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PR00027

Identifier
PAIREDBOX  [View Relations]  [View Alignment]  
Accession
PR00027
No. of Motifs
4
Creation Date
07-JUN-1993  (UPDATE 07-JUN-1999)
Title
Paired box signature 
Database References

PROSITE; PS00034 PAIRED_BOX
BLOCKS; BL00034
PFAM; PF00292 PAX
INTERPRO; IPR001523
Literature References
1. XUE, Z.G., GEHRING, W.J. AND LE DOURAIN, N.M.
Quox-1, A quail homeobox gene expressed in the embryonic central nervous
system, including the forebrain.
PROC.NATL.ACAD.SCI.U.S.A. 88(6) 2427-2431 (1991).
 
2. GEHRING, W.J.
Homeo boxes in the study of development.
SCIENCE 236 1245-1252 (1987).
 
3. ANGERER, L.M., DOLECKI, G.J., GAGNON, M.L., LUM, R., WANG, G., YANG, Q., 
HUMPHREYS, T. AND ANGERER, R.C.
Progressively restricted expression of a homeo box gene within the aboral
ectoderm of developing sea urchin embryos.
GENES DEV. 3(3) 370-383 (1989).
 
4. SASAKI, H., YOKOYAMA, E. AND KUROIWA, A.
Specific DNA-binding of the 2 chicken deformed fmily homeodomain proteins,
Chox-1.4 AND Chox-A.
NUCLEIC ACIDS RES. 18 1739-1747 (1990).
 
5. BRENNAN, R.G., TAKEDA, Y., KIM, J., ANDERSON, W.F. AND  MATTHEWS, B.W.
Crystallization of a complex of cro repressor with a 17 base pair operator.
J.MOL.BIOL. 188 115-118 (1986).

Documentation
Organisms develop according to a precise program that specifies the body
plan in intricate detail and also determines the timing of developmental
events [1]. The highly complex nature of these events has suggested that 
the process may be regulated by proteins capable of controlling the 
temporal and spatial expression of many structural genes. The genes for 
this process were first discovered as homeotic mutations in Drosophila [2],
and many similar genes are now known in a wide variety of organisms.
 
Proteins that regulate developmental gene expression are nuclear proteins 
[3] that contain a conserved domain known as the homeobox, the flanking
sequences of which differ considerably among different proteins. The homeo 
domain includes the helix-turn-helix (HTH) motif, which binds to DNA in a 
sequence specific manner to exert a temporal and spatial regulation of 
developmental gene expression [4]. The second helix of the HTH motif binds
to DNA via a number of hydrogen bonds and hydrophobic interactions, which
occur between specific side chains and the exposed bases and thymine methyl
groups within the major groove. The first helix may help to stablise the 
structure [5].
 
Many homeodomain-containing proteins have now been sequenced and, while
the homeodomain flanking regions vary, characteristic conserved sequences 
upstream of the domain allow the proteins to be grouped into 3 subfamilies:
the so-called antennapedia, engrailed and `paired box' proteins. The paired 
box is a conserved 124 amino acid N-terminal domain of unknown function. 
This usually, but not always, precedes a homeobox domain. Paired box genes 
are expressed in alternate segments of the developing fruit fly, the 
observed grouping of segments into pairs depending on the position of the 
segment in the segmental array, and not on the identity of the segment as 
in the case of homeotic genes. This implies that the genes affect different
processes from those altered by homeotic genes.
 
PAIREDBOX is a 4-element fingerprint that provides a signature for the 
paired box domain. The fingerprint was derived from an initial alignment
of 6 sequences: the motifs span the first 80 residues of the domain,
2 and 3 including the region encoded by PROSITE pattern PAIRED_BOX 
(PS00034). Two iterations on OWL20.0 were required to reach convergence,
at which point a true set comprising 23 sequences was identified.
 
