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PR00480

Identifier
ASTACIN  [View Relations]  [View Alignment]  
Accession
PR00480
No. of Motifs
5
Creation Date
07-MAR-1996  (UPDATE 22-JUN-1999)
Title
Astacin family signature
Database References

PROSITE; PS00142 ZINC_PROTEASE; PS00740 MAM
INTERPRO; IPR001506
PDB; 1AST
SCOP; 1AST
Literature References
1. BOND, J.S. AND BEYNON, R.J.
The astacin family of metalloendopeptidases
PROTEIN SCI. 4 1247-1261 (1995).
 
2. GOMIS-RUTH, F.X., STOCKER, W., HUBER, R., ZWILLING R. AND BODE, W.
Refined 1.8 A X-ray crystal structure of astacin, a zinc-endopeptidase
from the crayfish Astacus astacus L. Structure determination, refinement,
molecular structure and comparison with thermolysin.
J.MOL.BIOL. 229 945-968 (1993).

Documentation
The astacin family of metalloendopeptidases encompasses a range of proteins
found in hydra to humans, in mature and developmental systems [1]. Their
functions include activation of growth factors, degradation of polypeptides,
and processing of extracellular proteins [1]. The proteins are synthesised
with N-terminal signal and pro-enzyme sequences, and many contain multiple
domains C-terminal to the protease domain. They are either secreted from
cells, or are associated with the plasma membrane.
 
The astacin molecule adopts a kidney shape, with a deep active-site cleft
between its N- and C-terminal domains [2]. The zinc ion, which lies at the
bottom of the cleft, exhibits a unique penta-coordinated mode of binding,
involving 3 histidine residues, a tyrosine and a water molecule (which is
also bound to the carboxylate side chain of Glu93) [2]. The N-terminal
domain comprises 2 alpha-helices and a 5-stranded beta-sheet. The overall
topology of this domain is shared by the archetypal zinc-endopeptidase
thermolysin. Astacin protease domains also share common features with
serralysins, matrix metalloendopeptidases, and snake venom proteases; they
cleave peptide bonds in polypeptides such as insulin B chain and bradykinin,
and in proteins such as casein and gelatin; and they have arylamidase
activity [1]. 
 
ASTACIN is a 5-element fingerprint that provides a signature for the
astacin family. The fingerprint was derived from an initial alignment of
9 sequences: the motifs were drawn from short conserved regions within
the central portion of the alignment, motif 2 including the region encoded
by PROSITE pattern ZINC_PROTEASE (PS00142), the histidines of which are
zinc ligands and the glutamic acid the active site residue - motifs 1 and 2
span the two N-terminal domain alpha helices; motifs 3 and 4 encode
C-terminal domain beta strands; and motif 5 spans the C-terminal domain
C-terminal helix. Two iterations on OWL27.0 were required to reach
convergence, at which point a true set comprising 31 sequences was
identified. Several partial matches were also found: some are astacin
family members that fail to make significant matches motifs 1 or 5;
UVS2_XENLA is a fragment lacking the portion of sequence bearing the first
3 motifs; and the rest are members of the zinc protease superfamily that
match motifs 1 and 2. 
 
