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PR00453

Identifier
VWFADOMAIN  [View Relations]  [View Alignment]  
Accession
PR00453
No. of Motifs
3
Creation Date
01-FEB-1995  (UPDATE 22-JUN-1999)
Title
Von Willebrand factor type A domain signature
Database References

PFAM; PF00092 vwa
INTERPRO; IPR002035
PDB; 1LFA
Literature References
1. RUGGERI, Z.M. AND WARE, J.
von Willebrand factor.
FASEB J. 7 308-316 (1993).
 
2. COLOMBATTI, A., BONALDO, P. AND DOLIANA, R.
Type A modules: interacting domains found in several non-fibrillar 
collagens and in other extracellular matrix proteins.
MATRIX 13 297-306 (1993).
 
3. PERKINS, S.J., SMITH, K.F., WILLIAMS, S.C., HARIS, P.I., CHAPMAN, D.
AND SIM, R.B.
The secondary structure of the von Willebrand factor type A domain in 
factor B of human complement by Fourier transform infrared spectroscopy. 
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and
other proteins by averaged structure predictions.
J.MOL.BIOL. 238 104-119 (1994).
 
4. BORK, P. AND ROHDE, K.
More von Willebrand factor type A domains? Sequence similarities with 
malaria thrombospondin-related anonymous protein, dihydropyridine-
sensitive calcium channel and inter-alpha-trypsin inhibitor.
BIOCHEM.J. 279 908-910 (1991).
 
5. EDWARDS, Y.J.K. AND PERKINS, S.J. 
The protein fold of the von Willebrand factor type A domain is predicted 
to be similar to the open twisted beta-sheet flanked by alpha-helices 
found in human ras-p21.
FEBS LETT. 358 283-286 (1995).
 
6. LEE, J.O., RIEU, P., ARNAOUT, M.A. AND LIDDINGTON, R. 
Crystal structure of the A domain from the alpha subunit of integrin CR3 
CELL 80 631-638 (1995).
 
7. QU, A. AND LEAHY, D.J.
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, 
alpha L beta 2) integrin.
PROC.NATL.ACAD.SCI.U.S.A. 92 10277-10281 (1995).

Documentation
The von Willebrand factor is a large multimeric glycoprotein found in blood
plasma. Mutant forms are involved in the aetiology of bleeding disorders 
[1]. In von Willebrand factor, the type A domain (vWF) is the prototype for
a protein superfamily. The vWF domain is found in various plasma proteins:
complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen 
types VI, VII, XII and XIV; and other extracellular proteins [2-4]. Proteins
that incorporate vWF domains participate in numerous biological events
(e.g., cell adhesion, migration, homing, pattern formation, and signal
transduction), involving interaction with a large array of ligands [2]. 
 
Secondary structure prediction from 75 aligned vWF sequences has revealed
a largely alternating sequence of alpha-helices and beta-strands [3]. Fold
recognition algorithms were used to score sequence compatibility with a
library of known structures: the vWF domain fold was predicted to be a
doubly-wound, open, twisted beta-sheet flanked by alpha-helices [5]. 
 
3D structures have been determined for the I-domains of integrins CD11b
(with bound magnesium) [6] and CD11a (with bound manganese) [7]. The domain 
adopts a classic alpha/beta Rossmann fold and contains an unusual metal 
ion coordination site at its surface. It has been suggested that this site
represents a general metal ion-dependent adhesion site (MIDAS) for binding 
protein ligands [6]. The residues constituting the MIDAS motif in the CD11b
and CD11a I-domains are completely conserved, but the manner in which the 
metal ion is coordinated differs slightly [7]. 
 
VWFADOMAIN is a 3-element fingerprint that provides a signature for the vWF
domain superfamily. The fingerprint was derived from an initial alignment 
of 14 sequences. Motif 1 includes the first beta-strand and 3 conserved 
residues involved in metal ion coordination in I-domains (Asp and 2 serines
in positions 8, 10 and 12, respectively); motif 2 spans strands beta-2 and
beta-2'; and motif 3 encodes beta-strand 3 and a conserved Asp (in position
7), which coordinates the metal ion [6,7]. Three iterations on OWL27.0 were
required to reach convergence, at which point a true set comprising 56
sequences was identified. Numerous partial matches were also found.
 