An update on SPTR37_9f identified a true set of 89 sequences, and 1
partial match.
Summary Information
  89 codes involving  4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
489898989
31101
20000
1234
True Positives
GSBD_DROME    GSBP_DROME    HMPR_DROME    O02015        
O02016 O16117 O16800 O16801
O16802 O18381 O42292 O42293
O42348 O42349 O42612 O57416
O57417 O57418 O57419 O57420
O57581 O57582 O57583 O57584
O57676 O57677 O57678 O57679
O57680 O57681 O57682 O57684
O57685 O61616 O61617 O61988
O61990 O61991 O61992 O76121
O88436 O88437 O88438 O88439
O93370 O93373 P70053 P91739
P91751 P91781 PAX1_MOUSE PAX2_BRARE
PAX2_HUMAN PAX2_MOUSE PAX3_HUMAN PAX3_MOUSE
PAX4_HUMAN PAX5_HUMAN PAX5_MOUSE PAX6_BRARE
PAX6_COTJA PAX6_HUMAN PAX6_MOUSE PAX6_ORYLA
PAX6_RAT PAX6_XENLA PAX7_HUMAN PAX8_MOUSE
PAX8_RAT PAX9_MOUSE POXN_DROME PX8A_CANFA
PX8A_HUMAN PX8D_HUMAN PX8G_CANFA Q09546
Q12785 Q16339 Q17132 Q17359
Q17627 Q19466 Q21263 Q21272
Q25411 Q26046 Q91886 Q98865
Q98866
True Positive Partials
Codes involving 3 elements
O61989
Sequence Titles
GSBD_DROME  GOOSEBERRY DISTAL PROTEIN (BSH9) - DROSOPHILA MELANOGASTER (FRUIT FLY). 
GSBP_DROME GOOSEBERRY PROXIMAL PROTEIN (BSH4) - DROSOPHILA MELANOGASTER (FRUIT FLY).
HMPR_DROME SEGMENTATION PROTEIN PAIRED - DROSOPHILA MELANOGASTER (FRUIT FLY).
O02015 PAX-A - HYDRA LITTORALIS.
O02016 PAX-B - HYDRA LITTORALIS.
O16117 SPARKLING PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
O16800 PAIRED BOX PROTEIN - PARACENTROTUS LIVIDUS (COMMON SEA URCHIN).
O16801 PAIRED BOX PROTEIN - PARACENTROTUS LIVIDUS (COMMON SEA URCHIN).
O16802 PAIRED BOX PROTEIN - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
O18381 PAIRED BOX PROTEIN PAX-6 (EY) - DROSOPHILA MELANOGASTER (FRUIT FLY).
O42292 PAX-6 PROTEIN - ASTYANAX FASCIATUS (BLIND CAVE FISH) (ASTYANAX MEXICANUS).
O42293 PAX-6 PROTEIN - ASTYANAX FASCIATUS (BLIND CAVE FISH) (ASTYANAX MEXICANUS).
O42348 PAX6 PROTEIN - GALLUS GALLUS (CHICKEN).
O42349 PAX7 PROTEIN - GALLUS GALLUS (CHICKEN).
O42612 PAX-6 PROTEIN - ASTYANAX FASCIATUS (BLIND CAVE FISH) (ASTYANAX MEXICANUS).
O57416 TRANSCRIPTION FACTOR PAX3 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O57417 TRANSCRIPTION FACTOR PAX7A - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O57418 TRANSCRIPTION FACTOR PAX7C - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O57419 TRANSCRIPTION FACTOR PAX7D - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O57420 TRANSCRIPTION FACTOR PAX7E - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O57581 PAX6 LS - CYNOPS PYRRHOGASTER (JAPANESE COMMON NEWT).
O57582 PAX6 SS - CYNOPS PYRRHOGASTER (JAPANESE COMMON NEWT).
O57583 PAX6 LL - CYNOPS PYRRHOGASTER (JAPANESE COMMON NEWT).
O57584 PAX6 SL - CYNOPS PYRRHOGASTER (JAPANESE COMMON NEWT).
O57676 PAIRED BOX PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O57677 PAIRED BOX PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O57678 PAIRED BOX GENE - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O57679 PAIRED BOX PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O57680 PAIRED BOX PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O57681 PAIRED BOX PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O57682 PAIRED BOX PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O57684 PAIRED BOX PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O57685 PAIRED BOX PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O61616 PAIRED BOX PROTEIN PAX-2 ALPHA ISOFORM - BRANCHIOSTOMA FLORIDAE (FLORIDA LANCELET) (AMPHIOXUS).
O61617 PAIRED BOX PROTEIN PAX-2 BETA ISOFORM - BRANCHIOSTOMA FLORIDAE (FLORIDA LANCELET) (AMPHIOXUS).
O61988 PAX6 GENE (AMPHIPAX6) CLONE 12.1 (AMPHIPAX6) - BRANCHIOSTOMA FLORIDAE (FLORIDA LANCELET) (AMPHIOXUS).
