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PR02005

Identifier
INSLNLIKEGF1  [View Relations]  [View Alignment]  
Accession
PR02005
No. of Motifs
4
Creation Date
17-APR-2009
Title
Insulin-like growth factor I signature
Database References
PRINTS; PR00276 INSULINFAMLY; PR02002 INSLNLIKEGF
PDB; 1A7F; 1AI0; 1AIY; 1APH; 1B9E; 1B9G; 1BEN; 1BPH

PDB; 1BQT; 1CPH
SCOP; 1A7F; 1AI0; 1AIY; 1APH; 1B9E; 1B9G; 1BEN; 1BPH

SCOP; 1BQT; 1CPH
CATH; 1A7F; 1AI0; 1AIY; 1APH; 1B9E; 1B9G; 1BEN; 1BPH

CATH; 1BQT; 1CPH
MIM; 147440; 176730; 608747
Literature References
1. BLUNDELL, T.L. AND HUMBEL, R.E. 
Hormone families: pancreatic hormones and homologous growth factors. 
NATURE 287 781-7 (1980). 
 
2. BELL, G.I., PICTET, R.L., RUTTER, W.J., CORDELL, B., TISCHER, E. AND
GOODMAN, H.M.
Sequence of the human insulin gene.
NATURE 284 26-32 (1980).
 
3. BELL, G.I., SWAIN, W.F., PICTET, R.L., CORDELL, B., GOODMAN, H.M. AND
RUTTER, W.J.
Nucleotide sequence of a cDNA clone encoding human preproinsulin.
NATURE 282 525-527 (1979).
 
4. GARIBAY-TUPAS, J.L., CSISZAR, K., FOX, M., POVEY, S. AND 
BRYANT-GREENWOOD, G.D. 
Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes
and their chromosomal localization on chromosome 9p24.1 by radiation hybrid
and breakpoint mapping. 
J.MOL.ENDOCRINOL. 23 355-365 (1999). 
 
5. GUNNERSEN, J.M., FU, P., ROCHE, P.J. AND TREGEAR, G.W. 
Expression of human relaxin genes: characterization of a novel 
alternatively-spliced human relaxin mRNA species. 
MOL.CELL.ENDOCRINOL. 118 85-94 (1996). 
 
6. KONDO, H., INO, M., SUZUKI, A., ISHIZAKI, H. AND IWAMI, M. 
Multiple gene copies for bombyxin, an insulin-related peptide of the 
silkmoth Bombyx mori: structural signs for gene rearrangement and 
duplication responsible for generation of multiple molecular forms of
bombyxin. 
J.MOL.BIOL. 259 926-937 (1996). 
 
7. COOKE, R.M., HARVEY, T.S. AND CAMPBELL, I.D. 
Solution structure of human insulin-like growth factor 1: a nuclear magnetic 
resonance and restrained molecular dynamics study. 
BIOCHEMISTRY 30 5484-5491 (1991). 
 
8. SATO, A., NISHIMURA, S., OHKUBO, T., KYOGOKU, Y., KOYAMA, S.,
KOBAYASHI, M., YASUDA, T. AND KOBAYASHI, Y. 
1H-NMR assignment and secondary structure of human insulin-like growth
factor-I (IGF-I) in solution. 
J.BIOCHEM. 111 529-536 (1992). 
 
9. BRANGE, J., DODSON, G.G., EDWARDS, D.J., HOLDEN, P.H. AND
WHITTINGHAM, J.L. 
A model of insulin fibrils derived from the X-ray crystal structure of a 
monomeric insulin (despentapeptide insulin). 
PROTEINS 27 507-516 (1997). 
 
10. DULL, T.J., GRAY, A., HAYFLICK, J.S. AND ULLRICH, A.
Insulin-like growth factor II precursor gene organization in relation to 
insulin gene family.
NATURE 310 777-781 (1984).
 
11. WOODS, K.A., CAMACHO-HUBNER, C., SAVAGE, M.O. AND CLARK, A.J.L. 
Intrauterine growth retardation and postnatal growth failure associated
with deletion of the insulin-like growth factor I gene. 
NEW ENG.J.MED. 335 1363-1367 (1996).

Documentation
The insulin family of proteins groups together several evolutionarily
related active peptides [1]: these include insulin [2,3], relaxin [4,5],
insect prothoracicotropic hormone (bombyxin) [6], insulin-like growth
factors (IGF1 and IGF2) [7,8], mammalian Leydig cell-specific insulin-like
peptide (gene INSL3), early placenta insulin-like peptide (ELIP) (gene 
INSL4), locust insulin-related peptide (LIRP), molluscan insulin-related
peptides (MIP) and Caenorhabditis elegans insulin-like peptides. The 3D
structures of a number of family members have been determined [7-9]. The
fold comprises two polypeptide chains (A and B) linked by two disulphide 
bonds: all share a conserved arrangement of 4 cysteines in their A chain,
the first of which is linked by a disulphide bond to the third, while the
second and fourth are linked by interchain disulphide bonds to cysteines
in the B chain.
 
The IGFs, or somatomedins, play a key role in pre-adolescent mammalian 
growth. IGFI expression is regulated by growth hormone and mediates post-
natal growth [10]. Defects in IGF1 are the cause of insulin-like growth
factor I deficiency (IGF1 deficiency), an autosomal recessive disorder
characterised by growth retardation, sensorineural deafness and mental
retardation [11].
 
