Literature References | 1. KIKKAWA, U., KISHIMOTO, A. AND NISHIZUKA, Y.
The protein kinase C family: heterogeneity and its implications.
ANNU.REV.BIOCHEMISTRY 58 31-44 (1989).
2. ONO, Y., FUJII, T., IGARASHI, K., TANAKA, C., KIKKAWA, U.
AND NISHIZUKA, Y.
Phorbol ester binding to protein kinase C requires a cysteine
zinc-finger-like sequence.
PROC.NATL.ACAD.SCI.U.S.A. 86 4868-4871 (1989).
3. BOGUSKI, M.S., BAIROCH, A., ATTWOOD, T.K. AND MICHAELS, G.S.
Proto-vav and gene expression.
NATURE 358 113 (1992).
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Documentation | Diacylglycerol (DAG) is an important second messenger; phorbol esters
(PE) are analogues of DAG and are potent tumour promoters that cause
a variety of physiological changes when administered to both cells and
tissues. DAG activates a family of Ser/Thr protein kinases known
collectively as protein kinase C (PKC) [1]: PE's can stimulate PKC
directly. The N-terminal region of PKC, known as C1, has been shown to
bind PE and DAG in a phospholipid-dependent fashion [2]. The C1 region
of PKC contains 1 or 2 copies of a Cys-rich region of about 50 amino acid
residues, which is essential for DAG/PE binding.
DAGPEDOMAIN is a 4-element fingerprint that encodes this Cys-rich region.
The fingerprint was derived from an initial alignment of 13 sequences
(A.Bairoch, personal communication): the motifs span the full length of
the DAG/PE binding domain. Two iterations on OWL10.0 were required to
reach convergence, at which point every known occurrence of the motif was
detected (38 in all), together with an additional protein - the human vav
oncogene. The implication is that the vav oncogene may well bind DAG
and/or PE's and could thus be involved in signal transduction [3].
An update on SPTR37_9f identified a true set of 101 sequences, and 25
partial matches.
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Sequence Titles | CHIN_HUMAN N-CHIMAERIN (NC) (N-CHIMERIN) (ALPHA CHIMERIN) (A-CHIMAERIN) - HOMO SAPIENS (HUMAN). CHIN_RAT N-CHIMAERIN (NC) (N-CHIMERIN) (ALPHA CHIMERIN) (A-CHIMAERIN) - RATTUS NORVEGICUS (RAT). CHIO_HUMAN BETA-CHIMAERIN (BETA-CHIMERIN) - HOMO SAPIENS (HUMAN). CHIO_RAT BETA-CHIMAERIN (BETA-CHIMERIN) - RATTUS NORVEGICUS (RAT). KDGA_HUMAN DIACYLGLYCEROL KINASE, ALPHA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- ALPHA) (DAG KINASE ALPHA) (80 KD DIACYLGLYCEROL KINASE) - HOMO SAPIENS (HUMAN). KDGA_PIG DIACYLGLYCEROL KINASE, ALPHA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- ALPHA) (DAG KINASE ALPHA) (80 KD DIACYLGLYCEROL KINASE) - SUS SCROFA (PIG). KDGA_RAT DIACYLGLYCEROL