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PR00653

Identifier
ACTIVIN2R  [View Relations]  [View Alignment]  
Accession
PR00653
No. of Motifs
6
Creation Date
05-MAR-1997  (UPDATE 09-JUN-1999)
Title
Activin type II receptor signature
Database References

INTERPRO; IPR000333
Literature References
1. DONALDSON, C.J., MATHEWS, L.S. AND VALE, W.W.
Molecular cloning and binding properties of the human type II 
activin receptor.
BIOCHEM.BIOPHYS.RES.COMMUN. 184(1) 310-316 (1992).

Documentation
Activin type II receptors are proteins of around 500 residues that share
a high degree of similarity (human and mouse sequences are 99% identical).
The receptor, which is involved in transmembrane signalling, consists of
an extracellular domain that specifically binds activin A, a single
membrane-spanning domain, and an intracellular kinase domain with
predicted serine/threonine specificity [1]. 
 
ACTIVIN2R is a 6-element fingerprint that provides a signature for type II
activin receptors. The fingerprint was derived from an initial alignment of
9 sequences: motifs 1-3 were drawn from the N-terminal portion of the
alignment (the putative extracellular domain), and motifs 4-6 from the
C-terminal portion (the cytoplasmic protein kinase domain). Two iterations
on OWL29.1 were required to reach convergence, at which point a true set
comprising 19 sequences was identified. Several partial matches were
also found: S27268 and I38935 are N- and C-terminal fragments; the
remaining matches are either activin fragments or serine/threonine protein 
kinases that match motifs 4 and 5.
 
An update on SPTR37_9f identified a true set of 15 sequences, and 16
partial matches.
Summary Information
  15 codes involving  6 elements
0 codes involving 5 elements
1 codes involving 4 elements
2 codes involving 3 elements
13 codes involving 2 elements
Composite Feature Index
6151515151515
5000000
4111100
3002121
200210113
123456
True Positives
AVR2_BOVIN    AVR2_HUMAN    AVR2_MOUSE    AVR2_RAT      
AVR2_SHEEP AVR2_XENLA AVRB_HUMAN AVRB_MOUSE
AVRB_XENLA O13102 Q90669 Q90670
Q90745 Q91962 Q95126
True Positive Partials
Codes involving 4 elements
Q91347
Codes involving 3 elements
O16149 P79954
Codes involving 2 elements
AVR1_RAT DAF4_CAEEL O35607 O42124
O45139 Q13873 Q24229 Q24468
Q90999 TGR2_HUMAN TGR2_MOUSE TGR2_RAT
YQD2_CAEEL
Sequence Titles
AVR2_BOVIN  ACTIVIN RECEPTOR TYPE II PRECURSOR (EC 2.7.1.-) (ACTR-II) - BOS TAURUS (BOVINE). 
AVR2_HUMAN ACTIVIN RECEPTOR TYPE II PRECURSOR (EC 2.7.1.-) (ACTR-II) (ACTRIIA) - HOMO SAPIENS (HUMAN).
AVR2_MOUSE ACTIVIN RECEPTOR TYPE II PRECURSOR (EC 2.7.1.-) (ACTR-II) - MUS MUSCULUS (MOUSE).
AVR2_RAT ACTIVIN RECEPTOR TYPE II PRECURSOR (EC 2.7.1.-) (ACTR-II) - RATTUS NORVEGICUS (RAT).
AVR2_SHEEP ACTIVIN RECEPTOR TYPE II PRECURSOR (EC 2.7.1.-) (ACTR-II) - OVIS ARIES (SHEEP).
AVR2_XENLA ACTIVIN RECEPTOR TYPE II PRECURSOR (EC 2.7.1.-) (ACTR-II) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
AVRB_HUMAN ACTIVIN RECEPTOR TYPE IIB PRECURSOR (EC 2.7.1.-) (ACTR-IIB) - HOMO SAPIENS (HUMAN).
AVRB_MOUSE ACTIVIN RECEPTOR TYPE IIB PRECURSOR (EC 2.7.1.-) (ACTR-IIB) - MUS MUSCULUS (MOUSE).
AVRB_XENLA ACTIVIN RECEPTOR TYPE IIB PRECURSOR (EC 2.7.1.-) (ACTR-IIB) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O13102 ACTIVIN TYPE IIB RECEPTOR PRECURSOR - CARASSIUS AURATUS (GOLDFISH).
Q90669 ACTIVIN RECEPTOR IIA - GALLUS GALLUS (CHICKEN).
Q90670 ACTIVIN RECEPTOR IIB - GALLUS GALLUS (CHICKEN).
Q90745 ACTIVIN RECEPTOR, TYPE IIA - GALLUS GALLUS (CHICKEN).
Q91962 ACTIVIN RECEPTOR - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q95126 ACTIVIN RECEPTOR TYPE IIB PRECURSOR - BOS TAURUS (BOVINE).

