| Literature References | 1. ISOBE, T., ICHIMURA, T., SUNAYA, T., OKUYAMA, T., TAKAHASHI, N.,
KUWANO, R. AND TAKAHASHI, Y.
Distinct forms of the protein kinase-dependent activator of tyrosine and
tryptophan hydroxylases.
J.MOL.BIOL. 217 125-132 (1991).
2. KIDOU, S., UMEDA, M., KATA, A. AND ICHIMIYA, H.
Isolation and characterization of a rice cDNA similar to the bovine
brain-specific 14-3-3 protein gene.
PLANT MOL.BIOL. 21 191-194 (1993).
3. ZUPAN, L.A., STEFFENS, D.L., BERRY, C.A., LANDT, M. AND GOSS, R.W.
Cloning and expression of a human 14-3-3 protein mediating phospholipolysis.
Identification of an arachidonyl-enzyme intermediate during catalysis.
J.BIOL.CHEM. 267 8707-8710 (1992).
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| Documentation | The 14-3-3 proteins are a family of related proteins found in mammalian
brain cells, preferentially in neurons, although similar proteins have been
identified in all eukaryotic species studied to date. They are homodimeric,
acidic proteins [1] with multiple biological activities: they act as
protein kinase-dependent activators of tyrosine and tryptophan hydroxy-
lases, key enzymes in the biosynthetic pathway of neurotransmitters such
as dopamine and serotonin; some act as inhibitors of protein kinase C; and
some display phospholipase A2 activity on choline and ethanolamine glycero-
phospholipids [1-3]. In yeast, a 14-3-3-like protein is involved in growth
regulation. Although the proteins have different biological functions, their
sequences are well conserved.
1433ZETA is a 6-element fingerprint that provides a signature for 14-3-3
zeta proteins. The fingerprint was derived from an initial alignment of 7
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length, motifs 1 and 6 including the perfectly conserved
regions encoded by PROSITE patterns 1433_1 (PS00796) and 1433_2 (PS00797).
Two iterations on OWL24.0 were required to reach convergence, at which
point a true set comprising 37 sequences was identified. Eight partial
matches were also found, all of which are 14-3-3 protein fragments.
An update on SPTR37_9f identified a true set of 92 sequences, and 2
partial matches.
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| Sequence Titles | 1431_ENTHI 14-3-3 PROTEIN 1 (14-3-3-1) - ENTAMOEBA HISTOLYTICA.
1431_LYCES 14-3-3-LIKE PROTEIN 1 - LYCOPERSICON ESCULENTUM (TOMATO).
1431_MAIZE 14-3-3-LIKE PROTEIN GF14-6 - ZEA MAYS (MAIZE).
1431_SCHMA 14-3-3 PROTEIN HOMOLOG 1 - SCHISTOSOMA MANSONI (BLOOD FLUKE).
1432_ENTHI 14-3-3 PROTEIN 2 (14-3-3-2) - ENTAMOEBA HISTOLYTICA.
1432_LYCES 14-3-3-LIKE PROTEIN 2 - LYCOPERSICON ESCULENTUM (TOMATO).
1432_MAIZE 14-3-3-LIKE PROTEIN GF14-12 - ZEA MAYS (MAIZE).
1433_CAEEL 14-3-3-LIKE PROTEIN 1 - CAENORHABDITIS ELEGANS.
1433_CANAL 14-3-3 PROTEIN HOMOLOG - CANDIDA ALBICANS (YEAST).
1433_CHLRE 14-3-3-LIKE PROTEIN - CHLAMYDOMONAS REINHARDTII.
1433_DICDI 14-3-3-LIKE PROTEIN - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
1433_FUCVE 14-3-3-LIKE PROTEIN - FUCUS VESICULOSUS.
1433_LYCES 14-3-3-LIKE PROTEIN 3 (PBLT3) - LYCOPERSICON ESCULENTUM (TOMATO).
1433_MESCR 14-3-3-LIKE PROTEIN (G-BOX BINDING FACTOR) - MESEMBRYANTHEMUM CRYSTALLINUM (COMMON ICE PLANT).
1433_NEOCA 14-3-3 PROTEIN HOMOLOG - NEOSPORA CANINUM.
1433_OENHO 14-3-3-LIKE PROTEIN - OENOTHERA HOOKERI (HOOKER'S EVENING PRIMROSE).
1433_ORYSA 14-3-3-LIKE PROTEIN S94 - ORYZA SATIVA (RICE).
1433_PEA 14-3-3-LIKE PROTEIN - PISUM SATIVUM (GARDEN PEA).
1433_SOLTU 14-3-3-LIKE PROTEIN - SOLANUM TUBEROSUM (POTATO).
