Literature References | 1. ISOBE, T., ICHIMURA, T., SUNAYA, T., OKUYAMA, T., TAKAHASHI, N.,
KUWANO, R. AND TAKAHASHI, Y.
Distinct forms of the protein kinase-dependent activator of tyrosine and
tryptophan hydroxylases.
J.MOL.BIOL. 217 125-132 (1991).
2. KIDOU, S., UMEDA, M., KATA, A. AND ICHIMIYA, H.
Isolation and characterization of a rice cDNA similar to the bovine
brain-specific 14-3-3 protein gene.
PLANT MOL.BIOL. 21 191-194 (1993).
3. ZUPAN, L.A., STEFFENS, D.L., BERRY, C.A., LANDT, M. AND GOSS, R.W.
Cloning and expression of a human 14-3-3 protein mediating phospholipolysis.
Identification of an arachidonyl-enzyme intermediate during catalysis.
J.BIOL.CHEM. 267 8707-8710 (1992).
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Documentation | The 14-3-3 proteins are a family of related proteins found in mammalian
brain cells, preferentially in neurons, although similar proteins have been
identified in all eukaryotic species studied to date. They are homodimeric,
acidic proteins [1] with multiple biological activities: they act as
protein kinase-dependent activators of tyrosine and tryptophan hydroxy-
lases, key enzymes in the biosynthetic pathway of neurotransmitters such
as dopamine and serotonin; some act as inhibitors of protein kinase C; and
some display phospholipase A2 activity on choline and ethanolamine glycero-
phospholipids [1-3]. In yeast, a 14-3-3-like protein is involved in growth
regulation. Although the proteins have different biological functions, their
sequences are well conserved.
1433ZETA is a 6-element fingerprint that provides a signature for 14-3-3
zeta proteins. The fingerprint was derived from an initial alignment of 7
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length, motifs 1 and 6 including the perfectly conserved
regions encoded by PROSITE patterns 1433_1 (PS00796) and 1433_2 (PS00797).
Two iterations on OWL24.0 were required to reach convergence, at which
point a true set comprising 37 sequences was identified. Eight partial
matches were also found, all of which are 14-3-3 protein fragments.
An update on SPTR37_9f identified a true set of 92 sequences, and 2
partial matches.
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Sequence Titles | 1431_ENTHI 14-3-3 PROTEIN 1 (14-3-3-1) - ENTAMOEBA HISTOLYTICA. 1431_LYCES 14-3-3-LIKE PROTEIN 1 - LYCOPERSICON ESCULENTUM (TOMATO). 1431_MAIZE 14-3-3-LIKE PROTEIN GF14-6 - ZEA MAYS (MAIZE). 1431_SCHMA 14-3-3 PROTEIN HOMOLOG 1 - SCHISTOSOMA MANSONI (BLOOD FLUKE). 1432_ENTHI 14-3-3 PROTEIN 2 (14-3-3-2) - ENTAMOEBA HISTOLYTICA. 1432_LYCES 14-3-3-LIKE PROTEIN 2 - LYCOPERSICON ESCULENTUM (TOMATO). 1432_MAIZE 14-3-3-LIKE PROTEIN GF14-12 - ZEA MAYS (MAIZE). 1433_CAEEL 14-3-3-LIKE PROTEIN 1 - CAENORHABDITIS ELEGANS. 1433_CANAL 14-3-3 PROTEIN HOMOLOG - CANDIDA ALBICANS (YEAST). 1433_CHLRE 14-3-3-LIKE PROTEIN - CHLAMYDOMONAS REINHARDTII. 1433_DICDI 14-3-3-LIKE PROTEIN - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD). 1433_FUCVE 14-3-3-LIKE PROTEIN - FUCUS VESICULOSUS. 1433_LYCES 14-3-3-LIKE PROTEIN 3 (PBLT3) - LYCOPERSICON ESCULENTUM (TOMATO). 1433_MESCR 14-3-3-LIKE PROTEIN (G-BOX BINDING FACTOR) - MESEMBRYANTHEMUM CRYSTALLINUM (COMMON ICE PLANT). 1433_NEOCA 14-3-3 PROTEIN HOMOLOG - NEOSPORA CANINUM. 1433_OENHO 14-3-3-LIKE PROTEIN - OENOTHERA HOOKERI (HOOKER'S EVENING PRIMROSE). 