Identifier | REVINTRACTNG  [View Relations]  [View Alignment]  
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Accession | PR00405 |
No. of Motifs | 3 |
Creation Date | 14-DEC-1995  (UPDATE 29-JUL-1999) |
Title | HIV Rev interacting protein signature |
Database References | INTERPRO; IPR001164
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Literature References | 1. FRITZ, C.C., ZAPP, M.L. AND GREEN, M.R.
A human nucleoporin-like protein that specifically interacts with HIV Rev.
NATURE 376 530-533 (1995).
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Documentation | The Rev protein of human immunodeficiency virus type 1 (HIV-1) facilitates
nuclear export of unspliced and partly-spliced viral RNAs [1]. Rev contains
an RNA-binding domain and an effector domain; the latter is believed to
interact with a cellular cofactor required for the Rev response and hence
HIV-1 replication [1]. Human Rev interacting protein (hRIP) specifically
interacts with the Rev effector. The amino acid sequence of hRIP is
characterised by an N-terminal, C-4 class zinc finger motif.
REVINTRACTNG is a 3-element fingerprint that provides a signature for the
hRIP family of zinc finger proteins. The fingerprint was derived from an
initial alignment of 7 sequences: the motifs span the full zinc finger
domain. Two iterations on OWL26.3 were required to reach convergence, at
which point a true set comprising 12 sequences was identified. Three
partial matches were also found, all of which match motif 2, but fail to
make significant matches with either motifs 1 or 3.
An update on SPTR37_9f identified a true set of 29 sequences, and 1
partial match.
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Summary Information | 29 codes involving 3 elements 1 codes involving 2 elements
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Composite Feature Index | |
True Positives | GCS1_YEAST GLO3_YEAST GTS1_YEAST NUPL_HUMAN O02753 O02780 O04097 O18181 O18358 O43150 O49557 O49688 O64666 O74345 O77092 O80925 O82171 O82484 O88768 P90904 Q62848 Q63629 SP18_YEAST Y050_HUMAN Y148_HUMAN Y167_HUMAN YDBH_SCHPO YIE4_YEAST YQP4_CAEEL |
True Positive Partials | |
Sequence Titles | GCS1_YEAST ZINC FINGER PROTEIN GCS1 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). GLO3_YEAST ZINC FINGER PROTEIN GLO3 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). GTS1_YEAST GTS1 PROTEIN (LSR1 PROTEIN) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). NUPL_HUMAN NUCLEOPORIN-LIKE PROTEIN RIP (REV INTERACTING PROTEIN) (REV/REX ACTIVATION DOMAIN-BINDING PROTEIN) - HOMO SAPIENS (HUMAN). O02753 PHOSPHATIDYLINOSITOL-3,4,5-TRIPHOSPHATE BINDING PROTEIN (PTDINS(3,4,5)P3-BINDING PROTEIN) - BOS TAURUS (BOVINE). O02780 INOSITOL(1,3,4,5)TETRAKISPHOSPHATE RECEPTOR - SUS SCROFA (PIG). O04097 BRCA1-ASSOCIATED RING DOMAIN PROTEINISOLOG - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O18181 W09D10.1 PROTEIN - CAENORHABDITIS ELEGANS. O18358 PUTATIVE ARF1 GTPASE ACTIVATING PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY). O43150 KIAA0400 - HOMO SAPIENS (HUMAN). O49557 HYPOTHETICAL 41.0 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O49688 