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PR00025

Identifier
ANTENNAPEDIA  [View Relations]  [View Alignment]  
Accession
PR00025
No. of Motifs
2
Creation Date
08-JUN-1993  (UPDATE 22-JUN-1999)
Title
Homeotic antennapedia protein signature
Database References

PROSITE; PS00032 ANTENNAPEDIA
BLOCKS; BL00032
INTERPRO; IPR001827
Literature References
1. XUE, Z.G., GEHRING, W.J. AND LE DOURAIN, N.M.
Quox-1, A quail homeobox gene expressed in the embryonic central nervous
system, including the forebrain.
PROC.NATL.ACAD.SCI.U.S.A. 88(6) 2427-2431 (1991).
 
2. GEHRING, W.J.
Homeo boxes in the study of development.
SCIENCE 236 1245-1252 (1987).
 
3. ANGERER, L.M., DOLECKI, G.J., GAGNON, M.L., LUM, R., WANG, G., YANG, Q., 
HUMPHREYS, T. AND ANGERER, R.C.
Progressively restricted expression of a homeobox gene within the aboral
ectoderm of developing sea urchin embryos.
GENES DEV. 3(3) 370-383 (1989).
 
4. SASAKI, H., YOKOYAMA, E. AND KUROIWA, A.
Specific DNA-binding of the 2 chicken deformed family homeodomain proteins,
Chox-1.4 AND Chox-A.
NUCLEIC ACIDS RES. 18 1739-1747 (1990).
 
5. BRENNAN, R.G., TAKEDA, Y., KIM, J., ANDERSON, W.F. AND  MATTHEWS, B.W.
Crystallization of a complex of cro repressor with a 17 base pair operator.
J.MOL.BIOL. 188 115-118 (1986).

Documentation
Organisms develop according to a precise program that specifies the body
plan in intricate detail, and also determines the timing of developmental
events [1]. The highly complex nature of these events has suggested that 
the process may be regulated by proteins capable of controlling the 
temporal and spatial expression of many structural genes. The genes for 
this process were first discovered as homeotic mutations in Drosophila [2],
and many similar genes are now known in a wide variety of organisms.
 
Proteins that regulate developmental gene expression are nuclear proteins 
[3] that contain a conserved domain known as the homeobox, the flanking 
sequences of which differ considerably among different proteins. The homeo 
domain includes the helix-turn-helix (HTH) motif, which binds to DNA in a 
sequence-specific manner to exert a temporal and spatial regulation of 
developmental gene expression [4]. The second helix of this motif binds 
to DNA via a number of hydrogen bonds and hydrophobic interactions, which
occur between specific side chains and the exposed bases and thymine methyl
groups within the major groove. The first helix may help to stabilise the 
structure [5].
 
Many homeodomain-containing proteins have now been sequenced and, while
the homeodomain flanking regions vary, characteristic conserved sequences
upstream of the domain allow the proteins to be grouped into 3 subfamilies:
the so-called antennapedia, engrailed and `paired box' proteins. Antenna-
pedia, which regulates the formation of leg structures in Drosophila, was 
one of the first homeotic genes studied and led to the discovery of the 
homeobox domain. Over expression of this gene in the wrong segment of the 
fruit fly can lead to the formation of leg structures in these segments. 
For example, over expression in the head segment can lead to the formation 
of legs instead of antennae (hence the name antennapedia). The sequences of
the antennapedia proteins contain a conserved hexapeptide 5-16 residues 
upstream of the homeobox, the specific function of which is unclear.
 
ANTENNAPEDIA is a 2-element fingerprint that provides a signature for the
antennapedia-type homeobox proteins. The fingerprint was derived from an 
initial alignment of 10 sequences: motif 1 encodes the conserved hexa-
peptide (cf. PROSITE pattern PS00032)). Five iterations on OWL20.0 were
required to reach convergence, at which point a true set comprising 79 
sequences was identified.
 
An update on SPTR37_9f identified a true set of 140 sequences.
Summary Information
140 codes involving  2 elements
Composite Feature Index
2140140
12
True Positives
CDX1_HUMAN    CDX1_MOUSE    CDX4_HUMAN    CDX4_MOUSE    
H114_BRARE HB7A_XENLA HB7B_XENLA HM8_XENLA
HMAA_DROME HMAN_DROME HMB1_STRPU HMCA_DROME
HMD1_CHICK HMDF_DROME HMPB_DROME HMUX_DROME
HMX1_HUMAN HMX1_MOUSE HMXX_CHICK HOX3_BRAFL
HX11_HUMAN HX11_MOUSE HXA1_BRARE HXA1_HUMAN
HXA1_MOUSE HXA2_CHICK HXA2_MOUSE HXA2_RAT
HXA3_MOUSE HXA4_CHICK HXA4_HUMAN HXA4_MOUSE
HXA5_HUMAN HXA5_MOUSE HXA7_COTJA HXA7_HUMAN
HXA7_MOUSE HXA7_XENLA HXB1_CHICK HXB1_CYPCA
HXB1_HUMAN HXB1_MOUSE HXB2_HUMAN HXB3_CHICK
HXB3_HUMAN HXB3_MOUSE HXB4_CHICK HXB4_HUMAN
HXB4_MOUSE HXB4_XENLA HXB5_BRARE HXB5_HUMAN
HXB5_MOUSE HXB6_BRARE HXB6_HUMAN HXB6_MOUSE
HXB7_HUMAN HXB7_MOUSE HXB8_MOUSE HXC4_HUMAN
HXC4_MOUSE HXC5_BRARE HXC5_HUMAN HXC5_MOUSE
HXC6_HUMAN HXC6_MOUSE HXC6_NOTVI HXC6_SHEEP
HXC6_XENLA HXC8_MOUSE HXD1_MOUSE HXD1_XENLA
HXD3_HUMAN HXD3_MOUSE HXD4_CHICK HXD4_HUMAN
HXD4_MOUSE HXD8_CHICK HXD8_MOUSE IPF1_HUMAN
IPF1_MESAU IPF1_MOUSE IPF1_RAT LI39_CAEEL
MAB5_CAEEL O08656 O13073 O13074
O18313 O42139 O42503 O42504
O43363 O43364 O43365 O43366
O43367 O43368 O43711 O43763
O44269 O44937 O55144 O57374
O60594 O61575 O62523 O73726
O76758 O76759 O76760 O76761
O76842 O76938 O76939 O93353
O93365 O93366 O93367 P91714
P92161 Q17188 Q17243 Q23990
Q24508 Q24645 Q25131 Q25213
Q26445 Q26469 Q26868 Q61663
Q90235 Q90262 Q90320 Q91542
Q91622 Q91767 Q99955 SCR_DROME
Sequence Titles
CDX1_HUMAN  HOMEOBOX PROTEIN CDX-1 (CAUDAL-TYPE HOMEOBOX PROTEIN 1) - HOMO SAPIENS (HUMAN). 
