| Literature References | 1. JENNE, D. AND STANLEY, K.K.
Nucleotide-sequence and organisation of the human S-protein gene -
Repeating peptide motifs in the pexin family and a model for their
evolution.
BIOCHEMISTRY 26 6735-6742 (1987).
2. JENNE, D.
Homology of placental protein II and pea seed albumin-2 with vitronectin.
BIOCHEM.BIOPHYS.RES.COMMUN. 176 1000-1006 (1991).
3. REBBE, N.F., TONG, B.D., FINLEY, E.M. AND HICKMAN, S.
Identification of nucleotide pyrophosphate alkaline phosphodiesterase-1
acitivity associated with mouse plasma-cell differentiation antigen PC-1.
PROC.NATL.ACAD.SCI.U.S.A. 88 5192-5196 (1991).
4. GRUNDMANN, E., ROMISCH, J., SIEBOLD, B., BOHN, H. AND AMANN, E.
Cloning and expression of a cDNA encoding human placental protein 11, a
putative serine protease with diagnostic significance as a tumor marker.
DNA CELL BIOL. 9 243-250 (1990).
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| Documentation | Somatomedin B, a serum factor of unknown function, is a 45-residue,
cysteine-rich peptide, derived proteolytically from the N-terminus of the
cell-substrate adhesion protein vitronectin [1]. Cys-rich somatomedin
B-like domains [2] are found in a number of proteins, including plasma-
cell membrane glycoprotein (which has nucleotide pyrophosphate and
alkaline phosphodiesterase I activities) [3] and placental protein 11 [4]
(which appears to possess amidolytic activity).
SOMATOMEDINB is a 3-element fingerprint that provides a signature for
somatomedin B-like domains. The fingerprint was derived from an initial
alignment of 5 sequences: the motifs include 8 conserved Cys residues,
motifs 2 and 3 spanning the region encoded by PROSITE pattern SOMATOMEDIN_B
(PS00524). Two iterations on OWL24.0 were required to reach convergence,
at which point a true set comprising 13 sequences was identified.
An update on SPTR37_9f identified a true set of 17 sequences, and 2
partial matches.
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