An update on SPTR37_9f identified a true set of 60 sequences, and 28
partial matches.
Summary Information
  60 codes involving  5 elements
7 codes involving 4 elements
5 codes involving 3 elements
16 codes involving 2 elements
Composite Feature Index
56060606060
466772
342333
21515011
12345
True Positives
ASTA_ASTFL    ASTL_COTJA    BMP1_HUMAN    BMP1_MOUSE    
BMP1_XENLA BMPH_STRPU BP10_PARLI HCE1_ORYLA
HCE2_ORYLA LCE_ORYLA MEPA_HUMAN MEPA_MOUSE
MEPA_RAT MEPB_HUMAN MEPB_MOUSE MEPB_RAT
O13116 O17264 O42326 O43897
O44072 O57381 O57382 O57460
O62558 P91972 Q13292 Q18206
Q18439 Q19269 Q20459 Q20942
Q20958 Q20975 Q21059 Q21178
Q21179 Q21180 Q21181 Q21252
Q21388 Q21661 Q22396 Q23995
Q24132 Q26051 Q47899 Q62381
Q91925 Q93243 Q93542 Q99422
Q99423 SPAN_STRPU TLD_DROME TOH2_CAEEL
UVS2_XENLA YC92_CAEEL YPD6_CAEEL YPF4_CAEEL
True Positive Partials
Codes involving 4 elements
O16977 P91828 Q21432 Q22401
Q22710 YPZ8_CAEEL YVD3_CAEEL
Codes involving 3 elements
O62243 P91137 Q20200 Q22398
Q99421
Codes involving 2 elements
COG3_RABIT COGT_HUMAN COGT_MOUSE COGT_RABIT
COGT_RAT COGU_HUMAN COGV_HUMAN COGV_RAT
COGX_HUMAN O08645 O35369 O35541
Q14111 Q14824 Q20176 Q98947
Sequence Titles
ASTA_ASTFL  ASTACIN PRECURSOR (EC 3.4.24.21) (CRAYFISH SMALL-MOLECULE PROTEINASE) - ASTACUS FLUVIATILIS (BROAD-FINGERED CRAYFISH) (ASTACUS ASTACUS). 
ASTL_COTJA ASTACIN LIKE METALLOENDOPEPTIDASE (EC 3.4.24.-) - COTURNIX COTURNIX JAPONICA (JAPANESE QUAIL).
BMP1_HUMAN BONE MORPHOGENETIC PROTEIN 1 PRECURSOR (EC 3.4.24.-) (BMP-1) - HOMO SAPIENS (HUMAN).
BMP1_MOUSE BONE MORPHOGENETIC PROTEIN 1 PRECURSOR (EC 3.4.24.-) (BMP-1) - MUS MUSCULUS (MOUSE).
BMP1_XENLA BONE MORPHOGENETIC PROTEIN 1 PRECURSOR (EC 3.4.24.-) (BMP-1) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
BMPH_STRPU BONE MORPHOGENETIC PROTEIN 1 HOMOLOG PRECURSOR (EC 3.4.24.-) (SUBMP) - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
BP10_PARLI BLASTULA PROTEASE-10 PRECURSOR (EC 3.4.24.-) - PARACENTROTUS LIVIDUS (COMMON SEA URCHIN).
HCE1_ORYLA HIGH CHORIOLYTIC ENZYME 1 PRECURSOR (EC 3.4.24.67) (HATCHING ENZYME ZINC-PROTEASE HCE 1 SUBUNIT) (CHORIOLYSIN H 1) - ORYZIAS LATIPES (MEDAKA FISH).
HCE2_ORYLA HIGH CHORIOLYTIC ENZYME 2 PRECURSOR (EC 3.4.24.67) (HATCHING ENZYME ZINC-PROTEASE HCE 2 SUBUNIT) (CHORIOLYSIN H 2) - ORYZIAS LATIPES (MEDAKA FISH).
LCE_ORYLA LOW CHORIOLYTIC ENZYME PRECURSOR (EC 3.4.24.66) (HATCHING ENZYME ZINC-PROTEASE LCE SUBUNIT) (CHORIOLYSIN L) - ORYZIAS LATIPES (MEDAKA FISH).
MEPA_HUMAN MEPRIN A ALPHA-SUBUNIT PRECURSOR (EC 3.4.24.18) (ENDOPEPTIDASE-2) (N- BENZOYL-L-TYROSYL-P-AMINO-BENZOIC ACID HYDROLASE ALPHA SUBUNIT) (PABA PEPTIDE HYDROLASE) (PPH ALPHA) - HOMO SAPIENS (HUMAN).
MEPA_MOUSE MEPRIN A ALPHA-SUBUNIT PRECURSOR (EC 3.4.24.18) (ENDOPEPTIDASE-2) (MEP-1) - MUS MUSCULUS (MOUSE).
MEPA_RAT MEPRIN A ALPHA-SUBUNIT PRECURSOR (EC 3.4.24.18) (ENDOPEPTIDASE-2) (MEP-1) (ENDOPEPTIDASE-24.18 ALPHA-SUBUNIT) (E-24.18) - RATTUS NORVEGICUS (RAT).
MEPB_HUMAN MEPRIN A BETA-SUBUNIT PRECURSOR (EC 3.4.24.18) (ENDOPEPTIDASE-2) (N- BENZOYL-L-TYROSYL-P-AMINO-BENZOIC ACID HYDROLASE BETA SUBUNIT) (PABA PEPTIDE HYDROLASE) (PPH BETA) - HOMO SAPIENS (HUMAN).
MEPB_MOUSE MEPRIN A BETA-SUBUNIT PRECURSOR (EC 3.4.24.18) (ENDOPEPTIDASE-2) - MUS MUSCULUS (MOUSE).
MEPB_RAT MEPRIN A BETA-SUBUNIT PRECURSOR (EC 3.4.24.18) (ENDOPEPTIDASE-2) - RATTUS NORVEGICUS (RAT).
O13116 CHORIOLYSIN H - ORYZIAS LATIPES (MEDAKA FISH).
O17264 T23F4.4 PROTEIN - CAENORHABDITIS ELEGANS.
O42326 NEPHROSIN PRECURSOR - CYPRINUS CARPIO (COMMON CARP).
O43897 TOLLOID-LIKE PROTEIN - HOMO SAPIENS (HUMAN).
O44072 ASTACUS EGG ASTACIN PRECURSOR - ASTACUS FLUVIATILIS (BROAD-FINGERED CRAYFISH) (ASTACUS ASTACUS).
O57381 BONE MORPHOGENETIC PROTEIN 1B - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O57382 XOLLOID - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O57460 TOLLOID - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O62558 PMP1 PROTEIN PRECURSOR - PODOCORYNE CARNEA.
P91972 TBL-1 - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE).
Q13292 PROCOLLAGEN C-PROTEINASE - HOMO SAPIENS (HUMAN).
Q18206 C26C6.3 PROTEIN - Caenorhabditis elegans.
Q18439 COSMID C34D4 - CAENORHABDITIS ELEGANS.
Q19269 F09E8.6 PROTEIN - CAENORHABDITIS ELEGANS.
Q20459 F46C5.3 PROTEIN - CAENORHABDITIS ELEGANS.
Q20942 SIMILAR TO S. PURPURATUS SPAN PROTEIN - CAENORHABDITIS ELEGANS.
Q20958 SIMILAR TO BLASTULA PROTEASE 10 FROM SEA URCHIN - CAENORHABDITIS ELEGANS.
Q20975 F58B4.1 PROTEIN - CAENORHABDITIS ELEGANS.
Q21059 HCH-1 - CAENORHABDITIS ELEGANS.
Q21178 K03B8.2 PROTEIN - CAENORHABDITIS ELEGANS.
Q21179 K03B8.3 PROTEIN - CAENORHABDITIS ELEGANS.
Q21180 K03B8.1 PROTEIN - CAENORHABDITIS ELEGANS.
Q21181 K03B8.5 PROTEIN - CAENORHABDITIS ELEGANS.
Q21252 K06A4.1 PROTEIN - CAENORHABDITIS ELEGANS.
Q21388 K09C8.3 PROTEIN - CAENORHABDITIS ELEGANS.
Q21661 F39D8.4 PROTEIN - CAENORHABDITIS ELEGANS.
Q22396 T11F9.3 PROTEIN - CAENORHABDITIS ELEGANS.
Q23995 TOLLOID RELATED-1 - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q24132 TOLKIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q26051 BLASTULA PROTEASE-10 - PARACENTROTUS LIVIDUS (COMMON SEA URCHIN).
Q47899 FLAVASTACIN PRECURSOR (EC 3.4.24.-) (ASTACIN METALLOENDOPEPTIDASE) - FLAVOBACTERIUM MENINGOSEPTICUM.
Q62381 TOLLOID-LIKE (MAMMALIAN TOLLOID-LIKE PROTEIN) - MUS MUSCULUS (MOUSE).
Q91925 XTLD PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q93243 C17G1.6 PROTEIN - Caenorhabditis elegans.
Q93542 F20G2.4 PROTEIN - CAENORHABDITIS ELEGANS.
Q99422 BONE MORPHOGENETIC PROTEIN BMP1-5 - HOMO SAPIENS (HUMAN).
Q99423 BONE MORPHOGENETIC PROTEIN BMP1-6 - HOMO SAPIENS (HUMAN).
SPAN_STRPU SPAN PROTEIN PRECURSOR (EC 3.4.24.-) - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
TLD_DROME DORSAL-VENTRAL PATTERNING TOLLOID PROTEIN PRECURSOR (EC 3.4.24.-) - DROSOPHILA MELANOGASTER (FRUIT FLY).
TOH2_CAEEL Zinc metalloproteinase toh-2 precursor (EC 3.4.24.-) - Caenorhabditis elegans.
UVS2_XENLA EMBRYONIC PROTEIN UVS.2 PRECURSOR (EC 3.4.24.-) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
YC92_CAEEL HYPOTHETICAL ZINC METALLOPROTEINASE T04G9.2 (EC 3.4.24.-) - CAENORHABDITIS ELEGANS.
YPD6_CAEEL HYPOTHETICAL ZINC METALLOPROTEINASE C05D11.6 (EC 3.4.24.-) - CAENORHABDITIS ELEGANS.
YPF4_CAEEL HYPOTHETICAL ZINC METALLOPROTEINASE C07D10.4 (EC 3.4.24.-) - CAENORHABDITIS ELEGANS.