An update on SPTR37_9f identified a true set of 52 sequences, and 11
partial matches.
Summary Information
  52 codes involving  3 elements
9 codes involving 2 elements
Composite Feature Index
3525252
2945
123
True Positives
CA16_CHICK    CA16_MOUSE    CA17_HUMAN    CA1C_CHICK    
CA1C_HUMAN CA1C_MOUSE CA1E_CHICK CA26_CHICK
CA26_MOUSE CA36_CHICK CA36_HUMAN CAMA_CHICK
CAMA_HUMAN CAMA_MOUSE CFAB_HUMAN CFAB_MOUSE
ITA1_HUMAN ITA1_RAT ITA2_HUMAN ITA2_MOUSE
ITAE_HUMAN ITAE_MOUSE ITAL_HUMAN ITAL_MOUSE
ITAM_HUMAN ITAM_MOUSE ITAX_HUMAN O08746
O35701 O42094 O42163 O42401
O43405 O43746 O43981 O45052
O75578 O88340 O88493 O89029
O89030 Q04588 Q09165 Q13910
Q14054 Q20732 Q21540 Q28311
Q63870 Q90583 VWF_CANFA VWF_HUMAN
True Positive Partials
Codes involving 2 elements
O01545 O76430 P79816 Q18048
Q31430 Q90422 Q91701 Q91900
YLS8_CAEEL
Sequence Titles
CA16_CHICK  COLLAGEN ALPHA 1(VI) CHAIN PRECURSOR - GALLUS GALLUS (CHICKEN). 
CA16_MOUSE COLLAGEN ALPHA 1(VI) CHAIN PRECURSOR - MUS MUSCULUS (MOUSE).
CA17_HUMAN COLLAGEN ALPHA 1(VII) CHAIN PRECURSOR (LONG-CHAIN COLLAGEN) (LC COLLAGEN) - HOMO SAPIENS (HUMAN).
CA1C_CHICK COLLAGEN ALPHA 1(XII) CHAIN PRECURSOR (FIBROCHIMERIN) - GALLUS GALLUS (CHICKEN).
CA1C_HUMAN COLLAGEN ALPHA 1(XII) CHAIN PRECURSOR - HOMO SAPIENS (HUMAN).
CA1C_MOUSE COLLAGEN ALPHA 1(XII) CHAIN PRECURSOR - MUS MUSCULUS (MOUSE).
CA1E_CHICK COLLAGEN ALPHA 1(XIV) CHAIN PRECURSOR (UNDULIN) - GALLUS GALLUS (CHICKEN).
CA26_CHICK COLLAGEN ALPHA 2(VI) CHAIN PRECURSOR - GALLUS GALLUS (CHICKEN).
CA26_MOUSE COLLAGEN ALPHA 2(VI) CHAIN PRECURSOR - MUS MUSCULUS (MOUSE).
CA36_CHICK COLLAGEN ALPHA 3(VI) CHAIN PRECURSOR - GALLUS GALLUS (CHICKEN).
CA36_HUMAN COLLAGEN ALPHA 3(VI) CHAIN PRECURSOR - HOMO SAPIENS (HUMAN).
CAMA_CHICK CARTILAGE MATRIX PROTEIN PRECURSOR (MATRILIN-1) - GALLUS GALLUS (CHICKEN).
CAMA_HUMAN CARTILAGE MATRIX PROTEIN PRECURSOR (MATRILIN-1) - HOMO SAPIENS (HUMAN).
CAMA_MOUSE CARTILAGE MATRIX PROTEIN PRECURSOR (MATRILIN-1) - MUS MUSCULUS (MOUSE).
CFAB_HUMAN COMPLEMENT FACTOR B PRECURSOR (EC 3.4.21.47) (C3/C5 CONVERTASE) (PROPERDIN FACTOR B) (GLYCINE-RICH BETA GLYCOPROTEIN) (GBG) (PBF2) - HOMO SAPIENS (HUMAN).
CFAB_MOUSE COMPLEMENT FACTOR B PRECURSOR (EC 3.4.21.47) (C3/C5 CONVERTASE) - MUS MUSCULUS (MOUSE).
ITA1_HUMAN INTEGRIN ALPHA-1 (LAMININ AND COLLAGEN RECEPTOR) (VLA-1) (CD49A) - HOMO SAPIENS