HYPOTHETICAL 120.4 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O64666 F22O13.17 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O74345 PUTATIVE TRANSCRIPTION FACTOR OF THE GCS1-GLO3-SPS18 FAMILY - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). O77092 ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN - PLASMODIUM BERGHEI YOELII. O80925 PUTATIVE ARF1 GTPASE ACTIVATING PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O82171 T4C15.12 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O82484 T12H20.8 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O88768 IP4/PIP3 BINDING PROTEIN - RATTUS NORVEGICUS (RAT). P90904 K02B12.7 PROTEIN - CAENORHABDITIS ELEGANS. Q62848 ADP-RIBOSYLATION FACTOR 1-DIRECTED GTPASE ACTIVATING PROTEIN - RATTUS NORVEGICUS (RAT). Q63629 CENTAURIN ALPHA - RATTUS NORVEGICUS (RAT). SP18_YEAST SPORULATION PROTEIN SPS18 (SPORULATION-SPECIFIC PROTEIN SPX18) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). Y050_HUMAN HYPOTHETICAL PROTEIN KIAA0050 - HOMO SAPIENS (HUMAN). Y148_HUMAN HYPOTHETICAL PROTEIN KIAA0148 - HOMO SAPIENS (HUMAN). Y167_HUMAN HYPOTHETICAL PROTEIN KIAA0167 - HOMO SAPIENS (HUMAN). YDBH_SCHPO HYPOTHETICAL 53.0 KD PROTEIN C22E12.17C IN CHROMOSOME I - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). YIE4_YEAST HYPOTHETICAL 32.6 KD PROTEIN IN MET30-PIG2 INTERGENIC REGION - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). YQP4_CAEEL HYPOTHETICAL 127.4 KD PROTEIN F07F6.4 IN CHROMOSOME III - CAENORHABDITIS ELEGANS. YAUA_SCHPO HYPOTHETICAL 104.5 KD PROTEIN C26A3.10 IN CHROMOSOME I - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
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Scan History | OWL26_3 2 200 NSINGLE SPTR37_9f 4 100 NSINGLE
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Initial Motifs | Motif 1 width=20 Element Seqn Id St Int Rpt NRVCFDCGNKNPTWTSVPFG GLO3_YEAST 28 28 - NKKCMDCGAPNPQWATPKFG GCS1_YEAST 23 23 - NNNCFECKSVNPQFVSCSFG SX18_YEAST 25 25 - NRKCFDCDQRGPTYVNMTVG HSRNANLP 26 26 - NRKCFDCDQRGPTYVNMTVG HUMRABCCF 26 26 - NASCCDCGLADPRWASINLG HUMORFV 265 265 - NAQCCDCREPAPEWASINLG HUMORFKG1K 417 417 - Motif 2 width=18 Element Seqn Id St Int Rpt GSFVCTSCSGSLRGLNPP HUMRABCCF 45 -1 - GAFICLECAGIHRGLGVH GCS1_YEAST 42 -1 - GVMLCIQCSAVHRNMGVH GLO3_YEAST 47 -1 - GSFVCTSCSGSLRGLNPP HSRNANLP 45 -1 - GIFICVNCANLLRGMGTN SX18_YEAST 44 -1 - GITLCIECSGIHRSLGVH HUMORFV 284 -1 - GVTLCIQCSGIHRSLGVH HUMORFKG1K 436 -1 - Motif 3 width=22 Element Seqn Id St Int Rpt VKSSTLDKWTINNLRRFKLGGN GLO3_YEAST 68 3 - VKSITMDNFEEKDVRRVEKSGN SX18_YEAST 65 3 - VKSISMTTFTQQEIEFLQKHGN HSRNANLP 65 2 - VKSISMTTFTQQEIEFLQKHGN HUMRABCCF 65 2 - VRSLTLDTWEPELLKLMCELGN HUMORFV 305 3 - VRSLTLDSWEPELVKLMCELGN HUMORFKG1K 457 3 - VRSITMDQFKPEELLRMEKGGN GCS1_YEAST 63 3 -