Q91347 ACTIVIN RECEPTOR - XENOPUS LAEVIS (AFRICAN CLAWED FROG).

O16149 TGF-B TYPE I RECEPTOR - BRUGIA PAHANGI.
P79954 BMP TYPE II RECEPTOR - XENOPUS LAEVIS (AFRICAN CLAWED FROG).

AVR1_RAT ACTIVIN RECEPTOR TYPE I PRECURSOR (EC 2.7.1.-) (ACTR-I) (SERINE/THREONINE-PROTEIN KINASE RECEPTOR R1) (SKR1) (TGF-B SUPERFAMILY RECEPTOR TYPE I) (TSR-I) - RATTUS NORVEGICUS (RAT).
DAF4_CAEEL CELL-SURFACE RECEPTOR DAF-4 PRECURSOR (EC 2.7.1.-) - CAENORHABDITIS ELEGANS.
O35607 BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR - MUS MUSCULUS (MOUSE).
O42124 BMP TYPE II RECEPTOR (BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE II) - GALLUS GALLUS (CHICKEN).
O45139 C. ELEGANS DAUER LARVA DEVELOPMENT REGULATORY PROTEIN (SEE CELDAF4LAR) - CAENORHABDITIS ELEGANS.
Q13873 TYPE II RECEPTOR FOR BONE MORPHOGENETIC PROTEIN-4 PRECURSOR (BMPR-II) - HOMO SAPIENS (HUMAN).
Q24229 ACTIVIN RECEPTOR - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q24468 PUNT RECEPTOR SERINE/THREONINE KINASE - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q90999 TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR PRECURSOR - GALLUS GALLUS (CHICKEN).
TGR2_HUMAN TGF-BETA RECEPTOR TYPE II PRECURSOR (EC 2.7.1.37) (TGFR-2) (TGF-BETA TYPE II RECEPTOR) - HOMO SAPIENS (HUMAN).
TGR2_MOUSE TGF-BETA RECEPTOR TYPE II PRECURSOR (EC 2.7.1.37) (TGFR-2) (TGF-BETA TYPE II RECEPTOR) - MUS MUSCULUS (MOUSE).
TGR2_RAT TGF-BETA RECEPTOR TYPE II PRECURSOR (EC 2.7.1.37) (TGFR-2) (TGF-BETA TYPE II RECEPTOR) - RATTUS NORVEGICUS (RAT).
YQD2_CAEEL PUTATIVE SERINE/THREONINE-PROTEIN KINASE C32D5.2 IN CHROMOSOME II (EC 2.7.1.-) - CAENORHABDITIS ELEGANS.
Scan History
OWL29_1    2  100  NSINGLE    
SPTR37_9f 2 100 NSINGLE
Initial Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
GRSETQECLFFNANWERDRT AVR2_RAT 23 23 -
GRSETQECIYYNANWEKDKT S23089 23 23 -
GRSETQECLFFNANWEKDRT HUMACTRIIA 23 23 -
GRLETKECIYYNANWEKDKT S21171 23 23 -
GRSETQECIFYNANWERDRT BOVACTRII 23 23 -
GRSETQECIYYNANWEKDKT GGU31222 23 23 -
GRSETKECIYYNANWEKDKT AVR2_XENLA 24 24 -
GRSETQECLFFNANWEKDRT AVR2_HUMAN 23 23 -
GRSETQECLFFNANWERDRT AVR2_MOUSE 23 23 -