KINASE, ALPHA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- ALPHA) (DAG KINASE ALPHA) (80 KD DIACYLGLYCEROL KINASE) - RATTUS NORVEGICUS (RAT). KDGB_RAT DIACYLGLYCEROL KINASE, BETA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- BETA) (DAG KINASE BETA) (90 KD DIACYLGLYCEROL KINASE) - RATTUS NORVEGICUS (RAT). KDGD_HUMAN DIACYLGLYCEROL KINASE, DELTA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- DELTA) (DAG KINASE DELTA) (80 KD DIACYLGLYCEROL KINASE) - HOMO SAPIENS (HUMAN). KDGG_HUMAN DIACYLGLYCEROL KINASE, GAMMA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- GAMMA) (DAG KINASE GAMMA) - HOMO SAPIENS (HUMAN). KDGG_RAT DIACYLGLYCEROL KINASE, GAMMA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- GAMMA) (DAG KINASE GAMMA) (88 KD DIACYLGLYCEROL KINASE) - RATTUS NORVEGICUS (RAT). KDGL_CAEEL PROBABLE DIACYLGLYCEROL KINASE (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK) (DAG KINASE) - CAENORHABDITIS ELEGANS. KMIL_CHICK MIL PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) - GALLUS GALLUS (CHICKEN). KPC1_CAEEL PROTEIN KINASE C-LIKE 1 (EC 2.7.1.-) (PKC) - CAENORHABDITIS ELEGANS. KPC1_DROME PROTEIN KINASE C, BRAIN ISOZYME (EC 2.7.1.-) (PKC) (DPKC53E(BR)) - DROSOPHILA MELANOGASTER (FRUIT FLY). KPC1_HUMAN PROTEIN KINASE C, BETA-I TYPE (EC 2.7.1.-) (PKC-BETA-1) - HOMO SAPIENS (HUMAN). KPC1_RABIT PROTEIN KINASE C, BETA-I TYPE (EC 2.7.1.-) (PKC-BETA-1) - ORYCTOLAGUS CUNICULUS (RABBIT). KPC1_RAT PROTEIN KINASE C, BETA-I TYPE (EC 2.7.1.-) (PKC-BETA-1) - RATTUS NORVEGICUS (RAT). KPC2_BOVIN PROTEIN KINASE C, BETA-II TYPE (EC 2.7.1.-) (PKC-BETA-2) - BOS TAURUS (BOVINE). KPC2_CAEEL PROTEIN KINASE C-LIKE 2 (EC 2.7.1.-) (PKC1B) - CAENORHABDITIS ELEGANS. KPC2_DROME PROTEIN KINASE C, EYE ISOZYME (EC 2.7.1.-) (PKC) (DPKC53E(EY)) (PROTEIN INAC) (PHOTORECEPTOR-SPECIFIC PKC) (EYE-PKC) - DROSOPHILA MELANOGASTER (FRUIT FLY). KPC2_HUMAN PROTEIN KINASE C, BETA-II TYPE (EC 2.7.1.-) (PKC-BETA-2) - HOMO SAPIENS (HUMAN). KPC2_MOUSE PROTEIN KINASE C, BETA-II TYPE (EC 2.7.1.-) (PKC-BETA-2) - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT). KPC2_RABIT PROTEIN KINASE C, BETA-II TYPE (EC 2.7.1.-) (PKC-BETA-2) - ORYCTOLAGUS CUNICULUS (RABBIT). KPC3_DROME PROTEIN KINASE C (EC 2.7.1.-) (PKC) (DPKC98F) - DROSOPHILA MELANOGASTER (FRUIT FLY). KPCA_BOVIN PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - BOS TAURUS (BOVINE). KPCA_HUMAN PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - HOMO SAPIENS (HUMAN). KPCA_MOUSE PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - MUS MUSCULUS (MOUSE). KPCA_RABIT PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - ORYCTOLAGUS CUNICULUS (RABBIT). KPCA_RAT PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - RATTUS NORVEGICUS (RAT). KPCD_HUMAN PROTEIN KINASE C, DELTA TYPE (EC 2.7.1.