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PR01970

Identifier
TNFACTORR19L  [View Relations]  [View Alignment]  
Accession
PR01970
No. of Motifs
5
Creation Date
24-JUN-2009
Title
Tumour necrosis factor receptor 19-like signature
Database References

MIM; 611211
Literature References
1. ARMITAGE, R.
Tumor necrosis factor receptor superfamily members and their ligands.
CURR.OPIN.IMMUNOL. 6 407-413 (1994).
 
2. BANNER D., D'ARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C.,
LOETSCHER, H. AND LESSLAUER, W.
Crystal structure of the soluble human 55 kD TNF receptor-human TNF-beta
complex: implications for TNF receptor activation.
CELL 73 431-445 (1993).
 
3. WU, H.
Assembly of post-receptor signaling complexes for the tumor necrosis factor
receptor superfamily.
ADV.PROTEIN CHEM. 68 225-279 (2004).
 
4. LOCKSLEY, R., KILLEEN, N. AND LENARDO, M.
The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology.
CELL 104 487-501 (2001).
 
5. GRAVESTEIN, L. AND BORST, J.
Tumor necrosis factor receptor family members in the immune system.
SEMIN.IMMUNOL. 10 423-434 (1998).
 
6. LOENEN, W.
D27 and (TNFR) relatives in the immune system: their role in health and
disease.
SEMIN.IMMUNOL. 10 417-422 (1998).
 
7. SICA, G., ZHU, G., TAMADA, K., LIU, D., NI, J. AND CHEN, L.
RELT, a new member of the tumor necrosis factor receptor superfamily, is 
selectively expressed in hematopoietic tissues and activates transcription 
factor NF-kappaB.
BLOOD 97 2702-2707 (2001).

Documentation
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more
than 20 type-I transmembrane proteins. Family members are defined based on
similarity in their extracellular domain - a region that contains many
cysteine residues arranged in a specific repetitive pattern [1]. The
cysteines allow formation of an extended rod-like structure, responsible for
ligand binding [2].
 
Upon receptor activation, different intracellular signalling complexes are
assembled for different members of the TNFR superfamily, depending on their
intracellular domains and sequences [3]. Activation of TNFRs can therefore
induce a range of disparate effects, including cell proliferation,
differentiation, survival, or apoptotic cell death, depending upon the
receptor involved [4,5].
 
TNFRs are widely distributed and play important roles in many crucial
biological processes, such as lymphoid and neuronal development, innate and
adaptive immunity, and maintenance of cellular homeostasis [3]. Drugs that
manipulate their signalling have potential roles in the prevention and
treatment of many diseases, such as viral infections, coronary heart
disease, transplant rejection, and immune disease [6].
 
TNF receptor 19-like (also known as receptor expressed in lymphoid tissues 
(RELT)) is abundantly expressed in hematologic tissues such as spleen, lymph
node, and peripheral blood leukocytes, as well as in leukemias and 
lymphomas [7]. The receptor may play a role in the regulation of immune 
responses [7].
 
TNFACTORR19L is a 5-element fingerprint that provides a signature for tumour
necrosis factor receptor 19-like. The fingerprint was derived from an 
initial alignment of 4 sequences: the motifs were drawn from conserved
regions in the N-terminal three quarters of the alignment, focusing on those
sections that characterise TNF receptor 19-like but distinguish it from
other TNF receptor subtypes - motifs 1, 2 and 3 lie within the extracellular 
N-terminal region, and motifs 4 and 5 reside within the intracellular 
C-terminal region. Two iterations on SPTR57_40f were required to reach 
convergence, at which point a true set comprising 5 sequences was 
identified. A single partial match was also found, B3KPY6_HUMAN, a 
translated human cDNA sequence that fails to match motifs 1-3.
Summary Information
   5 codes involving  5 elements
0 codes involving 4 elements
0 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
555555
400000
300000
200011
12345
True Positives
Q497Z8_MOUSE  Q6NZ11_DANRE  TR19L_HUMAN   TR19L_MACFA   
TR19L_MOUSE
True Positive Partials
Codes involving 2 elements
B3KPY6_HUMAN
Sequence Titles
Q497Z8_MOUSE RELT tumor necrosis factor receptor - Mus musculus (Mouse). 
Q6NZ11_DANRE RELT tumor necrosis factor receptor - Danio rerio (Zebrafish) (Brachydanio rerio).
TR19L_HUMAN Tumor necrosis factor receptor superfamily member 19L - Homo sapiens (Human).
TR19L_MACFA Tumor necrosis factor receptor superfamily member 19L - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
TR19L_MOUSE Tumor necrosis factor receptor superfamily member 19L - Mus musculus (Mouse).

