| Literature References | 1. RAWLINGS, N.D. AND BARRETT, A.J.
Families of serine peptidases.
METHODS ENZYMOL. 244 19-61 (1994).
2. RAWLINGS, N.D. AND BARRETT, A.J.
Evolutionary familes of peptidases.
BIOCHEM.J. 290 205-218 (1993).
3. SIEZEN, R.J. AND LEUNISSEN, J.A.M.
Subtilases: The superfamily of subtilisin-like serine proteases.
PROTEIN SCI. 6 501-523 (1997).
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| Documentation | Proteolytic enzymes that exploit serinein their catalytic activity are
ubiquitous, being found in viruses, bacteria and eukaryotes [1]. They
include a wide range of peptidase activity, including exopeptidase, endo-
peptidase, oligopeptidase and omega-peptidase activity. Over 20 families
(denoted S1 - S27) of serine protease have been identified, these being
grouped into 6 clans (SA, SB, SC, SE, SF and SG) on the basis of structural
similarity and other functional evidence [1]. Structures are known for four
of the clans (SA, SB, SC and SE): these appear to be totally unrelated,
suggesting at least four evolutionary origins of serine peptidases and
possibly many more [1].
Notwithstanding their different evolutionary origins, there are similarities
in the reaction mechanisms of several peptidases. Chymotrypsin, subtilisin
and carboxypeptidase C clans have a catalytic triad of serine, aspartate and
histidine in common: serine acts as a nucleophile, aspartate as an
electrophile, and histidine as a base [1]. The geometric orientations of
the catalytic residues are similar between families, despite different
protein folds [1]. The linear arrangements of the catalytic residues
commonly reflect clan relationships. For example the catalytic triad in
the chymotrypsin clan (SA) is ordered HDS, but is ordered DHS in the
subtilisin clan (SB) and SDH in the carboxypeptidase clan (SC) [1,2].
The subtilisin family (S8) is the second largest serine protease family
characterised to date. It is widespread, being found in eubacteria,
archaebacteria, eukaryotes and viruses [1]. The vast majority of the
family are endopeptidases, although there is an exopeptidase, tri-
peptidyl peptidase [1,2]. Structures have been determined for several
members of the subtilisin family: they exploit the same catalytic triad as
the chymotrypsins, although the residues occur in a different order (HDS in
chymotrypsin and DHS in subtilisin), but the structures show no other
similarity [1,2]. Some subtilisins are mosaic proteins, and others
contain N- and C-terminal extensions that show no sequence similarity to
any other known protein [1].
The proprotein-processing endopeptidases kexin, furin and related enzymes
form a distinct subfamily known as the kexin subfamily. These preferentially
cleave C-terminally to paired basic amino acids. Members of this subfamily
can be identified by subtly different motifs around the active site [1,2].
Members of the kexin family, along with endopeptidases R, T and K from the
yeast Tritirachium and cuticle-degrading peptidase from Metarhizium, require
thiol activation. This can be attributed to the presence of Cys-173 near to
the active histidine [2].
Only 1 viral member of the subtilisin family is known, a 56kDa protease
from herpes virus 1, which infects the channel catfish [1]. The virus
possesses a unique open reading frame insert, within which the protease
is found [1]; this has almost certainly been `captured' from another host.
SUBTILISIN is a 3-element fingerprint that provides a signature for the
subtilisin-like family of serine proteases. The fingerprint was derived
from an initial alignment of 18 sequences: the motifs were drawn from
conserved regions surrounding the active site - motif 1 includes the
region encoded by PROSITE pattern SUBTILASE_ASP (PS00136), which contains
the active Asp; motif 2 spans the region encoded by PROSITE pattern
SUBTILASE_HIS (PS00137), which contains the active His; and motif 3
includes the region encoded by PROSITE pattern SUBTILASE_SER (PS00138),
which contains the active Ser. Two iterations on OWL28.2 were required to
reach convergence, at which point a true set comprising 201 sequences was
identified. Three partial matches were also found: NRL_2SBT2 is a fragment
that lacks the first motif; ASPA_AERSA is a subtilase-like protease from
Aeromonas salmonicida that fails to make a significant match with motif 2,
although the catalytic histidine is present; and PRCA_ANAVA is calcium-
dependent protease from Anabaena variabilis that matches poorly with motif 3
and lacks the catalytic serine.
An update on SPTR37_9f identified a true set of 235 sequences, and 5
partial matches.
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| Sequence Titles | AEP_YARLI ALKALINE EXTRACELLULAR PROTEASE PRECURSOR (EC 3.4.21.-) (AEP) - YARROWIA LIPOLYTICA (CANDIDA LIPOLYTICA).
ALP_CEPAC ALKALINE PROTEINASE PRECURSOR (EC 3.4.21.-) (ALP) - CEPHALOSPORIUM ACREMONIUM (ACREMONIUM CHRYSOGENUM).
ALP_TRIHA ALKALINE PROTEINASE PRECURSOR (EC 3.4.21.-) (ALP) - TRICHODERMA HARZIANUM.