ITA1_RAT INTEGRIN ALPHA-1 PRECURSOR (LAMININ AND COLLAGEN RECEPTOR) (VLA-1) (CD49A) - RAT
ITA2_HUMAN PLATELET MEMBRANE GLYCOPROTEIN IA PRECURSOR (GPIA) (COLLAGEN RECEPTOR) (INTEGRIN
ITA2_MOUSE PLATELET MEMBRANE GLYCOPROTEIN IA PRECURSOR (GPIA) (COLLAGEN RECEPTOR) (INTEGRIN
ITAE_HUMAN INTEGRIN ALPHA-E PRECURSOR (MUCOSAL LYMPHOCYTE-1 ANTIGEN) (HML-1 ANTIGEN) (CD103
ITAE_MOUSE INTEGRIN ALPHA-E PRECURSOR (INTEGRIN ALPHA M290) - MUS MUSCULUS (MOUSE).
ITAL_HUMAN LEUKOCYTE ADHESION GLYCOPROTEIN LFA-1 ALPHA CHAIN PRECURSOR (LEUKOCYTE FUNCTION
ITAL_MOUSE LEUKOCYTE ADHESION GLYCOPROTEIN LFA-1 ALPHA CHAIN PRECURSOR (LEUKOCYTE FUNCTION
ITAM_HUMAN CELL SURFACE GLYCOPROTEIN MAC-1 ALPHA SUBUNIT PRECURSOR (CR-3 ALPHA CHAIN) (CD11
ITAM_MOUSE CELL SURFACE GLYCOPROTEIN MAC-1 ALPHA SUBUNIT PRECURSOR (CR-3 ALPHA CHAIN) (CD11
ITAX_HUMAN LEUKOCYTE ADHESION GLYCOPROTEIN P150,95 ALPHA CHAIN PRECURSOR (LEUKOCYTE ADHESIO
O08746 MATRILIN-2 - MUS MUSCULUS (MOUSE).
O35701 MATRILIN-3 PRECURSOR - MUS MUSCULUS (MOUSE).
O42094 ALPHA1 INTEGRIN - GALLUS GALLUS (CHICKEN).
O42163 COCH-5B2 - GALLUS GALLUS (CHICKEN).
O42401 MATRILIN-3 PRECURSOR - GALLUS GALLUS (CHICKEN).
O43405 COCH-5B2 - HOMO SAPIENS (HUMAN).
O43746 CELL SURFACE GLYCOPROTEIN CD11A PRECURSOR - HOMO SAPIENS (HUMAN).
O43981 MICRONEME PROTEIN PRECURSOR ETMIC-1 - Eimeria tenella.
O45052 C05G6.3 PROTEIN - CAENORHABDITIS ELEGANS.
O75578 INTEGRIN SUBUNIT ALPHA 10 PRECURSOR - HOMO SAPIENS (HUMAN).
O88340 INTEGRIN ALPHA E1 - RATTUS NORVEGICUS (RAT).
O88493 TYPE VI COLLAGEN ALPHA 3 SUBUNIT - MUS MUSCULUS (MOUSE).
O89029 MATRILIN-4 PRECURSOR - MUS MUSCULUS (MOUSE).
O89030 MATRILIN-4 PRECURSOR, ALTERNATE SPLICE PRODUCT - MUS MUSCULUS (MOUSE).
Q04588 MICRONEME PROTEIN ETP100 - Eimeria maxima.
Q09165 HYPOTHETICAL 1368.6 KD PROTEIN K07E12.1 IN CHROMOSOME III - CAENORHABDITIS ELEGANS.
Q13910 ALPHA-2 COLLAGEN TYPE VI-A - HOMO SAPIENS (HUMAN).
Q14054 COLLAGEN TYPE VII PRECURSOR - HOMO SAPIENS (HUMAN).
Q20732 HYPOTHETICAL PROTEIN C29A12.6 - CAENORHABDITIS ELEGANS.
Q21540 M142.2 PROTEIN - CAENORHABDITIS ELEGANS.
Q28311 VON WILLEBRAND FACTOR - CANIS FAMILIARIS (DOG).
Q63870 TYPE VII COLLAGEN - MUS MUSCULUS (MOUSE).
Q90583 TYPE VI COLLAGEN SUBUNIT ALPHA2 - GALLUS GALLUS (CHICKEN).
VWF_CANFA VON WILLEBRAND FACTOR PRECURSOR - CANIS FAMILIARIS (DOG).
VWF_HUMAN VON WILLEBRAND FACTOR PRECURSOR - HOMO SAPIENS (HUMAN).