INSLNLIKEGF1 is a 4-element fingerprint that provides a signature for 
insulin-like growth factor I. The fingerprint was derived from an initial
alignment of 18 sequences: the motifs were drawn from conserved regions 
spanning virtually the full alignment length, focusing on those sections
that characterise insulin-like growth factor I but distinguish it from 
closely related members of the insulin family. Three iterations on 
SPTR55_38f were required to reach convergence, at which point a true set 
comprising 93 sequences was identified. A single partial match was also
found, Q91442_SQUAC, an insulin-like growth factor I from Squalus acanthias
(Spiny dogfish) that fails to make a signficant match with motif 4.
Summary Information
  93 codes involving  4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
493939393
31110
20000
1234
True Positives
A0FJ28_SHEEP  A0N8V2_SHEEP  A1X594_9PLEU  A1XX00_CARAU  
A1Z0Z7_CEREL A2IT63_ANAPL A2IX61_9PERC A4GUE7_SALSA
A5HKY0_CYPCA A5JSH0_SPAAU A7BK19_ANGJA A7BK20_ANGJA
A7LH99_9PLEU A7LHD8_HORSE A7LKM7_ANAPL A7UEC0_CTEID
A8CG79_9PERO A8CG83_9PERO A9XU11_SPAAU A9XU12_SPAAU
A9YN29_9SMEG B0FBP3_VULLA IGF1_AILFU IGF1_AILME
IGF1_BOVIN IGF1_CAPHI IGF1_CAVPO IGF1_CHICK
IGF1_ONCKI IGF1_ONCMY IGF1_PANTA IGF1_PIG
IGF1_PYGRO IGF1_RABIT IGF1_SHEEP IGF1_XENLA
IGFA_CYPCA IGFA_HUMAN IGFA_MOUSE IGFA_RAT
IGFB_CYPCA IGFB_HUMAN O42289 O42336
O57436 O73720 O93380 O93527
O93607 P79824 P97899 Q0PPT2_PIG
Q0PPT3_PIG Q0Q005_MICSA Q0WY75_SOLSE Q14620
Q14WA7_9AVES Q1PCW8_9TELE Q27YE0_ACIRT Q29U99_9PERO
Q2TU60_9TELE Q38JX3_DANAE Q45QB4_PIG Q4G1F3_SPAAU
Q4VJB9_MOUSE Q4VJC0_MOUSE Q506L8_9TELE Q547V2_MOUSE
Q5BQH3_9TELE Q5Q0U4_DICLA Q5RK13_RAT Q5U743_HUMAN
Q6R527_EPICO Q6T8S2_MUGCE Q6V293_ICTPU Q70BT5_PERFL
Q70BT6_PERFL Q7LZC6_CLAMA Q7T1A7_PERFV Q800D5_9TELE
Q800Y5_SIGGU Q8CAR0_MOUSE Q90VV9_DANRE Q91230
Q91231 Q91965 Q98SR6_MEGAM Q9IBI0_CYPCA
Q9NP10_HUMAN Q9PSX5_PAROL Q9PWK2_CARAU Q9YI57_ACASC
Q9YI82_CARAU
True Positive Partials
Codes involving 3 elements
Q91442
Sequence Titles
A0FJ28_SHEEP Insulin-like growth factor I - Ovis aries (Sheep). 
A0N8V2_SHEEP Insuline-like growth factor-I (2) - Ovis aries (Sheep).
A1X594_9PLEU Insulin-like growth factor I precursor - Paralichthys lethostigma (southern flounder).
A1XX00_CARAU Insulin-like growth factor 1 - Carassius auratus (Goldfish).
A1Z0Z7_CEREL Insulin-like growth factor - Cervus elaphus (Red deer).
A2IT63_ANAPL Insulin-like growth factor-I - Anas platyrhynchos (Domestic duck).
A2IX61_9PERC Insulin-like growth factor I - Cottus kazika.
A4GUE7_SALSA Insulin-like growth factor I - Salmo salar (Atlantic salmon).
A5HKY0_CYPCA Insulin-like growth factor I - Cyprinus carpio (Common carp).
A5JSH0_SPAAU Insulin-like growth factor I - Sparus aurata (Gilthead sea bream).
A7BK19_ANGJA Insulin-like growth factor I Ea1 - Anguilla japonica (Japanese eel).
A7BK20_ANGJA Insulin-like growth factor I Ea2 - Anguilla japonica (Japanese eel).
A7LH99_9PLEU Insulin-like growth factor I - Paralichthys adspersus (fine flounder).
A7LHD8_HORSE Insulin-like growth factor 1 - Equus caballus (Horse).
A7LKM7_ANAPL Insulin-like growth factor 1 - Anas platyrhynchos (Domestic duck).
A7UEC0_CTEID Insulin-like growth factor I - Ctenopharyngodon idella (Grass carp).
A8CG79_9PERO Preproinsulin-growth factor I - Pagrus auriga.
A8CG83_9PERO Preproinsulin-growth factor I - Diplodus sargus (white seabream).
A9XU11_SPAAU Insulin-like growth factor 1 isoform b - Sparus aurata (Gilthead sea bream).
A9XU12_SPAAU Insulin-like growth factor 1 isoform c - Sparus aurata (Gilthead sea bream).
A9YN29_9SMEG Preproinsulin-like growth factor-I - Odontesthes bonariensis (pejerrey).
B0FBP3_VULLA Insulin-like growth factor 1 - Vulpes lagopus (Arctic fox) (Alopex lagopus).
IGF1_AILFU Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Ailurus fulgens (Lesser panda) (Red panda).
IGF1_AILME Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Ailuropoda melanoleuca (Giant panda).
IGF1_BOVIN Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Bos taurus (Bovine).
IGF1_CAPHI Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Capra hircus (Goat).
IGF1_CAVPO Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Cavia porcellus (Guinea pig).
IGF1_CHICK Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Gallus gallus (Chicken).
IGF1_ONCKI Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Oncorhynchus kisutch (Coho salmon).
IGF1_ONCMY Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
IGF1_PANTA Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Panthera tigris altaica (Siberian tiger).
IGF1_PIG Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Sus scrofa (Pig).
IGF1_PYGRO Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Pygathrix roxellana (Golden snub-nosed monkey) (Rhinopithecus roxellana).
IGF1_RABIT Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Oryctolagus cuniculus (Rabbit).
IGF1_SHEEP Insulin-like growth factor I precursor (IGF-I) (Somatomedin) - Ovis aries (Sheep).
IGF1_XENLA INSULIN-LIKE GROWTH FACTOR I PRECURSOR (IGF-I) (SOMATOMEDIN) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
IGFA_CYPCA INSULIN-LIKE GROWTH FACTOR I, ADULT FORM PRECURSOR - CYPRINUS CARPIO (COMMON CARP).
IGFA_HUMAN INSULIN-LIKE GROWTH FACTOR IA PRECURSOR (IGF-IA) (SOMATOMEDIN C) - HOMO SAPIENS (HUMAN).
IGFA_MOUSE INSULIN-LIKE GROWTH FACTOR IA PRECURSOR (IGF-IA) (SOMATOMEDIN) - MUS MUSCULUS (MOUSE).
IGFA_RAT INSULIN-LIKE GROWTH FACTOR IA PRECURSOR (IGF-IA) (SOMATOMEDIN) - RATTUS NORVEGICUS (RAT).
IGFB_CYPCA INSULIN-LIKE GROWTH FACTOR I, JUVENILE FORM PRECURSOR - CYPRINUS CARPIO (COMMON CARP).
IGFB_HUMAN INSULIN-LIKE GROWTH FACTOR IB PRECURSOR (IGF-IB) (SOMATOMEDIN C) - HOMO SAPIENS (HUMAN).
O42289 INSULIN-LIKE GROWTH FACTOR I PRECURSOR - OREOCHROMIS MOSSAMBICUS (MOZAMBIQUE TILAPIA) (TILAPIA MOSSAMBICA).
O42336 INSULIN-LIKE GROWTH FACTOR PRECURSOR - MYOXOCEPHALUS SCORPIUS (SHORTHORN SCULPIN) (DADDY SCULPIN).
O57436 INSULIN-LIKE GROWTH FACTOR I - PARALICHTHYS OLIVACEUS (FLOUNDER).
O73720 INSULIN-LIKE GROWTH FACTOR I - OREOCHROMIS MOSSAMBICUS (MOZAMBIQUE TILAPIA) (TILAPIA MOSSAMBICA).
O93380 INSULIN-LIKE GROWTH FACTOR-I PRECURSOR - MELEAGRIS GALLOPAVO (COMMON TURKEY).
O93527 INSULIN-LIKE GROWTH FACTOR I - PARALICHTHYS OLIVACEUS (FLOUNDER).
O93607 PREPROINSULIN-LIKE GROWTH FACTOR IA - PARALICHTHYS OLIVACEUS (FLOUNDER).
P79824 PREPRO INSULIN-LIKE GROWTH FACTOR I PRECURSOR - OREOCHROMIS MOSSAMBICUS (MOZAMBIQUE TILAPIA) (TILAPIA MOSSAMBICA).
P97899 INSULIN-LIKE GROWTH FACTOR I - RATTUS NORVEGICUS (RAT).
Q0PPT2_PIG Class 2 insulin-like growth factor I - Sus scrofa (Pig).
Q0PPT3_PIG Class 1 insulin-like growth factor I - Sus scrofa (Pig).
Q0Q005_MICSA Insulin-like growth factor I - Micropterus salmoides (Largemouth bass).
Q0WY75_SOLSE PreproInsulin-growth factor I - Solea senegalensis (Sole).
Q14620 INSULIN-LIKE GROWTH FACTOR I PRECURSOR - HOMO SAPIENS (HUMAN).
Q14WA7_9AVES Insulin-like growth factor I - Anser anser (domestic goose).
Q1PCW8_9TELE Insulin-like growth factor I - Spinibarbus sinensis.
Q27YE0_ACIRT Insulin-like growth factor 1 precursor - Acipenser ruthenus (Sterlet).
Q29U99_9PERO Insulin-like growth factor I - Umbrina cirrosa.
Q2TU60_9TELE Insulin-like growth factor-I - Pimephales promelas.
Q38JX3_DANAE Insulin-like growth factor 1 - Danio aequipinnatus (Giant danio) (Brachydanio aequipinnatus).
Q45QB4_PIG Insulin-like growth factor I precursor - Sus scrofa (Pig).
Q4G1F3_SPAAU Insulin-like growth factor 1 - Sparus aurata (Gilthead sea bream).
Q4VJB9_MOUSE Insulin-like growth factor 1 isoform Eb - Mus musculus (Mouse).
Q4VJC0_MOUSE Insulin-like growth factor 1 isoform Ea (Adult male kidney cDNA, RIKEN full-length enriched library, clone:F530012N08 product:insulin-like growth factor 1, full insert sequence) (NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630227L18 product:insulin-like growth factor 1, full insert sequence) - Mus musculus (Mouse).
Q506L8_9TELE Insulin-like growth factor-1 - Cirrhinus molitorella (mud carp).
Q547V2_MOUSE Insulin-like growth factor 1 - Mus musculus (Mouse).
Q5BQH3_9TELE Insulin-like growth factor I - Gymnocypris przewalskii.
Q5Q0U4_DICLA Insulin-like growth factor-1 - Dicentrarchus labrax (European sea bass).
Q5RK13_RAT Igf1 protein - Rattus norvegicus (Rat).
Q5U743_HUMAN Insulin-like growth factor 1 (Somatomedin C) (Insulin-like growth factor 1 (Somatomedin C), isoform CRA_d) - Homo sapiens (Human).
Q6R527_EPICO Preproinsulin-like growth factor I precursor - Epinephelus coioides (Orange-spotted grouper).
Q6T8S2_MUGCE Insulin-like growth factor I - Mugil cephalus (Flathead mullet) (Mugil japonicus).
Q6V293_ICTPU Insulin-like growth factor I - Ictalurus punctatus (Channel catfish).
Q70BT5_PERFL Insulin-like growth factor 1 precursor - Perca fluviatilis (Perch).
Q70BT6_PERFL Insulin-like growth factor 1 precursor - Perca fluviatilis (Perch).
Q7LZC6_CLAMA Insulin-like growth factor I, brain-specific - Clarias macrocephalus (Thai catfish).
Q7T1A7_PERFV Insulin-like growth factor Ib precursor - Perca flavescens (Yellow perch).
Q800D5_9TELE Insulin-like growth factor I - Megalobrama terminalis.
Q800Y5_SIGGU Preproinsulin-like growth factor I precursor - Siganus guttatus (Rabbitfish).
Q8CAR0_MOUSE 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130080F01 product:insulin-like growth factor 1, full insert sequence - Mus musculus (Mouse).
Q90VV9_DANRE Insulin-like growth factor 1 precursor (Insulin-like growth factor 1) (Insulin-like growth factor 1b) (Insulin-like growth factor IL) - Danio rerio (Zebrafish) (Brachydanio rerio).
Q91230 INSULIN-LIKE GROWTH FACTOR-I - ONCORHYNCHUS TSCHAWYTSCHA (CHINOOK SALMON) (KING SALMON).
Q91231 INSULIN-LIKE GROWTH FACTOR-I - ONCORHYNCHUS TSCHAWYTSCHA (CHINOOK SALMON) (KING SALMON).
Q91965 INSULIN-LIKE GROWTH FACTOR-I - ONCORHYNCHUS TSCHAWYTSCHA (CHINOOK SALMON) (KING SALMON).
Q98SR6_MEGAM Insulin-like growth factor I - Megalobrama amblycephala (Chinese blunt snout bream) (Brema carp).
Q9IBI0_CYPCA Insulin-like growth factor I subtype Ea2 (Insulin-like growth factor- I) - Cyprinus carpio (Common carp).
Q9NP10_HUMAN IGF1 protein precursor - Homo sapiens (Human).
Q9PSX5_PAROL Preproinsulin-like growth factor Ib - Paralichthys olivaceus (Japanese flounder).
Q9PWK2_CARAU Insulin-like growth factor-I - Carassius auratus (Goldfish).
Q9YI57_ACASC Prepro-insulin-like growth factor I - Acanthopagrus schlegeli (Black porgy).
Q9YI82_CARAU Insulin-like growth factor-I - Carassius auratus (Goldfish).