O61990 PAX6 GENE (AMPHIPAX6), CLONE 4.1 - BRANCHIOSTOMA FLORIDAE (FLORIDA LANCELET) (AMPHIOXUS).
O61991 PAX6 GENE (AMPHIPAX6), CLONE 4.2 - BRANCHIOSTOMA FLORIDAE (FLORIDA LANCELET) (AMPHIOXUS).
O61992 PAX6 GENE (AMPHIPAX6), CLONE 12.2 - BRANCHIOSTOMA FLORIDAE (FLORIDA LANCELET) (AMPHIOXUS).
O76121 HRPAX-258 PROTEIN - HALOCYNTHIA RORETZI (SEA SQUIRT).
O88436 PAX4A - RATTUS NORVEGICUS (RAT).
O88437 PAX4B - RATTUS NORVEGICUS (RAT).
O88438 PAX4C - RATTUS NORVEGICUS (RAT).
O88439 PAX4D - RATTUS NORVEGICUS (RAT).
O93370 TRANSCRIPTION FACTOR - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O93373 TRANSCRIPTION FACTOR - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
P70053 PAX-6 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
P91739 PAX-37 - HALOCYNTHIA RORETZI (SEA SQUIRT).
P91751 PAX-6 - LOLIGO OPALESCENS (CALIFORNIA MARKET SQUID).
P91781 PAX-6 - PHALLUSIA MAMMILATA.
PAX1_MOUSE PAIRED BOX PROTEIN PAX-1 - MUS MUSCULUS (MOUSE).
PAX2_BRARE PAIRED BOX PROTEIN PAX[ZF-B] (PAX-2) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
PAX2_HUMAN PAIRED BOX PROTEIN PAX-2 - HOMO SAPIENS (HUMAN).
PAX2_MOUSE PAIRED BOX PROTEIN PAX-2 - MUS MUSCULUS (MOUSE).
PAX3_HUMAN PAIRED BOX PROTEIN PAX-3 (HUP2) - HOMO SAPIENS (HUMAN).
PAX3_MOUSE PAIRED BOX PROTEIN PAX-3 - MUS MUSCULUS (MOUSE).
PAX4_HUMAN PAIRED BOX PROTEIN PAX-4 - HOMO SAPIENS (HUMAN).
PAX5_HUMAN PAIRED BOX PROTEIN PAX-5 (B-CELL SPECIFIC TRANSCRIPTION FACTOR) (BSAP) - HOMO SAPIENS (HUMAN).
PAX5_MOUSE PAIRED BOX PROTEIN PAX-5 (B-CELL SPECIFIC TRANSCRIPTION FACTOR) (BSAP) - MUS MUSCULUS (MOUSE).
PAX6_BRARE PAIRED BOX PROTEIN PAX[ZF-A] (PAX-6) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
PAX6_COTJA PAIRED BOX PROTEIN PAX-6 (PAX-QNR) - COTURNIX COTURNIX JAPONICA (JAPANESE QUAIL).
PAX6_HUMAN PAIRED BOX PROTEIN PAX-6 (OCULORHOMBIN) (ANIRIDIA, TYPE II PROTEIN) - HOMO SAPIENS (HUMAN).
PAX6_MOUSE PAIRED BOX PROTEIN PAX-6 - MUS MUSCULUS (MOUSE).
PAX6_ORYLA PAIRED BOX PROTEIN PAX-6 - ORYZIAS LATIPES (MEDAKA FISH).
PAX6_RAT PAIRED BOX PROTEIN PAX-6 - RATTUS NORVEGICUS (RAT).
PAX6_XENLA PAIRED BOX PROTEIN PAX-6 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
PAX7_HUMAN PAIRED BOX PROTEIN PAX-7 (HUP1) - HOMO SAPIENS (HUMAN).
PAX8_MOUSE PAIRED BOX PROTEIN PAX-8 - MUS MUSCULUS (MOUSE).
PAX8_RAT PAIRED BOX PROTEIN PAX-8 - RATTUS NORVEGICUS (RAT).
PAX9_MOUSE PAIRED BOX PROTEIN PAX-9 - MUS MUSCULUS (MOUSE).
POXN_DROME PAIRED BOX POX-NEURO PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
PX8A_CANFA PAIRED BOX PROTEIN PAX-8, ISOFORM 8A - CANIS FAMILIARIS (DOG).
PX8A_HUMAN PAIRED BOX PROTEIN PAX-8, ISOFORMS 8A/8B - HOMO SAPIENS (HUMAN).
PX8D_HUMAN PAIRED BOX PROTEIN PAX-8, ISOFORMS 8C/8D - HOMO SAPIENS (HUMAN).
PX8G_CANFA PAIRED BOX PROTEIN PAX-8, ISOFORM 8G - CANIS FAMILIARIS (DOG).
Q09546 HYPOTHETICAL 37.0 KD PROTEIN F27E5.2 IN CHROMOSOME II - CAENORHABDITIS ELEGANS.
Q12785 PAX3 PROTEIN-FORKHEAD TRANSCRIPTION FACTOR FUSION - HOMO SAPIENS (HUMAN).
Q16339 PAX8 - HOMO SAPIENS (HUMAN).
Q17132 AMPHIPAX-1 - BRANCHIOSTOMA FLORIDAE (FLORIDA LANCELET) (AMPHIOXUS).
Q17359 VARIABLE ABNORMAL-3 - CAENORHABDITIS ELEGANS.
Q17627 C04G2.7 - CAENORHABDITIS ELEGANS.
Q19466 VAB-3 PROTEIN - CAENORHABDITIS ELEGANS.
Q21263 SIMILAR TO PAIRED BOX TRANSCRIPTION FACTOR. NCBI GI: 1208883 - CAENORHABDITIS ELEGANS.
Q21272 SIMILARITY TO PAIRED BOX TRANSCRIPTION FACTORS - CAENORHABDITIS ELEGANS.
Q25411 PAX6-LIKE PROTEIN - LINEUS SANGUINEUS (RIBBON WORM).
Q26046 PAX-6 - PARACENTROTUS LIVIDUS (COMMON SEA URCHIN).
Q91886 PAIRED-TYPE HOMEODOMAIN PAX-6 PROTEIN (XPAX6) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q98865 PAX9A - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
Q98866 PAX9B - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).

