SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR01967

Identifier
TNFACTORR17  [View Relations]  [View Alignment]  
Accession
PR01967
No. of Motifs
3
Creation Date
24-JUN-2009
Title
Tumour necrosis factor receptor 17 signature
Database References

PFAM; PF09257 BCMA-Tall_bind
INTERPRO; IPR015337
PDB; 1OQD; 1XU2
SCOP; 1OQD; 1XU2
CATH; 1OQD; 1XU2
MIM; 109545
Literature References
1. ARMITAGE, R.
Tumor necrosis factor receptor superfamily members and their ligands.
CURR.OPIN.IMMUNOL. 6 407-413 (1994).
 
2. BANNER D., D'ARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C.,
LOETSCHER, H. AND LESSLAUER, W.
Crystal structure of the soluble human 55 kD TNF receptor-human TNF-beta
complex: implications for TNF receptor activation.
CELL 73 431-445 (1993).
 
3. WU, H.
Assembly of post-receptor signaling complexes for the tumor necrosis factor
receptor superfamily.
ADV.PROTEIN CHEM. 68 225-279 (2004).
 
4. LOCKSLEY, R., KILLEEN, N. AND LENARDO, M.
The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology.
CELL 104 487-501 (2001).
 
5. GRAVESTEIN, L. AND BORST, J.
Tumor necrosis factor receptor family members in the immune system.
SEMIN.IMMUNOL. 10 423-434 (1998).
 
6. LOENEN, W.
D27 and (TNFR) relatives in the immune system: their role in health and
disease.
SEMIN.IMMUNOL. 10 417-422 (1998).
 
7. PATEL, D., WALLWEBER, H., YIN, J., SHRIVER, S., MARSTERS, S., GORDON, N.,
STAROVASNIK, M. AND KELLEY, R.
Engineering an APRIL-specific B cell maturation antigen.
J.BIOL.CHEM. 279 16727-16735 (2004).
 
8. LAABI, Y., GRAS, M., BROUET, J., BERGER, R., LARSEN, C. AND TSAPIS, A.
The BCMA gene, preferentially expressed during B lymphoid maturation, is 
bidirectionally transcribed.
NUCLEIC ACIDS RES. 22 1147-1154 (1994).

Documentation
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more
than 20 type-I transmembrane proteins. Family members are defined based on
similarity in their extracellular domain - a region that contains many
cysteine residues arranged in a specific repetitive pattern [1]. The
cysteines allow formation of an extended rod-like structure, responsible for
ligand binding [2].
 
Upon receptor activation, different intracellular signalling complexes are
assembled for different members of the TNFR superfamily, depending on their
intracellular domains and sequences [3]. Activation of TNFRs can therefore
induce a range of disparate effects, including cell proliferation,
differentiation, survival, or apoptotic cell death, depending upon the
receptor involved [4,5].
 
TNFRs are widely distributed and play important roles in many crucial
biological processes, such as lymphoid and neuronal development, innate and
adaptive immunity, and maintenance of cellular homeostasis [3]. Drugs that
manipulate their signalling have potential roles in the prevention and
treatment of many diseases, such as viral infections, coronary heart
disease, transplant rejection, and immune disease [6].
 
TNF receptor 17 acts as a receptor for both a proliferation-inducing ligand 
(APRIL) and B cell-activating factor (BAFF) [7]. It is preferentially 
expressed by mature B-cells, suggesting a potential role for the receptor in
the B-cell developmental process [8]. 
 
TNFACTORR17 is a 3-element fingerprint that provides a signature for tumour
necrosis factor receptor 17. The fingerprint was derived from an initial
alignment of 2 sequences: the motifs were drawn from conserved regions in 
the N-terminal three quarters of the alignment, focusing on those sections
that characterise TNF receptor 17 but distinguish it from other TNF receptor
subtypes - motif 1 lies in the extracellular N-terminal region; motif 2 
resides partially in the transmembrane domain and partially in the 
intracellular C-terminal region; and motif 3 lies wholly within the 
intracellular C-terminal region. Two iterations on SPTR57_40f were required 
to reach convergence, at which point a true set comprising 3 sequences was 
identified. A single partial match was also also found, Q2TQ40_HUMAN, a
human splice variant that fails to match motif 2.
Summary Information
   3 codes involving  3 elements
1 codes involving 2 elements
Composite Feature Index
3333
2101
123
True Positives
Q6PE46_HUMAN  TNR17_HUMAN   TNR17_MOUSE   
True Positive Partials
Codes involving 2 elements
Q2TQ40_HUMAN
Sequence Titles
Q6PE46_HUMAN Tumor necrosis factor receptor superfamily, member 17 - Homo sapiens (Human). 
TNR17_HUMAN Tumor necrosis factor receptor superfamily member 17 - Homo sapiens (Human).
TNR17_MOUSE Tumor necrosis factor receptor superfamily member 17 - Mus musculus (Mouse).

Q2TQ40_HUMAN Tumor necrosis factor receptor superfamily member 17 (B cell maturation antigen transcript variant 4) - Homo sapiens (Human).
Scan History
SPTR57_40f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
QCSQNEYFDSLLHACIPC TNR17_HUMAN 7 7 -
QCFHSEYFDSLLHACKPC TNR17_MOUSE 4 4 -

Motif 2 width=14
Element Seqn Id St Int Rpt
FLLRKISSEPLKDE TNR17_HUMAN 75 50 -
FLLRKMNPEALKDE TNR17_MOUSE 70 48 -

Motif 3 width=18
Element Seqn Id St Int Rpt
GDEIILPRGLEYTVEECT TNR17_HUMAN 110 21 -
GDDRIFPRSLEYTVEECT TNR17_MOUSE 109 25 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
QCSQNEYFDSLLHACIPC TNR17_HUMAN 7 7 -
QCSQNEYFDSLLHACIPC Q6PE46_HUMAN 7 7 -
QCFHSEYFDSLLHACKPC TNR17_MOUSE 4 4 -

Motif 2 width=14
Element Seqn Id St Int Rpt
FLLRKISSEPLKDE TNR17_HUMAN 75 50 -
FLLRKISSEPLEDE Q6PE46_HUMAN 75 50 -
FLLRKMNPEALKDE TNR17_MOUSE 70 48 -

Motif 3 width=18
Element Seqn Id St Int Rpt
GDEIILPRGLEYTVEECT TNR17_HUMAN 110 21 -
GDEIILPRGLEYTVEECT Q6PE46_HUMAN 110 21 -
GDDRIFPRSLEYTVEECT TNR17_MOUSE 109 25 -