1433_TRIHA 14-3-3 PROTEIN HOMOLOG (TH1433) - TRICHODERMA HARZIANUM.
1434_CAEEL 14-3-3-LIKE PROTEIN 2 - CAENORHABDITIS ELEGANS.
1434_LYCES 14-3-3-LIKE PROTEIN 4 (PBLT4) - LYCOPERSICON ESCULENTUM (TOMATO).
1434_SOLTU 14-3-3-LIKE PROTEIN RA215 - SOLANUM TUBEROSUM (POTATO).
1435_LYCES 14-3-3-LIKE PROTEIN 5 - LYCOPERSICON ESCULENTUM (TOMATO).
1435_SOLTU 14-3-3-LIKE PROTEIN 16R - SOLANUM TUBEROSUM (POTATO).
1436_LYCES 14-3-3-LIKE PROTEIN 6 - LYCOPERSICON ESCULENTUM (TOMATO).
143A_HORVU 14-3-3-LIKE PROTEIN A (14-3-3A) - HORDEUM VULGARE (BARLEY).
143A_SOYBN 14-3-3-LIKE PROTEIN A (SGF14A) - GLYCINE MAX (SOYBEAN).
143A_TOBAC 14-3-3-LIKE PROTEIN A - NICOTIANA TABACUM (COMMON TOBACCO).
143A_VICFA 14-3-3-LIKE PROTEIN A (VFA-1433A) - VICIA FABA (BROAD BEAN).
143B_BOVIN 14-3-3 PROTEIN BETA/ALPHA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) - BOS TAURUS (BOVINE), AND OVIS ARIES (SHEEP).
143B_HORVU 14-3-3-LIKE PROTEIN B (14-3-3B) - HORDEUM VULGARE (BARLEY).
143B_HUMAN 14-3-3 PROTEIN BETA/ALPHA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (PROTEIN 1054) - HOMO SAPIENS (HUMAN).
143B_RAT 14-3-3 PROTEIN BETA/ALPHA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (PREPRONERVE GROWTH FACTOR RNH-1) - RATTUS NORVEGICUS (RAT).
143B_TOBAC 14-3-3-LIKE PROTEIN B - NICOTIANA TABACUM (COMMON TOBACCO).
143B_VICFA 14-3-3-LIKE PROTEIN B (VFA-1433B) - VICIA FABA (BROAD BEAN).
143C_ARATH 14-3-3-LIKE PROTEIN GF14 CHI - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
143C_SOYBN 14-3-3-LIKE PROTEIN C (SGF14C) - GLYCINE MAX (SOYBEAN).
143C_TOBAC 14-3-3-LIKE PROTEIN C (14-3-3-LIKE PROTEIN B) - NICOTIANA TABACUM (COMMON TOBACCO).
143D_SOYBN 14-3-3-LIKE PROTEIN D (SGF14D) - GLYCINE MAX (SOYBEAN).
143D_TOBAC 14-3-3-LIKE PROTEIN D - NICOTIANA TABACUM (COMMON TOBACCO).
143E_ARATH 14-3-3-LIKE PROTEIN GF14 EPSILON - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
143E_DROME 14-3-3 PROTEIN EPSILON (SUPPRESSOR OF RAS1 3-9) - DROSOPHILA MELANOGASTER (FRUIT FLY).
143E_HUMAN 14-3-3 PROTEIN EPSILON (MITOCHONDRIAL IMPORT STIMULATION FACTOR L SUBUNIT) (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (14-3-3E) - HOMO SAPIENS (HUMAN), MUS MUSCULUS (MOUSE), RATTUS NORVEGICUS (RAT), BOS TAURUS (BOVINE), AND OVIS ARIES (SHEEP).
143E_TOBAC 14-3-3-LIKE PROTEIN E - NICOTIANA TABACUM (COMMON TOBACCO).
143F_HUMAN 14-3-3 PROTEIN ETA (PROTEIN AS1) - HOMO SAPIENS (HUMAN).
143F_MOUSE 14-3-3 PROTEIN ETA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) - MUS MUSCULUS (MOUSE), RATTUS NORVEGICUS (RAT), AND BOS TAURUS (BOVINE).
143F_TOBAC 14-3-3-LIKE PROTEIN F - NICOTIANA TABACUM (COMMON TOBACCO).
143G_BOVIN 14-3-3 PROTEIN GAMMA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) - BOS TAURUS (BOVINE), AND OVIS ARIES (SHEEP).
143G_RAT 14-3-3 PROTEIN GAMMA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) - RATTUS NORVEGICUS (RAT).