AQL1_THEAQ AQUALYSIN I PRECURSOR (EC 3.4.21.-) - THERMUS AQUATICUS.
BLI4_CAEEL ENDOPROTEASE BLI-4 PRECURSOR (EC 3.4.21.-) (BLISTERASES A, B, C AND D) - CAENORHABDITIS ELEGANS.
BPRV_BACNO EXTRACELLULAR BASIC PROTEASE PRECURSOR (EC 3.4.21.-) - BACTEROIDES NODOSUS (DICHELOBACTER NODOSUS).
BPRX_BACNO EXTRACELLULAR SUBTILISIN-LIKE PROTEASE PRECURSOR (EC 3.4.21.-) - BACTEROIDES NODOSUS (DICHELOBACTER NODOSUS).
CUDP_METAN CUTICLE-DEGRADING PROTEASE PRECURSOR (EC 3.4.21.-) (PR1) (CHYMOELASTASE) - METARHIZIUM ANISOPLIAE.
ELY1_BACSP ALKALINE PROTEASE PRECURSOR (EC 3.4.21.-) - BACILLUS SP. (STRAIN 221).
ELY2_BACSP THERMOSTABLE ALKALINE PROTEASE PRECURSOR (EC 3.4.21.-) - BACILLUS SP. (STRAIN AH-101).
ELYA_BACAO ALKALINE PROTEASE PRECURSOR (EC 3.4.21.-) - BACILLUS ALCALOPHILUS.
ELYA_BACSP ALKALINE ELASTASE YAB PRECURSOR (EC 3.4.21.-) - BACILLUS SP. (STRAIN YAB).
EPIP_STAEP Epidermin leader peptide processing serine protease EPIP precursor (EC 3.4.21.-) - Staphylococcus epidermidis.
FUR1_XENLA FURIN 1 PRECURSOR (EC 3.4.21.75) (PAIRED BASIC AMINO ACID RESIDUE CLEAVING ENZYME) (PACE) (DIBASIC PROCESSING ENZYME) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
FUR2_DROME FURIN-LIKE PROTEASE 2 PRECURSOR (EC 3.4.21.75) (FURIN 2) - DROSOPHILA MELANOGASTER (FRUIT FLY).
FURI_BOVIN FURIN PRECURSOR (EC 3.4.21.75) (PAIRED BASIC AMINO ACID RESIDUE CLEAVING ENZYME) (PACE) (DIBASIC PROCESSING ENZYME) (TRANS GOLGI NETWORK PROTEASE FURIN) - BOS TAURUS (BOVINE).
FURI_HUMAN FURIN PRECURSOR (EC 3.4.21.75) (PAIRED BASIC AMINO ACID RESIDUE CLEAVING ENZYME) (PACE) (DIBASIC PROCESSING ENZYME) - HOMO SAPIENS (HUMAN).
FURI_MOUSE FURIN PRECURSOR (EC 3.4.21.75) (PAIRED BASIC AMINO ACID RESIDUE CLEAVING ENZYME) (PACE) (DIBASIC PROCESSING ENZYME) - MUS MUSCULUS (MOUSE).
FURI_RAT FURIN PRECURSOR (EC 3.4.21.75) (PAIRED BASIC AMINO ACID RESIDUE CLEAVING ENZYME) (PACE) (DIBASIC PROCESSING ENZYME) - RATTUS NORVEGICUS (RAT).
FURL_DROME FURIN-LIKE PROTEASE 1, LONG-FORM PRECURSOR (EC 3.4.21.75) (FURIN 1) (KEX2-LIKE ENDOPROTEASE 1) (DKLIP-1) (FURIN1-CRR) - DROSOPHILA MELANOGASTER (FRUIT FLY).
FURS_DROME FURIN-LIKE PROTEASE 1, SHORT-FORM PRECURSOR (EC 3.4.21.75) (FURIN 1) (KEX2-LIKE ENDOPROTEASE 1) (DKLIP-1) - DROSOPHILA MELANOGASTER (FRUIT FLY).
HLY_HAL17 HALOLYSIN PRECURSOR (EC 3.4.21.-) - HALOPHILIC BACTERIA STRAIN 172P1.
ISP1_BACSU MAJOR INTRACELLULAR SERINE PROTEASE (EC 3.4.21.-) (ISP-1) - BACILLUS SUBTILIS.
ISP6_SCHPO SEXUAL DIFFERENTIATION PROCESS PUTATIVE SUBTILASE-TYPE PROTEINASE ISP6 (EC 3.4.21.-) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
ISP_BACSP INTRACELLULAR ALKALINE PROTEASE (EC 3.4.21.-) - BACILLUS SP. (STRAIN 221).
ISP_PAEPO INTRACELLULAR SERINE PROTEASE (EC 3.4.21.-) - PAENIBACILLUS POLYMYXA (BACILLUS POLYMYXA).
KEX1_KLULA KEX1 PROTEASE PRECURSOR (EC 3.4.21.-) - KLUYVEROMYCES LACTIS (YEAST).