Q91442 INSULIN-LIKE GROWTH FACTOR I PRECURSOR - SQUALUS ACANTHIAS (SPINY DOGFISH).
Scan History
SPTR55_38f 3  250  NSINGLE    
Initial Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
HTLSLLLCVLTLTSAAT IGF1_ONCMY 26 26 -
HTLSLLLCVLTLTSAAT IGF1_ONCKI 26 26 -
HLLYLALCLLTFTSSAT IGF1_AILFU 31 31 -
HLLYLALCLLTFTSSAT IGF1_PYGRO 31 31 -
HLFYLALCLLTFTSSAT IGF1_RABIT 15 15 -
HLFYLALCLLTFTSSAT IGF1_AILME 31 31 -
HLFYLALCLLTFTSSAT IGFA_HUMAN 31 31 -
HLFYLALCLLTFTSSAT IGFB_HUMAN 31 31 -
HLFYLGLCLLTFTSSAT IGF1_PANTA 31 31 -
HLFYLALCLLAFTSSAT IGF1_BOVIN 32 32 -
HLFYLALCLLAFTSSAT IGF1_CAPHI 32 32 -
HLFYLALCLLSFTSSAT IGF1_PIG 31 31 -
HLFYLALCLLTFTSSAT IGFA_RAT 31 31 -
HLFYLAFCLLVLTSSAT IGF1_CAVPO 8 8 -
HLFYLALCLLTFTSSTT IGFA_MOUSE 31 31 -
HLFYLALCLLAFSSSAT IGF1_SHEEP 32 32 -
HFFYLGLCLLTLTSSAA IGF1_CHICK 31 31 -
HLLYLVLCFLTLTHSAA IGF1_XENLA 31 31 -