O01545 SIMILAR TO PFAM FAMILY VWA - CAENORHABDITIS ELEGANS.
O76430 C24B9.3 PROTEIN - CAENORHABDITIS ELEGANS.
P79816 BF/C2 PROTEIN - ORYZIAS LATIPES (MEDAKA FISH).
Q18048 SIMILARITY TO COLLAGEN CHAIN ALPHA - CAENORHABDITIS ELEGANS.
Q31430 COMPLEMENT FACTOR B - LAMPETRA JAPONICA (JAPANESE LAMPREY).
Q90422 COMPLEMENT FACTOR B PRECURSOR - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
Q91701 XENOPUS BF B - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q91900 COMPLEMENT FACTOR B - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
YLS8_CAEEL HYPOTHETICAL 83.6 KD PROTEIN F09G8.8 IN CHROMOSOME III - CAENORHABDITIS ELEGANS.
Scan History
OWL27_0    3  200  NSINGLE    
SPTR37_9f 3 400 NSINGLE
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
TDLVFVVDSSRSVRPVEF CAMA_HUMAN 40 40 -
TDLVFLIDGSKSVRPENF CAMA_HUMAN 274 274 -
ISVYFVIDTSESIALQTV CA26_CHICK 45 45 -
LDIMFVIDSSESIGYTNF CA26_CHICK 614 614 -
VDIVFLLDGSERIGEQNF CA26_CHICK 832 832 -
LDIVIVLDGSNSIYPWES ITA1_RAT 171 171 -
VDLVFLFDGSMSLQPDEF ITAL_HUMAN 155 155 -
SDIVFLIDGSGSINNIDF ITAM_MOUSE 149 149 -
IDVVVVCDESNSIYPWDA ITA2_HUMAN 173 173 -
LDLVFLLDGSSRLSEAEF VWF_HUMAN 1276 1276 -
LDVAFVLEGSDKIGEADF VWF_HUMAN 1497 1497 -
LDVILLLDGSSSFPASYF VWF_HUMAN 1690 1690 -
MNIYLVLDGSDSIGASNF CFAB_HUMAN 269 269 -
MNIYLVLDGSDSIGSSNF CFAB_MOUSE 266 266 -