-) (NPKC-DELTA) - HOMO SAPIENS (HUMAN). KPCD_MOUSE PROTEIN KINASE C, DELTA TYPE (EC 2.7.1.-) (NPKC-DELTA) - MUS MUSCULUS (MOUSE). KPCD_RAT PROTEIN KINASE C, DELTA TYPE (EC 2.7.1.-) (NPKC-DELTA) - RATTUS NORVEGICUS (RAT). KPCE_HUMAN PROTEIN KINASE C, EPSILON TYPE (EC 2.7.1.-) (NPKC-EPSILON) - HOMO SAPIENS (HUMAN). KPCE_MOUSE PROTEIN KINASE C, EPSILON TYPE (EC 2.7.1.-) (NPKC-EPSILON) - MUS MUSCULUS (MOUSE). KPCE_RABIT PROTEIN KINASE C, EPSILON TYPE (EC 2.7.1.-) (NPKC-EPSILON) - ORYCTOLAGUS CUNICULUS (RABBIT). KPCE_RAT PROTEIN KINASE C, EPSILON TYPE (EC 2.7.1.-) (NPKC-EPSILON) - RATTUS NORVEGICUS (RAT). KPCG_HUMAN PROTEIN KINASE C, GAMMA TYPE (EC 2.7.1.-) (PKC-GAMMA) - HOMO SAPIENS (HUMAN). KPCG_MOUSE PROTEIN KINASE C, GAMMA TYPE (EC 2.7.1.-) (PKC-GAMMA) - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT). KPCG_RABIT PROTEIN KINASE C, GAMMA TYPE (EC 2.7.1.-) (PKC-GAMMA) (DELTA) - ORYCTOLAGUS CUNICULUS (RABBIT). KPCI_HUMAN PROTEIN KINASE C, IOTA TYPE (EC 2.7.1.-) (NPKC-IOTA) - HOMO SAPIENS (HUMAN). KPCL_HUMAN PROTEIN KINASE C, ETA TYPE (EC 2.7.1.-) (NPKC-ETA) (PKC-L) - HOMO SAPIENS (HUMAN). KPCL_MOUSE PROTEIN KINASE C, ETA TYPE (EC 2.7.1.-) (NPKC-ETA) (PKC-L) - MUS MUSCULUS (MOUSE). KPCL_RAT PROTEIN KINASE C, ETA TYPE (EC 2.7.1.-) (NPKC-ETA) (PKC-L) - RATTUS NORVEGICUS (RAT). KPCM_HUMAN PROTEIN KINASE C, MU TYPE (EC 2.7.1.-) (NPKC-MU) - HOMO SAPIENS (HUMAN). KPCT_HUMAN PROTEIN KINASE C, THETA TYPE (EC 2.7.1.-) (NPKC-THETA) - HOMO SAPIENS (HUMAN). KPCT_MOUSE PROTEIN KINASE C, THETA TYPE (EC 2.7.1.-) (NPKC-THETA) - MUS MUSCULUS (MOUSE). KPCZ_HUMAN PROTEIN KINASE C, ZETA TYPE (EC 2.7.1.-) (NPKC-ZETA) - HOMO SAPIENS (HUMAN). KPCZ_MOUSE PROTEIN KINASE C, ZETA TYPE (EC 2.7.1.-) (NPKC-ZETA) - MUS MUSCULUS (MOUSE). KPCZ_RABIT PROTEIN KINASE C, ZETA TYPE (EC 2.7.1.-) (NPKC-ZETA) - ORYCTOLAGUS CUNICULUS (RABBIT). KPCZ_RAT PROTEIN KINASE C, ZETA TYPE (EC 2.7.1.-) (NPKC-ZETA) - RATTUS NORVEGICUS (RAT). KRAA_HUMAN A-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) (ONCOGENE PKS2) - HOMO SAPIENS (HUMAN). KRAA_PIG A-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) (A-RAF-1) - SUS SCROFA (PIG). KRAA_RAT A-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) - RATTUS NORVEGICUS (RAT). KRAB_HUMAN B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) (P94) - HOMO SAPIENS (HUMAN). KRAF_HUMAN RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) (RAF-1) (C-RAF) - HOMO SAPIENS (HUMAN). KRAF_RAT RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) (RAF-1) (C-RAF) - RATTUS NORVEGICUS (RAT). KRAF_XENLA RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) - XENOPUS LAEVIS (AFRICAN CLAWED FROG). O01583 SIMILAR TO SERINE/THREONINE-PROTEIN KINASE - CAENORHABDITIS ELEGANS. O01715 PROTEIN KINASE C - HYDRA ATTENUATA (HYDRA) (HYDRA VULGARIS). O14795 MUNC13 - HOMO SAPIENS (HUMAN). O17665 UNC-13 PROTEIN - CAENORHABDITIS ELEGANS. O44368 GENGHIS KHAN - DROSOPHILA MELANOGASTER (FRUIT FLY). O44588 F48G7.9 PROTEIN - CAENORHABDITIS ELEGANS. O44590 F48G7.10 PROTEIN - CAENORHABDITIS ELEGANS. O45720 R12G8.1 PROTEIN - CAENORHABDITIS ELEGANS. O45818 T25E12.4A PROTEIN - CAENORHABDITIS ELEGANS. O54874 MYTONIC DYSTROPHY KINASE-RELATED CDC42-BINDING KINASE - RATTUS NORVEGICUS (RAT). O54875 MYOTONIC DYSTROPHY KINASE-RELATED CDC42-BINDING KINASE MRCK-BETA - RATTUS NORVEGICUS (RAT). O61224 SERINE/THREONINE PROTEIN KINASE - SYCON RAPHANUS. O61225 SERINE/THREONINE PROTEIN KINASE - SYCON RAPHANUS. O62567 SERINE/THREONINE PROTEIN KINASE - SUBERITES DOMUNCULA. O62569 SERINE/THREONINE PROTEIN KINASE - SUBERITES DOMUNCULA. O76664 ALTERNATIVELY SPLICED FORM OF C. ELEGANS PROTEIN KINASE C-LIKE TPA-1 (SW: P34722) - CAENORHABDITIS ELEGANS. O76850 EYE-SPECIFIC PROTEIN KINASE C - CALLIPHORA VICINA (BLUE BLOWFLY) (CALLIPHORA ERYTHROCEPHALA). O88469 RAS GUANYL RELEASING PROTEIN - RATTUS NORVEGICUS (RAT). P90980 PROTEIN KINASE C2 A ISOFORM - CAENORHABDITIS ELEGANS. P90981 PROTEIN KINASE C2 B ISOFORM - CAENORHABDITIS ELEGANS. Q15144 PROTEIN KINASE C DELTA-TYPE - HOMO SAPIENS (HUMAN). Q15207 PROTEIN KINASE C, ZETA TYPE (EC 2.7.1.-) (NPKC-ZETA) - HOMO SAPIENS (HUMAN). Q16975 CALCIUM-INDEPENDENT PROTEIN KINASE C (EC 2.7.1.-) (APL II) - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE). Q17860 DIACYLGLYCEROL KINASE - CAENORHABDITIS ELEGANS. Q19025 SIMILAR TO PROTEIN KINASE C - CAENORHABDITIS ELEGANS. Q19266 SIMILAR TO PROTEIN KINASE C - CAENORHABDITIS ELEGANS. Q19770 F25B3.3 PROTEIN - CAENORHABDITIS ELEGANS. Q20953 KIN-13 PROTEIN - CAENORHABDITIS ELEGANS. Q25378 PROTEIN KINASE C (EC 2.7.1.-) - LYTECHINUS PICTUS (PAINTED SEA URCHIN). Q62074 PROTEIN KINASE C, IOTA TYPE (EC 2.7.1.-) (NPKC-IOTA) (PROTEIN KINASE C LAMBDA) - MUS MUSCULUS (MOUSE). Q62101 PROTEIN KINASE C, MU (SERINE/THREONINE PROTEIN KINASE) - MUS MUSCULUS (MOUSE). Q62768 MUNC13-1 - RATTUS NORVEGICUS (RAT). Q62769 MUNC13-2 - RATTUS NORVEGICUS (RAT). Q62770 MUNC13-3 - RATTUS NORVEGICUS (RAT). Q91569 PROTEIN KINASE C SUBSPECIES LAMBDA/IOTA - XENOPUS LAEVIS (AFRICAN CLAWED FROG). Q92153 HAT-2 - SERINUS CANARIA (CANARY). RMIL_CHICK RMIL SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) - GALLUS