Motif 2 width=18
Element Seqn Id St Int Rpt
SKPTGYGPSSRRSHNRGI IGF1_ONCMY 70 27 -
SKPTGYGPSSRRSHNRGI IGF1_ONCKI 70 27 -
NKPTGYGSSSRRAPQTGI IGF1_AILFU 74 26 -
NKPTGYGSSSRRAPQTGI IGF1_PYGRO 74 26 -
NKPTGYGSSSRRAPQTGI IGF1_RABIT 58 26 -
NKPTGYGSSSRRAPQTGI IGF1_AILME 74 26 -
NKPTGYGSSSRRAPQTGI IGFA_HUMAN 74 26 -
NKPTGYGSSSRRAPQTGI IGFB_HUMAN 74 26 -
NKPTGYGSSSRRAPQTGI IGF1_PANTA 74 26 -
NKPTGYGSSSRRAPQTGI IGF1_BOVIN 75 26 -
NKPTGYGSSSRRAPQTGI IGF1_CAPHI 75 26 -
NKPTGYGSSSRRAPQTGI IGF1_PIG 74 26 -
NKPTGYGSSIRRAPQTGI IGFA_RAT 74 26 -
NKPTGYGSSSRRAPQTGI IGF1_CAVPO 51 26 -
NKPTGYGSSIRRAPQTGI IGFA_MOUSE 74 26 -
NKPTGYGSSSRRAPQTGI IGF1_SHEEP 75 26 -
SKPTGYGSSSRRLHHKGI IGF1_CHICK 74 26 -
SKPTGYGSNNRRSHHRGI IGF1_XENLA 74 26 -

Motif 3 width=19
Element Seqn Id St Int Rpt
ELRRLEMYCAPVKSGKAAR IGF1_ONCMY 97 9 -
ELRRLEMYCAPVKSGKAAR IGF1_ONCKI 97 9 -
DLRRLEMYCAPLKPAKSAR IGF1_AILFU 101 9 -
DLRRLEMYCAPLKPAKSAR IGF1_PYGRO 101 9 -
DLRRLEMYCAPLKPAKAAR IGF1_RABIT 85 9 -
DLRRLEMYCAPLKPAKSAR IGF1_AILME 101 9 -
DLRRLEMYCAPLKPAKSAR IGFA_HUMAN 101 9 -
DLRRLEMYCAPLKPAKSAR IGFB_HUMAN 101 9 -
DLRRLEMYCAPLKPAKSAR IGF1_PANTA 101 9 -
DLRRLEMYCAPLKPAKSAR IGF1_BOVIN 102 9 -
DLRRLEMYCAPLKPTKSAR IGF1_CAPHI 102 9 -
DLRRLEMYCAPLKPAKSAR IGF1_PIG 101 9 -
DLRRLEMYCAPLKPTKSAR IGFA_RAT 101 9 -
DLRRLEMYCAPLKPAKSAR IGF1_CAVPO 78 9 -
DLRRLEMYCAPLKPTKAAR IGFA_MOUSE 101 9 -
DLRRLEMYCAPLKAAKSAR IGF1_SHEEP 102 9 -
DLRRLEMYCAPIKPPKSAR IGF1_CHICK 101 9 -
DFRRLEMYCAPAKQAKSAR IGF1_XENLA 101 9 -