Motif 2 width=15
Element Seqn Id St Int Rpt
RVGMVNYASTVKQEF CAMA_HUMAN 79 21 -
QVGLVQYSSSVRQEF CAMA_HUMAN 313 21 -
MFGGLHYSDVVEIYS CA26_CHICK 96 33 -
RVGVVQYSHEGTFEA CA26_CHICK 659 27 -
RIALLQYGSEREQNV CA26_CHICK 876 26 -
QVGIVQYGENVTHEF ITA1_RAT 208 19 -
QFAAVQFSTSYKTEF ITAL_HUMAN 192 19 -
LFSLMQYSDEFRIHF ITAM_MOUSE 186 19 -
QVGLIQYANNPRVVF ITA2_HUMAN 210 19 -
RVAVVEYHDGSHAYI VWF_HUMAN 1315 21 -
HVTVLQYSYMVTVEY VWF_HUMAN 1536 21 -
QVSVLQYGSITTIDV VWF_HUMAN 1729 21 -
RYGLVTYATYPKIWV CFAB_HUMAN 308 21 -
RYGLLTYATVPKVLV CFAB_MOUSE 305 21 -

Motif 3 width=9
Element Seqn Id St Int Rpt
VVIVVTDGR CAMA_HUMAN 148 54 -
VGIVFTDGR CAMA_HUMAN 379 51 -
FAVVITDGH CA26_CHICK 156 45 -
FAVVITDGR CA26_CHICK 726 52 -
SFVFITDGI CA26_CHICK 946 55 -
VMVIVTDGE ITA1_RAT 275 52 -
VLIIITDGE ITAL_HUMAN 258 51 -
ILVVITDGE ITAM_MOUSE 252 51 -
VMVVVTDGE ITA2_HUMAN 277 52 -
ALLLMASQE VWF_HUMAN 1381 51 -
LVYMVTGNP VWF_HUMAN 1603 52 -
VVILVTDVS VWF_HUMAN 1796 52 -
VIILMTDGL CFAB_HUMAN 383 60 -
VIIIMTDGL CFAB_MOUSE 380 60 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
LDLVFLIDGSKSVRPENF CAMA_CHICK 271 271 -
ADIVFLVDGSYSIGIANF CA1C_HUMAN 439 439 -
TDLVFVVDSSRSVRPVEF CAMA_HUMAN 40 40 -
TDLVFLIDGSKSVRPENF CAMA_HUMAN 274 274 -
ADVVFLVDGSYSIGIANF CA1C_CHICK 438 438 -
TDLVFLIDGSKSVRPENF CAMA_MOUSE 278 278 -
IDLVFVIDGSKSLGEENF O08746 654 654 -
ADIVFLVDGSYSIGTANF CA1C_MOUSE 443 443 -
ADLVFLVDGSWSIGDDNF CA1E_CHICK 1041 1041 -
ADIVFLLDGSSSIGRSNF CA17_HUMAN 37 37 -
ADIVFLLDGSSSIGRSNF Q14054 37 37 -
ADIVFLLDGSSSIGRSNF Q63870 38 38 -
VDLVLLVDGSKSVRPQNF O89030 197 197 -
VDLVLLVDGSKSVRPQNF O89029 387 387 -
VDLLFVLDSSESIGLQNF CA16_CHICK 612 612 -
RDIVFLVDGSSSLGPSNF O88493 36 36 -
LDVVFVIDSSESIGYTNF CA26_MOUSE 624 624 -
LDVVFVIDSSESIGYTNF Q13910 24 24 -
ISVYFVIDTSESIALQTV CA26_CHICK 45 45 -
LDIMFVIDSSESIGYTNF CA26_CHICK 614 614 -
VDIVFLLDGSERIGEQNF CA26_CHICK 832 832 -
LDIMFVIDSSESIGYTNF Q90583 614 614 -
RDIVFLVDGSSALGLANF CA36_HUMAN 444 444 -
LDIVIVLDGSNSIYPWES ITA1_RAT 171 171 -
LDIVIVLDGSNSIYPWDS ITA1_HUMAN 143 143 -
ADLIFLIDGSDNIGSVNF CA36_CHICK 240 240 -
LDIVIVLDGSNSIYPWES O42094 161 161 -
VDLVFLFDGSMSLQPDEF O43746 155 155 -
VDLVFLFDGSMSLQPDEF ITAL_HUMAN 155 155 -
VDLVFLFDGSQSLDRKDF ITAL_MOUSE 152 152 -
LDLVFIIDSSRSVRPLEF O35701 77 77 -
TEIAIVLDGSGSIGPSDF ITAE_MOUSE 194 194 -
ADIAFLIDGSFNIGQRRF O43405 164 164 -
MDVVIVLDGSNSIYPWSE O75578 166 166 -
SDIVFLIDGSGSINNIDF ITAM_MOUSE 149 149 -
TEIAIVLDGSGSIEPSDF O88340 194 194 -
LDLVFIIDSSRSVRPEEF O42401 53 53 -
IDVVVVCDESNSIYPWDA ITA2_HUMAN 173 173 -
SDIAFLIDGSGSIIPHDF ITAM_HUMAN 149 149 -
VDVVVVCDESNSIYPWEA ITA2_MOUSE 170 170 -
ADIAFLIDGSYNIGQRRF O42163 161 161 -
QDIVFLIDGSGSISSRNF ITAX_HUMAN 150 150 -
TEIAIILDGSGSIDPPDF ITAE_HUMAN 200 200 -
IDILFVLDSSESIGLQNF CA16_MOUSE 613 613 -
VEVILLLDASGSIGDDTF Q21540 46 46 -
LDLVFLLDGSSKLSEDEF VWF_CANFA 1276 1276 -
LDLVFLLDGSSKLSEDEF Q28311 1276 1276 -
LDLVFLLDGSSRLSEAEF VWF_HUMAN 1276 1276 -
LDVAFVLEGSDKIGEADF VWF_HUMAN 1497 1497 -
LDVILLLDGSSSFPASYF VWF_HUMAN 1690 1690 -
MNIYLVLDGSDSIGASNF CFAB_HUMAN 269 269 -
ADVFFLVDVSQGTGDKSQ Q20732 142 142 -
MNIYLVLDGSDSIGSSNF CFAB_MOUSE 266 266 -
LDLVLVLDFSTTTDPVYN O45052 113 113 -
LDVMLVVDESGSIGTSNY Q04588 46 46 -
LDVMLVVDESGSIGTSNF O43981 49 49 -
IDLLLVIDSSNNIKVLDY Q09165 12121 12121 -

