| Literature References | 1. DODGSON, J.B., BROWNE, D.L. AND BLACK, A.J.
Chicken chromosomal protein HMG-14 and HMG-17 cDNA clones: isolation,
characterization and sequence comparison.
GENE 63 287-295 (1988).
2. LANDSMAN, D., MCBRIDE, O.W., SOARES, N., CRIPPA, M.P., SRIKANTHA, T.
AND BUSTIN, M.
Chromosomal protein HMG-14. Identification, characterization, and
chromosome localization of a functional gene from the large human
multigene family.
J.BIOL.CHEM. 264 3421-3427 (1989).
3. LANDSMAN D., SOARES N., GONZALEZ F.J. AND BUSTIN M.
Chromosomal protein HMG-17. Complete human cDNA sequence and evidence
for a multigene family.
J.BIOL.CHEM. 261 7479-7484 (1986).
4. WATSON, D.C., WONG, N.C. AND DIXON, G.H.
The complete amino-acid sequence of a trout testis non-histone protein, H6,
localized in a subset of nucleosomes and its similarity to calf thymus
non-histone proteins HMG-14 and HMG-17.
EUR.J.BIOCHEMISTRY 95 193-202 (1979).
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| Documentation | High mobility group (HMG) proteins constitute a family of relatively low
molecular weight non-histone components in chromatin. HMG14 and HMG17 are
highly-similar proteins of about 100 amino acid residues; the sequence of
chicken HMG14 is almost as similar to chicken HMG17 as it is to mammalian
HMG14 polypeptides [1]. The proteins bind to the inner side of the nucleo-
somal DNA, altering the interaction between the DNA and the histone octamer
[1,2]. It is thought that they may be involved in the process that confers
specific chromatin conformations to transcribable regions in the genome [3].
H6 (histone T) is a basic non-histone protein isolated from the chromatin of
rainbow trout [4]. Protein H6 possesses 69 residues and, in spite of its
shorter length, shows considerable similarities to the 89-residue calf
thymus HMG17 protein family [4].
NONHISHMG17 is a 4-element fingerprint that provides a signature for the
non-histone chromosomal HMG-17 protein family. The fingerprint was derived
from an initial alignment of 12 sequences: the motifs were drawn from
short conserved regions spanning virtually the full alignment length. Two
iterations on OWL30.2 were required to reach convergence, at which point
a true set comprising 13 sequences was identified. Two partial matches
were also found: HG17_BOVIN is a bovine non-histone chromosomal protein
whose sequence is poorly defined in the region of motif 4; and HSU90549
is a human non-histone chromosomal protein that fails to make a significant
match with motif 4.
An update on SPTR37_9f identified a true set of 13 sequences, and 2
partial matches.
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