KEX2_CANAL KEXIN PRECURSOR (EC 3.4.21.61) (KEX2 PROTEASE) - CANDIDA ALBICANS (YEAST).
KEX2_YEAST KEXIN PRECURSOR (EC 3.4.21.61) (KEX2 PROTEASE) (PROTEINASE YSCF) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
KRP1_SCHPO DIBASIC PROCESSING ENDOPROTEASE PRECURSOR (EC 3.4.21.-) (KEX2-RELATED PROTEASE) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
NEC1_HUMAN NEUROENDOCRINE CONVERTASE 1 PRECURSOR (EC 3.4.21.93) (NEC 1) (PC1) (PROHORMONE CONVERTASE 1) (PROPROTEIN CONVERTASE 1) - HOMO SAPIENS (HUMAN).
NEC1_MOUSE NEUROENDOCRINE CONVERTASE 1 PRECURSOR (EC 3.4.21.93) (NEC 1) (PC1) (PROHORMONE CONVERTASE 1) (PROPROTEIN CONVERTASE 1) (PC3) (FURIN HOMOLOG) (PROPEPTIDE PROCESSING PROTEASE) - MUS MUSCULUS (MOUSE), AND MUS COOKII.
NEC1_RAT NEUROENDOCRINE CONVERTASE 1 PRECURSOR (EC 3.4.21.93) (NEC 1) (PC1) (PROHORMONE CONVERTASE 1) (PROPROTEIN CONVERTASE 1) - RATTUS NORVEGICUS (RAT).
NEC2_HUMAN NEUROENDOCRINE CONVERTASE 2 PRECURSOR (EC 3.4.21.94) (NEC 2) (PC2) (PROHORMONE CONVERTASE 2) (PROPROTEIN CONVERTASE 2) (KEX2-LIKE ENDOPROTEASE 2) - HOMO SAPIENS (HUMAN).
NEC2_MOUSE NEUROENDOCRINE CONVERTASE 2 PRECURSOR (EC 3.4.21.94) (NEC 2) (PC2) (PROHORMONE CONVERTASE 2) (PROPROTEIN CONVERTASE 2) (KEX2-LIKE ENDOPROTEASE 2) - MUS MUSCULUS (MOUSE).
NEC2_PIG NEUROENDOCRINE CONVERTASE 2 PRECURSOR (EC 3.4.21.94) (NEC 2) (PC2) (PROHORMONE CONVERTASE 2) (PROPROTEIN CONVERTASE 2) (KEX2-LIKE ENDOPROTEASE 2) - SUS SCROFA (PIG).
NEC2_RAT NEUROENDOCRINE CONVERTASE 2 PRECURSOR (EC 3.4.21.94) (NEC 2) (PC2) (PROHORMONE CONVERTASE 2) (PROPROTEIN CONVERTASE 2) (KEX2-LIKE ENDOPROTEASE 2) - RATTUS NORVEGICUS (RAT).
NEC3_MOUSE NEUROENDOCRINE CONVERTASE 3 PRECURSOR (EC 3.4.21.61) (NEC 3) (PC4) (PROHORMONE CONVERTASE 3) (KEX2-LIKE ENDOPROTEASE 3) - MUS MUSCULUS (MOUSE).
NECA_HYDAT PC3-LIKE ENDOPROTEASE VARIANT A PRECURSOR (EC 3.4.21.-) (SPC3) - HYDRA ATTENUATA (HYDRA) (HYDRA VULGARIS).
NECB_HYDAT PC3-LIKE ENDOPROTEASE VARIANT B PRECURSOR (EC 3.4.21.-) (SPC3) - HYDRA ATTENUATA (HYDRA) (HYDRA VULGARIS).
NISP_LACLA Nisin leader peptide processing serine protease NISP precursor (EC 3.4.21.-) - Lactococcus lactis (subsp. lactis) (Streptococcus lactis).
O04190 PUTATIVE CUCUMISIN SERINE PROTEASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O04678 SUBTILISIN-LIKE PROTEASE - LYCOPERSICON ESCULENTUM (TOMATO).
O05458 HYPOTHETICAL 55.6 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O05461 HYPOTHETICAL 45.1 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O06316 HYPOTHETICAL 46.0 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O07613 SUBTILISIN E PRECURSOR - BACILLUS SUBTILIS.
O13304 PROTEASE 1 - PNEUMOCYSTIS CARINII F. SP. CARINII.
O13305 PROTEASE 1 - PNEUMOCYSTIS CARINII F. SP. CARINII.
O13464 PROTEASE - EPICHLOE TYPHINA.
O17797 F11A6.1A PROTEIN - CAENORHABDITIS ELEGANS.
O17798 F11A6.1B PROTEIN - CAENORHABDITIS ELEGANS.
O31788 ALKALINE SERINE PROTEASE - BACILLUS SUBTILIS.
O33076 HYPOTHETICAL 45.7 KD PROTEIN - MYCOBACTERIUM LEPRAE.
