| Literature References | 1. STEWART, C. AND ROTWEIN, P.
Growth, differentiation and survival: multiple physiological functions for
insulin-like growth factors.
PHYSIOL.REV. 76 1005-1026 (1996).
2. HWA, V., OH, Y. AND ROSENFELD, R.
The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily.
ENDOCR.REV. 20 761-787 (1999).
3. OH, Y., MULLER. H., PHAM, H. AND ROSENFELD, R.
Demonstration of receptors for insulin-like growth factor binding
protein-3 on Hs578T human breast cancer cells.
J.BIOL.CHEM. 268 26045-26048 (1993).
4. ANDRESS, D.
Heparin modulates the binding of insulin-like growth factor (IGF) binding
protein-5 to a membrane protein in osteoblastic cells.
J.BIOL.CHEM. 270 28289-28296 (1995).
5. MOHAN, S., NAKAO, Y., HONDA, Y., LANDALE, E., LESSER, U., DONY, C.,
LANG, K. AND BAYLINK, D.
Studies on the mechanisms by which insulin-like growth factor (IGF) binding
protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells.
J.BIOL.CHEM.270 20424-20431 (1995).
6. RAJAH, R., VALENTINIS, B. AND COHEN, P.
Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and
mediates the effects of transforming growth factor-beta1 on programmed cell
death through a p53- and IGF-independent mechanism.
J.BIOL.CHEM. 272 12181-12188 (1997).
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| Documentation | Insulin-like growth factors (IGFs)-I and -II are small secreted peptides
that stimulate the survival, and promote the proliferation and
differentiation, of many cell types [1]. In biological fluids, these growth
factors are usually bound to IGF-binding proteins (IGFBPs), which regulate
their availability and activity by prolonging their half-life and
modulating their receptor interactions.
To date, six IGFBP family members have been identified (termed IGFBP1-6)
[2]. They share a conserved gene (intron-exon) organisation and high IGF-
binding affinity. Structurally, the proteins also share a common domain
architecture, possessing a conserved N-terminal IGFBP domain, a highly
variable mid-section, and a thyroglobulin type-1 (Tg1) domain in their
C-terminal regions.
In addition to their role in the regulation of IGF activity, there is
evidence for the direct association of IGFBPs with a variety of
extracellular and cell surface molecules [3,4], with consequent effects
upon important biological processes. These include modulation of bone cell
proliferation [5], and growth arrest of breast and prostate cancer cells
[3,6].
IGFBPFAMILY is a 4-element fingerprint that provides a signature for the
insulin-like growth factor-binding protein family. The fingerprint was
derived from an initial alignment of 18 sequences: the motifs were drawn
from conserved regions in the N- and C-terminal thirds of the alignment -
motifs 1 and 2 reside within the IGFBP domain, and motifs 3 and 4 lie
within the Tg1 domain. Two iterations on SPTR57_40f were required to reach
convergence, at which point a true set comprising 81 sequences was
identified. Eighteen partial matches were also found, including several
Xenopus laevis IGFBPs and a number of translated cDNA sequences.
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| Sequence Titles | A4D2F4_HUMAN Insulin-like growth factor binding protein 1 (Insulin-like growth factor binding protein 1, isoform CRA_a) - Homo sapiens (Human).
A4IIA2_XENTR Igfbp2 protein - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
A5PLA3_DANRE Zgc:165472 protein - Danio rerio (Zebrafish) (Brachydanio rerio).
A6N8N6_CHICK Insulin-like growth factor-binding protein 3 - Gallus gallus (Chicken).
A6XND0_HUMAN Insulin-like growth factor binding protein 3 - Homo sapiens (Human).
A6XND1_HUMAN Insulin-like growth factor binding protein 3 isoform b - Homo sapiens (Human).
A6ZIC9_PIG Insulin-like growth factor binding protein 6 - Sus scrofa (Pig).
A8E5I5_DANRE Insulin-like growth factor binding protein 2 - Danio rerio (Zebrafish) (Brachydanio rerio).
A9NJ32_PIG Insulin-like growth factor binding protein-6 - Sus scrofa (Pig).
B0S525_DANRE Insulin-like growth factor binding protein 5 - Danio rerio (Zebrafish) (Brachydanio rerio).
B2CM69_DICLA Insulin-like growth factor binding protein-2 - Dicentrarchus labrax (European sea bass).
B2CZF1_CAPHI IBP4 - Capra hircus (Goat).
B3F211_DANRE Insulin-like growth factor binding protein 2b - Danio rerio (Zebrafish) (Brachydanio rerio).
B3GS77_SHEEP Insulin-like growth factor-binding protein-5 - Ovis aries (Sheep).
