNFA_MARMO TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - MARMOTA MONAX (WOODCHU
TNFA_MOUSE TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - MUS MUSCULUS (MOUSE).
TNFA_PAPHU TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - PAPIO HAMADRYAS URSINU
TNFA_PAPSP TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - PAPIO SP. (BABOON).
TNFA_PERLE TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - PEROMYSCUS LEUCOPUS (W
TNFA_PIG TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - SUS SCROFA (PIG).
TNFA_RABIT TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - ORYCTOLAGUS CUNICULUS
TNFA_RAT TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - RATTUS NORVEGICUS (RAT
TNFA_SHEEP TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - OVIS ARIES (SHEEP).
TNFA_TRIVU TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN) - TRICHOSURUS VULPECULA
TNFB_BOVIN LYMPHOTOXIN-ALPHA PRECURSOR (LT-ALPHA) (TNF-BETA) - BOS TAURUS (BOVINE).
TNFB_HUMAN LYMPHOTOXIN-ALPHA PRECURSOR (LT-ALPHA) (TNF-BETA) - HOMO SAPIENS (HUMAN).
TNFB_MOUSE LYMPHOTOXIN-ALPHA PRECURSOR (LT-ALPHA) (TNF-BETA) - MUS MUSCULUS (MOUSE).
TNFB_PIG LYMPHOTOXIN-ALPHA PRECURSOR (LT-ALPHA) (TNF-BETA) - SUS SCROFA (PIG).
TNFB_RABIT LYMPHOTOXIN-ALPHA PRECURSOR (LT-ALPHA) (TNF-BETA) - ORYCTOLAGUS CUNICULUS (RABBI
TNFB_RAT LYMPHOTOXIN-ALPHA PRECURSOR (LT-ALPHA) (TNF-BETA) - RATTUS NORVEGICUS (RAT).
TNFC_HUMAN LYMPHOTOXIN-BETA (LT-BETA) (TUMOR NECROSIS FACTOR C) - HOMO SAPIENS (HUMAN).
TNFC_MOUSE LYMPHOTOXIN-BETA (LT-BETA) (TUMOR NECROSIS FACTOR C) - MUS MUSCULUS (MOUSE).
Scan History
SPTR37_10f 2  100  NSINGLE    
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
KPVAHVVANPQAEGQLQW TNFA_MACMU 87 87 -
KPVAHVVANPQAEGQLQW TNFA_HUMAN 87 87 -
KPVAHVVANPQAEGQLQW TNFA_PAPSP 87 87 -
KPVAHVVANPQAEGQLQW TNFA_MACFA 87 87 -
KPVAHVVANPQAEGQLQW TNFA_HORSE 88 88 -
KPLAHVVANPQVEGQLQW TNFA_RABIT 90 90 -
KPVAHVVANVKAEGQLQW TNFA_PIG 86 86 -
KPVAHVVANHQVEEQLEW TNFA_MOUSE 90 90 -