CDX1_MOUSE HOMEOBOX PROTEIN CDX-1 (CAUDAL-TYPE HOMEOBOX PROTEIN 1) - MUS MUSCULUS (MOUSE).
CDX4_HUMAN HOMEOBOX PROTEIN CDX-4 (CAUDAL-TYPE HOMEOBOX PROTEIN 4) - HOMO SAPIENS (HUMAN).
CDX4_MOUSE HOMEOBOX PROTEIN CDX-4 (CAUDAL-TYPE HOMEOBOX PROTEIN 4) - MUS MUSCULUS (MOUSE).
H114_BRARE HOMEOBOX PROTEIN HOX-114 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
HB7A_XENLA HOMEOBOX PROTEIN HOX-B7 A (XLHBOX-2 A) (MM3) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HB7B_XENLA HOMEOBOX PROTEIN HOX-B7 B (XLHBOX-2 B) (P52) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HM8_XENLA HOMEOBOX PROTEIN 8 (XLHBOX-8) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HMAA_DROME HOMEOBOX PROTEIN ABDOMINAL-A - DROSOPHILA MELANOGASTER (FRUIT FLY).
HMAN_DROME HOMEOTIC ANTENNAPEDIA PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
HMB1_STRPU HOMEOBOX PROTEIN HB1 (SPHBOX1) - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
HMCA_DROME HOMEOTIC CAUDAL PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
HMD1_CHICK HOMEOBOX PROTEIN CHOX-CAD - GALLUS GALLUS (CHICKEN).
HMDF_DROME HOMEOTIC DEFORMED PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
HMPB_DROME HOMEOTIC PROBOSCIPEDIA PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
HMUX_DROME HOMEOTIC ULTRABITHORAX PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
HMX1_HUMAN HOMEOBOX PROTEIN MSX-1 (HOX-7) - HOMO SAPIENS (HUMAN).
HMX1_MOUSE HOMEOBOX PROTEIN MSX-1 (HOX-7) (HOX-7.1) - MUS MUSCULUS (MOUSE).
HMXX_CHICK HOMEOBOX PROTEIN GHOX-7 (CHOX-7) (HOX-7) - GALLUS GALLUS (CHICKEN).
HOX3_BRAFL HOMEOBOX PROTEIN HOX3 - BRANCHIOSTOMA FLORIDAE (FLORIDA LANCELET) (AMPHIOXUS).
HX11_HUMAN HOMEOBOX PROTEIN HOX-11 (TCL-3 PROTO-ONCOGENE) - HOMO SAPIENS (HUMAN).
HX11_MOUSE HOMEOBOX PROTEIN HOX-11 (T-CELL LEUKEMIA HOMEOBOX 1) (HOMEOBOX TLX-1) - MUS MUSCULUS (MOUSE).
HXA1_BRARE HOMEOBOX PROTEIN HOX-A1 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
HXA1_HUMAN HOMEOBOX PROTEIN HOX-A1 (HOX-1F) - HOMO SAPIENS (HUMAN).
HXA1_MOUSE HOMEOBOX PROTEIN HOX-A1 (HOX-1.6) (HOMEOTIC PROTEIN ERA-1-993) (EARLY RETINOIC ACID 1) (HOMEOBOXLESS PROTEIN ERA-1-399) - MUS MUSCULUS (MOUSE).
HXA2_CHICK HOMEOBOX PROTEIN HOX-A2 - GALLUS GALLUS (CHICKEN).
HXA2_MOUSE HOMEOBOX PROTEIN HOX-A2 (HOX-1.11) - MUS MUSCULUS (MOUSE).
HXA2_RAT HOMEOBOX PROTEIN HOX-A2 (HOX-1.11) - RATTUS NORVEGICUS (RAT).
HXA3_MOUSE HOMEOBOX PROTEIN HOX-A3 (HOX-1.5) (MO-10) - MUS MUSCULUS (MOUSE).
HXA4_CHICK HOMEOBOX PROTEIN HOX-A4 (CHOX-1.4) - GALLUS GALLUS (CHICKEN).
HXA4_HUMAN HOMEOBOX PROTEIN HOX-A4 (HOX-1D) (HOX-1.4) - HOMO SAPIENS (HUMAN).
HXA4_MOUSE HOMEOBOX PROTEIN HOX-A4 (HOX-1.4) (MH-3) - MUS MUSCULUS (MOUSE).
HXA5_HUMAN HOMEOBOX PROTEIN HOX-A5 (HOX-1C) - HOMO SAPIENS (HUMAN).