O16977 T02B11.7 PROTEIN - CAENORHABDITIS ELEGANS.
P91828 T23H4.3 PROTEIN - CAENORHABDITIS ELEGANS.
Q21432 COSMID K11G12 - CAENORHABDITIS ELEGANS.
Q22401 T11F9.5 PROTEIN - CAENORHABDITIS ELEGANS.
Q22710 T24A11.3 PROTEIN - CAENORHABDITIS ELEGANS.
YPZ8_CAEEL HYPOTHETICAL ZINC METALLOPROTEINASE F42A10.8 PRECURSOR (EC 3.4.24.-) - CAENORHABDITIS ELEGANS.
YVD3_CAEEL HYPOTHETICAL ZINC METALLOPROTEINASE K04E7.3 PRECURSOR (EC 3.4.24.-) - CAENORHABDITIS ELEGANS.

O62243 F45G2.1 PROTEIN - CAENORHABDITIS ELEGANS.
P91137 SIMILARITY TO THE PEPTIDASE FAMILY M12A - CAENORHABDITIS ELEGANS.
Q20200 F40E10.1 PROTEIN - CAENORHABDITIS ELEGANS.
Q22398 T11F9.6 PROTEIN - CAENORHABDITIS ELEGANS.
Q99421 BONE MORPHOGENETIC PROTEIN BMP1-4 - HOMO SAPIENS (HUMAN).

