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PR01182

Identifier
ORNDCRBXLASE  [View Relations]  [View Alignment]  
Accession
PR01182
No. of Motifs
7
Creation Date
18-SEP-1999
Title
Ornithine decarboxylase signature
Database References
PRINTS; PR01179 ODADCRBXLASE
INTERPRO; IPR002433
Literature References
1. MARTIN, C., CAMI, B., YEH, P., STRAGIER, P., PARSOT, C. AND PATTE, J.-C.
Pseudomonas aeruginosa diaminopimelate decarboxylase: evolutionary 
relationship with other amino acid decarboxylases.
MOL.BIOL.EVOL. 5 549-559 (1988).
 
2. SANDMEIER, E., HALE, T.I. AND CHRISTEN, P.
Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid
decarboxylases. 
EUR.J.BIOCHEMISTRY 221 997-1002 (1994).
 
3. JOHANNES, G.J. AND BERGER, F.G.
Domains within the mammalian ornithine decarboxylase messenger RNA have
evolved independently and episodically.
J.MOL.EVOL. 36 555-567 (1993). 
 
4. TOBIAS, K.E. AND KAHANA, C.
Intersubunit location of the active site of mammalian ornithine
decarboxylase as determined by hybridization of site-directed mutants.
BIOCHEMISTRY 32 5842-5847 (1993).
 
5. POULIN, R., LU, L., ACKERMANN, B., BEY, P. AND PEGG, A.E.
Mechanism of the irreversible inactivation of mouse ornithine decarboxylase
by alpha-difluoromethylornithine. Characterization of sequences at the
inhibitor and coenzyme binding sites.
J.BIOL.CHEM. 267 150-158 (1992).

Documentation
Pyridoxal-dependent decarboxylases that act on ornithine-, lysine-, 
arginine- and related substrates can be classified into different families
on the basis of sequence similarity [1,2]. One of these families includes:
eukaryotic ornithine decarboxylase (ODC), which catalyses the transformation
of ornithine into putrescine; prokaryotic diaminopimelic acid decarboxylase
(DAPDC), which catalyses the conversion of diaminopimelic acid into lysine,
the final step of lysine biosynthesis; Pseudomonas syringae pv. tabaci
protein, tabA, which is probably involved in tabtoxin biosynthesis and
is similar to DAPDC; and bacterial and plant biosynthetic arginine
decarboxylase (ADC), which catalyses the transformation of arginine 
into agmatine, the first step in putrescine synthesis from arginine.
 
Although these proteins, which are known collectively as group IV
decarboxylases [2], probably share a common evolutionary origin, their
levels of sequence similarity are low, being confined to a few short
conserved regions. 
 
Phylogenetic analysis of the mRNAs from several mammalian species suggests
that ODC is encoded by orthologous genes in the different species [3].
Analysis of divergence patterns in a number of subregions showed that the
domains have evolved in a noncoordinate fashion. Evolution of each subregion
has been episodic, with periods of both rapid and slow divergence, possibly
indicating the existence of selection pressures that were exerted in a 
time- and domain-specific manner during mammalian speciation [3].
 
The active form of mammalian ODC is a homodimer of 53kDa subunits (the 
monomer retains no enzymatic activity). In vitro hybridisation and cross-
linkage analysis have suggested that the active site of ODC is formed at 
the interface of the two monomers via the interaction of the cysteine-360-
containing region of one subunit with the lysine-69-containing region of 
the other [4]. 
 
