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PR00495

Identifier
LEPTIN  [View Relations]  [View Alignment]  
Accession
PR00495
No. of Motifs
7
Creation Date
22-MAR-1996  (UPDATE 07-JUN-1999)
Title
Obesity factor (leptin) signature
Database References

INTERPRO; IPR000065
Literature References
1. ZHANG, Y., PROENCA, R., MAFFEI, M., BARONE, M., LEOPOLD, L. AND
FRIEDMAN, J.M.
Positional cloning of the mouse obese gene and its human homologue.
NATURE 372 425-432 (1994).

Documentation
Leptin, a metabolic monitor of food intake and energy need, is expressed
by the ob obesity gene. The protein may function as part of a signalling
pathway from adipose tissue that acts to regulate the size of the body
fat depot [1], the hormone effectively turning the brain's appetite
message off when it senses that the body is satiated. Obese humans have
high levels of the protein, suggesting a similarity to type II (adult
onset) diabetes, in which sufferers over-produce insulin, but can't respond
to it metabolically - they have become insulin resistant. Similarly, it is
thought that obese individuals may be leptin resistant.
 
LEPTIN is a 7-element fingerprint that provides a signature for obesity
factor proteins. The fingerprint was derived from an initial alignment of
4 sequences: the motifs were drawn from well-conserved regions spanning
the full alignment length. A single iteration on OWL27.0 was required to
reach convergence, no further sequences being identified beyond the
starting set.
 
An update on SPTR37_9f identified a true set of 7 sequences, and 5
partial matches.
Summary Information
   7 codes involving  7 elements
5 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
77777777
60555555
50000000
40000000
30000000
20000000
1234567
True Positives
OB_BOVIN      OB_CHICK      OB_HUMAN      OB_MACMU      
OB_MOUSE OB_PIG OB_RAT
True Positive Partials
Codes involving 6 elements
OB_CANFA OB_GORGO OB_PANTR OB_PONPY
OB_SHEEP
Sequence Titles
OB_BOVIN    LEPTIN PRECURSOR (OBESITY FACTOR) - BOS TAURUS (BOVINE). 
OB_CHICK LEPTIN PRECURSOR (OBESITY FACTOR) - GALLUS GALLUS (CHICKEN).
OB_HUMAN LEPTIN PRECURSOR (OBESITY FACTOR) (OBESE PROTEIN) - HOMO SAPIENS (HUMAN).
OB_MACMU LEPTIN PRECURSOR (OBESITY FACTOR) - MACACA MULATTA (RHESUS MACAQUE).
OB_MOUSE LEPTIN PRECURSOR (OBESITY FACTOR) - MUS MUSCULUS (MOUSE).
OB_PIG LEPTIN PRECURSOR (OBESITY FACTOR) - SUS SCROFA (PIG).
OB_RAT LEPTIN PRECURSOR (OBESITY FACTOR) - RATTUS NORVEGICUS (RAT).

OB_CANFA LEPTIN (OBESITY FACTOR) - CANIS FAMILIARIS (DOG).
OB_GORGO LEPTIN (OBESITY FACTOR) - GORILLA GORILLA GORILLA (LOWLAND GORILLA).
OB_PANTR LEPTIN (OBESITY FACTOR) - PAN TROGLODYTES (CHIMPANZEE).
OB_PONPY LEPTIN (OBESITY FACTOR) - PONGO PYGMAEUS (ORANGUTAN).
OB_SHEEP LEPTIN (OBESITY FACTOR) - OVIS ARIES (SHEEP).
Scan History
OWL27_0    1  20   NSINGLE    
SPTR37_9f 2 13 NSINGLE
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
FLWLWSYLSYVQAVPIHKV PC4034 9 9 -
FLWLWPYLSYVEAVPIRKV BTU43943 9 9 -
FLWLWSYLSYVQAVPIQKV OB_MOUSE 9 9 -
FLWLWPYLFYVQAVPIQKV OB_HUMAN 9 9 -

Motif 2 width=19
Element Seqn Id St Int Rpt
DDTKTLIKTIVTRINDISH BTU43943 29 1 -
DDTKTLIKTIVTRINDISH OB_MOUSE 29 1 -
DDTKTLIKTIVTRINDISH OB_HUMAN 29 1 -
DDTKTLIKTIVTRINDISH PC4034 29 1 -

Motif 3 width=21
Element Seqn Id St Int Rpt
RVTGLDFIPGLHPILSLSKMD PC4034 56 8 -
RVTGLDFIPGLHPLLSLSKMD BTU43943 56 8 -
KVTGLDFIPGLHPILTLSKMD OB_HUMAN 56 8 -
RVTGLDFIPGLHPILSLSKMD OB_MOUSE 56 8 -

Motif 4 width=19
Element Seqn Id St Int Rpt
LAIYQQILTSLPSRNVVQI BTU43943 79 2 -
LAVYQQVLTSLPSQNVLQI OB_MOUSE 79 2 -
LAVYQQILTSMPSRNVIQI OB_HUMAN 79 2 -
LAVYQQILTSLPSQNVLQI PC4034 79 2 -

Motif 5 width=21
Element Seqn Id St Int Rpt
DLENLRDLLHLLAASKSCPLP BTU43943 100 2 -
DLENLRDLLHLLAFSKSCSLP PC4034 100 2 -
DLENLRDLLHLLAFSKSCSLP OB_MOUSE 100 2 -
DLENLRDLLHVLAFSKSCHLP OB_HUMAN 100 2 -