COG3_RABIT STROMELYSIN-1 PRECURSOR (EC 3.4.24.17) (MATRIX METALLOPROTEINASE-3) (MMP-3) (TRANSIN-1) (SL-1) - ORYCTOLAGUS CUNICULUS (RABBIT).
COGT_HUMAN MATRIX METALLOPROTEINASE-14 PRECURSOR (EC 3.4.24.-) (MMP-14) (MEMBRANE-TYPE MATRIX METALLOPROTEINASE 1) (MT-MMP 1) (MTMMP1) - HOMO SAPIENS (HUMAN).
COGT_MOUSE MATRIX METALLOPROTEINASE-14 PRECURSOR (EC 3.4.24.-) (MMP-14) (MEMBRANE-TYPE MATRIX METALLOPROTEINASE 1) (MT-MMP 1) (MTMMP1) - MUS MUSCULUS (MOUSE).
COGT_RABIT MATRIX METALLOPROTEINASE-14 PRECURSOR (EC 3.4.24.-) (MMP-14) (MEMBRANE-TYPE MATRIX METALLOPROTEINASE 1) (MT-MMP 1) (MTMMP1) - ORYCTOLAGUS CUNICULUS (RABBIT).
COGT_RAT MATRIX METALLOPROTEINASE-14 PRECURSOR (EC 3.4.24.-) (MMP-14) (MEMBRANE-TYPE MATRIX METALLOPROTEINASE 1) (MT-MMP 1) (MTMMP1) - RATTUS NORVEGICUS (RAT).
COGU_HUMAN MATRIX METALLOPROTEINASE-15 PRECURSOR (EC 3.4.24.-) (MMP-15) (MEMBRANE-TYPE MATRIX METALLOPROTEINASE 2) (MT-MMP 2) (MTMMP2) - HOMO SAPIENS (HUMAN).
COGV_HUMAN MATRIX METALLOPROTEINASE-16 PRECURSOR (EC 3.4.24.-) (MMP-16) (MEMBRANE-TYPE MATRIX METALLOPROTEINASE 3) (MT-MMP 3) (MTMMP3) (MMP-X2) - HOMO SAPIENS (HUMAN).
COGV_RAT MATRIX METALLOPROTEINASE-16 PRECURSOR (EC 3.4.24.-) (MMP-16) (MEMBRANE-TYPE MATRIX METALLOPROTEINASE 3) (MT-MMP 3) (MTMMP3) - RATTUS NORVEGICUS (RAT).
COGX_HUMAN STROMELYSIN-2 PRECURSOR (EC 3.4.24.22) (MATRIX METALLOPROTEINASE-10) (MMP-10) (TRANSIN-2) (SL-2) - HOMO SAPIENS (HUMAN).
O08645 MEMBRANE-TYPE MATRIX METALLOPROTEINASE 1 - MUS MUSCULUS (MOUSE).
O35369 MATRIX METALLOPROTEINASE-14 - MUS MUSCULUS (MOUSE).
O35541 MT3-MMP-DEL - RATTUS NORVEGICUS (RAT).
Q14111 MATRIX METALLOPROTEINASE, MT2MMP - HOMO SAPIENS (HUMAN).
Q14824 METALLOPROTEINASE PRECURSOR (EC 3.4.24.-) - HOMO SAPIENS (HUMAN).
Q20176 COSMID F38E9 - CAENORHABDITIS ELEGANS.
Q98947 MEMBRANE TYPE-MATRIX METALLOPROTEINASE - GALLUS GALLUS (CHICKEN).
Scan History
OWL27_0    2  100  NSINGLE    
SPTR37_9f 4 100 NSINGLE
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
IRNAMDHWEQNTCLRFEPR BP10_PARLI 122 122 -
ILNAFERYRLKTCIDFKPW MEPB_RAT 92 92 -
ILSGMQELEEKTCIRFVPR ASTA_ASTFL 30 30 -
ILHAFEMFRLKSCVDFKPY MEPA_MOUSE 107 107 -
ILHAFEMFRLKSCVDFKPY NRL_1IAF 30 30 -
FRQAMRHWEKHTCVTFLER BMP1_HUMAN 151 151 -
FKQAMRHWENFTCIKFVER TLD_DROME 157 157 -
IRNAMKEFAEKTCIHFVPR LCE_ORYLA 111 111 -
ILEAMAEFETLTCINFVKR ASTL_COTJA 23 23 -

Motif 2 width=19
Element Seqn Id St Int Rpt
CAYFGTIVHEIGHAIGFHH BP10_PARLI 182 41 -
CVYHGTIIHELMHAIGFYH ASTA_ASTFL 84 35 -
CDFKATIEHEILHALGFFH NRL_1IAF 82 33 -
CDFKATIEHEILHALGFFH MEPA_MOUSE 159 33 -
CDKFGIVVHELGHVVGFWH BMP1_HUMAN 205 35 -
CEKFGIIIHELGHTIGFHH TLD_DROME 213 37 -
CIKHAVIQHELLHALGFYH LCE_ORYLA 164 34 -
CMWKGIIQHELDHALGFLH ASTL_COTJA 76 34 -
CDRIATVQHEFLHALGFWH MEPB_RAT 145 34 -

Motif 3 width=18
Element Seqn Id St Int Rpt
EHTRMDRDNYVTINYQNV ASTA_ASTFL 103 0 -
EQSRTDRDNYVNIWWDQI NRL_1IAF 101 0 -
EHTRPDRDRHVSIVRENI BMP1_HUMAN 224 0 -
EHARGDRDKHIVINKGNI TLD_DROME 232 0 -
EHTRSDRDQHVKINWENI LCE_ORYLA 183 0 -
EHSRSDRDKYVKIMWEYI ASTL_COTJA 95 0 -
EQSRPDRDDYINVLYQNI BP10_PARLI 201 0 -
EQSRADRDDYITIVWDRI MEPB_RAT 164 0 -
EQSRTDRDDYVNIWWDQI MEPA_MOUSE 178 0 -

Motif 4 width=16
Element Seqn Id St Int Rpt
PYDYESLMHYGPFSFN NRL_1IAF 140 21 -
TYDFDSIMHYARNTFS BMP1_HUMAN 263 21 -
PYDLNSIMHYAKNSFS TLD_DROME 271 21 -
PYDYGSIMHYGRTAFG LCE_ORYLA 219 18 -
PYDYSSVMHYGPHTFT ASTL_COTJA 132 19 -
EYDVGSIMHYGGYGFS BP10_PARLI 240 21 -
PYDYTSVMHYSKTAFQ MEPB_RAT 203 21 -
DYQYYSIMHYGKYSFS ASTA_ASTFL 140 19 -
PYDYESLMHYGPFSFN MEPA_MOUSE 217 21 -