Motif 4 width=15
Element Seqn Id St Int Rpt
SVRAQRHTDMPRTPK IGF1_ONCMY 116 0 -
SVRAQRHTDMPRTPK IGF1_ONCKI 116 0 -
SVRAQRHTDMPKAQK IGF1_AILFU 120 0 -
SVRAQRHTDMPKAQK IGF1_PYGRO 120 0 -
SVRAQRHTDMPKTQK IGF1_RABIT 104 0 -
SVRAQRHTDMPKAQK IGF1_AILME 120 0 -
SVRAQRHTDMPKTQK IGFA_HUMAN 120 0 -
SVRAQRHTDMPKTQK IGFB_HUMAN 120 0 -
SVRAQRHTDMPKAQK IGF1_PANTA 120 0 -
SVRAQRHTDMPKAQK IGF1_BOVIN 121 0 -
SVRAQRHTDMPKAQK IGF1_CAPHI 121 0 -
SVRAQRHTDMPKAQK IGF1_PIG 120 0 -
SIRAQRHTDMPKTQK IGFA_RAT 120 0 -
SVRAQRHTDMPKTQK IGF1_CAVPO 97 0 -
SIRAQRHTDMPKTQK IGFA_MOUSE 120 0 -
SVRAQRHTDMPKAQK IGF1_SHEEP 121 0 -
SVRAQRHTDMPKAQK IGF1_CHICK 120 0 -
SVRTQRHTDMPKAQK IGF1_XENLA 120 0 -
Final Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
HTLSLLLCVLTLTSAAT A4GUE7_SALSA 26 26 -
HTLSLLLCVLTLTSAAT Q91965 26 26 -
HTLSLLLCVLTLTSAAT Q91231 26 26 -
HTLSLLLCVLTLTSAAT IGF1_ONCMY 26 26 -
HTLSLLLCVLTLTSAAT IGF1_ONCKI 26 26 -
HTLSLLLCDLTLTSAAT Q91230 26 26 -
HTLSLLLCVLTLTPTAT Q5Q0U4_DICLA 26 26 -
HTLSLLLCVLTLTPTAT A1X594_9PLEU 26 26 -
HTLSLLLCVLTLTPTAT Q9PSX5_PAROL 26 26 -
HTLSLLLCVLTLTPTAT Q7T1A7_PERFV 26 26 -
HTLSLLLCVLTLTPTAT Q70BT6_PERFL 26 26 -
HTLSLLLCVLTLTPTAT Q70BT5_PERFL 26 26 -
HTLSLLLCVLTLTPTAT O93607 26 26 -
HTLSLLLCVLTLTPTAT O93527 26 26 -
HTLSLLLCVLTLTPTAT O57436 26 26 -
HLLYLALCLLTFTSSAT IGF1_AILFU 31 31 -
HLLYLALCLLTFTSSAT IGF1_PYGRO 31 31 -
HTLSLLLCVLTLTPTAT Q0Q005_MICSA 26 26 -
HLFYLALCLLTFTSSAT IGF1_RABIT 15 15 -
HLFYLALCLLTFTSSAT A7LHD8_HORSE 31 31 -
HLFYLALCLLTFTSSAT IGF1_AILME 31 31 -
HLFYLALCLLTFTSSAT IGFA_HUMAN 31 31 -
HLFYLALCLLTFTSSAT Q9NP10_HUMAN 8 8 -
HLFYLALCLLTFTSSAT Q5U743_HUMAN 31 31 -
HLFYLALCLLTFTSSAT Q14620 15 15 -
HLFYLALCLLTFTSSAT IGFB_HUMAN 31 31 -
HTLSLVLCVLTLTPVVT A7BK19_ANGJA 26 26 -
HTLSLVLCVLTLTPVVT A7BK20_ANGJA 26 26 -
HLFYLGLCLLTFTSSAT IGF1_PANTA 31 31 -
HLFYLALCLLAFTSSAT IGF1_BOVIN 32 32 -
HTLSLLLCILTLTPTAT Q800Y5_SIGGU 26 26 -
HLFYLALCLLAFTSSAT A1Z0Z7_CEREL 32 32 -
HLFYLALCLLAFTSSAT IGF1_CAPHI 32 32 -
HTLSLLLCVLTLTPTAT Q29U99_9PERO 26 26 -
HLFYLALCLLSFTSSAT IGF1_PIG 31 31 -
HLFYLALCLLSFTSSAT Q45QB4_PIG 31 31 -
HTLSLLLCVLTLTPTAT Q6R527_EPICO 26 26 -
HTLSLLLCVLTLTPTAT A9YN29_9SMEG 26 26 -
HLFYLALCLLSFTSSAT Q0PPT2_PIG 15 15 -
HLFYLALCLLSFTSSAT Q0PPT3_PIG 31 31 -
HTLSLLLCVLTLTPTAT A7LH99_9PLEU 26 26 -
HLFYLALCLLAFTTSAT A0N8V2_SHEEP 16 16 -
HLFYLALCLLTFTSSAT IGFA_RAT 31 31 -
HLFYLALCLLTFTSSAT Q5RK13_RAT 5 5 -
HLFYLALCLLTFTSSAT P97899 5 5 -
HLFYLALCLLTFPSPAT B0FBP3_VULLA 31 31 -
HTLSLLLCVLTLTPTAT Q6T8S2_MUGCE 26 26 -
HLFYLAFCLLVLTSSAT IGF1_CAVPO 8 8 -
HTLSLVLCVLALTPATL IGFB_CYPCA 26 26 -
HTLSLVLCVLALTPATL Q9IBI0_CYPCA 43 43 -
HFFYLALCLLTLTSSAA O93380 31 31 -
HLFYLALCLLTFTSSTT IGFA_MOUSE 31 31 -
HLFYLALCLLTFTSSTT Q8CAR0_MOUSE 15 15 -
HLFYLALCLLTFTSSTT Q547V2_MOUSE 5 5 -
HLFYLALCLLTFTSSTT Q4VJC0_MOUSE 31 31 -
HLFYLALCLLTFTSSTT Q4VJB9_MOUSE 31 31 -
HLFYLALCLLAFSSSAT A0FJ28_SHEEP 32 32 -
HLFYLALCLLAFSSSAT IGF1_SHEEP 32 32 -
HTLSLVLCVLALTPATL Q90VV9_DANRE 26 26 -
HFFYLGLCLLTLTSSAA IGF1_CHICK 31 31 -
HTLSLVLCVLALTPATL A5HKY0_CYPCA 26 26 -
HTLSLVLCVLALTPATL IGFA_CYPCA 26 26 -
HTLSLLLCVLTLTPTAT O42289 26 26 -
HTLSLLLCVLTLTPTAT P79824 26 26 -
HTLSLLLCVLTLTPTAT O73720 26 26 -
HTLSLVLCVLALTPATL Q5BQH3_9TELE 43 43 -
HTLSLVLCVLALTPATL Q1PCW8_9TELE 26 26 -
HTLSLVLCVLALTPATL Q38JX3_DANAE 26 26 -
HTLSLVLCVLALTPATL Q506L8_9TELE 26 26 -
HTLSLLLCVLTLTPTAT A5JSH0_SPAAU 26 26 -
HTLSLLLCVLTLTPTAT Q9YI57_ACASC 26 26 -
HTLSLLLCVLTLTPTAT Q4G1F3_SPAAU 26 26 -
HTLSLLLCVLTLTPTAT A9XU12_SPAAU 26 26 -
HTLSLLLCVLTLTPTAT A9XU11_SPAAU 26 26 -
HTLSLLLCVLTLTPTAT A8CG79_9PERO 26 26 -
HFFYLGLCLLTLTSSVA A2IT63_ANAPL 31 31 -
HFFYLGLCLLTLTSSVA Q14WA7_9AVES 31 31 -
HFFYLGLCLLTLTSSVA A7LKM7_ANAPL 31 31 -
HTLSLVLCVLALTPATL A7UEC0_CTEID 26 26 -
HTLSLVLCVLALTPATL Q800D5_9TELE 26 26 -
HTLSLLLCVLALTPATL Q9YI82_CARAU 26 26 -
HTLSLVLCVLALTPPTL A1XX00_CARAU 26 26 -
HTLSLVLCVLASTPPTL Q9PWK2_CARAU 26 26 -
CTHYLLLCVLCLTQAAA Q27YE0_ACIRT 26 26 -
HLLYLVLCFLTLTHSAA IGF1_XENLA 31 31 -
HTLSLLLCVLTLTPTAT A8CG83_9PERO 26 26 -
HTLSLVLFVLALTPATL Q98SR6_MEGAM 26 26 -
HTLSLLLCVLTLTPTAA Q0WY75_SOLSE 27 27 -
HTLSLVLCVLALTPATL Q2TU60_9TELE 26 26 -
HTLSLLLCVLTLSLTAT O42336 26 26 -
ARLLLLLCALALTPVAA Q6V293_ICTPU 24 24 -
HTLSLLLCVLTLTPTAT A2IX61_9PERC 26 26 -
HTLSLLLTVLWLTGELG Q7LZC6_CLAMA 26 26 -