HXA5_MOUSE HOMEOBOX PROTEIN HOX-A5 (HOX-1.3) (M2) - MUS MUSCULUS (MOUSE).
HXA7_COTJA HOMEOBOX PROTEIN HOX-A7 (QUOX-1) - COTURNIX COTURNIX JAPONICA (JAPANESE QUAIL).
HXA7_HUMAN HOMEOBOX PROTEIN HOX-A7 (HOX-1A) - HOMO SAPIENS (HUMAN).
HXA7_MOUSE HOMEOBOX PROTEIN HOX-A7 (HOX-1.1) (M6-12) (M6) - MUS MUSCULUS (MOUSE).
HXA7_XENLA HOMEOBOX PROTEIN HOX-A7 (HLHBOX-3) (XHOX-36) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HXB1_CHICK HOMEOBOX PROTEIN HOX-B1 (GHOX-LAB) - GALLUS GALLUS (CHICKEN).
HXB1_CYPCA HOMEOBOX PROTEIN HOX-B1 - CYPRINUS CARPIO (COMMON CARP).
HXB1_HUMAN HOMEOBOX PROTEIN HOX-B1 (HOX-2I) - HOMO SAPIENS (HUMAN).
HXB1_MOUSE HOMEOBOX PROTEIN HOX-B1 (HOX-2.9) - MUS MUSCULUS (MOUSE).
HXB2_HUMAN HOMEOBOX PROTEIN HOX-B2 (HOX-2H) (HOX-2.8) (K8) - HOMO SAPIENS (HUMAN).
HXB3_CHICK HOMEOBOX PROTEIN HOX-B3 (CHOX-2.7) - GALLUS GALLUS (CHICKEN).
HXB3_HUMAN HOMEOBOX PROTEIN HOX-B3 (HOX-2G) (HOX-2.7) - HOMO SAPIENS (HUMAN).
HXB3_MOUSE HOMEOBOX PROTEIN HOX-B3 (HOX-2.7) (MH-23) - MUS MUSCULUS (MOUSE).
HXB4_CHICK HOMEOBOX PROTEIN HOX-B4 (CHOX-Z) - GALLUS GALLUS (CHICKEN).
HXB4_HUMAN HOMEOBOX PROTEIN HOX-B4 (HOX-2F) (HOX-2.6) - HOMO SAPIENS (HUMAN).
HXB4_MOUSE HOMEOBOX PROTEIN HOX-B4 (HOX-2.6) - MUS MUSCULUS (MOUSE).
HXB4_XENLA HOMEOBOX PROTEIN HOX-B4 (XHOX-1A) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HXB5_BRARE HOMEOBOX PROTEIN HOX-B5 (ZF-21) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
HXB5_HUMAN HOMEOBOX PROTEIN HOX-B5 (HOX-2A) (HHO.C10) (HU-1) - HOMO SAPIENS (HUMAN).
HXB5_MOUSE HOMEOBOX PROTEIN HOX-B5 (HOX-2.1) (MU-1) (H24.1) - MUS MUSCULUS (MOUSE).
HXB6_BRARE HOMEOBOX PROTEIN HOX-B6 (ZF-22) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
HXB6_HUMAN HOMEOBOX PROTEIN HOX-B6 (HOX-2B) (HOX-2.2) (HU-2) - HOMO SAPIENS (HUMAN).
HXB6_MOUSE HOMEOBOX PROTEIN HOX-B6 (HOX-2.2) (MH-22A) - MUS MUSCULUS (MOUSE).
HXB7_HUMAN HOMEOBOX PROTEIN HOX-B7 (HOX-2C) (HHO.C1) - HOMO SAPIENS (HUMAN).
HXB7_MOUSE HOMEOBOX PROTEIN HOX-B7 (HOX-2.3) (MUB1) (MH-22B) - MUS MUSCULUS (MOUSE).
HXB8_MOUSE HOMEOBOX PROTEIN HOX-B8 (HOX-2.4) - MUS MUSCULUS (MOUSE).
HXC4_HUMAN HOMEOBOX PROTEIN HOX-C4 (HOX-3E) (CP19) - HOMO SAPIENS (HUMAN).
HXC4_MOUSE HOMEOBOX PROTEIN HOX-C4 (HOX-3.5) - MUS MUSCULUS (MOUSE).
HXC5_BRARE HOMEOBOX PROTEIN HOX-C5 (HOX-3.4) (ZF-25) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
HXC5_HUMAN HOMEOBOX PROTEIN HOX-C5 (HOX-3D) (CP11) - HOMO SAPIENS (HUMAN).
HXC5_MOUSE HOMEOBOX PROTEIN HOX-C5 (HOX-3.4) (HOX-6.2) - MUS MUSCULUS (MOUSE).
HXC6_HUMAN HOMEOBOX PROTEIN HOX-C6 (HOX-3C) (HHO.C8) (CP25) - HOMO SAPIENS (HUMAN).
HXC6_MOUSE HOMEOBOX PROTEIN HOX-C6 (HOX-3.3) (HOX-6.1) - MUS MUSCULUS (MOUSE).
HXC6_NOTVI HOMEOBOX PROTEIN HOX-C6 (NVHOX-1) (FH-2) - NOTOPHTHALMUS VIRIDESCENS (EASTERN NEWT) (TRITURUS VIRIDESCENS).
HXC6_SHEEP HOMEOBOX PROTEIN HOX-C6 - OVIS ARIES (SHEEP).
HXC6_XENLA HOMEOBOX PROTEIN HOX-C6 (XLHBOX-1) (AC1) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HXC8_MOUSE HOMEOBOX PROTEIN HOX-C8 (HOX-3.1) (M31) - MUS MUSCULUS (MOUSE).