KPVAHVVANISAPGQLRW TNFA_SHEEP 88 88 -
KPVAHVVANHQVDEQLEW TNFA_PERLE 90 90 -
KPVAHVVANHQAEEQLEW TNFA_RAT 90 90 -
KPVAHVVADINSPGQLRW TNFA_BOVIN 87 87 -
KPVAHLIADQLAEGQLLW TNFA_TRIVU 87 87 -
KPAAHLVGDPSAQDSLRW TNFB_RABIT 54 54 -
KPAAHLVGYPSKQNSLLW TNFB_MOUSE 59 59 -
KPAAHLVGDPSTPDSLRW TNFB_PIG 61 61 -
KPAAHLVGDPSTQDSLRW TNFB_BOVIN 61 61 -
KPAAHLVGYPSKQNSLLW TNFB_RAT 59 59 -
KPAAHLIGDPSKQNSLLW TNFB_HUMAN 62 62 -
LPAAHLIGAPLKGQGLGW TNFC_HUMAN 87 87 -
LPAAHLIGAWMSGQGLSW TNFC_MOUSE 153 153 -

Motif 2 width=19
Element Seqn Id St Int Rpt
WLNRRANALLANGVELTDN TNFA_MACMU 104 -1 -
WLNRRANALLANGVELRDN TNFA_HUMAN 104 -1 -
WLNRRANALLANGVELRDN TNFA_PAPSP 104 -1 -
WLNRRANALVANGVELTDN TNFA_MACFA 104 -1 -
WLSGRANALLANGVKLTDN TNFA_HORSE 105 -1 -
WLSQRANALLANGMKLTDN TNFA_RABIT 107 -1 -
WQSGYANALLANGVKLKDN TNFA_PIG 103 -1 -
WLSQRANALLANGMDLKDN TNFA_MOUSE 107 -1 -
WGDSYANALMANGVELKDN TNFA_SHEEP 105 -1 -
WLSRGANALLANGMDLKDN TNFA_PERLE 107 -1 -
WLSQRANALLANGMDLKDN TNFA_RAT 107 -1 -
WWDSYANALMANGVKLEDN TNFA_BOVIN 104 -1 -
WVGDVANTLLMNGMELVDN TNFA_TRIVU 104 -1 -
WRANTDRAFLRHGFSLSNN TNFB_RABIT 71 -1 -
WRASTDRAFLRHGFSLSNN TNFB_MOUSE 76 -1 -
WRANTDRAFLRHGFLLSNN TNFB_PIG 78 -1 -
WRANTDRAFLRHGFSLSNN TNFB_BOVIN 78 -1 -
WRANTDRAFLRHGFSLNNN TNFB_RAT 76 -1 -
WRANTDRAFLQDGFSLSNN TNFB_HUMAN 79 -1 -
WETTKEQAFLTSGTQFSDA TNFC_HUMAN 104 -1 -
WEASQEEAFLRSGAQFSPT TNFC_MOUSE 170 -1 -

Motif 3 width=19
Element Seqn Id St Int Rpt
LTHTISRIAVSYQTKVNLL TNFA_MACMU 152 29 -
LTHTISRIAVSYQTKVNLL TNFA_HUMAN 152 29 -
LTHTISRIAVSYQTKVNLL TNFA_PAPSP 152 29 -
LTHTISRIAVSYQTKVNLL TNFA_MACFA 152 29 -
LTHTISRLAVSYPSKVNLL TNFA_HORSE 153 29 -
LTHTVSRFAVSYPNKVNLL TNFA_RABIT 154 28 -
LTHTISRIAVSYQTKVNLL TNFA_PIG 151 29 -
LTHTVSRFAISYQEKVNLL TNFA_MOUSE 154 28 -
LTHTISRIAVSYQTKVNIL TNFA_SHEEP 153 29 -
LTHTVSRFAVSYEDKVNLL TNFA_PERLE 154 28 -
LTHTVSRFAISYQEKVSLL TNFA_RAT 154 28 -
LTHTISRIAVSYQTKVNIL TNFA_BOVIN 152 29 -
LTHKISRFTLSYQKKVTLL TNFA_TRIVU 152 29 -
LAHEVQLFSSQYSFHVPLL TNFB_RABIT 123 33 -