Motif 2 width=19
Element Seqn Id St Int Rpt
SIEIVKQGCWLDDINCYDR AVR2_HUMAN 70 27 -
SIEIVKQGCWLDDINCYNK AVR2_XENLA 71 27 -
SIEIVKQGCWLDDINCYDR GGU31222 70 27 -
SIEIVKQGCWLDDINCYDR BOVACTRII 70 27 -
SIEIVKQGCWLDDVNCYNK S21171 70 27 -
SIEIVKQGCWLDDINCYDR HUMACTRIIA 70 27 -
SIEIVKQGCWLDDINCYDR S23089 70 27 -
SIEIVKQGCWLDDINCYDR AVR2_RAT 70 27 -
SIEIVKQGCWLDDINCYDR AVR2_MOUSE 70 27 -

Motif 3 width=24
Element Seqn Id St Int Rpt
CIEKKESPDVFFCCCEGNACNERF S21171 91 2 -
CIEKKDSPEVYFCCCEGNMCNERF BOVACTRII 91 2 -
CIEKKDSPEVFFCCCEGNMCNERF GGU31222 91 2 -
CTEKKDSPDVFFCCCEGNYCNEKF AVR2_XENLA 92 2 -
CVEKKDSPEVYFCCCEGNMCNEKF AVR2_HUMAN 91 2 -
CIEKKDSPEVYFCCCEGNMCNEKF AVR2_MOUSE 91 2 -
CIEKKDSPEVYFCCCEGNMCNEKF AVR2_RAT 91 2 -
CIEKKDSPEVFFCCCEGNMCNERF S23089 91 2 -
CVEKKDSPEVYFCCCEGNMCNEKF HUMACTRIIA 91 2 -

Motif 4 width=22
Element Seqn Id St Int Rpt
KNNLTACIADFGLALKFEAGKS BOVACTRII 331 216 -
KNNLTACIADFGLALKFVAGKS HUMACTRIIA 331 216 -
KNNLTACIADFGLALKFEAGKS AVR2_XENLA 332 216 -
KNNLTACIADFGLALKFEAGKS AVR2_HUMAN 331 216 -
KNNLTACIADFGLALKFEAGKS AVR2_MOUSE 331 216 -
KNNLTACIADFGLALKFEAGKS AVR2_RAT 331 216 -
KNNLTACIADFGLALKFEAGKS S23089 331 216 -
KNNLTACIADFGLALKFEAGKS GGU31222 331 216 -
KNNLTACIADFGLALKFEAGKS S21171 330 215 -

Motif 5 width=20
Element Seqn Id St Int Rpt
GMAMLCETIEECWDHDAEAR AVR2_MOUSE 450 97 -
GMAMLCETIEECWDHDAEAR S23089 450 97 -
GMAMLCETIEECWDHDAEAR GGU31222 450 97 -
GMAMLCETIEECWDHDAEAR BOVACTRII 450 97 -
GMAMLCETIEECWDHDAEAR S21171 449 97 -
GMAMLCETIEECWDHDAEAR HUMACTRIIA 450 97 -
GMAMLCETIEECWDHDAEAR AVR2_RAT 450 97 -
GMAMLCETIEECWDHDAEAR AVR2_HUMAN 450 97 -
GMAMLCETIEECWDHDAEAR AVR2_XENLA 451 97 -