O61989 PAX6 GENE (AMPHIPAX6), CLONE J2 - BRANCHIOSTOMA FLORIDAE (FLORIDA LANCELET) (AMPHIOXUS).
Scan History
OWL20_0    2  300  NSINGLE    
OWL26_0 1 500 NSINGLE
SPTR37_9f 2 91 NSINGLE
Initial Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
VNQLGGVFVNGRPLPN POXM_DROME 13 13 -
VNQLGGVFINGRPLPN HMGP_DROME 24 24 -
VNQLGGVFINGRPLPN Q05783 23 23 -
VNQLGGVFVNGRPLPD PAX6_HUMAN 8 8 -
VNQLGGVFVNGRPLPN PAX1_MOUSE 8 8 -
VNQLGGVFINGRPLPN HMPR_DROME 31 31 -

Motif 2 width=19
Element Seqn Id St Int Rpt
RRQIVEMAAAGVRPCVISR Q05783 41 2 -
RQKIVELAHSGARPCDISR PAX6_HUMAN 26 2 -
RLRIVELAQLGIRPCDISR PAX1_MOUSE 26 2 -
RLKIVEMAADGIRPCVISR HMPR_DROME 49 2 -
RMRIVELARLGIRPCDISR POXM_DROME 31 2 -
RLKIVEMAASGVRPCVISR HMGP_DROME 42 2 -