LAHEVQLFSSQYPFHVPLL TNFB_MOUSE 128 33 -
LAHEVQLFSSQYPFHVPLL TNFB_PIG 130 33 -
LAHEVQLFSPQYPFHVPLL TNFB_BOVIN 130 33 -
LAHEVQLFSSQYPFHVPLL TNFB_RAT 128 33 -
LAHEVQLFSSQYPFHVPLL TNFB_HUMAN 131 33 -
LRSSLYRAGGAYGPGTPEL TNFC_HUMAN 159 36 -
LRSALYRAGGAYGRGSPEL TNFC_MOUSE 224 35 -

Motif 4 width=24
Element Seqn Id St Int Rpt
WYEPIYLGGVFQLEKGDRLSAEIN TNFA_MACMU 190 19 -
WYEPIYLGGVFQLEKGDRLSAEIN TNFA_HUMAN 190 19 -
WYEPIYLGGVFQLEKGDRLSAEIN TNFA_PAPSP 190 19 -
WYEPIYLGGVFQLEKGDRLSAEIN TNFA_MACFA 190 19 -
WYEPIYLGGVFQLEKGDQLSAEIN TNFA_HORSE 191 19 -
WYEPIYLGGVFQLEKGDRLSTEVN TNFA_RABIT 192 19 -
WYEPIYLGGVFQLEKDDRLSAEIN TNFA_PIG 189 19 -
WYEPIYLGGVFQLEKGDQLSAEVN TNFA_MOUSE 192 19 -
WYEPIYQGGVFQLEKGDRLSAEIN TNFA_SHEEP 191 19 -
WYEPIYLGGVFQLEKGDRLSAEVN TNFA_PERLE 192 19 -
WYEPMYLGGVFQLEKGDLLSAEVN TNFA_RAT 192 19 -
WYEPIYQGGVFQLEKGDRLSAEIN TNFA_BOVIN 190 19 -
WYEPVYLAGVFQLTEGDKLVVDTN TNFA_TRIVU 190 19 -
WVRSVYQGAVFLLTQGDQLSTHTD TNFB_RABIT 155 13 -
WVRSMYQGAVFLLSKGDQLSTHTD TNFB_MOUSE 160 13 -
WVRSVYQGAVFLLTQGDQLSTHTD TNFB_PIG 162 13 -
WVRSVYQGAVFLLTRGDQLSTHTD TNFB_BOVIN 162 13 -
WVRSMYQGAVFLLSKGDQLSTHTD TNFB_RAT 160 13 -
WLHSMYHGAAFQLTQGDQLSTHTD TNFB_HUMAN 163 13 -
WYTSVGFGGLVQLRRGERVYVNIS TNFC_HUMAN 201 23 -
WYTSVGFGGLAQLRSGERVYVNIS TNFC_MOUSE 263 20 -

Motif 5 width=12
Element Seqn Id St Int Rpt
AESGQVYFGIIA TNFA_MACMU 221 7 -
AESGQVYFGIIA TNFA_HUMAN 221 7 -
AESGQVYFGIIA TNFA_PAPSP 221 7 -
AESGQVYFGIIA TNFA_MACFA 221 7 -
AESGQVYFGIIA TNFA_HORSE 222 7 -
AESGQVYFGIIA TNFA_RABIT 223 7 -
AESGQVYFGIIA TNFA_PIG 220 7 -
AESGQVYFGVIA TNFA_MOUSE 223 7 -
AESGQVYFGIIA TNFA_SHEEP 222 7 -
AESGQVYFGVIA TNFA_PERLE 223 7 -
TESGQVYFGVIA TNFA_RAT 223 7 -
AESGQVYFGIIA TNFA_BOVIN 221 7 -
AEPGQLYFGAIA TNFA_TRIVU 221 7 -
LSPSSVFFGAFA TNFB_RABIT 185 6 -
FSPSSVFFGAFA TNFB_MOUSE 190 6 -
LSPSSVFFGAFA TNFB_PIG 192 6 -
LSPSSVFFGAFA TNFB_BOVIN 192 6 -
FSPSTVFFGAFA TNFB_RAT 190 6 -
LSPSTVFFGAFA TNFB_HUMAN 193 6 -
FARGKTFFGAVM TNFC_HUMAN 231 6 -
YRRGKTFFGAVM TNFC_MOUSE 293 6 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