ORNDCRBXLASE is a 7-element fingerprint that provides a signature for
ornithine decarboxylases. The fingerprint was derived from an initial
alignment of 6 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length, focusing on those sections
that characterise the ornithine decarboxylases but distinguish them from
the rest of the ODA family - motif 2 contains the region encoded by PROSITE 
pattern ODR_DC_2_1 (PS00878), which includes a conserved lysine residue that
is the pyridoxal-P attachment site in mouse ODC [5]. Five iterations on
SPTR37_10f were required to reach convergence, at which point a true set
comprising 30 sequences was identified. Several partial matches were also
found, all of which are ornithine decarboxylases and homologues that fail
to match one or more motifs.
Summary Information
  30 codes involving  7 elements
2 codes involving 6 elements
0 codes involving 5 elements
2 codes involving 4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
730303030303030
61222122
50000000
41111121
31100010
20000000
1234567
True Positives
DCO1_DROME    DCOR_BOVIN    DCOR_CAEEL    DCOR_CANAL    
DCOR_CRIGR DCOR_DATST DCOR_HUMAN DCOR_LEIDO
DCOR_MOUSE DCOR_MUSPA DCOR_NEUCR DCOR_PANRE
DCOR_RAT DCOR_TRYBB DCOR_XENLA DCOR_YEAST
O14439 O14977 O15696 O22616
O35484 O50657 O82420 P90517
P93351 P93357 Q27702 Q63764
Q84527 Q94278
True Positive Partials
Codes involving 6 elements
DCO2_DROME O76203
Codes involving 4 elements
O01579 O66940
Codes involving 3 elements
O69865
Sequence Titles
DCO1_DROME  ORNITHINE DECARBOXYLASE 1 (EC 4.1.1.17) (ODC) - DROSOPHILA MELANOGASTER (FRUIT F 
DCOR_BOVIN ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - BOS TAURUS (BOVINE).
DCOR_CAEEL ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - CAENORHABDITIS ELEGANS.
DCOR_CANAL ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - CANDIDA ALBICANS (YEAST).
DCOR_CRIGR ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - CRICETULUS GRISEUS (CHINESE HAMSTE
DCOR_DATST ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - DATURA STRAMONIUM (JIMSONWEED) (CO
DCOR_HUMAN ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - HOMO SAPIENS (HUMAN).
DCOR_LEIDO ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - LEISHMANIA DONOVANI.
DCOR_MOUSE ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - MUS MUSCULUS (MOUSE).
DCOR_MUSPA ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - MUS PAHARI (SHREW MOUSE).
DCOR_NEUCR ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - NEUROSPORA CRASSA.
DCOR_PANRE ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - PANAGRELLUS REDIVIVUS.
DCOR_RAT ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - RATTUS NORVEGICUS (RAT).
DCOR_TRYBB ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - TRYPANOSOMA BRUCEI BRUCEI.
DCOR_XENLA ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - XENOPUS LAEVIS (AFRICAN CLAWED FRO
DCOR_YEAST ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC) - SACCHAROMYCES CEREVISIAE (BAKER'S
O14439 ORNITHINE DECARBOXYLASE - USTILAGO MAYDIS (SMUT FUNGUS).
O14977 ANTIZYME INHIBITOR - HOMO SAPIENS (HUMAN).
O15696 ORNITHINE DECARBOXYLASE - PLASMODIUM FALCIPARUM.
O22616 ORNITHINE DECARBOXYLASE - LYCOPERSICON ESCULENTUM (TOMATO).
O35484 ANTIZYME INHIBITOR - MUS MUSCULUS (MOUSE).
O50657 LYSINE/ORNITHINE DECARBOXYLASE (EC 4.1.1.17) - SELENOMONAS RUMINANTIUM.
O82420 ORNITHINE DECARBOXYLASE (EC 4.1.1.17) - LYCOPERSICON ESCULENTUM (TOMATO).
P90517 ORNITHINE DECARBOXYLASE (EC 4.1.1.17) - CRITHIDIA FASCICULATA.
P93351 ORNITHINE DECARBOXYLASE - NICOTIANA TABACUM (COMMON TOBACCO).
P93357 ORNITHINE DECARBOXYLASE - NICOTIANA TABACUM (COMMON TOBACCO).
Q27702 ORNITHINE DECARBOXYLASE (EC 4.1.1.17) - MUSCA DOMESTICA (HOUSE FLY).
Q63764 ANTIZYME INHIBITOR - RATTUS NORVEGICUS (RAT).
Q84527 SIMILAR TO HUMAN ORNITHINE DECARBOXYLASE - PARAMECIUM BURSARIA CHLORELLA VIRUS 1
Q94278 C. ELEGANS ORNITHINE DECARBOXYLASE (ODC-1) (SP:P41931) - CAENORHABDITIS ELEGANS.

DCO2_DROME ORNITHINE DECARBOXYLASE 2 (EC 4.1.1.17) (ODC) - DROSOPHILA MELANOGASTER (FRUIT F
O76203 ORNITHINE DECARBOXYLASE (EC 4.1.1.17) - HAEMONCHUS CONTORTUS.

O01579 SIMILARITY TO FAMILY 2 OF ORNITHINE - CAENORHABDITIS ELEGANS.
O66940 ORNITHINE DECARBOXYLASE - AQUIFEX AEOLICUS.