O42797 SUBTILISIN-LIKE SERINE PROTEASE - PODOSPORA ANSERINA.
O44762 ALTERNATIVELY SPLICE FORM OF C. ELEGANS BLI-4 (PID: G459701) - CAENORHABDITIS ELEGANS.
O44763 ALTERNATIVELY SPLICED FORM OF C. ELEGANS BLI-4 (PID: G459701) - CAENORHABDITIS ELEGANS.
O44764 ALTERNATIVELY SPLICED FORM OF C. ELEGANS BLI-4 (PID: G459701) - CAENORHABDITIS ELEGANS.
O44765 ALTERNATIVELY SPLICED FORM OF C. ELEGANS BLI-4 (PID: G459701) - CAENORHABDITIS ELEGANS.
O44766 ALTERNATIVELY SPLICED FORM OF C. ELEGANS BLI-4 (PID: G459701) - CAENORHABDITIS ELEGANS.
O48798 F24O1.6 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O49607 SUBTILISIN PROTEINASE - LIKE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O52767 EXTRACELLULAR ALKALINE SERINE PROTEASE - SHEWANELLA SP. AC10.
O53695 PUTATIVE PROTEASE - MYCOBACTERIUM TUBERCULOSIS.
O53945 HYPOTHETICAL 60.0 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O54327 TOXIN DEGRADING PROTEASE - BACILLUS SPHAERICUS.
O61142 SUBTILISIN-LIKE PROTEASE PRECURSOR (PFSUB-1) - PLASMODIUM FALCIPARUM.
O64481 PUTATIVE SERINE PROTEINASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O64495 F20D22.12 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O65351 CUCUMISIN-LIKE SERINE PROTEASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O65834 P69C PROTEIN - LYCOPERSICON ESCULENTUM (TOMATO).
O65835 P69E PROTEIN - LYCOPERSICON ESCULENTUM (TOMATO).
O65836 P69F PROTEIN - LYCOPERSICON ESCULENTUM (TOMATO).
O66153 APRN - BACILLUS SP.
O67764 SERINE PROTEASE - AQUIFEX AEOLICUS.
O74236 SERINE PROTEASE PRECURSOR - FUSARIUM OXYSPORUM F. SP. LYCOPERSICI.
O76251 TRIPEPTIDYL PEPTIDASE II - DROSOPHILA MELANOGASTER (FRUIT FLY).
O81324 F6N15.3 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O81899 HYPOTHETICAL 189.0 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O82006 SUBTILISIN-LIKE PROTEASE - LYCOPERSICON ESCULENTUM (TOMATO).
O82007 SERINE PROTEASE - LYCOPERSICON ESCULENTUM (TOMATO).
O82777 SUBTILISIN-LIKE PROTEASE - LYCOPERSICON ESCULENTUM (TOMATO).
O86642 SERINE PROTEASE - STREPTOMYCES COELICOLOR.
O86650 PUTATIVE SECRETED SERINE PROTEASE - STREPTOMYCES COELICOLOR.
O87655 SUBTILISIN - BACILLUS SUBTILIS.
O87811 SERINE PROTEASE - PSEUDOMONAS TOLAASII.
O88064 PUTATIVE SECRETED SERINE PROTEASE - STREPTOMYCES COELICOLOR.
O93577 PROPROTEIN CONVERTASE PC2 PRECURSOR - RANA RIDIBUNDA (LAUGHING FROG) (MARSH FROG).
O93583 PROHORMONE CONVERTASE 1 PRECURSOR - RANA RIDIBUNDA (LAUGHING FROG) (MARSH FROG).
ORYZ_ASPFL ORYZIN PRECURSOR (EC 3.4.21.63) (ALKALINE PROTEINASE) (ALP) (ELASTASE) (ELASTINOLYTIC SERINE PROTEINASE) - ASPERGILLUS FLAVUS.
ORYZ_ASPFU ORYZIN PRECURSOR (EC 3.4.21.63) (ALKALINE PROTEINASE) (ALP) (ELASTASE) (ELASTINOLYTIC SERINE PROTEINASE) - ASPERGILLUS FUMIGATUS (SARTORYA FUMIGATA).
ORYZ_ASPOR ORYZIN PRECURSOR (EC 3.4.21.63) (ALKALINE PROTEINASE) (ALP) (ASPERGILLUS PROTEINASE B) (ASPERGILLOPEPTIDASE B) - ASPERGILLUS ORYZAE.
P1P_LACLC PI-TYPE PROTEINASE PRECURSOR (EC 3.4.21.-) (WALL-ASSOCIATED SERINE PROTEINASE) - LACTOCOCCUS LACTIS (SUBSP. CREMORIS) (STREPTOCOCCUS CREMORIS).
P2P_LACLA PII-TYPE PROTEINASE PRECURSOR (EC 3.4.21.96) (LACTOCEPIN) (CELL WALL- ASSOCIATED SERINE PROTEINASE) (LP151) - LACTOCOCCUS LACTIS (SUBSP. LACTIS) (STREPTOCOCCUS LACTIS).