Motif 2 width=18
Element Seqn Id St Int Rpt
SKPTGYGPSSRRSHNRGI A4GUE7_SALSA 70 27 -
SKPTGYGPSSRRSHNRGI Q91965 70 27 -
SKPTGYGPSSRRSHNRGI Q91231 70 27 -
SKPTGYGPSSRRSHNRGI IGF1_ONCMY 70 27 -
SKPTGYGPSSRRSHNRGI IGF1_ONCKI 70 27 -
SKPTGYGPSSRRSHNRGI Q91230 70 27 -
SKPTGYGPNARRSRGIVD Q5Q0U4_DICLA 70 27 -
SKPTGYGPNARRSRGIVD A1X594_9PLEU 70 27 -
SKPTGYGPNARRSRGIVD Q9PSX5_PAROL 70 27 -
SKPTGYGPNARRSRGIVD Q7T1A7_PERFV 70 27 -
SKPTGYGPNARRSRGIVD Q70BT6_PERFL 70 27 -
SKPTGYGPNARRSRGIVD Q70BT5_PERFL 70 27 -
SKPTGYGPNARRSRGIVD O93607 70 27 -
SKPTGYGPNARRSRGIVD O93527 70 27 -
SKPTGYGPNARRSRGIVD O57436 70 27 -
NKPTGYGSSSRRAPQTGI IGF1_AILFU 74 26 -
NKPTGYGSSSRRAPQTGI IGF1_PYGRO 74 26 -
SKPTGYGPNARRSRGIVD Q0Q005_MICSA 70 27 -
NKPTGYGSSSRRAPQTGI IGF1_RABIT 58 26 -
NKPTGYGSSSRRAPQTGI A7LHD8_HORSE 74 26 -
NKPTGYGSSSRRAPQTGI IGF1_AILME 74 26 -
NKPTGYGSSSRRAPQTGI IGFA_HUMAN 74 26 -
NKPTGYGSSSRRAPQTGI Q9NP10_HUMAN 51 26 -
NKPTGYGSSSRRAPQTGI Q5U743_HUMAN 74 26 -
NKPTGYGSSSRRAPQTGI Q14620 58 26 -
NKPTGYGSSSRRAPQTGI IGFB_HUMAN 74 26 -
SKPTGYGSSSRRSHNRGI A7BK19_ANGJA 69 26 -
SKPTGYGSSSRRSHNRGI A7BK20_ANGJA 69 26 -
NKPTGYGSSSRRAPQTGI IGF1_PANTA 74 26 -
NKPTGYGSSSRRAPQTGI IGF1_BOVIN 75 26 -
SKPTGYGPNSRRPRGIVD Q800Y5_SIGGU 70 27 -
NKPTGYGSSSRRAPQTGI A1Z0Z7_CEREL 75 26 -
NKPTGYGSSSRRAPQTGI IGF1_CAPHI 75 26 -
SKPTGYGPNARRSRGIVD Q29U99_9PERO 70 27 -
NKPTGYGSSSRRAPQTGI IGF1_PIG 74 26 -
NKPTGYGSSSRRAPQTGI Q45QB4_PIG 74 26 -
SKPTGYGPNVRRSRGIVD Q6R527_EPICO 70 27 -
SKPTGYGPNARRSRGIVD A9YN29_9SMEG 70 27 -
NKPTGYGSSSRRAPQTGI Q0PPT2_PIG 58 26 -
NKPTGYGSSSRRAPQTGI Q0PPT3_PIG 74 26 -
SKPTGYGPNARRSRGIVD A7LH99_9PLEU 70 27 -
NKPTGYGSSSRRAPQTGI A0N8V2_SHEEP 59 26 -
NKPTGYGSSIRRAPQTGI IGFA_RAT 74 26 -
NKPTGYGSSIRRAPQTGI Q5RK13_RAT 48 26 -
NKPTGYGSSIRRAPQTGI P97899 48 26 -
NKPTGYGSSSRRAPQTGI B0FBP3_VULLA 74 26 -
SKPTGYGPNARRSRGIVD Q6T8S2_MUGCE 70 27 -
NKPTGYGSSSRRAPQTGI IGF1_CAVPO 51 26 -
SKPTGYGPSSRRSHNRGI IGFB_CYPCA 70 27 -
SKPTGYGPSSRRSHNRGI Q9IBI0_CYPCA 87 27 -
SKPTGYGSSSRRLHHKGI O93380 74 26 -
NKPTGYGSSIRRAPQTGI IGFA_MOUSE 74 26 -
NKPTGYGSSIRRAPQTGI Q8CAR0_MOUSE 58 26 -
NKPTGYGSSIRRAPQTGI Q547V2_MOUSE 48 26 -
NKPTGYGSSIRRAPQTGI Q4VJC0_MOUSE 74 26 -
NKPTGYGSSIRRAPQTGI Q4VJB9_MOUSE 74 26 -
NKPTGYGSSSRRAPQTGI A0FJ28_SHEEP 75 26 -
NKPTGYGSSSRRAPQTGI IGF1_SHEEP 75 26 -
SKPTGYGPSSRRSHNRGI Q90VV9_DANRE 70 27 -
SKPTGYGSSSRRLHHKGI IGF1_CHICK 74 26 -
SKPTGYGPSSRRSHNRGI A5HKY0_CYPCA 70 27 -
SKPTGYGPSSRRSHNRGI IGFA_CYPCA 70 27 -
NKPTGYGPSARRSRGIVD O42289 70 27 -
NKPTGYGPSARRSRGIVD P79824 70 27 -
NKPTGYGPSARRSRGIVD O73720 70 27 -
SKPTGYGPSSRRSHNRGI Q5BQH3_9TELE 87 27 -
SKPTGYGPSSRRSHNRGI Q1PCW8_9TELE 70 27 -
SKPTGYGPSSRRSHNRGI Q38JX3_DANAE 70 27 -
SKPTGYGPSSRRSHNRGI Q506L8_9TELE 70 27 -
FSKPGYGPNARRSRGIVD A5JSH0_SPAAU 69 26 -
FSKPGYGPNARRSRGIVD Q9YI57_ACASC 69 26 -
FSKPGYGPNARRSRGIVD Q4G1F3_SPAAU 69 26 -
FSKPGYGPNARRSRGIVD A9XU12_SPAAU 69 26 -
FSKPGYGPNARRSRGIVD A9XU11_SPAAU 69 26 -
FSKPGYGPNARRSRGIVD A8CG79_9PERO 69 26 -
SKPTGYGSSSRRLHHKGI A2IT63_ANAPL 74 26 -
SKPTGYGSSSRRLHHKGI Q14WA7_9AVES 74 26 -
SKPTGYGSSSRRLHHKGI A7LKM7_ANAPL 74 26 -
SKPTGYGPSSRRSHNRGI A7UEC0_CTEID 70 27 -
SKPTGYGPSSRRSHNRGI Q800D5_9TELE 70 27 -
SKPTGYGPNSRRSHNRGI Q9YI82_CARAU 70 27 -
SKPTGYGPSSRRSHNRGI A1XX00_CARAU 70 27 -
SKPTGYGPSSRRSHNRGI Q9PWK2_CARAU 70 27 -
NKPTGYGASSRRPHHRGI Q27YE0_ACIRT 69 26 -
SKPTGYGSNNRRSHHRGI IGF1_XENLA 74 26 -
FSKPGHGPNARRSRGIVD A8CG83_9PERO 69 26 -
SKPTGYGPSSRRSHNRGI Q98SR6_MEGAM 70 27 -
FSKPGYGYNTRRPSGIVD Q0WY75_SOLSE 70 26 -
NKPAGYGSNSRRSNNYGI Q2TU60_9TELE 70 27 -
SKPGGYGPNARRSRGIVD O42336 70 27 -
SKPTGYGPNSRRLHNRGI Q6V293_ICTPU 68 27 -
FSKPGYGPNARRSRGIVD A2IX61_9PERC 69 26 -
SRPMGYGSSTCWTHNRGI Q7LZC6_CLAMA 69 26 -