Motif 6 width=21
Element Seqn Id St Int Rpt
DSLGGVLEASGYSTEVVALSR OB_HUMAN 129 8 -
ESLGVVLEASLYSTEVVALSR BTU43943 129 8 -
ESLDGVLEASLYSTEVVALSR PC4034 129 8 -
ESLDGVLEASLYSTEVVALSR OB_MOUSE 129 8 -

Motif 7 width=16
Element Seqn Id St Int Rpt
LQGSLQDMLWQLDLSP OB_HUMAN 150 0 -
LQGSLQDMLRQLDLSP BTU43943 150 0 -
LQGSLQDILQQLDVSP OB_MOUSE 150 0 -
LQGSLQDILQQLDLSP PC4034 150 0 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
FLWLWSYLSYVQAVPIHKV OB_RAT 9 9 -
FLWLWSYLSYVQAVPIQKV OB_MOUSE 9 9 -
FLWLWPYLSYVEAVPIRKV OB_BOVIN 9 9 -
FLWLWPYLFYVQAVPIQKV OB_HUMAN 9 9 -
FLWLWPYLSYVEAVPIWRV OB_PIG 9 9 -
FLWLWPYLFYIQAVPIQKV OB_MACMU 9 9 -
LCRLWSYLVYVQAVPCQIF OB_CHICK 6 6 -

Motif 2 width=19
Element Seqn Id St Int Rpt
DDTKTLIKTIVTRINDISH OB_RAT 29 1 -
DDTKTLIKTIVTRINDISH OB_MOUSE 29 1 -
DDTKTLIKTIVTRINDISH OB_BOVIN 29 1 -
DDTKTLIKTIVTRINDISH OB_HUMAN 29 1 -
DDTKTLIKTIVTRISDISH OB_PIG 29 1 -
SDTKTLIKTIVTRINDISH OB_MACMU 29 1 -
DDTKTLIKTIVTRINDISH OB_CHICK 26 1 -

Motif 3 width=21
Element Seqn Id St Int Rpt
RVTGLDFIPGLHPILSLSKMD OB_RAT 56 8 -
RVTGLDFIPGLHPILSLSKMD OB_MOUSE 56 8 -
RVTGLDFIPGLHPLLSLSKMD OB_BOVIN 56 8 -
KVTGLDFIPGLHPILTLSKMD OB_HUMAN 56 8 -
RVTGLDFIPGLHPVLSLSKMD OB_PIG 56 8 -
RVTGLDFIPGLHPVLTLSQMD OB_MACMU 56 8 -
RVTGLDFIPGLHPILSLSKMD OB_CHICK 52 7 -

Motif 4 width=19
Element Seqn Id St Int Rpt
LAVYQQILTSLPSQNVLQI OB_RAT 79 2 -
LAVYQQVLTSLPSQNVLQI OB_MOUSE 79 2 -
LAIYQQILTSLPSRNVVQI OB_BOVIN 79 2 -
LAVYQQILTSMPSRNVIQI OB_HUMAN 79 2 -
LAIYQQILTSLPSRNVIQI OB_PIG 79 2 -
LAIYQQILINLPSRNVIQI OB_MACMU 79 2 -
LAVYQQVLTSLPSQNVLQI OB_CHICK 75 2 -

Motif 5 width=21
Element Seqn Id St Int Rpt
DLENLRDLLHLLAFSKSCSLP OB_RAT 100 2 -
DLENLRDLLHLLAFSKSCSLP OB_MOUSE 100 2 -
DLENLRDLLHLLAASKSCPLP OB_BOVIN 100 2 -
DLENLRDLLHVLAFSKSCHLP OB_HUMAN 100 2 -
DLENLRDLLHLLASSKSCPLP OB_PIG 100 2 -
DLENLRDLLHLLAFSKSCHLP OB_MACMU 100 2 -
DLENLRDLLHLLAFSKSCSLP OB_CHICK 96 2 -

Motif 6 width=21
Element Seqn Id St Int Rpt
ESLDGVLEASLYSTEVVALSR OB_RAT 129 8 -
ESLDGVLEASLYSTEVVALSR OB_MOUSE 129 8 -
ESLGVVLEASLYSTEVVALSR OB_BOVIN 129 8 -
DSLGGVLEASGYSTEVVALSR OB_HUMAN 129 8 -
ESLGGVLEASLYSTEVVALSR OB_PIG 129 8 -
ESLGDVLEASLYSTEVVALSR OB_MACMU 129 8 -
ESLDGVLEASLYSTEVVALSR OB_CHICK 125 8 -

Motif 7 width=16
Element Seqn Id St Int Rpt
LQGSLQDILQQLDLSP OB_RAT 150 0 -
LQGSLQDILQQLDVSP OB_MOUSE 150 0 -
LQGSLQDMLRQLDLSP OB_BOVIN 150 0 -
LQGSLQDMLWQLDLSP OB_HUMAN 150 0 -
LQGALQDMLRQLDLSP OB_PIG 150 0 -
LQGSLQDMLWQLDLSP OB_MACMU 150 0 -
LQGSLQDILQQLDISP OB_CHICK 146 0 -