P2P_LACPA PII-TYPE PROTEINASE PRECURSOR (EC 3.4.21.96) (LACTOCEPIN) (CELL WALL- ASSOCIATED SERINE PROTEINASE) (LP151) - LACTOBACILLUS PARACASEI.
P3P_LACLC PIII-TYPE PROTEINASE PRECURSOR (EC 3.4.21.96) (LACTOCEPIN) (CELL WALL- ASSOCIATED SERINE PROTEINASE) - LACTOCOCCUS LACTIS (SUBSP. CREMORIS) (STREPTOCOCCUS CREMORIS).
P70765 SERINE PROTEASE PRECURSOR - ALTEROMONAS SP.
P71402 SERINE PROTEASE HALOLYSIN R4 - HALOBACTERIUM MEDITERRANEI (HALOFERAX MEDITERRANEI).
P72186 PYROLYSIN - PYROCOCCUS FURIOSUS.
P74937 INTRACELLULAR ALKALINE PROTEASE - THERMOACTINOMYCES SP.
P87184 INTRACELLULAR VACUOLAR SERINE PROTEINASE PRECURSOR - ASPERGILLUS FUMIGATUS (SARTORYA FUMIGATA).
P87203 SERINE PROTEINASE PRECURSOR - AGARICUS BISPORUS (COMMON MUSHROOM).
P91863 F32A7.6 PROTEIN - CAENORHABDITIS ELEGANS.
P93204 SERINE PROTEASE, SBT1 - LYCOPERSICON ESCULENTUM (TOMATO).
P93205 SERINE PROTEASE, SBT2 - LYCOPERSICON ESCULENTUM (TOMATO).
P93221 PROTEINASE TMP - LYCOPERSICON ESCULENTUM (TOMATO).
P95684 SUBTILISIN-LIKE PROTEASE - STREPTOMYCES ALBOGRISEOLUS.
P96091 SERINE PROTEASE (DENTILISIN) FROM TREPONEMA DENTICOLA PRECURSOR (DENTILISIN) - TREPONEMA DENTICOLA.
P97097 PROTEASE - BACILLUS SP.
PAC4_HUMAN SUBTILISIN-LIKE PROTEASE PACE4 PRECURSOR (EC 3.4.21.-) - HOMO SAPIENS (HUMAN).
PAC4_RAT SUBTILISIN-LIKE PROTEASE PACE4 PRECURSOR (EC 3.4.21.-) - RATTUS NORVEGICUS (RAT).
PAC6_MOUSE SERINE PROTEASE PC6 PRECURSOR (EC 3.4.21.-) (SUBTILISIN/KEXIN-LIKE PROTEASE PC5) (CONVERTASE PC5) - MUS MUSCULUS (MOUSE).
PAC6_RAT SERINE PROTEASE PC6 PRECURSOR (EC 3.4.21.-) (SUBTILISIN/KEXIN-LIKE PROTEASE PC5) (CONVERTASE PC5) - RATTUS NORVEGICUS (RAT).
PEPC_ASPNG SUBTILISIN-LIKE SERINE PROTEASE PEPC PRECURSOR (EC 3.4.21.-) - ASPERGILLUS NIGER.
PROA_VIBAL ALKALINE SERINE EXOPROTEASE A PRECURSOR (EC 3.4.21.-) - VIBRIO ALGINOLYTICUS.
PROA_XANCP EXTRACELLULAR PROTEASE PRECURSOR (EC 3.4.21.-) - XANTHOMONAS CAMPESTRIS (PV. CAMPESTRIS).
PRTB_YEAST CEREVISIN PRECURSOR (EC 3.4.21.48) (VACUOLAR PROTEASE B) (PROTEINASE YSCB) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
PRTK_TRIAL PROTEINASE K PRECURSOR (EC 3.4.21.64) (TRITIRACHIUM ALKALINE PROTEINASE) (ENDOPEPTIDASE K) - TRITIRACHIUM ALBUM.
PRTM_BACSP M-PROTEASE (EC 3.4.21.-) - BACILLUS SP. (STRAIN KSM-K16).
PRTR_TRIAL PROTEINASE R PRECURSOR (EC 3.4.21.-) - TRITIRACHIUM ALBUM.
PRTS_SERMA EXTRACELLULAR SERINE PROTEASE PRECURSOR (EC 3.4.21.-) - SERRATIA MARCESCENS.
PRTT_SERMA EXTRACELLULAR SERINE PROTEASE PRECURSOR (EC 3.4.21.-) - SERRATIA MARCESCENS.
Q00206 SUBTILISIN-LIKE PROTEASE (EC 3.4.21.14) - ASPERGILLUS NIGER.
Q00208 ALKALINE PROTEASE - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).
Q00226 CUTICLE-DEGRADING SERINE PROTEASE PRECURSOR - ARTHROBOTRYS OLIGOSPORA.
Q00296 SUBTILISIN-LIKE PROTEASE PRECURSOR - BEAUVERIA BASSIANA (TRITIRACHIUM SHIOTAE).