HXD1_MOUSE HOMEOBOX PROTEIN HOX-D1 (HOX-4.9) - MUS MUSCULUS (MOUSE).
HXD1_XENLA HOMEOBOX PROTEIN HOX-D1 (HOX.LAB1) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HXD3_HUMAN HOMEOBOX PROTEIN HOX-D3 (HOX-4A) - HOMO SAPIENS (HUMAN).
HXD3_MOUSE HOMEOBOX PROTEIN HOX-D3 (HOX-4.1) (MH-19) - MUS MUSCULUS (MOUSE).
HXD4_CHICK HOMEOBOX PROTEIN HOX-D4 (CHOX-A) - GALLUS GALLUS (CHICKEN).
HXD4_HUMAN HOMEOBOX PROTEIN HOX-D4 (HOX-4B) (HOX-5.1) (HHO.C13) - HOMO SAPIENS (HUMAN).
HXD4_MOUSE HOMEOBOX PROTEIN HOX-D4 (HOX-4.2) (HOX-5.1) - MUS MUSCULUS (MOUSE).
HXD8_CHICK HOMEOBOX PROTEIN HOX-D8 (CHOX-M) - GALLUS GALLUS (CHICKEN).
HXD8_MOUSE HOMEOBOX PROTEIN HOX-D8 (HOX-4.3) (HOX-5.4) - MUS MUSCULUS (MOUSE).
IPF1_HUMAN INSULIN PROMOTER FACTOR 1 (IPF-1) (ISLET/DUODENUM HOMEOBOX-1) (IDX-1) (SOMATOSTATIN TRANSACTIVATING FACTOR-1) (STF-1) (PANCREAS/DUODENUM HOMEOBOX-1) (GLUCOSE SENSITIVE FACTOR) (GSF) - HOMO SAPIENS (HUMAN).
IPF1_MESAU INSULIN PROMOTER FACTOR 1 (IPF-1) (HOMEODOMAIN PROTEIN PDX1) - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
IPF1_MOUSE INSULIN PROMOTER FACTOR 1 (IPF-1) (ISLET/DUODENUM HOMEOBOX-1) (IDX-1) (SOMATOSTATIN TRANSACTIVATING FACTOR-1) (STF-1) (PANCREAS/DUODENUM HOMEOBOX-1) - MUS MUSCULUS (MOUSE).
IPF1_RAT INSULIN PROMOTER FACTOR 1 (IPF-1) (ISLET/DUODENUM HOMEOBOX-1) (IDX-1) (SOMATOSTATIN TRANSACTIVATING FACTOR-1) (STF-1) - RATTUS NORVEGICUS (RAT).
LI39_CAEEL HOMEOBOX PROTEIN LIN-39 - CAENORHABDITIS ELEGANS.
MAB5_CAEEL HOMEOBOX PROTEIN MAB-5 - CAENORHABDITIS ELEGANS.
O08656 HOMEOBOX PROTEIN HOX-A1 - RATTUS NORVEGICUS (RAT).
O13073 HOMEOBOX PROTEIN HOXB-1 - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
O13074 HOMEOBOX PROTEIN HOX-B4 (HOXB-4) - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
O18313 HOX 5 - CIONA INTESTINALIS.
O42139 HOMEOBOX PROTEIN PXHOXC8 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O42503 HOMEOBOX PROTEIN HOXC-8 - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
O42504 HOMEOBOX PROTEIN HOXC-6 - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
O43363 HOMEOBOX PROTEIN HOX-A1 (HOX-1F) - HOMO SAPIENS (HUMAN).
O43364 HOMEOBOX PROTEIN HOX-A2 - HOMO SAPIENS (HUMAN).
O43365 HOMEOBOX PROTEIN HOX-A3 (HOX-1E) - HOMO SAPIENS (HUMAN).
O43366 HOMEOBOX PROTEIN HOX-A4 (HOX-1D) (HOX-1.4) - HOMO SAPIENS (HUMAN).
O43367 HOMEOBOX PROTEIN HOX-A5 (HOX-1C) - HOMO SAPIENS (HUMAN).
O43368 HOMEOBOX PROTEIN HOX-A7 (HOX-1A) - HOMO SAPIENS (HUMAN).
O43711 HOMEOBOX PROTEIN HOX-11L2 - HOMO SAPIENS (HUMAN).
O43763 HOMEOBOX PROTEIN HOX-11L1 - HOMO SAPIENS (HUMAN).
O44269 ULTRABITHORAX - ACANTHOKARA KAPUTENSIS.
O44937 SPMSX - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
O55144 HOMEOBOX PROTEIN HOX-11L2 (T-CELL LEUKEMIA HOMEOBOX 3) (HOMEOBOX TLX- 3) - MUS MUSCULUS (MOUSE).
O57374 HOMEOBOX PROTEIN HOX-D4 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O60594 INSULIN UPSTREAM FACTOR 1 - HOMO SAPIENS (HUMAN).
O61575 HOMEOTIC PROTEIN - PRISTIONCHUS PACIFICUS.
O62523 MRNA ENCODING HOX3 GENE - CUPIENNIUS SALEI.
O73726 HOMEOBOX PROTEIN PDX-1 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O76758 ULTRABITHORAX HOMEOTIC PROTEIN IIA - ANOPHELES GAMBIAE (AFRICAN MALARIA MOSQUITO).
O76759 ULTRABITHORAX HOMEOTIC PROTEIN IVA - ANOPHELES GAMBIAE (AFRICAN MALARIA MOSQUITO).
O76760 SEX COMBS REDUCED HOMEOTIC PROTEIN - ANOPHELES GAMBIAE (AFRICAN MALARIA MOSQUITO).