B3KPY6_HUMAN cDNA FLJ32474 fis, clone SKNMC2000593, highly similar to Tumor necrosis factor receptor superfamily member 19L - Homo sapiens (Human).
Scan History
SPTR57_40f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
MKRTLLCWPLSCLFVLLPW TR19L_MOUSE 8 8 -
MKPSLLCRPLSCFLMLLPW TR19L_MACFA 1 1 -
MKPSLLCRPLSCFLMLLPW TR19L_HUMAN 1 1 -
MKNHLYCSAPVCLILLELW Q6NZ11_DANRE 1 1 -

Motif 2 width=22
Element Seqn Id St Int Rpt
RLEAQAGTATHDTMCGDCQHGW TR19L_MOUSE 83 56 -
RLEAQVGTATQDTLCGDCWPGW TR19L_MACFA 76 56 -
RLEAQVGMATRDTLCGDCWPGW TR19L_HUMAN 76 56 -
RWISTKPTSTSDAVCGGCLPGF Q6NZ11_DANRE 86 66 -

Motif 3 width=16
Element Seqn Id St Int Rpt
GNGTRAGGPEETAAQY TR19L_MOUSE 155 50 -
GNGTRAGGPEETAAQY TR19L_MACFA 148 50 -
GNGTRAGGPEETAAQY TR19L_HUMAN 148 50 -
GNTTSVQAPEEKTTEY Q6NZ11_DANRE 146 38 -

Motif 4 width=14
Element Seqn Id St Int Rpt
ALEELLKEYHSKQL TR19L_MOUSE 247 76 -
ALEELLKEYHSKQL TR19L_MACFA 240 76 -
ALEELLKEYHSKQL TR19L_HUMAN 240 76 -
ALEELLQEYEDKQM Q6NZ11_DANRE 240 78 -

Motif 5 width=14
Element Seqn Id St Int Rpt
VQGLASLSGPCCSR TR19L_MOUSE 291 30 -
VQGLASLSGPCCSR TR19L_MACFA 284 30 -
VQGLASLSGPCCSR TR19L_HUMAN 284 30 -
INGLASRSGVCCSR Q6NZ11_DANRE 288 34 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
MKRTLLCWPLSCLFVLLPW Q497Z8_MOUSE 8 8 -
MKRTLLCWPLSCLFVLLPW TR19L_MOUSE 8 8 -
MKPSLLCRPLSCFLMLLPW TR19L_MACFA 1 1 -
MKPSLLCRPLSCFLMLLPW TR19L_HUMAN 1 1 -
MKNHLYCSAPVCLILLELW Q6NZ11_DANRE 1 1 -

Motif 2 width=22
Element Seqn Id St Int Rpt
RLEAQAGTATHDTMCGDCQHGW Q497Z8_MOUSE 83 56 -
RLEAQAGTATHDTMCGDCQHGW TR19L_MOUSE 83 56 -
RLEAQVGTATQDTLCGDCWPGW TR19L_MACFA 76 56 -
RLEAQVGMATRDTLCGDCWPGW TR19L_HUMAN 76 56 -
RWISTKPTSTSDAVCGGCLPGF Q6NZ11_DANRE 86 66 -

Motif 3 width=16
Element Seqn Id St Int Rpt
GNGTRAGGPEETAAQY Q497Z8_MOUSE 155 50 -
GNGTRAGGPEETAAQY TR19L_MOUSE 155 50 -
GNGTRAGGPEETAAQY TR19L_MACFA 148 50 -
GNGTRAGGPEETAAQY TR19L_HUMAN 148 50 -
GNTTSVQAPEEKTTEY Q6NZ11_DANRE 146 38 -

Motif 4 width=14
Element Seqn Id St Int Rpt
ALEELLKEYHSKQL Q497Z8_MOUSE 247 76 -
ALEELLKEYHSKQL TR19L_MOUSE 247 76 -
ALEELLKEYHSKQL TR19L_MACFA 240 76 -
ALEELLKEYHSKQL TR19L_HUMAN 240 76 -
ALEELLQEYEDKQM Q6NZ11_DANRE 240 78 -

Motif 5 width=14
Element Seqn Id St Int Rpt
VQGLASLSGPCCSR Q497Z8_MOUSE 291 30 -
VQGLASLSGPCCSR TR19L_MOUSE 291 30 -
VQGLASLSGPCCSR TR19L_MACFA 284 30 -
VQGLASLSGPCCSR TR19L_HUMAN 284 30 -
INGLASRSGVCCSR Q6NZ11_DANRE 288 34 -