O69865 PUTATIVE LYSINE/ORNITHINE DECARBOXYLASE - STREPTOMYCES COELICOLOR.
Scan History
SPTR37_10f 5  45   NSINGLE    
Initial Motifs
Motif 1  width=25
Element Seqn Id St Int Rpt
DAFYVADLGDVLKKHLRWLKALPRV DCOR_RAT 38 38 -
DAFYVADLGDILKKHLRWLKALPRV DCOR_MUSPA 38 38 -
DAFYVADLGDILKKHLRWLKALPRV DCOR_HUMAN 38 38 -
DPFFVADLGDIVRKHETWKKCLPRV DCOR_TRYBB 58 58 -
DSFFVCDLGEIINSVNQWQQILPMV DCOR_CANAL 75 75 -
DPFYIIDLGRVVEQMARWRHELPMV DCOR_LEIDO 257 257 -

Motif 2 width=28
Element Seqn Id St Int Rpt
PFYAVKCNDSRAIVSTLAAIGTGFDCAS DCOR_RAT 64 1 -
PFYAVKCNDSRAIVSTLAATGTGFDCAS DCOR_MUSPA 64 1 -
PFYAVKCNDSKAIVKTLAATGTGFDCAS DCOR_HUMAN 64 1 -
PFYAVKCNDDWRVLGTLAALGTGFDCAS DCOR_TRYBB 84 1 -
PYYAVKCNSNPQILTTLSELGVNFDCAS DCOR_CANAL 101 1 -
PYFAVKSNPQPAVLEVLSALGAGFDCAS DCOR_LEIDO 283 1 -

Motif 3 width=25
Element Seqn Id St Int Rpt
IIYANPCKQVSQIKYAASNGVQMMT DCOR_RAT 108 16 -
IIYANPCKQVSQIKYAASSGVQMMT DCOR_MUSPA 108 16 -
IIYANPCKQVSQIKYAANNGVQMMT DCOR_HUMAN 108 16 -
IIYANPCKQISHIRYARDSGVDVMT DCOR_TRYBB 128 16 -
IIYANPCKTNSFIRHAADENVNLTT DCOR_CANAL 147 18 -
IIFANPCKQLGDLREAQACGVTYVT DCOR_LEIDO 329 18 -

Motif 4 width=23
Element Seqn Id St Int Rpt
ELMKVARAHPKAKLVLRIATDDS DCOR_RAT 138 5 -
ELMKVARAHPKAKLVLRIATDDS DCOR_MUSPA 138 5 -
ELMKVARAHPKAKLVLRIATDDS DCOR_HUMAN 138 5 -
ELEKVAKTHPKAKMVLRISTDDS DCOR_TRYBB 158 5 -
ELYKLAKFHPHCKILIRLITDDS DCOR_CANAL 177 5 -
EMEKISRLMPSAHAIIRIKTNDS DCOR_LEIDO 359 5 -

Motif 5 width=14
Element Seqn Id St Int Rpt
DGVYGSFNCILYDH DCOR_RAT 320 159 -
DGVYGSFNCILYDH DCOR_MUSPA 320 159 -
DGVYGSFNCILYDH DCOR_HUMAN 320 159 -
DGVYGSFNCILYDH DCOR_TRYBB 340 159 -
DGVYGNLNCILFDH DCOR_CANAL 356 156 -
DGLYHSFNCILFDH DCOR_LEIDO 550 168 -

Motif 6 width=11
Element Seqn Id St Int Rpt
SIWGPTCDGLD DCOR_RAT 354 20 -
SIWGPTCDGLD DCOR_MUSPA 354 20 -
SIWGPTCDGLD DCOR_HUMAN 354 20 -
SVWGPTCDGLD DCOR_TRYBB 374 20 -
SIWGPTCDGLD DCOR_CANAL 411 41 -
TIFGPTCDSMD DCOR_LEIDO 628 64 -