O76761 ANTENNAPEDIA HOMEOTIC PROTEIN - ANOPHELES GAMBIAE (AFRICAN MALARIA MOSQUITO).
O76842 HOMEOBOX PROTEIN - CUPIENNIUS SALEI.
O76938 HOMEODOMAIN PROTEIN - DUGESIA TIGRINA (PLANARIAN).
O76939 DTHOXE PROTEIN - DUGESIA TIGRINA (PLANARIAN).
O93353 HOMEOBOX PROTEIN HOX-D3 - GALLUS GALLUS (CHICKEN).
O93365 HOMEOBOX TRANSCRIPTION FACTOR - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O93366 HOMEOBOX PROTEIN HOX-11 (HOMEOBOX TLX-1) - GALLUS GALLUS (CHICKEN).
O93367 HOMEOBOX PROTEIN HOX-11L2 (HOMEOBOX TLX-3) - GALLUS GALLUS (CHICKEN).
P91714 HOMEODOMAIN PROTEIN - DUGESIA TIGRINA (PLANARIAN).
P92161 TRANSCRIPTION FACTOR DEFORMED (TC DEFORMED) - TRIBOLIUM CASTANEUM (RED FLOUR BEETLE).
Q17188 ANTENNAPEDIA HOMOLOGUE PROTEIN - BOMBYX MORI (SILK MOTH).
Q17243 CAD PROTEIN - BOMBYX MORI (SILK MOTH).
Q23990 SEX COMBS REDUCED HOMEODOMAIN PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q24508 SCR GENE EXON1 - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q24645 ANTENNAPEDIA HOMEOTIC GENE (ANTP), EXONS 4-7 - DROSOPHILA SUBOBSCURA (FRUIT FLY).
Q25131 HRHOX-1 - HALOCYNTHIA RORETZI (SEA SQUIRT).
Q25213 ABDOMINAL-A HOMEODOMAIN PROTEIN - JUNONIA COENIA (PEACOCK BUTTERFLY) (PRECIS COENIA).
Q26445 LOX4=ULTRABITHORAX/ABDOMINAL-A HOMOLOG - HIRUDO MEDICINALIS (MEDICINAL LEECH).
Q26469 HOMEOTIC PROTEIN - SCHISTOCERCA AMERICANA (AMERICAN GRASSHOPPER).
Q26868 FUSHI-TARAZU - TRIBOLIUM CASTANEUM (RED FLOUR BEETLE).
Q61663 HOMEOBOX PROTEIN HOX-11L1 (T-CELL LEUKEMIA HOMEOBOX 2) (HOMEOBOX TLX- 2) (PMUR10F) - MUS MUSCULUS (MOUSE).
Q90235 MSX1 PROTEIN - AMBYSTOMA MEXICANUM (AXOLOTL).
Q90262 ZF-CAD1 PROTEIN - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
Q90320 CAUDAL HOMOLOG CDX1 - CYPRINUS CARPIO (COMMON CARP).
Q91542 (XCAD-3) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q91622 XCAD2 PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q91767 ORGANIZER SPECIFIC HOMEOBOX XLAB - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q99955 HOMEOBOX PROTEIN HOX-D3 (HOX-4A) - HOMO SAPIENS (HUMAN).
SCR_DROME HOMEOTIC SEX COMBS REDUCED PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
Scan History
OWL20_0    5  300  NSINGLE    
OWL26_0 2 500 NSINGLE
SPTR37_9f 2 400 NSINGLE
Initial Motifs
Motif 1  width=8
Element Seqn Id St Int Rpt
QIYPWMKR HMSC_DROME 299 299 -
QIYPWMTK HM5_XENLA 4 4 -
RIYPWMRS HM3_XENLA 110 110 -
PVFPWMKM HMMA_CAEEL 113 113 -
RIYPWMRS HM1_COTJA 117 117 -
VVYPWMKK HM51_HUMAN 132 132 -
IIYPWMKK HMDF_DROME 342 342 -
PLYPWMRS HMAN_DROME 282 282 -
VVYPWMRK HM26_MOUSE 139 139 -
QLFPWMRP HM24_CHICK 26 26 -

Motif 2 width=16
Element Seqn Id St Int Rpt
KRGRQTYTRYQTLELE HMAN_DROME 298 8 -
RRGRQTYSRYQTLELE HM24_CHICK 40 6 -
KRSRTAYTRQQVLELE HM51_HUMAN 155 15 -
KRSRTAYTRQQVLELE HM26_MOUSE 162 15 -
KRQRTSYTRYQTLELE HMSC_DROME 321 14 -
KRSRTSYTRYQTLELE HM5_XENLA 21 9 -
KRGRQTYTRYQTLELE HM3_XENLA 123 5 -
KRTRQTYSRSQTLELE HMMA_CAEEL 129 8 -
KRGRQTYTRYQTLELE HM1_COTJA 130 5 -
KRQRTAYTRHQILELE HMDF_DROME 367 17 -
Final Motifs
Motif 1  width=8