Motif 5 width=14
Element Seqn Id St Int Rpt
MLQTDANQINNLYT ASTA_ASTFL 182 26 -
FSAIDLIRLNRMYN MEPA_MOUSE 257 24 -
LSKGDIAQARKLYK BMP1_HUMAN 305 26 -
FSAIDLIRLNRMYN NRL_1IAF 180 24 -
LSRGDIVQANLLYK TLD_DROME 313 26 -
MSDIDILRVNKLYK LCE_ORYLA 257 22 -
LSNLDVAKINKLYN ASTL_COTJA 171 23 -
LSPADIELANLIYE BP10_PARLI 279 23 -
FSDYDLLKLNQLYS MEPB_RAT 242 23 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
FRQAMRHWEKHTCVTFLER BMP1_MOUSE 156 156 -
FRQAMRHWEKHTCVTFLER BMP1_HUMAN 151 151 -
FRQAMRHWEKHTCVTFLER Q99423 151 151 -
FRQAMRHWEKHTCVTFLER Q99422 151 151 -
FRQAMRHWEKHTCVTFLER Q13292 151 151 -
FRQAMRHWEKHTCVTFLER O57381 141 141 -
FRQAMRHWEKHTCVTFLER BMP1_XENLA 114 114 -
FKQAMRHWEKHTCVTFTER Q62381 178 178 -
FKQAMRHWEKHTCVTFIER O43897 178 178 -
FKQAMRHWKKHTCVTFVER O57382 183 183 -
FRQAMRHWEKHTCVTFLER Q91925 142 142 -
FKLAMRHWENSTCIKFVER Q23995 550 550 -
FKLAMRHWENSTCIKFVER Q24132 550 550 -
LKQAMRHWEKQTCVTFIEK O57460 187 187 -
FKQAMRHWENYTCITFVER BMPH_STRPU 131 131 -
IEGAMRAFNGKTCIRFVRR HCE1_ORYLA 108 108 -
FKQAMRHWENFTCIKFVER TLD_DROME 157 157 -
IEGAMRAFNGKTCIRFVRR O13116 104 104 -
IRNAMKEFAEKTCIHFVPR LCE_ORYLA 111 111 -
IEGAMRAFNGRTCIRFVRR HCE2_ORYLA 117 117 -
FKLAMRHWENLTCLVFKDK P91972 241 241 -
ILEAMAEFETLTCINFVKR ASTL_COTJA 23 23 -
AIDAMAEFDEITCVRFVPR O44072 80 80 -
IRNAMDHWEQNTCLRFEPR BP10_PARLI 122 122 -
IRNAMDHWEQNTCLRFEPR Q26051 122 122 -
IANAMNEYHTKTCVKFVAR YPD6_CAEEL 144 144 -
IAEAIEEYRKKTCIDFSPK Q21661 217 217 -
FKKAIQEFEALTCVRFVPW UVS2_XENLA 125 125 -
IELALEHWHNITCLNFQRN TOH2_CAEEL 158 158 -
IRSAMDHWEQNTCLRFEPL SPAN_STRPU 122 122 -
IAQAFDEYKTKTCVRFVPK Q19269 146 146 -
ILNAFERYRLKTCIDFKPW MEPB_MOUSE 92 92 -
ILNAFERYRLKTCIDFKPW MEPB_HUMAN 91 91 -
IAASMQEYASHTCIRWVPK YC92_CAEEL 194 194 -
ILNAFERYRLKTCIDFKPW MEPB_RAT 92 92 -
ILSGMQELEEKTCIRFVPR ASTA_ASTFL 30 30 -
IKQGLNSFTGISCIRFVPH O42326 113 113 -
IANAIAQYHKHTCLRFHKR O62558 81 81 -
LAKAVKQYHEKTCIRFVPR YPF4_CAEEL 132 132 -
VLAGVAKWEQETCARFTRL Q21059 153 153 -
IIAAIRFWEDSTCITFENV Q18206 157 157 -
ILNAFEMFRLKSCVDFKPY MEPA_RAT 96 96 -
IRSAIRHVEQNVCFKFKEN Q93243 144 144 -
ILHAFEMFRLKSCVDFKPY MEPA_MOUSE 107 107 -
ILYAFEMFRLKSCVDFKPY MEPA_HUMAN 95 95 -
LARSFQAYHDKTCVRFVPR Q18439 52 52 -
FRSAMLLWQQHTCLRFEEG Q20942 171 171 -
FEQAVAFWQNVTCINIMQS Q20975 164 164 -
VRLAIEELQAWTCIRFQNV Q20459 16 16 -
ILKAVHFWYRETCIEFHPR Q20958 74 74 -
ILSAMEAFRDVTCVRFRPR Q21252 91 91 -
VLEAMQFWSEKTCVTFHEN O17264 123 123 -
VRGAISEIEQKTCIRFKYF Q21388 347 347 -
MLFSMNFISSQTCVTFEEN Q21179 108 108 -
FRDAINYLENHTCLKFEYN Q22396 2 2 -
MSYAMAHISSNTCVKFQES Q21178 111 111 -
MKFAMNFISSQTCVTFEEN Q21180 115 115 -
INKAFDMISSKTSVKFVQR Q47899 129 129 -
VESAIAYIANHTCIRFNED Q21181 153 153 -
VKSAIAYIANHTCIKFNED Q93542 56 56 -