Motif 6 width=23
Element Seqn Id St Int Rpt
TTEDIVTVVTMVTNVDFPPKESS GGU31222 490 20 -
TTEDIVTVVTMVTNVDFPPKESS AVR2_MOUSE 490 20 -
TTEDIVTVVTMVTNVDFPPKESS S23089 490 20 -
TTEDIVTVVTMVTNVDFPPKESS AVR2_HUMAN 490 20 -
TTEDIVTVVTMVTNVDFPPKESS AVR2_XENLA 491 20 -
TTEDIVTVVTMVTNVDFPPKESS AVR2_RAT 490 20 -
TTEDIVTVVTMVTNVDFPPKESS HUMACTRIIA 490 20 -
TTEDIVTVVTMVTNVDFPPKESS S21171 489 20 -
TTEDIVTVVTMVTNVDFPPKESS BOVACTRII 490 20 -
Final Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
GRSETQECIYYNANWEKDKT Q90745 23 23 -
GRSETQECIYYNANWEKDKT Q90669 23 23 -
GRSETQECIFYNANWERDRT AVR2_BOVIN 23 23 -
GRSETQECLFFNANWERDRT AVR2_RAT 23 23 -
GRSETQECLFFNANWERDRT AVR2_MOUSE 23 23 -
GRSETQECIFYNANWERDRT AVR2_SHEEP 23 23 -
GRSETQECLFFNANWEKDRT AVR2_HUMAN 23 23 -
GRSETKECIYYNANWEKDKT AVR2_XENLA 24 24 -
GEAETRECIYYNANWELEKT Q90670 22 22 -
GEAETRECIYYNANWELERT Q95126 22 22 -
GEAETRECIYYNANWELERT AVRB_HUMAN 22 22 -
GEAETRECIYYNANWELERT AVRB_MOUSE 22 22 -
DEVETRECIYYNANWELEKT AVRB_XENLA 23 23 -
DEVETRECIYYNANWELEKT Q91962 23 23 -
AEVETHECLYFNINWEVEKT O13102 22 22 -

Motif 2 width=19
Element Seqn Id St Int Rpt
SIEIVKQGCWLDDINCYDR Q90745 70 27 -
SIEIVKQGCWLDDINCYDR Q90669 70 27 -
SIEIVKQGCWLDDINCYDR AVR2_BOVIN 70 27 -
SIEIVKQGCWLDDINCYDR AVR2_RAT 70 27 -
SIEIVKQGCWLDDINCYDR AVR2_MOUSE 70 27 -
SIDIVKQGCWLDDINCYDR AVR2_SHEEP 70 27 -
SIEIVKQGCWLDDINCYDR AVR2_HUMAN 70 27 -
SIEIVKQGCWLDDINCYNK AVR2_XENLA 71 27 -
SIELVKKGCWLDDFNCYDR Q90670 69 27 -
TIELVKKGCWLDDFNCYDR Q95126 69 27 -
TIELVKKGCWLDDFNCYDR AVRB_HUMAN 69 27 -
TIELVKKGCWLDDFNCYDR AVRB_MOUSE 69 27 -
FIELVKKGCWLDDFNCYDR AVRB_XENLA 71 28 -
FIELVKKGCWLDDFNCYDR Q91962 70 27 -
SIQLVKKGCWLDDFNCYDR O13102 69 27 -

Motif 3 width=24
Element Seqn Id St Int Rpt
CIEKKDSPEVFFCCCEGNMCNERF Q90745 91 2 -
CIEKKDSPEVFFCCCEGNMCNERF Q90669 91 2 -
CIEKKDSPEVYFCCCEGNMCNERF AVR2_BOVIN 91 2 -
CIEKKDSPEVYFCCCEGNMCNEKF AVR2_RAT 91 2 -
CIEKKDSPEVYFCCCEGNMCNEKF AVR2_MOUSE 91 2 -
CIEKKDSPEVYFCCCEGNMCNERF AVR2_SHEEP 91 2 -
CVEKKDSPEVYFCCCEGNMCNEKF AVR2_HUMAN 91 2 -
CTEKKDSPDVFFCCCEGNYCNEKF AVR2_XENLA 92 2 -
CVATEENPQVFFCCCEGNYCNEKF Q90670 90 2 -
CVATEENPQVYFCCCEGNFCNERF Q95126 90 2 -
CVATEENPQVYFCCCEGNFCNERF AVRB_HUMAN 90 2 -
CVATEENPQVYFCCCEGNFCNERF AVRB_MOUSE 90 2 -
CIAKEENPQVFFCCCEGNYCNKKF AVRB_XENLA 92 2 -
CIAKEENPQVFFCCCEGNYCNKKF Q91962 91 2 -
CVATEENPQVFFCCCEGDFCNERF O13102 90 2 -