Motif 2 width=15
Element Seqn Id St Int Rpt
QVGLVQYSSSVRQEF CAMA_CHICK 310 21 -
QVSFVQYSDEVKSEF CA1C_HUMAN 2362 1905 -
RVGMVNYASTVKQEF CAMA_HUMAN 79 21 -
QVGLVQYSSSVRQEF CAMA_HUMAN 313 21 -
QVSLVQYSDEAQSEF CA1C_CHICK 2366 1910 -
QVGLVQYSSSIRQEF CAMA_MOUSE 317 21 -
RVGLLQYSTQVRTEF O08746 693 21 -
QVSFVQYSDEVKSEF CA1C_MOUSE 2368 1907 -
QVAIIQFSDDPRTEF CA1E_CHICK 1081 22 -
RFATVQYSDDPRTEF CA17_HUMAN 78 23 -
RFATVQYSDDPRTEF Q14054 78 23 -
RFATVQYSDDPQTEF Q63870 79 23 -
RVGLVQFSSRVRTEF O89030 236 21 -
RVGLVQFSSRVRTEF O89029 426 21 -
RVGVVQYSHNNTQEL CA16_CHICK 657 27 -
RVGLVQYNSDPTDEF O88493 1067 1013 -
RVGVVQYSHEGTFEA CA26_MOUSE 669 27 -
RVGVVQYSHEGTFEA Q13910 69 27 -
MFGGLHYSDVVEIYS CA26_CHICK 96 33 -
RVGVVQYSHEGTFEA CA26_CHICK 659 27 -
RIALLQYGSEREQNV CA26_CHICK 876 26 -
RVGVVQYSHEGTFEA Q90583 659 27 -
RVGLVQFSDTPVTEF CA36_HUMAN 677 215 -
QVGIVQYGENVTHEF ITA1_RAT 208 19 -
QVGIVQYGENVTHEF ITA1_HUMAN 180 19 -
RVGLVQFSDTPKTEF CA36_CHICK 682 424 -
QVGIVQYGQTVVHEF O42094 198 19 -
QFAAVQFSTSYKTEF O43746 192 19 -
QFAAVQFSTSYKTEF ITAL_HUMAN 192 19 -
QFAAVQFSTDCRTEF ITAL_MOUSE 189 19 -
RVAVVNYASTVKIEF O35701 116 21 -
NFALVQYGAVIQTEF ITAE_MOUSE 233 21 -
HVGLVQASEHPKIEF O43405 203 21 -
QVGLVQYGESPVHEW O75578 203 19 -
LFSLMQYSDEFRIHF ITAM_MOUSE 186 19 -
NFALVQYGAVIQTEF O88340 233 21 -
RVAVMNYASTVKVEF O42401 92 21 -
QVGLIQYANNPRVVF ITA2_HUMAN 210 19 -
LFSLMQYSEEFRIHF ITAM_HUMAN 186 19 -
QVALIQYANEPRIIF ITA2_MOUSE 207 19 -
HVGVVQASEHPKIEF O42163 200 21 -
QFSLMQFSNKFQTHF ITAX_HUMAN 187 19 -
NFALVQYGGVIQTEF ITAE_HUMAN 239 21 -
HAGVVQYSHNQMQEH CA16_MOUSE 658 27 -
HMALIQYAETPKLEF Q21540 85 21 -
HVTVLQYSYMVTVEY VWF_CANFA 1536 242 -
HVTVLQYSYMVTVEY Q28311 1536 242 -
RVAVVEYHDGSHAYI VWF_HUMAN 1315 21 -
HVTVLQYSYMVTVEY VWF_HUMAN 1536 21 -
QVSVLQYGSITTIDV VWF_HUMAN 1729 21 -
RYGLVTYATYPKIWV CFAB_HUMAN 308 21 -
RVGLISYSGPGRTHV Q20732 180 20 -
RYGLLTYATVPKVLV CFAB_MOUSE 305 21 -
QVAAVTFATVGRTRV O45052 151 20 -
RVGLVTFGTSAVTRW Q04588 85 21 -
RVGLITFATRSKVRW O43981 88 21 -
RVGLVKYGDGAEIPV Q09165 12161 22 -