B3KVF9_HUMAN cDNA FLJ16507 fis, clone HCHON2000364, highly similar to Insulin-like growth factor-binding protein 3 - Homo sapiens (Human).
B4DN53_HUMAN cDNA FLJ52568, highly similar to Insulin-like growth factor-binding protein 3 - Homo sapiens (Human).
B4DP07_HUMAN cDNA FLJ53634, highly similar to Insulin-like growth factor-binding protein 3 - Homo sapiens (Human).
B5AN56_SHEEP Insulin-like growth factor-binding protein-6 - Ovis aries (Sheep).
B5AZT5_SHEEP Insulin-like growth factor binding protein-4 - Ovis aries (Sheep).
B5LNQ9_SALSA Insulin-like growth factor binding protein 4 - Salmo salar (Atlantic salmon).
B5X2D8_SALSA Insulin-like growth factor-binding protein 6 - Salmo salar (Atlantic salmon).
B6RNJ3_FUGRU Insulin-like growth factor binding protein 4 - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
B9VQ08_SHEEP Insulin-like growth factor-binding protein-1 - Ovis aries (Sheep).
IBP1_BOVIN Insulin-like growth factor-binding protein 1 - Bos taurus (Bovine).
IBP1_HUMAN Insulin-like growth factor-binding protein 1 - Homo sapiens (Human).
IBP1_MOUSE Insulin-like growth factor-binding protein 1 - Mus musculus (Mouse).
IBP1_PIG Insulin-like growth factor-binding protein 1 - Sus scrofa (Pig).
IBP1_RAT Insulin-like growth factor-binding protein 1 - Rattus norvegicus (Rat).
IBP1_SPETR Insulin-like growth factor-binding protein 1 - Spermophilus tridecemlineatus (Thirteen-lined ground squirrel).
IBP2_BOVIN Insulin-like growth factor-binding protein 2 - Bos taurus (Bovine).
IBP2_CHICK Insulin-like growth factor-binding protein 2 - Gallus gallus (Chicken).
IBP2_DANRE Insulin-like growth factor-binding protein 2 - Danio rerio (Zebrafish) (Brachydanio rerio).
IBP2_HUMAN Insulin-like growth factor-binding protein 2 - Homo sapiens (Human).
IBP2_MOUSE Insulin-like growth factor-binding protein 2 - Mus musculus (Mouse).
IBP2_PIG Insulin-like growth factor-binding protein 2 - Sus scrofa (Pig).
IBP2_RAT Insulin-like growth factor-binding protein 2 - Rattus norvegicus (Rat).
IBP2_SHEEP Insulin-like growth factor-binding protein 2 - Ovis aries (Sheep).
IBP3_BOVIN Insulin-like growth factor-binding protein 3 - Bos taurus (Bovine).
IBP3_HUMAN Insulin-like growth factor-binding protein 3 - Homo sapiens (Human).
IBP3_MOUSE Insulin-like growth factor-binding protein 3 - Mus musculus (Mouse).
IBP3_PIG Insulin-like growth factor-binding protein 3 - Sus scrofa (Pig).
IBP3_RAT Insulin-like growth factor-binding protein 3 - Rattus norvegicus (Rat).
IBP4_BOVIN Insulin-like growth factor-binding protein 4 - Bos taurus (Bovine).
IBP4_HUMAN Insulin-like growth factor-binding protein 4 - Homo sapiens (Human).
IBP4_MOUSE Insulin-like growth factor-binding protein 4 - Mus musculus (Mouse).
IBP4_PIG Insulin-like growth factor-binding protein 4 - Sus scrofa (Pig).
IBP4_RAT Insulin-like growth factor-binding protein 4 - Rattus norvegicus (Rat).
IBP4_SHEEP Insulin-like growth factor-binding protein 4 - Ovis aries (Sheep).
IBP5_BOVIN Insulin-like growth factor-binding protein 5 - Bos taurus (Bovine).
IBP5_HUMAN Insulin-like growth factor-binding protein 5 - Homo sapiens (Human).
IBP5_MOUSE Insulin-like growth factor-binding protein 5 - Mus musculus (Mouse).
IBP5_PIG Insulin-like growth factor-binding protein 5 - Sus scrofa (Pig).
IBP5_RAT Insulin-like growth factor-binding protein 5 - Rattus norvegicus (Rat).
IBP6_BOVIN Insulin-like growth factor-binding protein 6 - Bos taurus (Bovine).
IBP6_HUMAN Insulin-like growth factor-binding protein 6 - Homo sapiens (Human).
IBP6_MOUSE Insulin-like growth factor-binding protein 6 - Mus musculus (Mouse).