Motif 3 width=18
Element Seqn Id St Int Rpt
LQVSNGCVSKILGRYYET PAX6_HUMAN 46 1 -
LRVSHGCVSKILNRYQET HMGP_DROME 62 1 -
LRVSHGCVSKILNRFQET Q05783 61 1 -
LRVSHGCVSKILARYNET PAX1_MOUSE 46 1 -
LRVSHGCVSKILNRYQET HMPR_DROME 69 1 -
LRVSHGCVSKILARYHET POXM_DROME 51 1 -

Motif 4 width=18
Element Seqn Id St Int Rpt
GSIRPGVIGGSKPRVATP Q05783 79 0 -
GSILPGAIGGSKPRVTTP PAX1_MOUSE 64 0 -
GSIRPGVIGGSKPRIATP HMPR_DROME 87 0 -
GSILPGAIGGSKPRVTTP POXM_DROME 69 0 -
GSIRPGVIGGSKPKVTSP HMGP_DROME 80 0 -
GSIRPRAIGGSKPRVATP PAX6_HUMAN 64 0 -
Final Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
VNQLGGVFVNGRPLPD O93373 19 19 -
VNQLGGVFVNGRPLPD O57676 20 20 -
VNQLGGVFVNGRPLPD O57677 20 20 -
VNQLGGVFVNGRPLPD O57678 19 19 -
VNQLGGVFVNGRPLPD O57680 20 20 -
VNQLGGVFVNGRPLPD O57681 20 20 -
VNQLGGVFVNGRPLPD O57682 20 20 -
VNQLGGVFVNGRPLPD O57684 20 20 -
VNQLGGVFVNGRPLPD O93370 19 19 -
VNQLGGVFVNGRPLPD PAX2_BRARE 19 19 -
VNQLGGVFVNGRPLPD PAX2_HUMAN 20 20 -
VNQLGGVFVNGRPLPD PAX2_MOUSE 19 19 -
VNQLGGVFVNGRPLPD PAX5_HUMAN 20 20 -
VNQLGGVFVNGRPLPD PAX5_MOUSE 20 20 -
VNQLGGVFVNGRPLPD O16800 20 20 -
VNQLGGVFVNGRPLPD O61990 7 7 -
VNQLGGVFVNGRPLPD O42612 27 27 -
VNQLGGVFVNGRPLPD O57582 25 25 -
VNQLGGVFVNGRPLPD O57584 25 25 -
VNQLGGVFVNGRPLPD PAX6_BRARE 27 27 -
VNQLGGVFVNGRPLPD PAX6_COTJA 8 8 -
VNQLGGVFVNGRPLPD PAX6_HUMAN 8 8 -
VNQLGGVFVNGRPLPD PAX6_MOUSE 8 8 -
VNQLGGVFVNGRPLPD PAX6_ORYLA 27 27 -
VNQLGGVFVNGRPLPD PAX6_RAT 8 8 -
VNQLGGVFVNGRPLPD PAX6_XENLA 8 8 -
VNQLGGVFVNGRPLPD Q26046 22 22 -
VNQLGGVFVNGRPLPD Q91886 39 39 -
VNQLGGVFVNGRPLPD P91751 16 16 -
VNQLGGVFVNGRPLPD O57685 20 20 -
VNQLGGVFVNGRPLPD O57679 19 19 -
VNQLGGVFVGGRPLPD O61991 30 30 -
VNQLGGVFVDGRPLPD O61992 7 7 -
VNQLGGVFVNGRPLPD Q25411 51 51 -
VNQLGGVFVNGRPLPD O42348 8 8 -
VNQLGGVFVNGRPLPD O57581 25 25 -
VNQLGGVFVNGRPLPD O57583 25 25 -
VNQLGGVFVNGRPLPD P70053 8 8 -
VNQLGGVFVNGRPLPD O42292 9 9 -
VNQLGGVFVNGRPLPD O42293 35 35 -
VNQLGGVFVGGRPLPD O61988 30 30 -
VNQLGGVYVNGRPLPD O61616 26 26 -
VNQLGGVYVNGRPLPD O61617 26 26 -
VNQLGGVFVGGRPLPD O18381 60 60 -
LNQLGGAFVNGRPLPE PAX8_MOUSE 13 13 -
LNQLGGAFVNGRPLPE Q16339 13 13 -
LNQLGGAFVNGRPLPE PX8G_CANFA 13 13 -
LNQLGGAFVNGRPLPE PX8D_HUMAN 13 13 -
LNQLGGAFVNGRPLPE PX8A_HUMAN 13 13 -
LNQLGGAFVNGRPLPE PX8A_CANFA 13 13 -
LNQLGGAFVNGRPLPE PAX8_RAT 13 13 -
VNQLGGVFVNGRPLPD O16117 179 179 -
VNQLGGVFVNGRPLPN Q17132 11 11 -
VNQLGGMFVNGRPLPD P91781 40 40 -
VNQLGGVFVNGRPLPN PAX1_MOUSE 8 8 -
VNQLGGVFVNGRPLPN PAX9_MOUSE 8 8 -
VNQLGGVFVNGRPLPN Q98865 8 8 -
VNQLGGVFVNGRPLPN Q98866 8 8 -
INQLGGVYVNGRPLPD O76121 41 41 -
VNQLGGVFVNGRPLPD Q17359 9 9 -
VNQLGGVFVNGRPLPD Q19466 45 45 -
VNQLGGVFVNGRPLPD O02015 16 16 -
VNQLGGVFVNGRPLPD Q21263 41 41 -
VNQLGGVFINGRPLPN HMPR_DROME 31 31 -
INQLGGTFVNGRPLIE O02016 88 88 -
VNQLGGVFINGRPLPN PAX3_HUMAN 38 38 -
VNQLGGVFINGRPLPN PAX3_MOUSE 38 38 -
VNQLGGVFINGRPLPN Q12785 38 38 -
VNQLGGVFINGRPLPN GSBD_DROME 23 23 -
VNQLGGVFINGRPLPN O57416 38 38 -
VNQLGGVFINGRPLPN GSBP_DROME 24 24 -
VNQLGGCFANGRPLPI O16801 71 71 -
VNQLGGVFVNGRPLAD Q17627 33 33 -
VNQLGGVFINGRPLPN O42349 38 38 -
VNQLGGVFINGRPLPN O57417 38 38 -
VNQLGGVFINGRPLPN O57418 38 38 -
VNQLGGVFINGRPLPN O57419 38 38 -
VNQLGGVFINGRPLPN O57420 38 38 -
VNQLGGVFINGRPLPN PAX7_HUMAN 38 38 -
VNQLGGCFANGRPLPT O16802 57 57 -
VNQLGGVFINGRPLPN P91739 20 20 -
VNQLGGVFVNGRPLPD POXN_DROME 9 9 -
VNQLGGLFVNGRPLPL O88436 9 9 -
VNQLGGLFVNGRPLPL O88437 9 9 -
VNQLGGLFVNGRPLPL O88438 9 9 -
VNQLGGLFVNGRPLPL O88439 9 9 -
MNQLGGLFVNGRPLPL PAX4_HUMAN 9 9 -
VNQLGGVFVNGRPLPF Q21272 65 65 -
VNQLGGVFINGRPLPI Q09546 17 17 -