Element Seqn Id St Int Rpt
QIYPWMRK O43367 175 175 -
QIYPWMRK HXA5_MOUSE 175 175 -
QIYPWMRK HXA5_HUMAN 175 175 -
QIYPWMKR Q23990 301 301 -
QIYPWMKR SCR_DROME 301 301 -
QIYPWMKR Q24508 303 303 -
IIYPWMKR O18313 125 125 -
QIFPWMRK HXB5_BRARE 181 181 -
QIFPWMRK HXB5_HUMAN 175 175 -
QIFPWMRK HXB5_MOUSE 175 175 -
QIYPWMRK P92161 209 209 -
RIYPWMRS O43368 118 118 -
RIYPWMRS HXB7_MOUSE 125 125 -
RIYPWMRS HXB7_HUMAN 125 125 -
RIYPWMRS HXA7_XENLA 110 110 -
RIYPWMRS HXA7_MOUSE 117 117 -
RIYPWMRS HXA7_HUMAN 118 118 -
RIYPWMRS HXA7_COTJA 117 117 -
RIYPWMRS HB7B_XENLA 126 126 -
RIYPWMRS HB7A_XENLA 128 128 -
HIYPWMKR O76760 259 259 -
QIYPWMTK HXC5_BRARE 149 149 -
QIYPWMTK HXC5_MOUSE 139 139 -
QIYPWMTK HXC5_HUMAN 139 139 -
IIYPWMKK HMDF_DROME 342 342 -
VVYPWMKK HXA4_CHICK 187 187 -
VVYPWMKK O57374 144 144 -
VVYPWMKK O43366 193 193 -
VVYPWMKK O13074 141 141 -
VVYPWMKK HXD4_MOUSE 130 130 -
VVYPWMKK HXD4_HUMAN 132 132 -
VVYPWMKK HXD4_CHICK 122 122 -
VVYPWMKK HXB4_XENLA 119 119 -
VVYPWMKK HXB4_CHICK 128 128 -
VVYPWMKK HXA4_MOUSE 158 158 -
VVYPWMKK HXA4_HUMAN 193 193 -
IVYPWMKK HXC4_MOUSE 134 134 -
PLYPWMRS HMAN_DROME 282 282 -
PLYPWMRS O76761 233 233 -
PLYPWMRS Q17188 167 167 -
PLYPWMRS Q24645 298 298 -
PLYPWMRS Q25213 203 203 -
PLYPWMRS Q26469 236 236 -
VVYPWMRK HXB4_HUMAN 140 140 -
VVYPWMRK HXB4_MOUSE 139 139 -
LPFPWMKS HM8_XENLA 118 118 -
LPFPWMKS O73726 107 107 -
LPFPWMKS O60594 117 117 -
LPFPWMKS IPF1_RAT 117 117 -
LPFPWMKS IPF1_MOUSE 118 118 -
LPFPWMKS IPF1_MESAU 117 117 -
LPFPWMKS IPF1_HUMAN 117 117 -
IVYPWMKK HXC4_HUMAN 134 134 -
PVYPWMQR HXB6_BRARE 131 131 -
PVYPWMQR HXB6_HUMAN 126 126 -
PVYPWMQR HXB6_MOUSE 126 126 -
NFYPWMKA Q26868 167 167 -
QIFPWMKE HXA3_MOUSE 155 155 -
QIFPWMKE HXB3_CHICK 123 123 -
QIFPWMKE HXB3_HUMAN 128 128 -
QIFPWMKE HXB3_MOUSE 128 128 -
QIFPWMKE O43365 154 154 -
QIFPWMKE O93353 136 136 -
PVYPWMTR O61575 97 97 -
PFYPWMNV O44269 120 120 -
KIYPWMKE HOX3_BRAFL 97 97 -
QIFPWMKE HXD3_HUMAN 143 143 -
QIFPWMKE Q99955 159 159 -
QIFPWMKE HXD3_MOUSE 144 144 -
PEYPWMKE HMPB_DROME 163 163 -
PEYPWMKE HXA2_CHICK 93 93 -
PEYPWMKE HXA2_MOUSE 95 95 -
PEYPWMKE HXA2_RAT 95 95 -
PEYPWMKE O43364 93 93 -
QIYPWMQR HXC6_HUMAN 39 39 -
QIYPWMQR HXC6_XENLA 121 121 -
QIYPWMQR HXC6_SHEEP 39 39 -
QIYPWMQR HXC6_NOTVI 121 121 -
QIYPWMQR HXC6_MOUSE 121 121 -
PIYPWMQR O42504 120 120 -
VVYPWMNP O76939 209 209 -
AVYPWMTR LI39_CAEEL 147 147 -
PEFPWMKE HXB2_HUMAN 93 93 -
SGYPWMPV HMB1_STRPU 172 172 -
PVFPWMKM MAB5_CAEEL 255 255 -
PRYPWMTL HMAA_DROME 367 367 -
PIYPWMVD O62523 174 174 -
TFYPWMAI HMUX_DROME 238 238 -
TFYPWMAI O76759 205 205 -
TFYPWMAI O76758 205 205 -
QLFPWMRP HXB8_MOUSE 133 133 -
PFYPWMSV Q26445 94 94 -
HEFPWMKE O93365 102 102 -
PAFPWMQK O76938 99 99 -
QMFPWMRP HXD8_CHICK 82 82 -
QMFPWMRP HXD8_MOUSE 182 182 -
MKYPWMRE H114_BRARE 106 106 -
QIWPWMTV P91714 247 247 -
LMFPWMRP HXC8_MOUSE 137 137 -
LMFPWMRP O42503 137 137 -
LMFPWMRP O42139 151 151 -
LTFPWMDS O43763 111 111 -
LTFPWMDS Q61663 116 116 -
LTFPWMES HX11_HUMAN 172 172 -