KPVAHVVANPEAEGQLQW TNFA_CANFA 87 87 -
KPVAHVVANPQAEGQLQW TNFA_MACMU 87 87 -
KPVAHVVANPQAEGQLQW TNFA_HUMAN 87 87 -
KPVAHVVANPQAEGQLQW TNFA_PAPSP 87 87 -
KPVAHVVANPQAEGQLQW TNFA_MACFA 87 87 -
KPVVHVVANPQAEGQLQW TNFA_PAPHU 87 87 -
KPVAHVVANPQAEGQLQW TNFA_HORSE 88 88 -
KPLAHVVANPQVEGQLQW TNFA_RABIT 90 90 -
KPVAHVVANPEAEGQLQR TNFA_FELCA 87 87 -
KPVAHVVANVKAEGQLQW TNFA_PIG 86 86 -
KPVAHVVANHQVEEQLEW O35853 87 87 -
KPVAHVVANHQVEEQLEW TNFA_MOUSE 90 90 -
KPVAHVVANISAPGQLRW TNFA_SHEEP 88 88 -
KPVAHVVANISAPGQLRW Q28320 88 88 -
KPVAHVVANHQVDEQLEW TNFA_PERLE 90 90 -
KPVAHVVANHQAEEQLEW TNFA_RAT 90 90 -
KPVAHVVAKNEDKEQLVW TNFA_MARMO 88 88 -
KPVAHVVADINSPGQLRW O18779 87 87 -
KPVAHVVADINSPGQLRW TNFA_BOVIN 87 87 -
KPVAHVVANQQAEEELQW TNFA_CAVPO 89 89 -
KPVAHVIADPLAEGKLQW O77764 87 87 -
KPVAHLIADQLAEGQLLW TNFA_TRIVU 87 87 -
KPAAHLVGDPSAQDSLRW TNFB_RABIT 54 54 -
KPAAHLVGYPSKQNSLLW TNFB_MOUSE 59 59 -
KPAAHLVGDPSTPDSLRW TNFB_PIG 61 61 -
KPAAHLVGDPSTQDSLRW TNFB_BOVIN 61 61 -
KPAAHLVGYPSKQNSLLW TNFB_RAT 59 59 -
KPAAHLIGDPSKQNSLLW TNFB_HUMAN 62 62 -
LPAAHLIGAPLKGQGLGW TNFC_HUMAN 87 87 -
LPAAHLIGAWMSGQGLSW TNFC_MOUSE 153 153 -

Motif 2 width=19
Element Seqn Id St Int Rpt
WLSRRANALLANGVELTDN TNFA_CANFA 104 -1 -
WLNRRANALLANGVELTDN TNFA_MACMU 104 -1 -
WLNRRANALLANGVELRDN TNFA_HUMAN 104 -1 -
WLNRRANALLANGVELRDN TNFA_PAPSP 104 -1 -
WLNRRANALVANGVELTDN TNFA_MACFA 104 -1 -
WLNRRANALLANGVELTDN TNFA_PAPHU 104 -1 -
WLSGRANALLANGVKLTDN TNFA_HORSE 105 -1 -
WLSQRANALLANGMKLTDN TNFA_RABIT 107 -1 -
RLSRRANALLANGVELTDN TNFA_FELCA 104 -1 -
WQSGYANALLANGVKLKDN TNFA_PIG 103 -1 -
WLSQRANALLANGMDLKDN O35853 104 -1 -
WLSQRANALLANGMDLKDN TNFA_MOUSE 107 -1 -
WGDSYANALMANGVELKDN TNFA_SHEEP 105 -1 -
WGDSYANALKANGVELKDN Q28320 105 -1 -
WLSRGANALLANGMDLKDN TNFA_PERLE 107 -1 -
WLSQRANALLANGMDLKDN TNFA_RAT 107 -1 -
WLSRRANALLANGMELIDN TNFA_MARMO 105 -1 -
WWDSYANALMANGVKLEDN O18779 104 -1 -
WWDSYANALMANGVKLEDN TNFA_BOVIN 104 -1 -
WLSKRANALLANGMGLSDN TNFA_CAVPO 106 -1 -