Motif 3 width=19
Element Seqn Id St Int Rpt
ELRRLEMYCAPVKSGKAAR A4GUE7_SALSA 97 9 -
ELRRLEMYCAPVKSGKAAR Q91965 97 9 -
ELRRLEMYCAPVKSGKAAR Q91231 97 9 -
ELRRLEMYCAPVKSGKAAR IGF1_ONCMY 97 9 -
ELRRLEMYCAPVKSGKAAR IGF1_ONCKI 97 9 -
ELRRLEMYCAPVKSGKAAR Q91230 97 9 -
ELRRLEMYCAPAKTGKAAR Q5Q0U4_DICLA 95 7 -
ELRRLEMYCAPAKTSKAAR A1X594_9PLEU 95 7 -
ELRRLEMYCAPAKTSKAAR Q9PSX5_PAROL 95 7 -
ELRRLEMYCAPAKTSKAAR Q7T1A7_PERFV 95 7 -
ELRRLEMYCAPAKTSKAAR Q70BT6_PERFL 95 7 -
ELRRLEMYCAPAKTSKAAR Q70BT5_PERFL 95 7 -
ELRRLEMYCAPAKTSKAAR O93607 95 7 -
ELRRLEMYCAPAKTSKAAR O93527 95 7 -
ELRRLEMYCAPAKTSKAAR O57436 95 7 -
DLRRLEMYCAPLKPAKSAR IGF1_AILFU 101 9 -
DLRRLEMYCAPLKPAKSAR IGF1_PYGRO 101 9 -
ELRRLEMYCAPAKTSKPAR Q0Q005_MICSA 95 7 -
DLRRLEMYCAPLKPAKAAR IGF1_RABIT 85 9 -
DLRRLEMYCAPLKPAKSAR A7LHD8_HORSE 101 9 -
DLRRLEMYCAPLKPAKSAR IGF1_AILME 101 9 -
DLRRLEMYCAPLKPAKSAR IGFA_HUMAN 101 9 -
DLRRLEMYCAPLKPAKSAR Q9NP10_HUMAN 78 9 -
DLRRLEMYCAPLKPAKSAR Q5U743_HUMAN 101 9 -
DLRRLEMYCAPLKPAKSAR Q14620 85 9 -
DLRRLEMYCAPLKPAKSAR IGFB_HUMAN 101 9 -
ELRRLEMYCAPVKPGKAAR A7BK19_ANGJA 96 9 -
ELRRLEMYCAPVKPGKAAR A7BK20_ANGJA 96 9 -
DLRRLEMYCAPLKPAKSAR IGF1_PANTA 101 9 -
DLRRLEMYCAPLKPAKSAR IGF1_BOVIN 102 9 -
ELRRLEMYCAPAKTSKAAR Q800Y5_SIGGU 95 7 -
DLRRLEMYCAPLKPTKAAR A1Z0Z7_CEREL 102 9 -
DLRRLEMYCAPLKPTKSAR IGF1_CAPHI 102 9 -
ELRRLEMYCAPAKTSKAAR Q29U99_9PERO 95 7 -
DLRRLEMYCAPLKPAKSAR IGF1_PIG 101 9 -
DLRRLEMYCAPLKPAKSAR Q45QB4_PIG 101 9 -
ELRRLEMNCAPAKTSKAAR Q6R527_EPICO 95 7 -
ELRRLEMYCAPAKSGKAAR A9YN29_9SMEG 95 7 -
DLRRLEMYCAPLKPAKSAR Q0PPT2_PIG 85 9 -
DLRRLEMYCAPLKPAKSAR Q0PPT3_PIG 101 9 -
ELRHLEMYCAPAKTSNAAR A7LH99_9PLEU 95 7 -
DLRRLEMYCAPLKAAKSAR A0N8V2_SHEEP 86 9 -
DLRRLEMYCAPLKPTKSAR IGFA_RAT 101 9 -
DLRRLEMYCAPLKPTKSAR Q5RK13_RAT 75 9 -
DLRRLEMYCAPLKPTKSAR P97899 75 9 -
DLRRLEMYCAPLKPAKSAR B0FBP3_VULLA 101 9 -
ELRRLEMYCAPAKTNKSVR Q6T8S2_MUGCE 95 7 -
DLRRLEMYCAPLKPAKSAR IGF1_CAVPO 78 9 -
ELRRLEMYCAPVKPGKTPR IGFB_CYPCA 97 9 -
ELRRLEMYCAPVKPGKTPR Q9IBI0_CYPCA 114 9 -
DLRRLEMYCAPIKPPKSAR O93380 101 9 -
DLRRLEMYCAPLKPTKAAR IGFA_MOUSE 101 9 -
DLRRLEMYCAPLKPTKAAR Q8CAR0_MOUSE 85 9 -
DLRRLEMYCAPLKPTKAAR Q547V2_MOUSE 75 9 -
DLRRLEMYCAPLKPTKAAR Q4VJC0_MOUSE 101 9 -
DLRRLEMYCAPLKPTKAAR Q4VJB9_MOUSE 101 9 -
DLRRLEMYCAPLKAAKSAR A0FJ28_SHEEP 102 9 -
DLRRLEMYCAPLKAAKSAR IGF1_SHEEP 102 9 -
ELRRLEMYCAPVKTGKSPR Q90VV9_DANRE 97 9 -
DLRRLEMYCAPIKPPKSAR IGF1_CHICK 101 9 -
ELRRLEMYCAPVKPGKTPR A5HKY0_CYPCA 97 9 -
ELRRLEMYCAPVKPGKTPR IGFA_CYPCA 97 9 -
ELQRLEMYCAPVKTPKISR O42289 95 7 -
ELQRLEMYCAPVKTPKISR P79824 95 7 -
ELQRLEMYCAPVKTPKISR O73720 95 7 -
ELRRLEMYCAPVKPGKSPR Q5BQH3_9TELE 114 9 -
ELRRLEMYCAPVKPGKTPR Q1PCW8_9TELE 97 9 -
ELRRLEMYCAPVKTGKTPR Q38JX3_DANAE 97 9 -
ELRRLEMYCAPVKPGKTPR Q506L8_9TELE 97 9 -
ELRRLEMYCAPAKTSKAAR A5JSH0_SPAAU 94 7 -
ELRRLEMYCAPAKTSKAAR Q9YI57_ACASC 94 7 -
ELRRLEMYCAPAKTSKAAR Q4G1F3_SPAAU 94 7 -
ELRRLEMYCAPAKTSKAAR A9XU12_SPAAU 94 7 -
ELRRLEMYCAPAKTSKAAR A9XU11_SPAAU 94 7 -
ELRRLEMYCAPAKTSKAAR A8CG79_9PERO 94 7 -
DLRRLEMYCAPIKPPKSAR A2IT63_ANAPL 101 9 -
DLRRLEMYCAPIKPPKSAR Q14WA7_9AVES 101 9 -
DLRRLEMYCAPIKPPKSAR A7LKM7_ANAPL 101 9 -
ELRRLEMYCAPVKTGKSPR A7UEC0_CTEID 97 9 -
ELRRLEMYCAPVKTGKTPR Q800D5_9TELE 97 9 -
ELRRLEMYCAPVKPGKTPR Q9YI82_CARAU 97 9 -
ELRRLEMYCAPVKPGKTPR A1XX00_CARAU 97 9 -
ELRRLEMYCAPVKPGKTPR Q9PWK2_CARAU 97 9 -
DLRRLEMYCAPVKPAKASR Q27YE0_ACIRT 96 9 -
DFRRLEMYCAPAKQAKSAR IGF1_XENLA 101 9 -
ELRRLEMYCAPAKTSKAAR A8CG83_9PERO 94 7 -
ELRRLEMYCAPVKTGKTPR Q98SR6_MEGAM 97 9 -
ELRRLEMYCAPAKTSKAAR Q0WY75_SOLSE 95 7 -
ELRRLEMYCAPVKTGKTPR Q2TU60_9TELE 97 9 -
ELRRLEMYCAPPKTSKAAR O42336 95 7 -
ELKRLEMYCAPVKSGKAPR Q6V293_ICTPU 95 9 -
ELRRLEMYCAPPKTSKAAR A2IX61_9PERC 94 7 -
QLRWIEMYCAAFEPSLVTR Q7LZC6_CLAMA 96 9 -