Motif 7 width=14
Element Seqn Id St Int Rpt
EMHVGDWMLFENMG DCOR_RAT 374 9 -
EMHVGDWMLFENMG DCOR_MUSPA 374 9 -
EMHVGDWMLFENMG DCOR_HUMAN 374 9 -
EMQVGEWLLFEDMG DCOR_TRYBB 394 9 -
NVQVGDWLFFENVG DCOR_CANAL 432 10 -
EMKLGDWLLVPDMG DCOR_LEIDO 648 9 -
Final Motifs
Motif 1  width=25
Element Seqn Id St Int Rpt
DAFYVADLGDVLKKHLRWLKALPRV DCOR_RAT 38 38 -
DAFYVADLGDILKKHLRWLKALPRV DCOR_MUSPA 38 38 -
DAFYVADLGDILKKHLRWLKALPRV DCOR_HUMAN 38 38 -
DAFYVADLGDILKKHLRWLKALPRV DCOR_BOVIN 38 38 -
DAFYVADLGDILKKHLRWLKALPRV DCOR_MOUSE 38 38 -
DAFYVADFGDIVKKHVRWFKALPRV DCOR_XENLA 38 38 -
DPFFVADLGDIVRKHETWKKCLPRV DCOR_TRYBB 58 58 -
QPFYVLDLGEVVSLMDQWNAGLPNI DCOR_DATST 63 63 -
QPFYVLDLGEVVSLMDQWKSALPNI P93351 65 65 -
QPFYVLDLGEVVSLMEQWNSALPNI O22616 63 63 -
QPFYVLDLGEVVSLMEQWNSALPNI O82420 63 63 -
QPFYVLDLGEVVSLMDQWKSALPNI P93357 65 65 -
DAFYVADLGDVLKKHLRWLKALPVT DCOR_CRIGR 37 37 -
NAFFVADLSEVYRQHLRWMRALPRI O14439 42 42 -
DTFFVADLGEVYRQHLRWKLNLPRV DCOR_NEUCR 83 83 -
DSFFVCDLGEIINSVNQWQQILPMV DCOR_CANAL 75 75 -
NSFFICDLGEVKRLFNNWVKELPRI DCOR_YEAST 85 85 -
SSFMLVDLDKIIERFQLWKRELPMI DCOR_CAEEL 40 40 -
SSFMLVDLDKIIERFQLWKRELPMI Q94278 40 40 -
NAFFVGDLGKIVKKHSQWQTVVAQI O35484 38 38 -
NAFFVGDLGKIVKKHSQWQNVVAQI O14977 38 38 -
NAFFVGDLGKIVKKHSQWQNVVAQI Q63764 38 38 -
DPFYIIDLGRVVEQMARWRHELPMV DCOR_LEIDO 257 257 -
DPFVVMNVSTIMAKVIQWQRTMPRV DCOR_PANRE 45 45 -
DPFYMIDLGRVVEQMARWRHELPMV P90517 287 287 -
EALFVCDLTRLKEKYDMWTKYMPRV Q27702 30 30 -
QALNICDLSSVERNVRLWQKLLPRI DCO1_DROME 31 31 -
TPFLVASLDKVEENYQFMRRHLPRA O50657 20 20 -
TSVVCINLQKILAQYVRFKKNLPHV O15696 365 365 -
KSFYVSSPKIVEDLIDQWTILFPRV Q84527 17 17 -