Motif 2 width=19
Element Seqn Id St Int Rpt
CDKFGIVVHELGHVIGFWH BMP1_MOUSE 210 35 -
CDKFGIVVHELGHVVGFWH BMP1_HUMAN 205 35 -
CDKFGIVVHELGHVVGFWH Q99423 205 35 -
CDKFGIVVHELGHVVGFWH Q99422 205 35 -
CDKFGIVVHELGHVVGFWH Q13292 205 35 -
CDKFGIVVHELGHVIGFWH O57381 195 35 -
CDKFGIVVHELGHVIGFWH BMP1_XENLA 168 35 -
CDKFGIVVHELGHVIGFWH Q62381 232 35 -
CDKFGIVVHELGHVIGFWH O43897 232 35 -
CDKFGIVVHELGHVVGFWH O57382 237 35 -
CDKFGIVVHELGHVIGFWH Q91925 196 35 -
CDKFGIVVHELGHVVGFWH Q23995 606 37 -
CDKFGIVVHELGHVVGFWH Q24132 606 37 -
CDKFGIVVHELGHVIGFWH O57460 241 35 -
CDKFGVVVHELGHVVGFWH BMPH_STRPU 189 39 -
CMYSGIIQHELNHALGFQH HCE1_ORYLA 161 34 -
CEKFGIIIHELGHTIGFHH TLD_DROME 213 37 -
CMYSGIIQHELNHALGFQH O13116 157 34 -
CIKHAVIQHELLHALGFYH LCE_ORYLA 164 34 -
CMYSGIIQHELNHALGFQH HCE2_ORYLA 170 34 -
CYYFGTVVHELGHVVGFWH P91972 296 36 -
CMWKGIIQHELDHALGFLH ASTL_COTJA 76 34 -
CMNTGIIQHELEHALGFYH O44072 133 34 -
CAYFGTIVHEIGHAIGFHH BP10_PARLI 182 41 -
CAYFGTIVHEIGHAIGFHH Q26051 182 41 -
CIQVGTIVHELMHAVGFFH YPD6_CAEEL 198 35 -
CIQKGIIIHELMHAVGFFH Q21661 261 25 -
CMNMGIIQHELNHALGFYH UVS2_XENLA 178 34 -
CIRLGVIAHEVAHALGFWH TOH2_CAEEL 214 37 -
CGYFGTIVHEIGHAIGFHH SPAN_STRPU 182 41 -
EARNGIIAHELMHALGFFH Q19269 216 51 -
CDRIATVQHEFLHALGFWH MEPB_MOUSE 145 34 -
CDRIATVQHEFLHALGFWH MEPB_HUMAN 144 34 -
CIQKGIILHELMHAVGFFH YC92_CAEEL 247 34 -
CDRIATVQHEFLHALGFWH MEPB_RAT 145 34 -
CVYHGTIIHELMHAIGFYH ASTA_ASTFL 84 35 -
CVYDYIVQHELLHALGFHH O42326 166 34 -
CWRTGIVMHEIGHSIGIYH O62558 134 34 -
CMEYATIIHEMMHVVGFYH YPF4_CAEEL 185 34 -
CTSLGTVCHEIGHALGFYH Q21059 211 39 -
FFVMGVIEHEIGHALGLWH Q18206 216 40 -
CDYKAIIEHEILHALGFFH MEPA_RAT 148 33 -
CDSLGIVSHETLHALGLWH Q93243 196 33 -
CDFKATIEHEILHALGFFH MEPA_MOUSE 159 33 -
CAYKAIIEHEILHALGFYH MEPA_HUMAN 147 33 -
CLQYDTAIHELMHSVGFYH Q18439 105 34 -
CDVVGIISHEIGHALGIFH Q20942 224 34 -
CEEFGTAAHELGHALGFFH Q20975 216 33 -
CWGMGTAIHELMHAIGIEH Q20459 92 57 -
CEHFGVTSHELAHALGIFH Q20958 129 36 -
YNGRGTVMHELMHILGFYH Q21252 161 51 -
TDHTFVVAHEIAHTLGFYH O17264 178 36 -
GNGRGIAVHETMHALGVNH Q21388 406 40 -
CIDFGTAVHELMHALGVIH Q21179 160 33 -
CASFGTAVHEIMHALGIAH Q22396 55 34 -
CLIFGTAVHEIMHSLGLFH Q21178 163 33 -
CMRFGSAVHELMHALGVLH Q21180 167 33 -
TTYPAIIAHEIMHSMGIMH Q47899 181 33 -
CDTIGSIVHEFSHSLGRFH Q21181 213 41 -
CANIGSIVHEFSHSLGRYH Q93542 115 40 -