Motif 4 width=15
Element Seqn Id St Int Rpt
SVRAQRHTDMPRTPK A4GUE7_SALSA 116 0 -
SVRAQRHTDMPRTPK Q91965 116 0 -
SVRAQRHTDMPRTPK Q91231 116 0 -
SVRAQRHTDMPRTPK IGF1_ONCMY 116 0 -
SVRAQRHTDMPRTPK IGF1_ONCKI 116 0 -
SVRAQRHTDMPRTPK Q91230 116 0 -
SVRAQRHTDMPRAPK Q5Q0U4_DICLA 114 0 -
SVRAQRHTDMPRAPK A1X594_9PLEU 114 0 -
SVRAQRHTDMPRAPK Q9PSX5_PAROL 114 0 -
SVRAQRHTDMPRAPK Q7T1A7_PERFV 114 0 -
SVRAQRHTDMPRAPK Q70BT6_PERFL 114 0 -
SVRAQRHTDMPRAPK Q70BT5_PERFL 114 0 -
SVRAQRHTDMPRAPK O93607 114 0 -
SVRAQRHTDMPRAPK O93527 114 0 -
SVRAQRHTDMPRAPK O57436 114 0 -
SVRAQRHTDMPKAQK IGF1_AILFU 120 0 -
SVRAQRHTDMPKAQK IGF1_PYGRO 120 0 -
SVRAQRHTDMPRAPK Q0Q005_MICSA 114 0 -
SVRAQRHTDMPKTQK IGF1_RABIT 104 0 -
SVRAQRHTDMPKAQK A7LHD8_HORSE 120 0 -
SVRAQRHTDMPKAQK IGF1_AILME 120 0 -
SVRAQRHTDMPKTQK IGFA_HUMAN 120 0 -
SVRAQRHTDMPKTQK Q9NP10_HUMAN 97 0 -
SVRAQRHTDMPKTQK Q5U743_HUMAN 120 0 -
SVRAQRHTDMPKTQK Q14620 104 0 -
SVRAQRHTDMPKTQK IGFB_HUMAN 120 0 -
SVRAQRHTDIPKTQK A7BK19_ANGJA 115 0 -
SVRAQRHTDIPKTQK A7BK20_ANGJA 115 0 -
SVRAQRHTDMPKAQK IGF1_PANTA 120 0 -
SVRAQRHTDMPKAQK IGF1_BOVIN 121 0 -
SVRAQRHTDMPRTPK Q800Y5_SIGGU 114 0 -
SVRAQRHTDMPKAQK A1Z0Z7_CEREL 121 0 -
SVRAQRHTDMPKAQK IGF1_CAPHI 121 0 -
SVRAQRHTDMPRAPE Q29U99_9PERO 114 0 -
SVRAQRHTDMPKAQK IGF1_PIG 120 0 -
SVRAQRHTDMPKAQK Q45QB4_PIG 120 0 -
SVRAQRHTDMPRAPK Q6R527_EPICO 114 0 -
SVRSQRHTDMPRAPK A9YN29_9SMEG 114 0 -
SVRAQRHTDMPKARK Q0PPT2_PIG 104 0 -
SVRAQRHTDMPKARK Q0PPT3_PIG 120 0 -
SVRAQRHTDMPRAPK A7LH99_9PLEU 114 0 -
SVRAQRHTDMPKAQK A0N8V2_SHEEP 105 0 -
SIRAQRHTDMPKTQK IGFA_RAT 120 0 -
SIRAQRHTDMPKTQK Q5RK13_RAT 94 0 -
SIRAQRHTDMPKTQK P97899 94 0 -
SVRAQRHTDMPKAQK B0FBP3_VULLA 120 0 -
SVRSQRHTDMPRTPK Q6T8S2_MUGCE 114 0 -
SVRAQRHTDMPKTQK IGF1_CAVPO 97 0 -
SVRAQRHTDSPRTAK IGFB_CYPCA 116 0 -
SVRAQRHTDSPRTAK Q9IBI0_CYPCA 133 0 -
SVRAQRHTDMPKAQK O93380 120 0 -
SIRAQRHTDMPKTQK IGFA_MOUSE 120 0 -
SIRAQRHTDMPKTQK Q8CAR0_MOUSE 104 0 -
SIRAQRHTDMPKTQK Q547V2_MOUSE 94 0 -
SIRAQRHTDMPKTQK Q4VJC0_MOUSE 120 0 -
SIRAQRHTDMPKTQK Q4VJB9_MOUSE 120 0 -
SVRAQRHTDMPKAQK A0FJ28_SHEEP 121 0 -
SVRAQRHTDMPKAQK IGF1_SHEEP 121 0 -
SLRAQRHTDIPRTPK Q90VV9_DANRE 116 0 -
SVRAQRHTDMPKAQK IGF1_CHICK 120 0 -
SLRAQRHTDSPRTPK A5HKY0_CYPCA 116 0 -
SLRAQRHTDSPRTPK IGFA_CYPCA 116 0 -
SVRSQRHTDMPRAPK O42289 114 0 -
SVRSQRHTDMPRAPK P79824 114 0 -
SVRSQRHTDMPRAPK O73720 114 0 -
SLRAQRHTDSPRTAK Q5BQH3_9TELE 133 0 -
SLRAQRHTDSPRTAK Q1PCW8_9TELE 116 0 -
SLRAQRHTDIPRTAK Q38JX3_DANAE 116 0 -
SIRAQRHTDSPKTAK Q506L8_9TELE 116 0 -
SVRAQRHTDMPRAPK A5JSH0_SPAAU 113 0 -
SVRAQRHTDMPRAPK Q9YI57_ACASC 113 0 -
SVRAQRHTDMPRAPK Q4G1F3_SPAAU 113 0 -
SVRAQRHTDMPRAPK A9XU12_SPAAU 113 0 -
SVRAQRHTDMPRAPK A9XU11_SPAAU 113 0 -
SVRAQRHTDMPRAPK A8CG79_9PERO 113 0 -
SVRAQRHTDMPKAQK A2IT63_ANAPL 120 0 -
SVRAQRHTDMPKAQK Q14WA7_9AVES 120 0 -
SVRAQRHTDMPKAQK A7LKM7_ANAPL 120 0 -
SLRAQRHTDITRTAK A7UEC0_CTEID 116 0 -
SLRAQRHTDITRTAK Q800D5_9TELE 116 0 -
SLRAQRHTDGTRTAK Q9YI82_CARAU 116 0 -
SLRAQRHTDGTRTAK A1XX00_CARAU 116 0 -
SLRAQRHTDGTRTAK Q9PWK2_CARAU 116 0 -
SVRAQRHTDMPKAQK Q27YE0_ACIRT 115 0 -
SVRTQRHTDMPKAQK IGF1_XENLA 120 0 -
SVRAQRHTDLPRAPK A8CG83_9PERO 113 0 -
SLRAQRHTDITRTAK Q98SR6_MEGAM 116 0 -
SVRAQRHTDMPRAPK Q0WY75_SOLSE 114 0 -
SLRAQRHTDITRTAK Q2TU60_9TELE 116 0 -
SVRAQRHTDRAPKVS O42336 114 0 -
SVREQRHTDTPKTPK Q6V293_ICTPU 114 0 -
SVRAQRHTDRAPKVS A2IX61_9PERC 113 0 -
SVRAQRVTDMCRTLK Q7LZC6_CLAMA 115 0 -