143H_ARATH 14-3-3-LIKE PROTEIN GF14 PHI - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
143K_ARATH 14-3-3-LIKE PROTEIN GF14 KAPPA - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
143L_ARATH 14-3-3-LIKE PROTEIN GF14 LAMBDA (14-3-3-LIKE PROTEIN AFT1) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
143M_ARATH 14-3-3-LIKE PROTEIN GF14 MU - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
143N_ARATH 14-3-3-LIKE PROTEIN GF14 NU - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
143O_ARATH 14-3-3-LIKE PROTEIN GF14 OMEGA - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
143P_ARATH 14-3-3-LIKE PROTEIN GF14 PSI (14-3-3-LIKE PROTEIN RCI1) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
143R_ARATH 14-3-3-LIKE PROTEIN RCI2 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
143S_HUMAN 14-3-3 PROTEIN SIGMA (STRATIFIN) (EPITHELIAL CELL MARKER PROTEIN 1) - HOMO SAPIENS (HUMAN).
143T_HUMAN 14-3-3 PROTEIN TAU (14-3-3 PROTEIN THETA) (14-3-3 PROTEIN T-CELL) (HS1 PROTEIN) - HOMO SAPIENS (HUMAN).
143T_RAT 14-3-3 PROTEIN TAU (14-3-3 PROTEIN THETA) - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT).
143U_ARATH 14-3-3-LIKE PROTEIN GF14 UPSILON - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
143Z_DROME 14-3-3-LIKE PROTEIN (LEONARDO PROTEIN) (14-3-3 ZETA) - DROSOPHILA MELANOGASTER (FRUIT FLY).
143Z_HUMAN 14-3-3 PROTEIN ZETA/DELTA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (FACTOR ACTIVATING EXOENZYME S) (FAS) - HOMO SAPIENS (HUMAN), AND BOS TAURUS (BOVINE).
143Z_MOUSE 14-3-3 PROTEIN ZETA/DELTA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (MITOCHONDRIAL IMPORT STIMULATION FACTOR S1 SUBUNIT) - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT).
143Z_SHEEP 14-3-3 PROTEIN ZETA/DELTA (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) - OVIS ARIES (SHEEP).
143Z_XENLA 14-3-3 PROTEIN ZETA - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
BMH1_YEAST BMH1 PROTEIN - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
BMH2_YEAST BMH2 PROTEIN - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O24001 14-3-3 PROTEIN - HORDEUM VULGARE (BARLEY).
O24221 GF14-B PROTEIN - ORYZA SATIVA (RICE).
O24222 GF14-C PROTEIN - ORYZA SATIVA (RICE).
O24223 GF14-D PROTEIN - ORYZA SATIVA (RICE).
O49082 GF14 PROTEIN - FRITILLARIA AGRESTIS.
O49152 14-3-3 PROTEIN HOMOLOG - MAACKIA AMURENSIS.
O57468 14-3-3 PROTEIN EPSILON - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O57469 14-3-3 PROTEIN ZETA - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O60955 14-3-3 PROTEIN HOMOLOGUE - TOXOPLASMA GONDII.
O61131 14-3-3 PROTEIN - PLASMODIUM KNOWLESI.
O65352 14-3-3-LIKE PROTEIN - HELIANTHUS ANNUUS (COMMON SUNFLOWER).
O70455 14-3-3 PROTEIN BETA - MUS MUSCULUS (MOUSE).
O70456 14-3-3 PROTEIN SIGMA - MUS MUSCULUS (MOUSE).
O70457 14-3-3 PROTEIN GAMMA - MUS MUSCULUS (MOUSE).
O77642 STRATIFIN - OVIS ARIES (SHEEP).
O80367 GF14 MU - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P93785 14-3-3 PROTEIN - SOLANUM TUBEROSUM (POTATO).
P93786 14-3-3 PROTEIN - SOLANUM TUBEROSUM (POTATO).
P93787 14-3-3 PROTEIN - SOLANUM TUBEROSUM (POTATO).
Q24902 EMMA14-3-3.1 - ECHINOCOCCUS MULTILOCULARIS.
Q39558 32KDA ENDONUCLEASE - CUCURBITA PEPO (VEGETABLE MARROW) (SUMMER SQUASH).
RA24_SCHPO DNA DAMAGE CHECKPOINT PROTEIN RAD24 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
RA25_SCHPO DNA DAMAGE CHECKPOINT PROTEIN RAD25 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
1433_TOBAC 14-3-3-LIKE PROTEIN - NICOTIANA TABACUM (COMMON TOBACCO).
Q21539 M117.3 PROTEIN - CAENORHABDITIS ELEGANS.
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