Motif 2 width=28
Element Seqn Id St Int Rpt
PFYAVKCNDSRAIVSTLAAIGTGFDCAS DCOR_RAT 64 1 -
PFYAVKCNDSRAIVSTLAATGTGFDCAS DCOR_MUSPA 64 1 -
PFYAVKCNDSKAIVKTLAATGTGFDCAS DCOR_HUMAN 64 1 -
PFYAVKCNDSRTIVKTLAAIGTGFDCAS DCOR_BOVIN 64 1 -
PFYAVKCNDSRAIVSTLAAIGTGFDCAS DCOR_MOUSE 64 1 -
PFYAVKCNDGKAIVKTLSILGAGFDCAS DCOR_XENLA 64 1 -
PFYAVKCNDDWRVLGTLAALGTGFDCAS DCOR_TRYBB 84 1 -
PFYAVKCNPEPSFLSMLSAMGSNFDCAS DCOR_DATST 89 1 -
PFYAVKCNPEPSFLSILSAMGSNFDCAS P93351 91 1 -
PFYAVKCNPEPSFLSMLSAMGSNFDCAS O22616 89 1 -
PFYAVKCNPEPSFLSMLSAMGSNFDCAS O82420 89 1 -
PFYAVKCNPEPSFLSILSAMGSNFDCAS P93357 91 1 -
PFYAVKCNDSRALVNTLAAITVDCASKT DCOR_CRIGR 62 0 -
PFYAVKCNPDPYVLQLLGALGTGFDCAS O14439 68 1 -
PFYAVKCHPDERLLQLLAALGTGFDCAS DCOR_NEUCR 109 1 -
PYYAVKCNSNPQILTTLSELGVNFDCAS DCOR_CANAL 101 1 -
PFYAVKCNPDTKVLSLLAELGVNFDCAS DCOR_YEAST 111 1 -
PFYAVKCNTDLVLIRILASLGCGFDCAS DCOR_CAEEL 66 1 -
PFYAVKCNTDLVLIRILASLGCGFDCAS Q94278 66 1 -
PFYTVKCNSTPAVLEILAALGTGFACSS O35484 64 1 -
PFYTVKCNSAPAVLEILAALGTGFACSS O14977 64 1 -
PFYMVKCNSTPAVLEILAALGTGFACST Q63764 64 1 -
PYFAVKSNPQPAVLEVLSALGAGFDCAS DCOR_LEIDO 283 1 -
PCYAVKCNDDKVLLRTLADLGMGFDCAS DCOR_PANRE 71 1 -
PHFAVKCNPNLAIMEVLGALGAGFDCAS P90517 313 1 -
PYYAVKCNDDGHIVKTLAELGTNFDCAS Q27702 56 1 -
PFYAVKCNDDPMVVRLLAQLGAGFDCAS DCO1_DROME 57 1 -
VFYAMKANPTPEILSLLAGLGSHFDVAS O50657 46 1 -
PFYSVKSNNDEVVIKFLYGLNCNFDCAS O15696 391 1 -
PHYAVKCNNDEVLLKTMCDKNVNFDCAS Q84527 43 1 -

Motif 3 width=25
Element Seqn Id St Int Rpt
IIYANPCKQVSQIKYAASNGVQMMT DCOR_RAT 108 16 -
IIYANPCKQVSQIKYAASSGVQMMT DCOR_MUSPA 108 16 -
IIYANPCKQVSQIKYAANNGVQMMT DCOR_HUMAN 108 16 -
IIYANPCKQVSQIKYAANNGVQMMT DCOR_BOVIN 108 16 -
VIYANPCKQVSQIKYAASNGVQMMT DCOR_MOUSE 108 16 -
IIYANPCKQVSQIKYAASCGVEKMT DCOR_XENLA 108 16 -
IIYANPCKQISHIRYARDSGVDVMT DCOR_TRYBB 128 16 -
IVFANPCKPESDIIFAAKVGVNLTT DCOR_DATST 133 16 -
IVFANPCKPESDIIFAAKVGVNLTT P93351 135 16 -
IVFANPCKPESDIIFAEKIGVNLTT O22616 133 16 -
IVFANPCKPESDIIFAEKIGVNLTT O82420 133 16 -
IVFANPCKPESDIIFAAKVGVNLTT P93357 135 16 -
VIYANPCKQVSQIKYAASNGVQMMT DCOR_CRIGR 104 14 -
IIYANPSKAASFVRHAAGHNVGLTT O14439 112 16 -
IIYAQPCKTNSYLRYVAQQGVRQMT DCOR_NEUCR 153 16 -
IIYANPCKTNSFIRHAADENVNLTT DCOR_CANAL 147 18 -
IVYANPCKVASFIRYAASKNVMKST DCOR_YEAST 155 16 -
IIYANPCKTRSFIAHAMDRDVKMMT DCOR_CAEEL 110 16 -
IIYANPCKTRSFIAHAMDRDVKMMT Q94278 110 16 -
IIFTSPCKQVSQIKYAAKVGVNIMT O35484 108 16 -
IIYISPCKQVSQIKYAAKVGVNILT O14977 108 16 -
IIYTSPCKQASQIKYAAKVGVNIMT Q63764 108 16 -
IIFANPCKQLGDLREAQACGVTYVT DCOR_LEIDO 329 18 -
IVYANPCKTRGFIAHAEAAGVKRMT DCOR_PANRE 114 15 -
IVFANPCKQLGDLREARACGVTYVT P90517 359 18 -
IIFAQPCKPISHLEYAKEMGVMTST Q27702 100 16 -
IIFANPCRPVSHLEYAKEHQVSNGT DCO1_DROME 101 16 -
MIYANPVKDARGLKAAADYNVRRFT O50657 90 16 -
IIFANTIKSINSLIYARKENINLCT O15696 437 18 -
IIFAHTMKTIDDLIFAKDQGVDIAT Q84527 87 16 -