Q01707 NEUROENDOCRINE CONVERTASE 2 PRECURSOR (EC 3.4.21.61) (NEC 2) (PC2) (PROHORMONE CONVERTASE 2) (KEX2-LIKE ENDOPROTEASE 2) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q05817 FURIN 1, ISOFORM DFURIN1-X PRECURSOR (EC 3.4.21.61) (FURIN 1-X) (KEX2-LIKE ENDOPROTEASE 1-X) - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q07213 NEUROENDOCRINE CONVERTASE 3-A PRECURSOR (EC 3.4.21.61) (NEC 3-A) (PC4-A) (PROHORMONE CONVERTASE 3-A) (KEX2-LIKE ENDOPROTEASE 3-A) - RATTUS NORVEGICUS (RAT).
Q07214 NEUROENDOCRINE CONVERTASE 3-B PRECURSOR (EC 3.4.21.61) (NEC 3-B) (PC4-B) (PROHORMONE CONVERTASE 3-B) (KEX2-LIKE ENDOPROTEASE 3-B) - RATTUS NORVEGICUS (RAT).
Q08845 NEUROENDOCRINE CONVERTASE 2 PRECURSOR (EC 3.4.21.61) (NEC 2) (PC2) (PROHORMONE CONVERTASE 2) (KEX2-LIKE ENDOPROTEASE 2) - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE).
Q10575 NEUROENDOCRINE CONVERTASE 2 PRECURSOR (EC 3.4.21.94) (NEC2) (PC2) (PROHORMONE CONVERTASE 2) (KEX2-LIKE ENDOPROTEASE 2) - CAENORHABDITIS ELEGANS.
Q14703 KIAA0091 PROTEIN - HOMO SAPIENS (HUMAN).
Q14927 NEUROENDOCRINE CONVERTASE 2 - HOMO SAPIENS (HUMAN).
Q15099 PACE4C - HOMO SAPIENS (HUMAN).
Q15100 PACE4D - HOMO SAPIENS (HUMAN).
Q16549 PC8 PRECURSOR - HOMO SAPIENS (HUMAN).
Q16926 VITELLOGENIN CONVERTASE - AEDES AEGYPTI (YELLOWFEVER MOSQUITO).
Q16944 PROHORMONE CONVERTASE 1 - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE).
Q16962 FURIN-LIKE PROHORMONE CONVERTASE - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE).
Q16966 FUR - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE).
Q16970 PC1A - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE).
Q16971 PC1B - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE).
Q16972 PREPRO-HORMONE CONVERTASE 2 PRECURSOR - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE).
Q16973 PC2 - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE).
Q17123 SPC2 - BRANCHIOSTOMA CALIFORNIENSIS (CALIFORNIA LANCELET) (AMPHIOXUS).
Q17124 SPC3 - BRANCHIOSTOMA CALIFORNIENSIS (CALIFORNIA LANCELET) (AMPHIOXUS).
Q17325 CELFURPC PROTEIN - CAENORHABDITIS ELEGANS.
Q24301 DFURIN2 - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q25409 STAGNALIS LPC2 - LYMNAEA STAGNALIS (GREAT POND SNAIL).
Q26352 LFUR2 - LYMNAEA STAGNALIS (GREAT POND SNAIL).
Q26489 ENDOPROTEASE FURIN - SPODOPTERA FRUGIPERDA (FALL ARMYWORM).
Q27235 DFURIN1-CRR - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q27436 FURIN1 - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q28959 PROHORMONE CONVERTASE PRECURSOR - SUS SCROFA (PIG).
Q38708 SUBTILISIN-LIKE PROTEASE - ALNUS GLUTINOSA (ALDER).
Q39547 PREPRO-CUCUMISIN PRECURSOR - CUCUMIS MELO (MUSKMELON).
Q40764 ANTIFREEZE-LIKE PROTEIN (AF70) - PICEA ABIES (NORWAY SPRUCE) (PICEA EXCELSA).
Q44684 PRECURSOR SUBTILISIN - BACILLUS AMYLOLIQUEFACIENS.
Q45299 SUBSTILISIN CARLSBERG PRECURSOR - BACILLUS LICHENIFORMIS.
Q45300 SUBSTILISIN CARLSBERG PRECURSOR - BACILLUS LICHENIFORMIS.
Q45301 SUBSTILISIN CARLSBERG PRECURSOR - BACILLUS LICHENIFORMIS.
Q45464 SPRB - BACILLUS SP.
Q45466 SPRC - BACILLUS SP.
Q45467 SPRD - BACILLUS SP.
Q45510 PARA - BACILLUS SUBTILIS.
Q45521 PREPRO APRM PRECURSOR - BACILLUS SP.
Q45522 PREPRO-SUBTILISIN SENDAI PRECURSOR - BACILLUS SP.
Q45523 PREPRO-SUBTILISIN ALP I PRECURSOR - BACILLUS SP.
Q45616 90K-PROTEASE (BACILLOPEPTIDASE F) PRECURSOR (BACILLOPEPTIDASE F) - BACILLUS SUBTILIS.