Motif 3 width=18
Element Seqn Id St Int Rpt
EHTRPDRDRHVSIVRENI BMP1_MOUSE 229 0 -
EHTRPDRDRHVSIVRENI BMP1_HUMAN 224 0 -
EHTRPDRDRHVSIVRENI Q99423 224 0 -
EHTRPDRDRHVSIVRENI Q99422 224 0 -
EHTRPDRDRHVSIVRENI Q13292 224 0 -
EHTRPDRDDHVSIIRENI O57381 214 0 -
EHTRPDRDDHVSIIRENI BMP1_XENLA 187 0 -
EHTRPDRDNHVTIIRENI Q62381 251 0 -
EHTRPDRDNHVTIIRENI O43897 251 0 -
EHTRPDRDEHVSIIRENI O57382 256 0 -
EHTRPDRDDNVSIIRENI Q91925 215 0 -
EHTRPDREKHVVIEHNNI Q23995 625 0 -
EHTRPDREKHVVIEHNNI Q24132 625 0 -
EHTRPDRDDHVTIIRDNI O57460 260 0 -
EHTRPDRNEFVGIVHQNI BMPH_STRPU 208 0 -
EQTRSDRDSYVRINWENI HCE1_ORYLA 180 0 -
EHARGDRDKHIVINKGNI TLD_DROME 232 0 -
EQTRSDRDSYVRINWENI O13116 176 0 -
EHTRSDRDQHVKINWENI LCE_ORYLA 183 0 -
EQTRSDRDSYVRINWQNI HCE2_ORYLA 189 0 -
EHNRPDRDKYVQIIRKNI P91972 315 0 -
EHSRSDRDKYVKIMWEYI ASTL_COTJA 95 0 -
EHSRSDRDTYVKIMWENI O44072 152 0 -
EQSRPDRDDYINVLYQNI BP10_PARLI 201 0 -
EQSRPDRDDYINVLYQNI Q26051 201 0 -
EQSRQDRDSYIDVVWQNV YPD6_CAEEL 217 0 -
EQSRADRDEYVKINWSNV Q21661 280 0 -
EQNRSDRDDYVIIHTENI UVS2_XENLA 197 0 -
EQSRPDRDQYVTVRWENI TOH2_CAEEL 233 0 -
EQSRPDRDEYINVHFENV SPAN_STRPU 201 0 -
EHSRTDRDDFVDINEDNI Q19269 235 0 -
EQSRADRDDYVIIVWDRI MEPB_MOUSE 164 0 -
EQSRSDRDDYVRIMWDRI MEPB_HUMAN 163 0 -
EQSRTDRDDHITIMWNNI YC92_CAEEL 266 0 -
EQSRADRDDYITIVWDRI MEPB_RAT 164 0 -
EHTRMDRDNYVTINYQNV ASTA_ASTFL 103 0 -
EQNRSDRDKHIKILFQNI O42326 185 0 -
EQSRPDRDSYVEIVWGNI O62558 153 0 -
EHERWDRDNFIDIIWQNI YPF4_CAEEL 204 0 -
EQARYDRDDYVSILTQNI Q21059 230 0 -
EQSRPDALGYVTIERDFI Q18206 235 0 -
EQSRTDRDDYVNIWWNEI MEPA_RAT 167 0 -
EQSRDDRDNFISIVADKI Q93243 215 0 -
EQSRTDRDDYVNIWWDQI MEPA_MOUSE 178 0 -
EQSRTDRDDYVNIWWDQI MEPA_HUMAN 166 0 -
EHERWDRDEHITILWHNI Q18439 124 0 -
EQARPDQERHIAINYNNI Q20942 243 0 -
TQSRYDRDNYISINYANI Q20975 235 0 -
TQSRSDRNRYLDILAQNI Q20459 111 0 -
EQSRFDRDESVVFNPRVV Q20958 148 0 -
EHQRDDRDRRIGGSASHY Q21252 180 0 -
EHARGDRDQFISIDYSNV O17264 197 0 -
QHLRMDRDKHIKVDWSNI Q21388 425 0 -
THSRLDRDNFLNINLTNV Q21179 179 0 -
GQARSDRDDYLIVDSTNS Q22396 74 0 -
THSRFDRDNFLSVSYKDV Q21178 182 0 -
THARFDRDNFLNVNLNKD Q21180 186 0 -
EQCRPDRDQYIIVDTNRA Q47899 200 0 -
EHTRPDRDNFMKVTTTVH Q21181 232 0 -
EHTRPDRDNSLKVTSTDY Q93542 134 0 -

Motif 4 width=16
Element Seqn Id St Int Rpt
TYDFDSIMHYARNTFS BMP1_MOUSE 268 21 -
TYDFDSIMHYARNTFS BMP1_HUMAN 263 21 -
TYDFDSIMHYARNTFS Q99423 263 21 -
TYDFDSIMHYARNTFS Q99422 263 21 -
TYDFDSIMHYARNTFS Q13292 263 21 -
TYDFDSIMHYARNTFS O57381 253 21 -
TYDFDSIMHYARNTFS BMP1_XENLA 226 21 -
RYDFDSIMHYARNTFS Q62381 290 21 -
RYDFDSIMHYARNTFS O43897 290 21 -
TYDFDSIMHYARNTFS O57382 295 21 -
TYDFDSIMHYARNTFS Q91925 254 21 -
AYDYDSIMHYARNTFS Q23995 664 21 -
AYDYDSIMHYARNTFS Q24132 664 21 -
PYDFDSIMHYARNTFS O57460 299 21 -
TYDFASIMHYARNTFS BMPH_STRPU 247 21 -
PYDYSSIMHYGRDAFS HCE1_ORYLA 216 18 -
PYDLNSIMHYAKNSFS TLD_DROME 271 21 -
PYDYSSIMHYGKDAFS O13116 212 18 -
PYDYGSIMHYGRTAFG LCE_ORYLA 219 18 -
PYDYSSIMHYGRDAFS HCE2_ORYLA 225 18 -
PYDYGSIMHYSRDKFS P91972 354 21 -
PYDYSSVMHYGPHTFT ASTL_COTJA 132 19 -
PYEYTSIMHYARYVYS O44072 188 18 -
EYDVGSIMHYGGYGFS BP10_PARLI 240 21 -
QYDVGSIMHYGGYGFS Q26051 240 21 -
PYDYASIMHYGPYAFS YPD6_CAEEL 256 21 -
KYDYGSVMHYAPTAFS Q21661 319 21 -
EYDYASVMHYSRYHYS UVS2_XENLA 233 18 -
PYDYGSIMHYRSKAFS TOH2_CAEEL 272 21 -
EYDVGSIMHYGGYGFS SPAN_STRPU 240 21 -
PYDYESVMHYHKLAFS Q19269 274 21 -
PYDYTSVMHYSKTAFQ MEPB_MOUSE 203 21 -
PYDYTSVMHYSKTAFQ MEPB_HUMAN 202 21 -
GYDYGSIMHYGTKAFS YC92_CAEEL 305 21 -
PYDYTSVMHYSKTAFQ MEPB_RAT 203 21 -
DYQYYSIMHYGKYSFS ASTA_ASTFL 140 19 -
PYDYNSVMHYSRFAFS O42326 221 18 -
PYDFRSMMHYSTTAIG O62558 192 21 -
PYDYKSILHYDSLAFS YPF4_CAEEL 243 21 -
GYDYGSVMHYDQAAFS Q21059 269 21 -
PYDLGSVMHYGSTAFS Q18206 273 20 -
PYDYESLMHYGPFSFN MEPA_RAT 206 21 -
PYDLGSVMHYGAKSFA Q93243 254 21 -
PYDYESLMHYGPFSFN MEPA_MOUSE 217 21 -
PYDYESLMHYQPFSFN MEPA_HUMAN 205 21 -
LYDYYSIMHYDSLAFS Q18439 163 21 -
PYDTGSVMHYGPYGFA Q20942 282 21 -
PYDYGSIMQYGATSAS Q20975 274 21 -
PYDYGSVMHYSADSFS Q20459 149 20 -
PYDIGSVMHYTPTEFS Q20958 187 21 -
GYDANSIMHYNFGSVP Q21252 212 14 -
AYEYGSVMHYSVDQFA O17264 236 21 -
KYAYDSIMHYNAYTGA Q21388 464 21 -
PYEYGSTMHYYANIST Q21179 215 18 -
PFDYGSVMLYARDPHS Q22396 103 11 -
PFEYGSTMLYRYNTFG Q21178 220 20 -
PYEYGSTLHYTADVSG Q21180 223 19 -
EFDFGSVMMYKSTDFA Q47899 236 18 -
PFEHGSVMMYHADTYG Q21181 264 14 -
PFEHGSIMMYHSSNYG Q93542 166 14 -