Motif 4 width=22
Element Seqn Id St Int Rpt
KNNLTACIADFGLALKFEAGKS Q90745 331 216 -
KNNLTACIADFGLALKFEAGKS Q90669 331 216 -
KNNLTACIADFGLALKFEAGKS AVR2_BOVIN 331 216 -
KNNLTACIADFGLALKFEAGKS AVR2_RAT 331 216 -
KNNLTACIADFGLALKFEAGKS AVR2_MOUSE 331 216 -
KNNLTACIADFGLALKFEAGKS AVR2_SHEEP 331 216 -
KNNLTACIADFGLALKFEAGKS AVR2_HUMAN 331 216 -
KNNLTACIADFGLALKFEAGKS AVR2_XENLA 332 216 -
KNDLTAVLADFGLAVRFEPGKP Q90670 330 216 -
KSDLTAVLADFGLAVRFEPGKP Q95126 330 216 -
KSDLTAVLADFGLAVRFEPGKP AVRB_HUMAN 330 216 -
KSDLTAVLADFGLAVRFEPGKP AVRB_MOUSE 354 240 -
RNDLTAILADFGLAVRFEPGKP AVRB_XENLA 329 213 -
RNDLTAILADFGLAVRFEPGKP Q91962 328 213 -
KSDLSAVLGDLGLAVRFEPGTP O13102 323 209 -

Motif 5 width=20
Element Seqn Id St Int Rpt
GMAMLCETIEECWDHDAEAR Q90745 450 97 -
GMAMLCETIEECWDHDAEAR Q90669 450 97 -
GMAMLCETIEECWDHDAEAR AVR2_BOVIN 450 97 -
GMAMLCETIEECWDHDAEAR AVR2_RAT 450 97 -
GMAMLCETIEECWDHDAEAR AVR2_MOUSE 450 97 -
GMAMLCETIEECWDHDAEAR AVR2_SHEEP 450 97 -
GMAMLCETIEECWDHDAEAR AVR2_HUMAN 450 97 -
GMAMLCETIEECWDHDAEAR AVR2_XENLA 451 97 -
GLAQLCVTIEECWDHDAEAR Q90670 449 97 -
GLAQLCVTIEECWDHDAEAR Q95126 449 97 -
GLAQLCVTIEECWDHDAEAR AVRB_HUMAN 449 97 -
GLAQLCVTIEECWDHDAEAR AVRB_MOUSE 473 97 -
GLAQLCVTIEECWDHDAEAR AVRB_XENLA 448 97 -
GLAQLCVTIEECWDHDAEAR Q91962 447 97 -
GLAQMCETIEECWDHDAEAR O13102 442 97 -

Motif 6 width=23
Element Seqn Id St Int Rpt
TTEDIVTVVTMVTNVDFPPKESS Q90745 490 20 -
TTEDIVTVVTMVTNVDFPPKESS Q90669 490 20 -
TTEDIVTVVTMVTNVDFPPKESS AVR2_BOVIN 490 20 -
TTEDIVTVVTMVTNVDFPPKESS AVR2_RAT 490 20 -
TTEDIVTVVTMVTNVDFPPKESS AVR2_MOUSE 490 20 -
TTEDIVTVVTVVTNVDFPPKESS AVR2_SHEEP 490 20 -
TTEDIVTVVTMVTNVDFPPKESS AVR2_HUMAN 490 20 -
TTEDIVTVVTMVTNVDFPPKESS AVR2_XENLA 491 20 -
TSDCLVSIVTSVTNVDLPPKESS Q90670 489 20 -
TSDCLVSLVTSVTNVDLPPKESS Q95126 489 20 -
TSDCLVSLVTSVTNVDLPPKESS AVRB_HUMAN 489 20 -
TSDCLVSLVTSVTNVDLLPKESS AVRB_MOUSE 513 20 -
TSDCLVSIVTSVTNVDLPPKESS AVRB_XENLA 488 20 -
TSDCLVSIVTSVTNVDLPPKESS Q91962 487 20 -
TTSDLLSTVTSLTNVDLSPKESR O13102 481 19 -