Motif 2 width=19
Element Seqn Id St Int Rpt
RQRIVELAHQGVRPCDISR O93373 37 2 -
RQRIVELAHQGVRPCDISR O57676 38 2 -
RQRIVELAHQGVRPCDISR O57677 38 2 -
RQRIVELAHQGVRPCDISR O57678 37 2 -
RQRIVELAHQGVRPCDISR O57680 38 2 -
RQRIVELAHQGVRPCDISR O57681 38 2 -
RQRIVELAHQGVRPCDISR O57682 38 2 -
RQRIVELAHQGVRPCDISR O57684 38 2 -
RQRIVELAHQGVRPCDISR O93370 37 2 -
RQRIVELAHQGVRPCDISR PAX2_BRARE 37 2 -
RQRIVELAHQGVRPCDISR PAX2_HUMAN 38 2 -
RQRIVELAHQGVRPCDISR PAX2_MOUSE 37 2 -
RQRIVELAHQGVRPCDISR PAX5_HUMAN 38 2 -
RQRIVELAHQGVRPCDISR PAX5_MOUSE 38 2 -
RQRIVDLAHSGVRPCDISR O16800 38 2 -
RQKIVELAHQGARPCDISR O61990 25 2 -
RQKIVELAHSGARPCDISR O42612 45 2 -
RQKIVELAHSGARPCDISR O57582 43 2 -
RQKIVELAHSGARPCDISR O57584 43 2 -
RQKIVELAHSGARPCDISR PAX6_BRARE 45 2 -
RQKIVELAHSGARPCDISR PAX6_COTJA 26 2 -
RQKIVELAHSGARPCDISR PAX6_HUMAN 26 2 -
RQKIVELAHSGARPCDISR PAX6_MOUSE 26 2 -
RQKIVELAHSGARPCDISR PAX6_ORYLA 45 2 -
RQKIVELAHSGARPCDISR PAX6_RAT 26 2 -
RQKIVELAHSGARPCDISR PAX6_XENLA 26 2 -
RQKIVELAHSGARPCDISR Q26046 40 2 -
RQKIVELAHSGARPCDISR Q91886 57 2 -
RQRIVELAHSGARPCDISR P91751 34 2 -
RQRIVELAHQGVRPCDISR O57685 38 2 -
RQRIVELAHQGVRPCDISR O57679 37 2 -
RQKIVELAHQGARPCDISR O61991 48 2 -
RQKIVELAHQGARPCDISR O61992 25 2 -
RQRIVELAHSGARPCDISR Q25411 69 2 -
RQKIVELAHSGARPCDISR O42348 26 2 -
RQKIVELAHSGARPCDISR O57581 43 2 -
RQKIVELAHSGARPCDISR O57583 43 2 -
RQKIVELAHSGARPCDISR P70053 26 2 -
RQKIVELAHSGARPCDISR O42292 27 2 -
RQKIVELAHSGARPCDISR O42293 53 2 -
RRKIVELAHQGARPCDISR O61988 48 2 -
RHRIVELAHQGVRPCDISR O61616 44 2 -
RHRIVELAHQGVRPCDISR O61617 44 2 -
RQKIVELAHSGARPCDISR O18381 78 2 -
RQRIVDLAHQGVRPCDISR PAX8_MOUSE 31 2 -
RQRIVDLAHQGVRPCDISR Q16339 31 2 -
RQRIVDLAHQGVRPCDISR PX8G_CANFA 31 2 -
RQRIVDLAHQGVRPCDISR PX8D_HUMAN 31 2 -
RQRIVDLAHQGVRPCDISR PX8A_HUMAN 31 2 -
RQRIVDLAHQGVRPCDISR PX8A_CANFA 31 2 -
RQRIVDLAHQGVRPCDISR PAX8_RAT 31 2 -
RQRIVELAHNGVRPCDISR O16117 197 2 -
RLRIVELAHVGIRPCDISR Q17132 29 2 -
RQKIVEFAHNGARPCDISR P91781 58 2 -
RLRIVELAQLGIRPCDISR PAX1_MOUSE 26 2 -
RLRIVELAQLGIRPCDISR PAX9_MOUSE 26 2 -
RLRIVELAQLGIRPCDISR Q98865 26 2 -
RLRIVELAQLGIRPCDISR Q98866 26 2 -
RQTIVDLAHQGVRPCDIAR O76121 59 2 -
RQRIVDLAHKGCRPCDISR Q17359 27 2 -
RQRIVDLAHKGCRPCDISR Q19466 63 2 -
RHRIIELAQCGVRPSEISR O02015 34 2 -
RAQIVEMSQHGTRPCDISR Q21263 59 2 -
RLKIVEMAADGIRPCVISR HMPR_DROME 49 2 -
RRKIVELAHQGVRPCDISR O02016 106 2 -
RHKIVEMAHHGIRPCVISR PAX3_HUMAN 56 2 -
RHKIVEMAHHGIRPCVISR PAX3_MOUSE 56 2 -
RHKIVEMAHHGIRPCVISR Q12785 56 2 -
RRQIVEMAAAGVRPCVISR GSBD_DROME 41 2 -
RHKIVEMAHHGIRPCVISR O57416 56 2 -
RLKIVEMAASGVRPCVISR GSBP_DROME 42 2 -
RQQIVELAREGVRPCDISR O16801 89 2 -
RAQIVEMSQHGTRPCDISR Q17627 51 2 -
RHKIVEMAHHGIRPCVISR O42349 56 2 -
RHKIVEMAHHGIRPCVISR O57417 56 2 -
RHKIVEMAHHGIRPCVISR O57418 56 2 -
RHKIVEMAHHGIRPCVISR O57419 56 2 -
RHKIVEMAHHGIRPCVISR O57420 56 2 -
RHKIVEMAHHGIRPCVISR PAX7_HUMAN 56 2 -
RTQIVELAREGVRPCDISR O16802 75 2 -
RHKIVEMAAHGIRPCVISR P91739 38 2 -
RRRIVDLALCGVRPCDISR POXN_DROME 27 2 -
RQQIVQLAIRGMRPCDISR O88436 27 2 -
RQQIVQLAIRGMRPCDISR O88437 27 2 -
RQQIVQLAIRGMRPCDISR O88438 27 2 -
RQQIVQLAIRGMRPCDISR O88439 27 2 -
RQQIVRLAVSGMRPCDISR PAX4_HUMAN 27 2 -
RCKIVELSRQGTRPCDISR Q21272 83 2 -
RHAIISMAKKGIKPCHISR Q09546 35 2 -