1433_ORYSA 14-3-3-LIKE PROTEIN S94 - ORYZA SATIVA (RICE). 1433_PEA 14-3-3-LIKE PROTEIN - PISUM SATIVUM (GARDEN PEA). 1433_SOLTU 14-3-3-LIKE PROTEIN - SOLANUM TUBEROSUM (POTATO). 1433_TRIHA 14-3-3 PROTEIN HOMOLOG (TH1433) - TRICHODERMA HARZIANUM. 1434_CAEEL 14-3-3-LIKE PROTEIN 2 - CAENORHABDITIS ELEGANS. 1434_LYCES 14-3-3-LIKE PROTEIN 4 (PBLT4) - LYCOPERSICON ESCULENTUM (TOMATO). 1434_SOLTU 14-3-3-LIKE PROTEIN RA215 - SOLANUM TUBEROSUM (POTATO). 1435_LYCES 14-3-3-LIKE PROTEIN 5 - LYCOPERSICON ESCULENTUM (TOMATO). 1435_SOLTU 14-3-3-LIKE PROTEIN 16R - SOLANUM TUBEROSUM (POTATO). 1436_LYCES 14-3-3-LIKE PROTEIN 6 - LYCOPERSICON ESCULENTUM (TOMATO). 143A_HORVU 14-3-3-LIKE PROTEIN A (14-3-3A) - HORDEUM VULGARE (BARLEY). 143A_SOYBN 14-3-3-LIKE PROTEIN A (SGF14A) - GLYCINE MAX (SOYBEAN). 143A_TOBAC 14-3-3-LIKE PROTEIN A - NICOTIANA TABACUM (COMMON TOBACCO). 143A_VICFA 14-3-3-LIKE PROTEIN A (VFA-1433A) - VICIA FABA (BROAD BEAN). 143B_BOVIN 14-3-3 PROTEIN BETA/ALPHA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) - BOS TAURUS (BOVINE), AND OVIS ARIES (SHEEP). 143B_HORVU 14-3-3-LIKE PROTEIN B (14-3-3B) - HORDEUM VULGARE (BARLEY). 143B_HUMAN 14-3-3 PROTEIN BETA/ALPHA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (PROTEIN 1054) - HOMO SAPIENS (HUMAN). 143B_RAT 14-3-3 PROTEIN BETA/ALPHA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (PREPRONERVE GROWTH FACTOR RNH-1) - RATTUS NORVEGICUS (RAT). 143B_TOBAC 14-3-3-LIKE PROTEIN B - NICOTIANA TABACUM (COMMON TOBACCO). 143B_VICFA 14-3-3-LIKE PROTEIN B (VFA-1433B) - VICIA FABA (BROAD BEAN). 143C_ARATH 14-3-3-LIKE PROTEIN GF14 CHI - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 143C_SOYBN 14-3-3-LIKE PROTEIN C (SGF14C) - GLYCINE MAX (SOYBEAN). 143C_TOBAC 14-3-3-LIKE PROTEIN C (14-3-3-LIKE PROTEIN B) - NICOTIANA TABACUM (COMMON TOBACCO). 143D_SOYBN 14-3-3-LIKE PROTEIN D (SGF14D) - GLYCINE MAX (SOYBEAN). 143D_TOBAC 14-3-3-LIKE PROTEIN D - NICOTIANA TABACUM (COMMON TOBACCO). 143E_ARATH 14-3-3-LIKE PROTEIN GF14 EPSILON - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 143E_DROME 14-3-3 PROTEIN EPSILON (SUPPRESSOR OF RAS1 3-9) - DROSOPHILA MELANOGASTER (FRUIT FLY). 143E_HUMAN 14-3-3 PROTEIN EPSILON (MITOCHONDRIAL IMPORT STIMULATION FACTOR L SUBUNIT) (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (14-3-3E) - HOMO SAPIENS (HUMAN), MUS MUSCULUS (MOUSE), RATTUS NORVEGICUS (RAT), BOS TAURUS (BOVINE), AND OVIS ARIES (SHEEP). 143E_TOBAC 14-3-3-LIKE PROTEIN E - NICOTIANA TABACUM (COMMON TOBACCO). 143F_HUMAN 14-3-3 PROTEIN ETA (PROTEIN AS1) - HOMO SAPIENS (HUMAN). 143F_MOUSE 14-3-3 PROTEIN ETA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) - MUS MUSCULUS (MOUSE), RATTUS NORVEGICUS (RAT), AND BOS TAURUS (BOVINE). 143F_TOBAC 14-3-3-LIKE PROTEIN F - NICOTIANA TABACUM (COMMON TOBACCO). 143G_BOVIN 14-3-3 PROTEIN GAMMA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) - BOS TAURUS (BOVINE), AND OVIS ARIES (SHEEP). 143G_RAT 14-3-3 PROTEIN GAMMA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) - RATTUS NORVEGICUS (RAT). 