Motif 3 width=9
Element Seqn Id St Int Rpt
VGIVFTDGR CAMA_CHICK 376 51 -
VLVVVTDGR CA1C_HUMAN 2428 51 -
VVIVVTDGR CAMA_HUMAN 148 54 -
VGIVFTDGR CAMA_HUMAN 379 51 -
VLVVVTDGR CA1C_CHICK 2432 51 -
VGIVFTDGR CAMA_MOUSE 383 51 -
VAIVFTDGR O08746 762 54 -
VLGVVTDGR CA1C_MOUSE 2433 50 -
VLVVITDGR CA1E_CHICK 1147 51 -
VCILITDGK CA17_HUMAN 143 50 -
VCILITDGK Q14054 143 50 -
VCILITDGK Q63870 144 50 -
VGLVFTDGR O89030 305 54 -
VGLVFTDGR O89029 495 54 -
VAIVITDGR CA16_CHICK 722 50 -
VVIHFTDGA O88493 1337 255 -
FAVVITDGR CA26_MOUSE 736 52 -
FAVVITDGR Q13910 136 52 -
FAVVITDGH CA26_CHICK 156 45 -
FAVVITDGR CA26_CHICK 726 52 -
SFVFITDGI CA26_CHICK 946 55 -
FAVVITDGR Q90583 726 52 -
VVIHFTDGA CA36_HUMAN 1947 1255 -
VMVIVTDGE ITA1_RAT 275 52 -
VMVIVTDGE ITA1_HUMAN 247 52 -
VLVLVTAGR CA36_CHICK 751 54 -
VMVIVTDGE O42094 265 52 -
VLIIITDGE O43746 258 51 -
VLIIITDGE ITAL_HUMAN 258 51 -
VLVIITDGE ITAL_MOUSE 256 52 -
VAIIVTDGR O35701 185 54 -
VMVVLTDGD ITAE_MOUSE 299 51 -
FLVIVTDGQ O43405 469 251 -
LLVVVTDGE O75578 270 52 -
ILVVITDGE ITAM_MOUSE 252 51 -
VMVVLTDGD O88340 299 51 -
VVIIVTDGR O42401 161 54 -
VMVVVTDGE ITA2_HUMAN 277 52 -
ILVVITDGE ITAM_HUMAN 252 51 -
VMVVVTDGE ITA2_MOUSE 274 52 -
FLVILTDGQ O42163 466 251 -
ILIVITDGK ITAX_HUMAN 253 51 -
VMVVLTDGG ITAE_HUMAN 305 51 -
IALVITDGR CA16_MOUSE 722 49 -
VAIVITDGQ Q21540 148 48 -
VVILVTDVS VWF_CANFA 1796 245 -
VVILVTDVS Q28311 1796 245 -
ALLLMASQE VWF_HUMAN 1381 51 -
LVYMVTGNP VWF_HUMAN 1603 52 -
VVILVTDVS VWF_HUMAN 1796 52 -
VIILMTDGL CFAB_HUMAN 383 60 -
VLVVFTDGY Q20732 248 53 -
VIIIMTDGL CFAB_MOUSE 380 60 -
VMVVFTDGW O45052 219 53 -
MILVMTDGA Q04588 153 53 -
LVLVMTDGA O43981 156 53 -
VVILITNGK Q09165 12437 261 -