Q45621 A INTRACELLULAR SERINE PROTEASE - BACILLUS SP.
Q45669 ALKALINE SERINE PROTEINASE - BACILLUS SMITHII.
Q45670 SERINE PROTEINASE - BACILLUS SP.
Q45681 MICROBIAL SERINE PROTEINASES (EC 3.4.21.14) - BACILLUS SUBTILIS.
Q46540 V2 PROTEASE PRECURSOR - BACTEROIDES NODOSUS (DICHELOBACTER NODOSUS).
Q46541 ACIDIC PROTEASE V5 - BACTEROIDES NODOSUS (DICHELOBACTER NODOSUS).
Q46547 SERINE PROTEASE PRECURSOR - BACTEROIDES NODOSUS (DICHELOBACTER NODOSUS).
Q48545 PROTEINASE (PRTB) PRECURSOR (PRTB) - LACTOBACILLUS DELBRUECKII.
Q48674 NISP (NISP PROTEIN) - Lactococcus lactis.
Q51846 SEROTYPE-1-SPECIFIC ANTIGEN - PASTEURELLA HAEMOLYTICA.
Q52055 CLYA PROTEIN - Enterococcus faecalis (Streptococcus faecalis).
Q52407 ALKALINE SERINE PROTEASE PRECURSOR - PSEUDOMONAS SP.
Q53294 THERMOSTABLE ALKALINE SERINE PROTEASE - BACILLUS SP. AH-101.
Q53401 ALKALINE SERINE PROTEASE II - ALTEROMONAS SP.
Q53521 KERATINASE - BACILLUS LICHENIFORMIS.
Q53637 SCPB - STREPTOCOCCUS AGALACTIAE.
Q53863 SERINE PROTEASE - STREPTOMYCES COELICOLOR.
Q54400 SUBTILISIN-LIKE PROTEASE PRECURSOR - STREPTOMYCES LIVIDANS.
Q54437 STABLE PROTEASE PRECURSOR - STAPHYLOTHERMUS MARINUS.
Q54483 SSP-H1 - SERRATIA MARCESCENS.
Q54484 SSP-H2 - SERRATIA MARCESCENS.
Q55477 SERINE PROTEINASE - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
Q56365 THERMOSTABLE ALKALINE PROTEASE - THERMOACTINOMYCES SP.
Q56700 ALKALINE SERINE PROTEASE (VAPT) (EC 3.4.21.14) - VIBRIO METSCHNIKOVII.
Q60424 TRUNCATED FURIN ENDOPROTEASE - CRICETULUS GRISEUS (CHINESE HAMSTER).
Q60425 TRUNCATED FURIN ENDOPROTEASE - CRICETULUS GRISEUS (CHINESE HAMSTER).
Q60426 FURIN ENDOPROTEASE - CRICETULUS GRISEUS (CHINESE HAMSTER).
Q61139 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7 PRECURSOR (SUBTILISIN-LIKE PROTEASE SPC7) (EC 3.4.21.-) (SERINE PROTEASE SPC7) (CONVERTASE SPC7) - MUS MUSCULUS (MOUSE).
Q62094 PROPROTEIN CONVERTASE 4 - MUS MUSCULUS (MOUSE).
Q62849 SERINE PROTEASE PC7 PRECURSOR (EC 3.4.21.-) (SUBTILISIN/KEXIN-LIKE PROTEASE PC7) (CONVERTASE PC7) - RATTUS NORVEGICUS (RAT).
Q64560 TRIPEPTIDYLPEPTIDASE II (EC 3.4.14.10) (TRIPEPTIDYL-PEPTIDASE II) (TRIPEPTIDYL AMINOPEPTIDASE) (TRIPEPTIDYL PEPTIDASE) - RATTUS NORVEGICUS (RAT).
Q91000 TRANS GOLGI NETWORK PROTEASE FURIN - GALLUS GALLUS (CHICKEN).
Q91065 ENDOPEPTIDASE PC1 - LOPHIUS AMERICANUS (AMERICAN GOOSEFISH) (ANGLERFISH).
Q92532 PROHORMONE CONVERTASE 3 - HOMO SAPIENS (HUMAN).
Q92824 PC6A PROTEASE - HOMO SAPIENS (HUMAN).
Q94595 KEX2-LIKE PROTEASE - TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHOE CRAB).
Q94977 PC2-LIKE PROHORMONE CONVERTASE - LUCILIA CUPRINA (GREENBOTTLE FLY) (AUSTRALIAN SHEEP BLOWFLY).
Q96478 SUBTILISIN-LIKE ENDOPROTEASE - LYCOPERSICON ESCULENTUM (TOMATO).
SCPA_STRPY C5A PEPTIDASE PRECURSOR (EC 3.4.21.-) (SCP) - STREPTOCOCCUS PYOGENES.
SEPR_THESP EXTRACELLULAR SERINE PROTEINASE PRECURSOR (EC 3.4.21.-) - THERMUS SP. (STRAIN RT41A).