143H_ARATH 14-3-3-LIKE PROTEIN GF14 PHI - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 143K_ARATH 14-3-3-LIKE PROTEIN GF14 KAPPA - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 143L_ARATH 14-3-3-LIKE PROTEIN GF14 LAMBDA (14-3-3-LIKE PROTEIN AFT1) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 143M_ARATH 14-3-3-LIKE PROTEIN GF14 MU - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 143N_ARATH 14-3-3-LIKE PROTEIN GF14 NU - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 143O_ARATH 14-3-3-LIKE PROTEIN GF14 OMEGA - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 143P_ARATH 14-3-3-LIKE PROTEIN GF14 PSI (14-3-3-LIKE PROTEIN RCI1) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 143R_ARATH 14-3-3-LIKE PROTEIN RCI2 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 143S_HUMAN 14-3-3 PROTEIN SIGMA (STRATIFIN) (EPITHELIAL CELL MARKER PROTEIN 1) - HOMO SAPIENS (HUMAN). 143T_HUMAN 14-3-3 PROTEIN TAU (14-3-3 PROTEIN THETA) (14-3-3 PROTEIN T-CELL) (HS1 PROTEIN) - HOMO SAPIENS (HUMAN). 143T_RAT 14-3-3 PROTEIN TAU (14-3-3 PROTEIN THETA) - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT). 143U_ARATH 14-3-3-LIKE PROTEIN GF14 UPSILON - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 143Z_DROME 14-3-3-LIKE PROTEIN (LEONARDO PROTEIN) (14-3-3 ZETA) - DROSOPHILA MELANOGASTER (FRUIT FLY). 143Z_HUMAN 14-3-3 PROTEIN ZETA/DELTA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (FACTOR ACTIVATING EXOENZYME S) (FAS) - HOMO SAPIENS (HUMAN), AND BOS TAURUS (BOVINE). 143Z_MOUSE 14-3-3 PROTEIN ZETA/DELTA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (MITOCHONDRIAL IMPORT STIMULATION FACTOR S1 SUBUNIT) - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT). 143Z_SHEEP 14-3-3 PROTEIN ZETA/DELTA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) - OVIS ARIES (SHEEP). 143Z_XENLA 14-3-3 PROTEIN ZETA - XENOPUS LAEVIS (AFRICAN CLAWED FROG). BMH1_YEAST BMH1 PROTEIN - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). BMH2_YEAST BMH2 PROTEIN - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). O24001 14-3-3 PROTEIN - HORDEUM VULGARE (BARLEY). O24221 GF14-B PROTEIN - ORYZA SATIVA (RICE). O24222 GF14-C PROTEIN - ORYZA SATIVA (RICE). O24223 GF14-D PROTEIN - ORYZA SATIVA (RICE). O49082 GF14 PROTEIN - FRITILLARIA AGRESTIS. O49152 14-3-3 PROTEIN HOMOLOG - MAACKIA AMURENSIS. O57468 14-3-3 PROTEIN EPSILON - XENOPUS LAEVIS (AFRICAN CLAWED FROG). O57469 14-3-3 PROTEIN ZETA - XENOPUS LAEVIS (AFRICAN CLAWED FROG). O60955 14-3-3 PROTEIN HOMOLOGUE - TOXOPLASMA GONDII. O61131 14-3-3 PROTEIN - PLASMODIUM KNOWLESI. O65352 14-3-3-LIKE PROTEIN - HELIANTHUS ANNUUS (COMMON SUNFLOWER). O70455 14-3-3 PROTEIN BETA - MUS MUSCULUS (MOUSE). O70456 14-3-3 PROTEIN SIGMA - MUS MUSCULUS (MOUSE). O70457 14-3-3 PROTEIN GAMMA - MUS MUSCULUS (MOUSE). O77642 STRATIFIN - OVIS ARIES (SHEEP). O80367 GF14 MU - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). P93785 14-3-3 PROTEIN - SOLANUM TUBEROSUM (POTATO). P93786 14-3-3 PROTEIN - SOLANUM TUBEROSUM (POTATO). P93787 14-3-3 PROTEIN - SOLANUM TUBEROSUM (POTATO). Q24902 EMMA14-3-3.1 - ECHINOCOCCUS MULTILOCULARIS. Q39558 32KDA ENDONUCLEASE - CUCURBITA PEPO (VEGETABLE MARROW) (SUMMER SQUASH). RA24_SCHPO DNA DAMAGE CHECKPOINT PROTEIN RAD24 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). RA25_SCHPO DNA DAMAGE CHECKPOINT PROTEIN RAD25 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). 1433_TOBAC 14-3-3-LIKE PROTEIN - NICOTIANA TABACUM (COMMON TOBACCO). Q21539 M117.3 PROTEIN - CAENORHABDITIS ELEGANS.
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