LTFPWMES HX11_MOUSE 174 174 -
LTFPWMES O93366 139 139 -
LSFPWMES O93367 129 129 -
LNFPWMES O43711 123 123 -
LNFPWMES O55144 123 123 -
PYFDWMKK HMCA_DROME 221 221 -
SPYAWMRK CDX4_MOUSE 153 153 -
SPYAWMRK CDX4_HUMAN 155 155 -
QTFDWMKV HXA1_HUMAN 198 198 -
QTFDWMKV O43363 203 203 -
QTFDWMKV O08656 202 202 -
QTFDWMKV HXA1_MOUSE 199 199 -
NTYDWMKI Q25131 62 62 -
SPYEWMKK Q17243 98 98 -
TPYEWMRR CDX1_HUMAN 131 131 -
TPYEWMRR CDX1_MOUSE 131 131 -
TPYEWMRR HMD1_CHICK 116 116 -
SSFPWMQA O44937 140 140 -
DPYEWMRR Q91622 126 126 -
PTFDWMKV HXA1_BRARE 182 182 -
PTYKWMQV O76842 15 15 -
ERTPWMQS HMX1_HUMAN 135 135 -
DRTPWMQS HMX1_MOUSE 135 135 -
ERSPWMQS HMXX_CHICK 130 130 -
RTFDWMKV HXB1_CHICK 187 187 -
STFDWMKV HXD1_XENLA 174 174 -
STFDWMKV Q91767 175 175 -
RTFDWMKV HXB1_HUMAN 178 178 -
RTFDWMKV HXB1_MOUSE 174 174 -
ERNPWMQS Q90235 73 73 -
KTFDWMKV HXB1_CYPCA 196 196 -
NSYQWMSK Q90320 131 131 -
NSYQWMSK Q90262 131 131 -
QTFDWMKV O13073 259 259 -
STFEWMKV HXD1_MOUSE 202 202 -
NSYEWMGK Q91542 131 131 -

Motif 2 width=16
Element Seqn Id St Int Rpt
KRARTAYTRYQTLELE O43367 196 13 -
KRARTAYTRYQTLELE HXA5_MOUSE 196 13 -
KRARTAYTRYQTLELE HXA5_HUMAN 196 13 -
KRQRTSYTRYQTLELE Q23990 323 14 -
KRQRTSYTRYQTLELE SCR_DROME 323 14 -
KRQRTSYTRYQTLELE Q24508 325 14 -
KRTRTAYTRYQTLELE O18313 143 10 -
KRARTAYTRYQTLELE HXB5_BRARE 201 12 -
KRARTAYTRYQTLELE HXB5_HUMAN 195 12 -
KRARTAYTRYQTLELE HXB5_MOUSE 195 12 -
KRQRTAYTRHQILELE P92161 234 17 -
KRGRQTYTRYQTLELE O43368 131 5 -
KRGRQTYTRYQTLELE HXB7_MOUSE 138 5 -
KRGRQTYTRYQTLELE HXB7_HUMAN 138 5 -
KRGRQTYTRYQTLELE HXA7_XENLA 123 5 -
KRGRQTYTRYQTLELE HXA7_MOUSE 130 5 -
KRGRQTYTRYQTLELE HXA7_HUMAN 131 5 -
KRGRQTYTRYQTLELE HXA7_COTJA 130 5 -
KRGRQTYTRYQTLELE HB7B_XENLA 139 5 -
KRGRQTYTRYQTLELE HB7A_XENLA 141 5 -
KRQRTSYTRYQTLELE O76760 281 14 -
KRSRTSYTRYQTLELE HXC5_BRARE 166 9 -
KRSRTSYTRYQTLELE HXC5_MOUSE 156 9 -
KRSRTSYTRYQTLELE HXC5_HUMAN 156 9 -
KRQRTAYTRHQILELE HMDF_DROME 367 17 -
KRSRTAYTRQQVLELE HXA4_CHICK 210 15 -
KRSRTAYTRQQVLELE O57374 167 15 -
KRSRTAYTRQQVLELE O43366 216 15 -
KRSRTAYTRQQVLELE O13074 164 15 -
KRSRTAYTRQQVLELE HXD4_MOUSE 153 15 -
KRSRTAYTRQQVLELE HXD4_HUMAN 155 15 -
KRSRTAYTRQQVLELE HXD4_CHICK 145 15 -
KRSRTAYTRQQVLELE HXB4_XENLA 142 15 -
KRSRTAYTRQQVLELE HXB4_CHICK 151 15 -
KRSRTAYTRQQVLELE HXA4_MOUSE 181 15 -
KRSRTAYTRQQVLELE HXA4_HUMAN 216 15 -
KRSRTAYTRQQVLELE HXC4_MOUSE 157 15 -
KRGRQTYTRYQTLELE HMAN_DROME 298 8 -
KRGRQTYTRYQTLELE O76761 245 4 -
KRGRQTYTRYQTLELE Q17188 179 4 -
KRGRQTYTRYQTLELE Q24645 314 8 -
KRGRQTYTRYQTLELE Q25213 215 4 -
KRGRQTYTRYQTLELE Q26469 248 4 -
KRSRTAYTRQQVLELE HXB4_HUMAN 163 15 -
KRSRTAYTRQQVLELE HXB4_MOUSE 162 15 -
KRTRTAYTRAQLLELE HM8_XENLA 148 22 -
KRTRTAYTRAQLLELE O73726 138 23 -
KRTRTAYTRAQLLELE O60594 147 22 -
KRTRTAYTRAQLLELE IPF1_RAT 147 22 -
KRTRTAYTRAQLLELE IPF1_MOUSE 148 22 -
KRTRTAYTRAQLLELE IPF1_MESAU 147 22 -
KRTRTAYTRAQLLELE IPF1_HUMAN 147 22 -
KRSRAAYTRQQVLELE HXC4_HUMAN 157 15 -
RRGRQTYTRYQTLELE HXB6_BRARE 151 12 -
RRGRQTYTRYQTLELE HXB6_HUMAN 147 13 -