Motif 5 width=14
Element Seqn Id St Int Rpt
LSKGDIAQARKLYK BMP1_MOUSE 310 26 -
LSKGDIAQARKLYK BMP1_HUMAN 305 26 -
LSKGDIAQARKLYK Q99423 305 26 -
LSKGDIAQARKLYK Q99422 305 26 -
LSKGDIAQARKLYK Q13292 305 26 -
LSSGDIAQAKKLYR O57381 295 26 -
LSSGDVAQARKLYK BMP1_XENLA 268 26 -
LSKGDIAQARKLYR Q62381 332 26 -
LSKGDIAQARKLYR O43897 332 26 -
LSQGDIAQAKKLYK O57382 337 26 -
LSSGDVAQARKLYK Q91925 296 26 -
LSQGDIAQANLLYK Q23995 706 26 -
LSQGDIAQANLLYK Q24132 706 26 -
LSKGDISQAKKLYR O57460 341 26 -
LSEGDIIQANLLYK BMPH_STRPU 290 27 -
MSRWDITRINVLYN HCE1_ORYLA 255 23 -
LSRGDIVQANLLYK TLD_DROME 313 26 -
MSRWDITRINVLYN O13116 251 23 -
MSDIDILRVNKLYK LCE_ORYLA 257 22 -
MSRWDITRSNVLYN HCE2_ORYLA 264 23 -
LNDGDVRQTNKLYK P91972 397 27 -
LSNLDVAKINKLYN ASTL_COTJA 171 23 -
ISQYDIAKINKLYN O44072 226 22 -
LSPADIELANLIYE BP10_PARLI 279 23 -
LSPADIELANLIYE Q26051 279 23 -
FSDIDVRKINKLYN YPD6_CAEEL 294 22 -
FSENDIYKINMLYN Q21661 445 110 -
LSILDISKINKLYE UVS2_XENLA 271 22 -
LSFNDIRLMNKIYC TOH2_CAEEL 312 24 -
LSAADIELANRIYE SPAN_STRPU 279 23 -
LSEMDSKKVNKLYQ Q19269 311 21 -
FSDYDLLKLNQLYN MEPB_MOUSE 242 23 -
FSDSDLLKLNQLYN MEPB_HUMAN 241 23 -
FSKVDKFKINTLYG YC92_CAEEL 342 21 -
FSDYDLLKLNQLYS MEPB_RAT 242 23 -
MLQTDANQINNLYT ASTA_ASTFL 182 26 -
MSPNDILRINRLYC O42326 259 22 -
FSEIDIKQINLMYC O62558 230 22 -
FSDVDISKINRMYN YPF4_CAEEL 280 21 -
PSFADVKRINFAYC Q21059 308 23 -
LSFYDVATINTAYC Q18206 313 24 -
FSATDLTRLNRMYN MEPA_RAT 246 24 -
LSFKDAKMINTRYC Q93243 294 24 -
FSAIDLIRLNRMYN MEPA_MOUSE 257 24 -
FSAIDLERLNRMYN MEPA_HUMAN 245 24 -
FSPIDILKMNLMYQ Q18439 202 23 -
PSFLDYQAINMAYG Q20942 322 24 -
VGFYDISMMNEHYK Q20975 312 22 -
PNFYDFDQINQYYQ Q20459 188 23 -
PSFVDVHIMNQHYQ Q20958 227 24 -
FSPSDIRNINTLYK Q21252 234 6 -
ATFQDVSRMNVLYN O17264 276 24 -
MSNADVEILNKMYC Q21388 506 26 -
VTFYDMVILNTAYN Q21179 247 16 -
VAFYDMVLLNKFYG Q22396 137 18 -
VSFYDLVNINVRYS Q21178 255 19 -
VTFYDMLTINTAYN Q21180 258 19 -
LSAGDYAGINHLYG Q47899 274 22 -
VTFYDMYKINQYYG Q21181 299 19 -
VTFYDMYKINQYYG Q93542 201 19 -