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PR00672

Identifier
INHIBINBC  [View Relations]  [View Alignment]  
Accession
PR00672
No. of Motifs
7
Creation Date
07-MAR-1997  (UPDATE 10-JUN-1999)
Title
Inhibin beta C chain signature
Database References

PROSITE; PS00250 TGF_BETA
INTERPRO; IPR001318
Literature References
1. MAYO, K.E., CERELLI, G.M., SPIESS, J., RIVIER, J., ROSENFELD, M.G.,
EVANS, R.M. AND VALE, W.
Inhibin A-subunit cDNAs from porcine ovary and human placenta.
PROC.NATL.ACAD.SCI.U.S.A. 83(16) 5849-5853 (1986).
 
2. THOMPSON, D.A., CRONIN, C.N. AND MARTIN, F.
Genomic cloning and sequence analyses of the bovine alpha-, beta A- and
beta B-inhibin/activin genes. Identification of transcription factor AP-2-
binding sites in the 5'-flanking regions by DNAse I footprinting.  
EUR.J.BIOCHEMISTRY 226(3) 751-764 (1994).
 
3. MASON, A.J., HAYFLICK, J.S., LING, N., ESCH, F., UENO, N., YING, S.Y.,
GUILLEMIN, R., NIALL, H. AND SEEBURG, P.H.
Complementary DNA sequences of ovarian follicular fluid inhibin show
precursor structure and homology with transforming growth factor-beta.
NATURE 318 659-663 (1985).

Documentation
Inhibins and activins are dimeric peptide hormones that regulate circulating
levels of follicle-stimulating hormone (FSH) [1,2]. In turn, FSH stimulates
inhibin gene expression in the ovarian follicle [2]; this effect is
probably mediated by cAMP [3]. Inhibin is a heterodimer, linked by one or
more disulphide bonds: inhibin A is a dimer of alpha and beta-A chains;
inhibin B is a dimer of alpha and beta-B; activin A is a dimer of beta-A;
and activin AB is a dimer of beta-A and beta-B. Inhibins belong to a gene
family that also includes transforming growth factor-beta (TGF-beta) [3].
 
INHIBINBC is a 7-element fingerprint that provides a signature for 
inhibin beta-C chains. The fingerprint was derived from an initial
alignment of 2 sequences: the motifs were drawn from conserved regions
spanning the N-terminal half of the alignment. A single iteration on
OWL29.1 was required to reach convergence, no further sequences being
identified beyond the starting set. Two partial matches were found, both
of which are fragments: JC415 is an activin beta-D chain and IHBB_RAT is
an inhibin beta-B chain.
 
An update on SPTR37_9f identified a true set of 2 sequences, and 3
partial matches.
Summary Information
   2 codes involving  7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
2 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
72222222
60000000
50000000
40000000
30122100
20011000
1234567
True Positives
IHBC_HUMAN    IHBC_MOUSE    
True Positive Partials
Codes involving 3 elements
O08717 Q91696
Codes involving 2 elements
O88959
Sequence Titles
IHBC_HUMAN  INHIBIN BETA C CHAIN PRECURSOR (ACTIVIN BETA-C CHAIN) - HOMO SAPIENS (HUMAN). 
IHBC_MOUSE INHIBIN BETA C CHAIN PRECURSOR (ACTIVIN BETA-C CHAIN) - MUS MUSCULUS (MOUSE).

O08717 INHIBIN BETA E CHAIN PRECURSOR (ACTIVIN BETA-E CHAIN) - MUS MUSCULUS (MOUSE).
Q91696 ACTIVIN D PRECURSOR - XENOPUS LAEVIS (AFRICAN CLAWED FROG).

O88959 INHIBIN BETA E CHAIN PRECURSOR (ACTIVIN BETA-E CHAIN) - RATTUS NORVEGICUS (RAT).
Scan History
OWL29_1    1  100  NSINGLE    
SPTR37_9f 2 67 NSINGLE
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
SSLLLAFLLLAPTTVATPR IHBC_HUMAN 3 3 -
SSLLLALLFLTPTTVVNPK IHBC_MOUSE 3 3 -

Motif 2 width=18
Element Seqn Id St Int Rpt
GQCPACGGPTLELESQRE IHBC_HUMAN 24 2 -
GPCPACWGAIFDLESQRE IHBC_MOUSE 24 2 -

Motif 3 width=20
Element Seqn Id St Int Rpt
LLLDLAKRSILDKLHLTQRP IHBC_HUMAN 42 0 -
LLLDLAKKSILDKLHLSQRP IHBC_MOUSE 42 0 -

Motif 4 width=17
Element Seqn Id St Int Rpt
RPVSRAALRTALQHLHG IHBC_HUMAN 65 3 -
RPVSRGALKTALQRLRG IHBC_MOUSE 65 3 -

Motif 5 width=23
Element Seqn Id St Int Rpt
EIISFAETGLSTINQTRLDFHFS IHBC_HUMAN 97 15 -
EIISFADTDLSSINQTRLEFHFS IHBC_MOUSE 98 16 -

Motif 6 width=18
Element Seqn Id St Int Rpt
RVLVLGPHNTNLTLATQY IHBC_HUMAN 151 31 -
RVLVLRPYDTNLTLTSQY IHBC_MOUSE 151 30 -

Motif 7 width=20
Element Seqn Id St Int Rpt
HLTLELVLEGQVAQSSVILG IHBC_HUMAN 194 25 -
HLTLELVPESQVAHSSLILG IHBC_MOUSE 194 25 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
SSLLLAFLLLAPTTVATPR IHBC_HUMAN 3 3 -
SSLLLALLFLTPTTVVNPK IHBC_MOUSE 3 3 -

Motif 2 width=18
Element Seqn Id St Int Rpt
GQCPACGGPTLELESQRE IHBC_HUMAN 24 2 -
GPCPACWGAIFDLESQRE IHBC_MOUSE 24 2 -

Motif 3 width=20
Element Seqn Id St Int Rpt
LLLDLAKRSILDKLHLTQRP IHBC_HUMAN 42 0 -
LLLDLAKKSILDKLHLSQRP IHBC_MOUSE 42 0 -

Motif 4 width=17
Element Seqn Id St Int Rpt
RPVSRAALRTALQHLHG IHBC_HUMAN 65 3 -
RPVSRGALKTALQRLRG IHBC_MOUSE 65 3 -

Motif 5 width=23
Element Seqn Id St Int Rpt
EIISFAETGLSTINQTRLDFHFS IHBC_HUMAN 97 15 -
EIISFADTDLSSINQTRLEFHFS IHBC_MOUSE 98 16 -

Motif 6 width=18
Element Seqn Id St Int Rpt
RVLVLGPHNTNLTLATQY IHBC_HUMAN 151 31 -
RVLVLRPYDTNLTLTSQY IHBC_MOUSE 151 30 -

Motif 7 width=20
Element Seqn Id St Int Rpt
HLTLELVLEGQVAQSSVILG IHBC_HUMAN 194 25 -
HLTLELVPESQVAHSSLILG IHBC_MOUSE 194 25 -