GALLUS (CHICKEN). RMIL_COTJA RMIL SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) - COTURNIX COTURNIX JAPONICA (JAPANESE QUAIL). UN13_CAEEL PHORBOL ESTER/DIACYLGLYCEROL-BINDING PROTEIN UNC-13 - CAENORHABDITIS ELEGANS. VAV_HUMAN VAV PROTO-ONCOGENE - HOMO SAPIENS (HUMAN). VAV_MOUSE VAV PROTO-ONCOGENE - MUS MUSCULUS (MOUSE). VAV_RAT VAV PROTO-ONCOGENE (P95) - RATTUS NORVEGICUS (RAT). YB65_SCHPO HYPOTHETICAL 72.2 KD PROTEIN C12C2.05C IN CHROMOSOME II - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). KPC1_ASPNG PROTEIN KINASE C-LIKE (EC 2.7.1.-) - ASPERGILLUS NIGER. KPC1_TRIRE PROTEIN KINASE C-LIKE (EC 2.7.1.-) - TRICHODERMA REESEI (HYPOCREA JECORINA). KPC1_YEAST PROTEIN KINASE C-LIKE 1 (EC 2.7.1.-) (PKC 1) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). O00538 F25B3.3 KINASE LIKE PROTEIN - HOMO SAPIENS (HUMAN). O88673 DIACYLGLYCEROL KINASE, ALPHA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- ALPHA) (DAG KINASE ALPHA) (80 KD DIACYLGLYCEROL KINASE) - MUS MUSCULUS (MOUSE). P87253 PROTEIN KINASE C-LIKE (EC 2.7.1.-) - NEUROSPORA CRASSA. PCK2_SCHPO PROTEIN KINASE C-LIKE 2 (EC 2.7.1.-) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). Q22744 T24F1.3 PROTEIN - CAENORHABDITIS ELEGANS. VAV2_HUMAN VAV2 PROTEIN - HOMO SAPIENS (HUMAN). VAV2_MOUSE VAV2 PROTEIN - MUS MUSCULUS (MOUSE). KDGH_HUMAN PUTATIVE DIACYLGLYCEROL KINASE ETA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK-ETA) (DAG KINASE ETA) (DIACYLGLYCEROL KINASE, DELTA) (KIAA0145) - HOMO SAPIENS (HUMAN). KDGH_MESAU DIACYLGLYCEROL KINASE ETA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- ETA) (DAG KINASE ETA) - MESOCRICETUS AURATUS (GOLDEN HAMSTER). KPC1_CANAL PROTEIN KINASE C-LIKE 1 (EC 2.7.1.-) (PKC 1) - CANDIDA ALBICANS (YEAST). KRAF_CAEEL RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) - CAENORHABDITIS ELEGANS. KRAF_DROME RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE DRAF-1 (EC 2.7.1.-) (POLE-HOLE PROTEIN) - DROSOPHILA MELANOGASTER (FRUIT FLY). O01738 SIMILARITY TO PROTEIN KINASE C - CAENORHABDITIS ELEGANS. O15463 PTPL1-ASSOCIATED RHOGAP - HOMO SAPIENS (HUMAN). O42632 PROTEIN KINASE C-LIKE (EC 2.7.1.-) - COCHLIOBOLUS HETEROSTROPHUS (DRECHSLERA MAYDIS). O44113 PUTATIVE GUANINE NUCLEOTIDE EXCHANGE FACTOR RHOGEF2 - DROSOPHILA MELANOGASTER (FRUIT FLY). O44381 SHAR PEI/DRHOGEF2 - DROSOPHILA MELANOGASTER (FRUIT FLY). P97306 STAC - MUS MUSCULUS (MOUSE). PCK1_SCHPO PROTEIN KINASE C-LIKE 1 (EC 2.7.1.-) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). Q99469 STAC - HOMO SAPIENS (HUMAN).
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