Motif 4 width=23
Element Seqn Id St Int Rpt
ELMKVARAHPKAKLVLRIATDDS DCOR_RAT 138 5 -
ELMKVARAHPKAKLVLRIATDDS DCOR_MUSPA 138 5 -
ELMKVARAHPKAKLVLRIATDDS DCOR_HUMAN 138 5 -
ELMKVARAHPKAKLVLRIATDDS DCOR_BOVIN 138 5 -
ELMKVARAHPKAKLVLRIATDDS DCOR_MOUSE 138 5 -
ELMKVARNHPNAKLVLRIATDDS DCOR_XENLA 138 5 -
ELEKVAKTHPKAKMVLRISTDDS DCOR_TRYBB 158 5 -
EVYKIRKHHPKCELLLRIKPMDD DCOR_DATST 163 5 -
EVYKIRKHHPKSELLLRIKPMLD P93351 165 5 -
EVYKIRKHHPKCELLLRIKPMTD O22616 163 5 -
EVYKIRKHHPKCELLLRIKPMTD O82420 163 5 -
EVNKIRKHHPKSELLLRIKPMLD P93357 165 5 -
ELMKVARAHPKVTKLVLRIATDD DCOR_CRIGR 134 5 -
ELEKMKRYHPSCKLVVRILTDDS O14439 142 5 -
ELRKIARLYPDAELFLRILTDDS DCOR_NEUCR 183 5 -
ELYKLAKFHPHCKILIRLITDDS DCOR_CANAL 177 5 -
ELHKIKKFHPESQLLLRIATDDS DCOR_YEAST 185 5 -
ELLKIAKLHPNAEMILRIAVSDP DCOR_CAEEL 140 5 -
ELLKIAKLHPNAEMILRIAVSDP Q94278 140 5 -
ELKKIARNHPNAKVLLHIATEDN O35484 138 5 -
ELKKIARNHPNAKVLLHIATEDN O14977 138 5 -
ELKKIARNHPNAKVLLHIATEDN Q63764 138 5 -
EMEKISRLMPSAHAIIRIKTNDS DCOR_LEIDO 359 5 -
ELTKIKQNHADPSLILRISVSDP DCOR_PANRE 144 5 -
EMEKIGRMLPSARAIIRIKTNDA P90517 389 5 -
EIHKLHKHFPESNLVIRFRCEAK Q27702 130 5 -
EVYKLHTHYPNSNLIVRFKSEAK DCO1_DROME 131 5 -
EIDKMAKAVPGADVLVRIAVRNN O50657 120 5 -
ELKKIYKYHPKCSLILRINVDFK O15696 467 5 -
ELDKIHTYHPNCKMILRIRCDDP Q84527 117 5 -

Motif 5 width=14
Element Seqn Id St Int Rpt
DGVYGSFNCILYDH DCOR_RAT 320 159 -
DGVYGSFNCILYDH DCOR_MUSPA 320 159 -
DGVYGSFNCILYDH DCOR_HUMAN 320 159 -
DGVYGSFNCILYDH DCOR_BOVIN 320 159 -
DGVYGSFNCILYDH DCOR_MOUSE 320 159 -
DGVYGSFNCILFDH DCOR_XENLA 321 160 -
DGVYGSFNCILYDH DCOR_TRYBB 340 159 -
DGLYGSMNCVLYDH DCOR_DATST 329 143 -
DGLYGSMNCVLYDH P93351 331 143 -
DGLYGSMNCVLYDH O22616 329 143 -
DGLYGSMNCVLYDH O82420 329 143 -
DGLYGSMNCVLYDH P93357 331 143 -
DGVYGSFNCILYDH DCOR_CRIGR 314 157 -
DGLYGSFNCVIFDH O14439 330 165 -
DGLYGNFSSIMFDH DCOR_NEUCR 370 164 -
DGVYGNLNCILFDH DCOR_CANAL 356 156 -
DGVYGNMNCILFDH DCOR_YEAST 351 143 -
DGVYGSFNCILFDH DCOR_CAEEL 320 157 -
DGVYGSFNCILFDH Q94278 320 157 -
DGVYGSFASKLSED O35484 318 157 -
DGVYGSFASKLSED O14977 318 157 -
DGVYGSFASKLSED Q63764 318 157 -
DGLYHSFNCILFDH DCOR_LEIDO 550 168 -
DGVYGSFNCKLFDH DCOR_PANRE 328 161 -
DGLYHSFNCIVFDH P90517 581 169 -
DGVYGSFNCILYDH Q27702 302 149 -
DGVYGSFNCILYDH DCO1_DROME 303 149 -
EGIYGCFSGIMYDH O50657 287 144 -
DSIYGCFSGIIFDE O15696 836 346 -
ESTYGGFSNVIFEK Q84527 284 144 -