RRGRQTYTRYQTLELE HXB6_MOUSE 147 13 -
KRTRQTYTRYQTLELE Q26868 184 9 -
KRARTAYTSAQLVELE HXA3_MOUSE 193 30 -
KRARTAYTSAQLVELE HXB3_CHICK 160 29 -
KRARTAYTSAQLVELE HXB3_HUMAN 189 53 -
KRARTAYTSAQLVELE HXB3_MOUSE 192 56 -
KRARTAYTSAQLVELE O43365 192 30 -
KRARTAYTSAQLVELE O93353 174 30 -
KRQRTAYTRNQVLELE O61575 117 12 -
KRGRQTYTRYQTLELE O44269 136 8 -
KRARTAYTSAQLVELE HOX3_BRAFL 136 31 -
KRVRTAYTSAQLVELE HXD3_HUMAN 179 28 -
KRVRTAYTSAQLVELE Q99955 195 28 -
KRVRTAYTSAQLVELE HXD3_MOUSE 180 28 -
RRLRTAYTNTQLLELE HMPB_DROME 199 28 -
RRLRTAYTNTQLLELE HXA2_CHICK 141 40 -
RRLRTAYTNTQLLELE HXA2_MOUSE 140 37 -
RRLRTAYTNTQLLELE HXA2_RAT 140 37 -
RRLRTAYTNTQLLELE O43364 144 43 -
RRGRQIYSRYQTLELE HXC6_HUMAN 60 13 -
RRGRQIYSRYQTLELE HXC6_XENLA 142 13 -
RRGRQIYSRYQTLELE HXC6_SHEEP 60 13 -
RRGRQIYSRYQTLELE HXC6_NOTVI 142 13 -
RRGRQIYSRYQTLELE HXC6_MOUSE 142 13 -
RRGRQIYSRYQTLELE O42504 141 13 -
KRSRQTYTRYQTLELE O76939 227 10 -
KRQRTAYTRNQVLELE LI39_CAEEL 166 11 -
RRLRTAYTNTQLLELE HXB2_HUMAN 144 43 -
KRCRQTYTRYQTLELE HMB1_STRPU 191 11 -
KRTRQTYSRSQTLELE MAB5_CAEEL 271 8 -
RRGRQTYTRFQTLELE HMAA_DROME 399 24 -
KRARTAYTSAQLVELE O62523 211 29 -
RRGRQTYTRYQTLELE HMUX_DROME 296 50 -
RRGRQTYTRYQTLELE O76759 220 7 -
RRGRQTYTRYQTLELE O76758 237 24 -
RRGRQTYSRYQTLELE HXB8_MOUSE 147 6 -
RRGRQTYSRYQTLELE Q26445 110 8 -
RRLRTAYTNTQLLELE O93365 159 49 -
KRCRQAYSRQQTLELE O76938 121 14 -
RRGRQTYSRFQTLELE HXD8_CHICK 96 6 -
RRGRQTYSRFQTLELE HXD8_MOUSE 196 6 -
KRARVAFTSSQLLELE H114_BRARE 146 32 -
RRGRQTYSRHQTLELE P91714 263 8 -
RSGRQTYSRYQTLELE HXC8_MOUSE 150 5 -
RNGRQTYSRYQTLELE O42503 226 81 -
RSGRQTYSRYQTLELE O42139 164 5 -
KKPRTSFSRSQVLELE O43763 150 31 -
KKPRTSFSRSQVLELE Q61663 158 34 -
KKPRTSFTRLQICELE HX11_HUMAN 202 22 -
KKPRTSFTRLQICELE HX11_MOUSE 204 22 -
KKPRTSFTRLQICELE O93366 169 22 -
KKPRTSFSRVQICELE O93367 173 36 -
KKPRTSFSRVQICELE O43711 167 36 -
KKPRTSFSRVQICELE O55144 167 36 -
DKYRVVYTDFQRLELE HMCA_DROME 244 15 -
EKYRVVYTDHQRLELE CDX4_MOUSE 172 11 -
EKYRVVYTDHQRLELE CDX4_HUMAN 174 11 -
NAVRTNFTTKQLTELE HXA1_HUMAN 225 19 -
NAVRTNFTTKQLTELE O43363 230 19 -
NAVRTNFTTKQLTELE O08656 229 19 -
NAVRTNFTTKQLTELE HXA1_MOUSE 226 19 -
GNGRTNFTTKQLTELE Q25131 95 25 -
DKYRVVYSDHQRLELE Q17243 121 15 -
DKYRVVYTDHQRLELE CDX1_HUMAN 155 16 -
DKYRVVYTDHQRLELE CDX1_MOUSE 155 16 -
DKYRVVYTDHQRLELE HMD1_CHICK 138 14 -
RKPRTPFTTSQLLALE O44937 179 31 -
DKYRVVYTDHQRLELE Q91622 151 17 -
NIIRTNFTTKQLTELE HXA1_BRARE 209 19 -
GSGRTNFTTKQLTELE O76842 68 45 -
RKPRTPFTTAQLLALE HMX1_HUMAN 167 24 -
RKPRTPFTTAQLLALE HMX1_MOUSE 167 24 -
RKPRTPFTTAQLLALE HMXX_CHICK 162 24 -
NTIRTNFTTKQLTELE HXB1_CHICK 214 19 -
CNVRTNFTTKQLTELE HXD1_XENLA 201 19 -
CNVRTNFTTKQLTELE Q91767 202 19 -
SGLRTNFTTRQLTELE HXB1_HUMAN 204 18 -
GGLRTNFTTRQLTELE HXB1_MOUSE 200 18 -
RKPRTPFTTSQLLALE Q90235 105 24 -
NTIRTNFTTKQLTELE HXB1_CYPCA 222 18 -
EKYRVVYTDHQRLELE Q90320 152 13 -
EKYRVVYTDHQRLELE Q90262 152 13 -
SAIRTNFSTRQLTELE O13073 287 20 -
SAIRTNFSTKQLTELE HXD1_MOUSE 229 19 -
EKYTVVYTDHQRLELE Q91542 152 13 -