SSA1_PASHA SEROTYPE-SPECIFIC ANTIGEN 1 PRECURSOR (EC 3.4.21.-) - PASTEURELLA HAEMOLYTICA.
SUBB_BACLE SUBTILISIN BL (EC 3.4.21.62) (ALKALINE PROTEASE) - BACILLUS LENTUS.
SUBE_BACSU MINOR EXTRACELLULAR PROTEASE EPR PRECURSOR (EC 3.4.21.-) - BACILLUS SUBTILIS.
SUBF_BACSU BACILLOPEPTIDASE F PRECURSOR (EC 3.4.21.-) (ESTERASE) (RP-I PROTEASE) (90 KD SERINE PROTEINASE) - BACILLUS SUBTILIS.
SUBN_BACNA SUBTILISIN NAT PRECURSOR (EC 3.4.21.62) - BACILLUS SUBTILIS VAR. NATTO.
SUBS_BACLE SUBTILISIN SAVINASE (EC 3.4.21.62) (ALKALINE PROTEASE) - BACILLUS LENTUS.
SUBT_BACAM SUBTILISIN BPN' PRECURSOR (EC 3.4.21.62) (SUBTILISIN NOVO) (ALKALINE PROTEASE) - BACILLUS AMYLOLIQUEFACIENS.
SUBT_BACLI SUBTILISIN CARLSBERG PRECURSOR (EC 3.4.21.62) - BACILLUS LICHENIFORMIS.
SUBT_BACMS SUBTILISIN (EC 3.4.21.62) (ALKALINE MESENTERICOPEPTIDASE) - BACILLUS MESENTERICUS.
SUBT_BACS9 SUBTILISIN PRECURSOR (EC 3.4.21.62) - BACILLUS SP. (STRAIN TA39).
SUBT_BACSA SUBTILISIN AMYLOSACCHARITICUS PRECURSOR (EC 3.4.21.62) - BACILLUS SUBTILIS VAR. AMYLOSACCHARITICUS.
SUBT_BACSD SUBTILISIN (EC 3.4.21.62) - BACILLUS SUBTILIS (STRAIN DY).
SUBT_BACST SUBTILISIN J PRECURSOR (EC 3.4.21.62) - BACILLUS STEAROTHERMOPHILUS.
SUBT_BACSU SUBTILISIN E PRECURSOR (EC 3.4.21.62) - BACILLUS SUBTILIS.
SUBV_BACSU MINOR EXTRACELLULAR PROTEASE VPR PRECURSOR (EC 3.4.21.-) - BACILLUS SUBTILIS.
TAGB_DICDI PRESTALK-SPECIFIC PROTEIN TAGB PRECURSOR (EC 3.4.21.-) - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
TAGC_DICDI PRESTALK-SPECIFIC PROTEIN TAGC PRECURSOR (EC 3.4.21.-) - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
THET_THEVU THERMITASE (EC 3.4.21.66) - THERMOACTINOMYCES VULGARIS.
TPP2_HUMAN TRIPEPTIDYL-PEPTIDASE II (EC 3.4.14.10) (TPP II) (TRIPEPTIDYL AMINOPEPTIDASE) - HOMO SAPIENS (HUMAN).
TPP2_MOUSE TRIPEPTIDYL-PEPTIDASE II (EC 3.4.14.10) (TPP II) (TRIPEPTIDYL AMINOPEPTIDASE) - MUS MUSCULUS (MOUSE).
WPRA_BACSU CELL WALL-ASSOCIATED PROTEASE PRECURSOR (EC 3.4.21.-) [CONTAINS: CELL WALL-ASSOCIATED POLYPEPTIDES CWBP23 AND CWBP52] - BACILLUS SUBTILIS.
XPR6_YARLI DIBASIC PROCESSING ENDOPROTEASE PRECURSOR (EC 3.4.21.-) - YARROWIA LIPOLYTICA (CANDIDA LIPOLYTICA).
YCT5_YEAST HYPOTHETICAL SUBTILASE-TYPE PROTEINASE IN TSM1-ARE1 INTERGENIC REGION PRECURSOR (EC 3.4.21.-) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
YQS6_CAEEL HYPOTHETICAL SUBTILASE-TYPE PROTEINASE F21H12.6 IN CHROMOSOME II (EC 3.4.21.-) - CAENORHABDITIS ELEGANS.
YSP3_YEAST SUBTILISIN-LIKE PROTEASE III PRECURSOR (EC 3.4.24.-) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
ASPA_AERSA MICROBIAL SERINE PROTEINASE PRECURSOR (EC 3.4.21.-) - AEROMONAS SALMONICIDA.
O23358 CUCUMISIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O28620 ALKALINE SERINE PROTEASE (APRM) - ARCHAEOGLOBUS FULGIDUS.
PRCA_ANAVA CALCIUM DEPENDENT PROTEASE PRECURSOR (EC 3.4.21.-) - ANABAENA VARIABILIS.
Q18772 C51E3.7B PROTEIN - CAENORHABDITIS ELEGANS.
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