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Final Motifs | Motif 1 width=20 Element Seqn Id St Int Rpt NNVCFECGAFNPQWVSVTYG Q62848 19 19 - NKVCFDCSAKNPTWASVTYG O49688 25 25 - NKICFDCNAKNPTWASVTYG O82171 22 22 - NSKCFECGTHNPQWVSVTYG O18358 19 19 - NNFCFECEANNPQWVSVSYG P90904 19 19 - NKVCVDCSQKNPQWASISYG O80925 16 16 - NNKCFDCGIPNPDWVSVNHG O77092 19 19 - NARCADCGAPDPDWASYTLG O02753 18 18 - NSRCADCGAPDPDWASYTLG Q63629 18 18 - NSRCADCGAPDPDWASYTLG O88768 18 18 - NAHCADCGAPDPDWASYTLG O02780 18 18 - NKYCADCQAKTPRWAAWNLG O18181 29 29 - NKKCMDCGAPNPQWATPKFG GCS1_YEAST 23 23 - NAQCCDCREPAPEWASINLG Y050_HUMAN 417 417 - NSICVDCGAPNPTWASLNLG Y167_HUMAN 587 587 - NKVCFDCGAKNPTWSSTTFG YDBH_SCHPO 21 21 - NRVCFDCGNKNPTWTSVPFG GLO3_YEAST 28 28 - NNLCADCSTRGVQWASWNLG O74345 20 20 - NDVCCDCGAPDPTWLSTNLG O43150 433 433 - NRVCADCGAPDPKWALIECY O49557 27 27 - NKLCFDCGARNPTWCTVTYG YQP4_CAEEL 25 25 - NNACAECNAPEPDWASLNLG O04097 235 235 - SHCADCKAQLHPRWASWSLG YIE4_YEAST 21 21 - SEVCADCSGPDPSWASVNRG Y148_HUMAN 8 8 - ANKCGECGNFYPTWCSVNLG GTS1_YEAST 27 27 - NNNCFECKSVNPQFVSCSFG SP18_YEAST 25 25 - NRKCFDCDQRGPTYVNMTVG NUPL_HUMAN 26 26 - NRRCINCNSLGPQYVCTTFW O64666 24 24 - VRSCFQYCALYPEDYSIKKY O82484 405 405 - Motif 2 width=18 Element Seqn Id St Int Rpt GIWICLECSGRHRGLGVH Q62848 38 -1 - GIFLCIDCSATHRNLGVH O49688 44 -1 - GIFLCIDCSAVHRSLGVH O82171 41 -1 - GIWICLECSGKHRSLGVH O18358 38 -1 - GIWICLECSGIHRSLGVH P90904 38 -1 - GIFMCLECSGKHRGLGVH O80925 35 -1 - GIFLCINCSGVHRSLGVH O77092 38 -1 - GVFICLSCSGIHRNIPHV O02753 37 -1 - GVFICLSCSGIHRNIPQV Q63629 37 -1 - GVFICLSCSGIHRNIPQV O88768 37 -1 - GVFICLSCSGIHRNIPQV O02780 37 -1 - GVFICIRCAGIHRNLGVH O18181 48 -1 - GAFICLECAGIHRGLGVH GCS1_YEAST 42 -1 - GVTLCIQCSGIHRSLGVH Y050_HUMAN 436 -1 - GALICIECSGIHRNLGTH Y167_HUMAN 606 -1 - GIYLCLDCSAAHRNMGVH YDBH_SCHPO 40 -1 - GVMLCIQCSAVHRNMGVH GLO3_YEAST 47 -1 - GIFLCLRCATIHRKLGTH O74345 39 -1 - GILTCIECSGIHRELGVH O43150 452 -1 - GVFICLKCCGVHRSLGSH O49557 78 31 - GVFLCIDCSAVHRNLGVH YQP4_CAEEL 44 -1 - GVLLCIQCSGVHRNLGVH O04097 254 -1 - GVFICIKCAGIHRSLGTH YIE4_YEAST 40 -1 - GTFLCDECCSVHRSLGRH Y148_HUMAN 27 -1 - GVFLCGRCASVHRKVFGS GTS1_YEAST 46 -1 - GIFICVNCANLLRGMGTN SP18_YEAST 44 -1 - GSFVCTSCSGSLRGLNPP NUPL_HUMAN 45 -1 - WTFVCMACSGIHREFTHR O64666 43 -1 - GSIAGISKLSSLRTLGLR O82484 622 197 - Motif 3 width=22 Element Seqn Id St Int Rpt VRSVTMDKWKDIELEKMKAGGN Q62848 59 3 - VRSTNLDSWSPEQLRTMMFGGN O49688 65 3 - VRSTNLDSWSSEQLKMMIYGGN O82171 62 3 - VRSVTMDKWKDIELEKMKAGGN O18358 59 3 - VRSVTMDKWKDIELAKMKAGGN P90904 59 3 - VRSVTMDSWSEIQIKKMDAGGN O80925 56 3 - VRSIKMDIFTDEQLKYMDKGGN O77092 59 3 - VKSVRLDTWEDVQVEFMASRGN O02753 57 2 - VKSVRLDAWDETQVEFMTSHGN Q63629 57 2 - VKSVRLDAWDETQVEFMTSHGN O88768 57 2 - VKSVRLDTWEEPQVEFMASRGN O02780 57 2 - VRSVNLDSWTPEQVQTMRVMGN O18181 69 3 - VRSITMDQFKPEELLRMEKGGN GCS1_YEAST 63 3 - VRSLTLDSWEPELVKLMCELGN Y050_HUMAN 457 3 - VRSLDLDDWPRELTLVLTAIGN Y167_HUMAN 627 3 - LRSTVLDSWTYAQLRVMRVGGN YDBH_SCHPO 64 6 - VKSSTLDKWTINNLRRFKLGGN GLO3_YEAST 68 3 - VKSISLDEWSNDQIEKMKHWGN O74345 60 3 - MQSLTLDVLGTSELLLAKNIGN O43150 473 3 - VLSVTLDEWSDEEVDSMIEIGG O49557 99 3 - VRSTNLDTNWTWLQLRAMQLGG YQP4_CAEEL 65 3 - SLSLDVKVWEPTILDLFRNLGN O04097 277 5 - VKSVDLDTWKEEHLVKLIQFKN YIE4_YEAST 61 3 - VRHLKHTPWPPTLLQMVETLYN Y148_HUMAN 48 3 - VKSLSMDRWTREDIDELVSLGG GTS1_YEAST 72 8 - VKSITMDNFEEKDVRRVEKSGN SP18_YEAST 65 3 - VKSISMTTFTQQEIEFLQKHGN NUPL_HUMAN 65 2 - VKSVSMSKFTSKEVEVLQNGGN O64666 61 0 - LRSLTMWNCEISEIEIERLTWN O82484 711 71 -
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