WLKRRANVLLSNGMDLVDN O77764 104 -1 -
WVGDVANTLLMNGMELVDN TNFA_TRIVU 104 -1 -
WRANTDRAFLRHGFSLSNN TNFB_RABIT 71 -1 -
WRASTDRAFLRHGFSLSNN TNFB_MOUSE 76 -1 -
WRANTDRAFLRHGFLLSNN TNFB_PIG 78 -1 -
WRANTDRAFLRHGFSLSNN TNFB_BOVIN 78 -1 -
WRANTDRAFLRHGFSLNNN TNFB_RAT 76 -1 -
WRANTDRAFLQDGFSLSNN TNFB_HUMAN 79 -1 -
WETTKEQAFLTSGTQFSDA TNFC_HUMAN 104 -1 -
WEASQEEAFLRSGAQFSPT TNFC_MOUSE 170 -1 -

Motif 3 width=19
Element Seqn Id St Int Rpt
LTHTISRFAVSYQTKVNLL TNFA_CANFA 152 29 -
LTHTISRIAVSYQTKVNLL TNFA_MACMU 152 29 -
LTHTISRIAVSYQTKVNLL TNFA_HUMAN 152 29 -
LTHTISRIAVSYQTKVNLL TNFA_PAPSP 152 29 -
LTHTISRIAVSYQTKVNLL TNFA_MACFA 152 29 -
LTHTISRIAVSYQTKVNLL TNFA_PAPHU 152 29 -
LTHTISRLAVSYPSKVNLL TNFA_HORSE 153 29 -
LTHTVSRFAVSYPNKVNLL TNFA_RABIT 154 28 -
LTHAISRFAVSYQTKVNLL TNFA_FELCA 152 29 -
LTHTISRIAVSYQTKVNLL TNFA_PIG 151 29 -
LTHTVSRFAISYQEKVNLL O35853 151 28 -
LTHTVSRFAISYQEKVNLL TNFA_MOUSE 154 28 -
LTHTISRIAVSYQTKVNIL TNFA_SHEEP 153 29 -
LTHTISRIAVSYQTKVNIL Q28320 153 29 -
LTHTVSRFAVSYEDKVNLL TNFA_PERLE 154 28 -
LTHTVSRFAISYQEKVSLL TNFA_RAT 154 28 -
LTHTVSRFAVSYQDKVNLL TNFA_MARMO 152 28 -
LTHTISRIAVSYQTKVNIL O18779 152 29 -
LTHTISRIAVSYQTKVNIL TNFA_BOVIN 152 29 -
LTHTVSRLAVSYPEKVNLL TNFA_CAVPO 153 28 -
LTHTVSRVALSYQSKVNLL O77764 152 29 -
LTHKISRFTLSYQKKVTLL TNFA_TRIVU 152 29 -
LAHEVQLFSSQYSFHVPLL TNFB_RABIT 123 33 -
LAHEVQLFSSQYPFHVPLL TNFB_MOUSE 128 33 -
LAHEVQLFSSQYPFHVPLL TNFB_PIG 130 33 -
LAHEVQLFSPQYPFHVPLL TNFB_BOVIN 130 33 -
LAHEVQLFSSQYPFHVPLL TNFB_RAT 128 33 -
LAHEVQLFSSQYPFHVPLL TNFB_HUMAN 131 33 -
LRSSLYRAGGAYGPGTPEL TNFC_HUMAN 159 36 -
LRSALYRAGGAYGRGSPEL TNFC_MOUSE 224 35 -

Motif 4 width=24
Element Seqn Id St Int Rpt
WYEPIYLGGVFQLEKGDRLSAEIN TNFA_CANFA 190 19 -
WYEPIYLGGVFQLEKGDRLSAEIN TNFA_MACMU 190 19 -
WYEPIYLGGVFQLEKGDRLSAEIN TNFA_HUMAN 190 19 -
WYEPIYLGGVFQLEKGDRLSAEIN TNFA_PAPSP 190 19 -
WYEPIYLGGVFQLEKGDRLSAEIN TNFA_MACFA 190 19 -
WYEPIYLGGVFQLEKGDRLSAEIN TNFA_PAPHU 190 19 -
WYEPIYLGGVFQLEKGDQLSAEIN TNFA_HORSE 191 19 -