Motif 6 width=11
Element Seqn Id St Int Rpt
SIWGPTCDGLD DCOR_RAT 354 20 -
SIWGPTCDGLD DCOR_MUSPA 354 20 -
SIWGPTCDGLD DCOR_HUMAN 354 20 -
SIWGPTCDGLD DCOR_BOVIN 354 20 -
SIWGPTCDGLD DCOR_MOUSE 354 20 -
SIWGPTCDGLD DCOR_XENLA 355 20 -
SVWGPTCDGLD DCOR_TRYBB 374 20 -
TVFGPTCDALD DCOR_DATST 370 27 -
TVFGPTCDALD P93351 372 27 -
TVFGPTCDALD O22616 370 27 -
TVFGPTCDALD O82420 370 27 -
TVFGPTCDAFD P93357 372 27 -
SIWGPTCDGLD DCOR_CRIGR 348 20 -
SVWGPTCDSID O14439 388 44 -
SIWGPTCDGID DCOR_NEUCR 416 32 -
SIWGPTCDGLD DCOR_CANAL 411 41 -
SIWGPTCDGLD DCOR_YEAST 405 40 -
TIWGPTCDSLD DCOR_CAEEL 353 19 -
TIWGPTCDSLD Q94278 353 19 -
SLWGPSCDELD O35484 352 20 -
SLWGPSCDELD O14977 352 20 -
SLWGPSCDELD Q63764 352 20 -
TIFGPTCDSMD DCOR_LEIDO 628 64 -
CVWGPTCDGLD DCOR_PANRE 362 20 -
TIFGPTCDSMD P90517 662 67 -
LIWGPTCDALD Q27702 337 21 -
LIWGPSCDALD DCO1_DROME 337 20 -
TFGGPSCDGID O50657 317 16 -
NVFGQSCDGLD O15696 877 27 -
VLYGCTCDGVD Q84527 318 20 -

Motif 7 width=14
Element Seqn Id St Int Rpt
EMHVGDWMLFENMG DCOR_RAT 374 9 -
EMHVGDWMLFENMG DCOR_MUSPA 374 9 -
EMHVGDWMLFENMG DCOR_HUMAN 374 9 -
EMHVGDWMLFENMG DCOR_BOVIN 374 9 -
EMHVGDWMLFENMG DCOR_MOUSE 374 9 -
ELQVGDWMLFENMG DCOR_XENLA 375 9 -
EMQVGEWLLFEDMG DCOR_TRYBB 394 9 -
ELQVNDWLIFPNMG DCOR_DATST 390 9 -
ELQVNDWLVFPNMG P93351 392 9 -
ELQVNDWLIFPNMG O22616 390 9 -
ELQVNDWLIFPNMG O82420 390 9 -
ELQVNDWLVFPNMG P93357 392 9 -
EMHVGDWMLFENMG DCOR_CRIGR 368 9 -
GLQVGDWLVYENMG O14439 409 10 -
ILDVGDWLYFEDMG DCOR_NEUCR 437 10 -
NVQVGDWLFFENVG DCOR_CANAL 432 10 -
DVIVGDWFYFPALG DCOR_YEAST 426 10 -
KMNVGEWLYYPDMG DCOR_CAEEL 373 9 -
KMNVGEWLYYPDMG Q94278 373 9 -
ELNVGDWLIFDNMG O35484 372 9 -
ELNVGDWLIFDNMG O14977 372 9 -
ELSVGDWLIFDNMG Q63764 372 9 -
EMKLGDWLLVPDMG DCOR_LEIDO 648 9 -
RLYEGDWLYYPDMG DCOR_PANRE 382 9 -
EMKLGDWLLAPDMG P90517 682 9 -
DLKCGDFLAFPNMG Q27702 357 9 -
NLNRGDLLGFRNMG DCO1_DROME 357 9 -
ELKIGDKVLVTEMG O50657 337 9 -
ECYINDWLLYEYAG O15696 897 9 -
ELHIGDWVYFPSWG Q84527 338 9 -