Motif 3 width=18
Element Seqn Id St Int Rpt
LRVSHGCVSKILGRYYET O93373 57 1 -
LRVSHGCVSKILGRYYET O57676 58 1 -
LRVSHGCVSKILGRYYET O57677 58 1 -
LRVSHGCVSKILGRYYET O57678 57 1 -
LRVSHGCVSKILGRYYET O57680 58 1 -
LRVSHGCVSKILGRYYET O57681 58 1 -
LRVSHGCVSKILGRYYET O57682 58 1 -
LRVSHGCVSKILGRYYET O57684 58 1 -
LRVSHGCVSKILGRYYET O93370 57 1 -
LRVSHGCVSKILGRYYET PAX2_BRARE 57 1 -
LRVSHGCVSKILGRYYET PAX2_HUMAN 58 1 -
LRVSHGCVSKILGRYYET PAX2_MOUSE 57 1 -
LRVSHGCVSKILGRYYET PAX5_HUMAN 58 1 -
LRVSHGCVSKILGRYYET PAX5_MOUSE 58 1 -
LRVSHGCVSKILGRYYET O16800 58 1 -
LQVSNGCVSKILGRYYET O61990 45 1 -
LQVSNGCVSKILGRYYET O42612 65 1 -
LQVSNGCVSKILGRYYET O57582 63 1 -
LQVSNGCVSKILGRYYET O57584 63 1 -
LQVSNGCVSKILGRYYET PAX6_BRARE 65 1 -
LQVSNGCVSKILGRYYET PAX6_COTJA 46 1 -
LQVSNGCVSKILGRYYET PAX6_HUMAN 46 1 -
LQVSNGCVSKILGRYYET PAX6_MOUSE 46 1 -
LQVSNGCVSKILGRYYET PAX6_ORYLA 65 1 -
LQVSNGCVSKILGRYYET PAX6_RAT 46 1 -
LQVSNGCVSKILGRYYET PAX6_XENLA 46 1 -
LQVSNGCVSKILGRYYET Q26046 60 1 -
LQVSNGCVSKILGRYYET Q91886 77 1 -
LQVSNGCVSKILGRYYET P91751 54 1 -
LRVSHGCVSKILGRYYET O57685 58 1 -
LRVSHGCVSKVLGRYYET O57679 57 1 -
LQVSNGCVSKILGRYYET O61991 68 1 -
LQVSNGCVSKILGRYYET O61992 45 1 -
LQVSNGCVTKILGRYYET Q25411 89 1 -
QNVSNGCVSKILGRYYET O42348 60 15 -
QNVSNGCVSKILGRYYET O57581 77 15 -
QNVSNGCVSKILGRYYET O57583 77 15 -
QNVSNGCVSKILGRYYET P70053 60 15 -
ENVSNGCVSKILGRYYET O42292 61 15 -
ENVSNGCVSKILGRYYET O42293 87 15 -
LQVSNGCVSKILGRYYET O61988 68 1 -
LRVSHGCVSKILRRYYET O61616 64 1 -
LRVSHGCVSKILRRYYET O61617 64 1 -
LQVSNGCVSKILGRYYET O18381 98 1 -
LRVSHGCVSKILGRYYET PAX8_MOUSE 51 1 -
LRVSHGCVSKILGRYYET Q16339 51 1 -
LRVSHGCVSKILGRYYET PX8G_CANFA 51 1 -
LRVSHGCVSKILGRYYET PX8D_HUMAN 51 1 -
LRVSHGCVSKILGRYYET PX8A_HUMAN 51 1 -
LRVSHGCVSKILGRYYET PX8A_CANFA 51 1 -
LRVSHGCVSKILGRYYET PAX8_RAT 51 1 -
LRVSHGCVSKILSRYYET O16117 217 1 -
LRVSHGCVSKILARYNET Q17132 49 1 -
LQVSNGCVSKILARYYET P91781 78 1 -
LRVSHGCVSKILARYNET PAX1_MOUSE 46 1 -
LRVSHGCVSKILARYNET PAX9_MOUSE 46 1 -
LRVSHGCVSKILARYNET Q98865 46 1 -
LRVSHGCVSKILARYNET Q98866 46 1 -
LRVSHGCVSKILARYYET O76121 79 1 -
LQVSNGCVSKILCRYYES Q17359 47 1 -
LQVSNGCVSKILCRYYES Q19466 83 1 -
LLVSHGCVSKILGRYYET O02015 54 1 -
LKVSHGCVSKILGRYYST Q21263 79 1 -
LRVSHGCVSKILNRYQET HMPR_DROME 69 1 -
LRVSHGCVSKILSRFYET O02016 126 1 -
LRVSHGCVSKILCRYQET PAX3_HUMAN 76 1 -
LRVSHGCVSKILCRYQET PAX3_MOUSE 76 1 -
LRVSHGCVSKILCRYQET Q12785 76 1 -
LRVSHGCVSKILNRFQET GSBD_DROME 61 1 -
LRVSHGCVSKILCRYQET O57416 76 1 -
LRVSHGCVSKILNRYQET GSBP_DROME 62 1 -
LKVSHGCVSKILVRFYET O16801 109 1 -
LKVSHGCVSKILGRYYST Q17627 71 1 -
LRVSHGCVSKILCRYQET O42349 76 1 -
LRVSHGCVSKILCRYQET O57417 76 1 -
LRVSHGCVSKILCRYQET O57418 76 1 -
LRVSHGCVSKILCRYQET O57419 76 1 -
LRVSHGCVSKILCRYQET O57420 76 1 -
LRVSHGCVSKILCRYQET PAX7_HUMAN 76 1 -
LKVSHGCVSKILVRFYET O16802 95 1 -
LRVSHGCVSKILCRYQET P91739 58 1 -
LLVSHGCVSKILTRFYET POXN_DROME 47 1 -
LKVSNGCVSKILGRYYRT O88436 47 1 -
LKVSNGCVSKILGRYYRT O88437 47 1 -
LKVSNGCVSKILGRYYRT O88438 47 1 -
LKVSNGCVSKILGRYYRT O88439 47 1 -
LKVSNGCVSKILGRYYRT PAX4_HUMAN 47 1 -
LKISHGCVSKILTRFSEN Q21272 103 1 -
LKVSHGAVSKILNRYAET Q09546 55 1 -