IBP6_RAT Insulin-like growth factor-binding protein 6 - Rattus norvegicus (Rat).
Q3HNB1_ONCMY Insulin-like growth factor binding protein 5 - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Q3HWG3_ONCMY Insulin-like growth factor binding protein 1 - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Q3HWG4_ONCMY Insulin-like growth factor binding protein 6 - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Q3I344_ONCMY Insulin-like growth factor binding protein 2 - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Q3I346_ONCMY Insulin-like growth factor binding protein 3 - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Q3UQV0_MOUSE Putative uncharacterized protein - Mus musculus (Mouse).
Q4TAM5_TETNG Chromosome undetermined SCAF7283, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer).
Q5GBG2_ONCTS Insulin-like growth factor binding protein-1 - Oncorhynchus tschawytscha (Chinook salmon) (King salmon).
Q5SVY8_MOUSE Insulin-like growth factor binding protein 1 - Mus musculus (Mouse).
Q5XHC5_XENLA LOC495038 protein - Xenopus laevis (African clawed frog).
Q66I28_DANRE Insulin-like growth factor binding protein 3 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q6PE62_MOUSE Igfbp3 protein - Mus musculus (Mouse).
Q6PEY6_HUMAN Insulin-like growth factor binding protein 1 - Homo sapiens (Human).
Q6PN72_CHICK Insulin-like growth factor binding protein 1 - Gallus gallus (Chicken).
Q800E1_DANRE Insulin-like growth factor binding protein 5 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q801D7_CHICK Insulin-like growth factor-binding protein-4 - Gallus gallus (Chicken).
Q8BSM9_MOUSE Putative uncharacterized protein - Mus musculus (Mouse).
Q8JHX6_DANRE Insulin-like growth factor binding protein 1 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q8UVU5_SPAAU Insulin-like growth factor binding protein-2 - Sparus aurata (Gilthead sea bream).
Q90YJ6_DANRE Insulin-like growth factor binding protein 3 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q90YJ7_DANRE Insulin-like growth factor binding protein 1 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q91WV8_MOUSE Insulin-like growth factor binding protein 1 - Mus musculus (Mouse).
Q91X24_MOUSE Igfbp6 protein - Mus musculus (Mouse).
Q9D057_MOUSE Putative uncharacterized protein - Mus musculus (Mouse).
A4K8J2_DANRE Insulin-like growth factor binding protein-1b - Danio rerio (Zebrafish) (Brachydanio rerio).
A6XNC9_HUMAN Insulin-like growth factor binding protein 3 isoform b - Homo sapiens (Human).
B3KTQ0_HUMAN cDNA FLJ38581 fis, clone HCHON2008672, highly similar to Insulin-like growth factor-binding protein 3 - Homo sapiens (Human).
B3KWK7_HUMAN cDNA FLJ43234 fis, clone HCHON2002964, highly similar to Insulin-like growth factor-binding protein 3 - Homo sapiens (Human).
B6MXY1_BRAFL Putative uncharacterized protein - Branchiostoma floridae (Florida lancelet) (Amphioxus).
IBP5_XENLA Insulin-like growth factor-binding protein 5 - Xenopus laevis (African clawed frog).
Q0IJ34_XENTR Putative uncharacterized protein - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Q499C6_XENTR Insulin-like growth factor binding protein 1 - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Q6PAX6_XENLA MGC68538 protein - Xenopus laevis (African clawed frog).
Q6ZSD0_HUMAN cDNA FLJ45630 fis, clone CHONS2001287, moderately similar to INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 - Homo sapiens (Human).
A1A5Q9_RAT Igfbp3 protein - Rattus norvegicus (Rat).
B3KRZ1_HUMAN cDNA FLJ35128 fis, clone PLACE6008768, moderately similar to Insulin-like growth factor-binding protein 3 - Homo sapiens (Human).
B3KTS0_HUMAN cDNA FLJ38655 fis, clone HHDPC2009208, highly similar to Insulin-like growth factor-binding protein 3 - Homo sapiens (Human).
B3KVY6_HUMAN cDNA FLJ41741 fis, clone HSYRA2003168, highly similar to Insulin-like growth factor-binding protein 3 - Homo sapiens (Human).
B4E351_HUMAN cDNA FLJ52130, highly similar to Insulin-like growth factor-binding protein 4 - Homo sapiens (Human).
Q4RIN2_TETNG Chromosome 11 SCAF15043, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer).
Q5XHD1_XENLA LOC495033 protein - Xenopus laevis (African clawed frog).
Q8BP94_MOUSE Putative uncharacterized protein - Mus musculus (Mouse).
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