WYEPIYLGGVFQLEKGDRLSTEVN TNFA_RABIT 192 19 -
WYEPIYLGGVFQLEKGDRLSTEIN TNFA_FELCA 190 19 -
WYEPIYLGGVFQLEKDDRLSAEIN TNFA_PIG 189 19 -
WYEPIYLGGVFQLEKGDQLSAEVN O35853 189 19 -
WYEPIYLGGVFQLEKGDQLSAEVN TNFA_MOUSE 192 19 -
WYEPIYQGGVFQLEKGDRLSAEIN TNFA_SHEEP 191 19 -
WYEPIYQGGVFQLEKGDRLSAEIN Q28320 191 19 -
WYEPIYLGGVFQLEKGDRLSAEVN TNFA_PERLE 192 19 -
WYEPMYLGGVFQLEKGDLLSAEVN TNFA_RAT 192 19 -
WYEPIYLGGVFELQKGDRLSAEVN TNFA_MARMO 190 19 -
WYEPIYQGGVFQLEKGDRLSAEIN O18779 190 19 -
WYEPIYQGGVFQLEKGDRLSAEIN TNFA_BOVIN 190 19 -
WYEPIYLGGVFQLQKGDRLSAEVN TNFA_CAVPO 191 19 -
WYEPIYLGGVFQLEKGDKLSADTN O77764 190 19 -
WYEPVYLAGVFQLTEGDKLVVDTN TNFA_TRIVU 190 19 -
WVRSVYQGAVFLLTQGDQLSTHTD TNFB_RABIT 155 13 -
WVRSMYQGAVFLLSKGDQLSTHTD TNFB_MOUSE 160 13 -
WVRSVYQGAVFLLTQGDQLSTHTD TNFB_PIG 162 13 -
WVRSVYQGAVFLLTRGDQLSTHTD TNFB_BOVIN 162 13 -
WVRSMYQGAVFLLSKGDQLSTHTD TNFB_RAT 160 13 -
WLHSMYHGAAFQLTQGDQLSTHTD TNFB_HUMAN 163 13 -
WYTSVGFGGLVQLRRGERVYVNIS TNFC_HUMAN 201 23 -
WYTSVGFGGLAQLRSGERVYVNIS TNFC_MOUSE 263 20 -

Motif 5 width=12
Element Seqn Id St Int Rpt
AESGQVYFGIIA TNFA_CANFA 221 7 -
AESGQVYFGIIA TNFA_MACMU 221 7 -
AESGQVYFGIIA TNFA_HUMAN 221 7 -
AESGQVYFGIIA TNFA_PAPSP 221 7 -
AESGQVYFGIIA TNFA_MACFA 221 7 -
AESGQVYFGIIA TNFA_PAPHU 221 7 -
AESGQVYFGIIA TNFA_HORSE 222 7 -
AESGQVYFGIIA TNFA_RABIT 223 7 -
AESGQVYFGIIA TNFA_FELCA 221 7 -
AESGQVYFGIIA TNFA_PIG 220 7 -
AESGQVYFGVIA O35853 220 7 -
AESGQVYFGVIA TNFA_MOUSE 223 7 -
AESGQVYFGIIA TNFA_SHEEP 222 7 -
AESGQVYFGIIA Q28320 222 7 -
AESGQVYFGVIA TNFA_PERLE 223 7 -
TESGQVYFGVIA TNFA_RAT 223 7 -
AESGQVYFGVIA TNFA_MARMO 221 7 -
AESGQVYFGIIA O18779 221 7 -
AESGQVYFGIIA TNFA_BOVIN 221 7 -
ADSGQIYFGVIA TNFA_CAVPO 222 7 -
AESGQVYFGVIA O77764 221 7 -
AEPGQLYFGAIA TNFA_TRIVU 221 7 -
LSPSSVFFGAFA TNFB_RABIT 185 6 -
FSPSSVFFGAFA TNFB_MOUSE 190 6 -
LSPSSVFFGAFA TNFB_PIG 192 6 -
LSPSSVFFGAFA TNFB_BOVIN 192 6 -
FSPSTVFFGAFA TNFB_RAT 190 6 -
LSPSTVFFGAFA TNFB_HUMAN 193 6 -
FARGKTFFGAVM TNFC_HUMAN 231 6 -
YRRGKTFFGAVM TNFC_MOUSE 293 6 -