Motif 4 width=18
Element Seqn Id St Int Rpt
GSIRPGVIGGSKPKVATP O93373 75 0 -
GSIKPGVIGGSKPKVATP O57676 76 0 -
GSIKPGVIGGSKPKVATP O57677 76 0 -
GSIKPGVIGGSKPKVATP O57678 75 0 -
GSIKPGVIGGSKPKVATP O57680 76 0 -
GSIKPGVIGGSKPKVATP O57681 76 0 -
GSIKPGVIGGSKPKVATP O57682 76 0 -
GSIKPGVIGGSKPKVATP O57684 76 0 -
GSIKPGVIGGSKPKVATP O93370 75 0 -
GSIKPGVIGGSKPKVATP PAX2_BRARE 75 0 -
GSIKPGVIGGSKPKVATP PAX2_HUMAN 76 0 -
GSIKPGVIGGSKPKVATP PAX2_MOUSE 75 0 -
GSIKPGVIGGSKPKVATP PAX5_HUMAN 76 0 -
GSIKPGVIGGSKPKVATP PAX5_MOUSE 76 0 -
GSIRPGVIGGSKPKVATP O16800 76 0 -
GSIRPRAIGGSKPRVATP O61990 63 0 -
GSIRPRAIGGSKPRVATP O42612 83 0 -
GSIRPRAIGGSKPRVATP O57582 81 0 -
GSIRPRAIGGSKPRVATP O57584 81 0 -
GSIRPRAIGGSKPRVATP PAX6_BRARE 83 0 -
GSIRPRAIGGSKPRVATP PAX6_COTJA 64 0 -
GSIRPRAIGGSKPRVATP PAX6_HUMAN 64 0 -
GSIRPRAIGGSKPRVATP PAX6_MOUSE 64 0 -
GSIRPRAIGGSKPRVATP PAX6_ORYLA 83 0 -
GSIRPRAIGGSKPRVATP PAX6_RAT 64 0 -
GSIRPRAIGGSKPRVATP PAX6_XENLA 64 0 -
GSIRPRAIGGSKPRVATP Q26046 78 0 -
GSIRPRAIGGSKPRVATP Q91886 95 0 -
GSIRPRAIGGSKPRVATP P91751 72 0 -
GSIKPGVIGGSKPKVTTP O57685 76 0 -
GSIKPGVIGGSKPKVATP O57679 75 0 -
GSIRPRAIGGSKPRVATP O61991 86 0 -
GSIRPRAIGGSKPRVATP O61992 63 0 -
GSIRPRAIGGSKPRVATP Q25411 107 0 -
GSIRPRAIGGSKPRVATP O42348 78 0 -
GSIRPRAIGGSKPRVATP O57581 95 0 -
GSIRPRAIGGSKPRVATP O57583 95 0 -
GSIRPRAIGGSKPRVATP P70053 78 0 -
GSIRPRAIGGSKPRVATP O42292 79 0 -
GSIRPRAIGGSKPRVATP O42293 105 0 -
GSIRPRAIGGSKPRVATP O61988 86 0 -
GSIKPGVIGGSKPKVATP O61616 82 0 -
GSIKPGVIGGSKPKVATP O61617 82 0 -
GSIRPRAIGGSKPRVATA O18381 116 0 -
GSIRPGVIGGSKPKVATP PAX8_MOUSE 69 0 -
GSIRPGVIGGSKPKVATP Q16339 69 0 -
GSIRPGVIGGSKPKVATP PX8G_CANFA 69 0 -
GSIRPGVIGGSKPKVATP PX8D_HUMAN 69 0 -
GSIRPGVIGGSKPKVATP PX8A_HUMAN 69 0 -
GSIRPGVIGGSKPKVATP PX8A_CANFA 69 0 -
GSIRPGVIGGSKPKVATP PAX8_RAT 69 0 -
GSFKAGVIGGSKPKVATP O16117 235 0 -
GSILPGAIGGSKPRVTTP Q17132 67 0 -
GTIRPRAIGGSKPRVATP P91781 96 0 -
GSILPGAIGGSKPRVTTP PAX1_MOUSE 64 0 -
GSILPGAIGGSKPRVTTP PAX9_MOUSE 64 0 -
GSILPGAIGGSKPRVTTP Q98865 64 0 -
GSILPGAIGGSKPRVTTP Q98866 64 0 -
GSIKPGVIGGSKPKVATP O76121 97 0 -
GTIRPRAIGGSKPRVATS Q17359 65 0 -
GTIRPRAIGGSKPRVATS Q19466 101 0 -
GSVRPGAIGGSKPKVATP O02015 72 0 -
GSVRPGVIGGSKPKVATP Q21263 97 0 -
GSIRPGVIGGSKPRIATP HMPR_DROME 87 0 -
GSVRPGVIGGSKPKVATP O02016 144 0 -
GSIRPGAIGGSKPKQVTT PAX3_HUMAN 94 0 -
GSIRPGAIGGSKPKQVTT PAX3_MOUSE 94 0 -
GSIRPGAIGGSKPKQVTT Q12785 94 0 -
GSIRPGVIGGSKPRVATP GSBD_DROME 79 0 -
GSIRPGAIGGSKPKQSTT O57416 94 0 -
GSIRPGVIGGSKPKVTSP GSBP_DROME 80 0 -
GSIKPGVIGGSKPKVATG O16801 127 0 -
GSVRPGVIGGSKPKVATP Q17627 89 0 -
GSIRPGAIGGSKPRQVAT O42349 94 0 -
GSIRPGAIGGSKPRQVAT O57417 94 0 -
GSIRPGAIGGSKPRQVAT O57418 94 0 -
GSIRPGAIGGSKPRQVAT O57419 94 0 -
GSIRPGAIGGSKPRQVAT O57420 94 0 -
GSIRPGAIGGSKPRQVAT PAX7_HUMAN 94 0 -
GSIKPGVIGGSKPKVATR O16802 113 0 -
GSIKPGAIGGSKPKVTNS P91739 76 0 -
GSIRPGSIGGSKTKQVAT POXN_DROME 65 0 -
GVLEPKGIGGSKPRLATP O88436 65 0 -
GVLEPKGIGGSKPRLATP O88437 65 0 -
GVLEPKGIGGSKPRLATP O88438 65 0 -
GVLEPKGIGGSKPRLATP O88439 65 0 -
GVLEPKGIGGSKPRLATP PAX4_HUMAN 65 0 -
GTIMPGTIGGSRPRVTTP Q21272 121 0 -
GSISPGQIGGSPRARLTV Q09546 73 0 -