| Literature References | 1. ARMITAGE, R.
Tumor necrosis factor receptor superfamily members and their ligands.
CURR.OPIN.IMMUNOL. 6 407-413 (1994).
2. BANNER D., D'ARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C.,
LOETSCHER, H. AND LESSLAUER, W.
Crystal structure of the soluble human 55 kD TNF receptor-human TNF-beta
complex: implications for TNF receptor activation.
CELL 73 431-445 (1993).
3. WU, H.
Assembly of post-receptor signaling complexes for the tumor necrosis factor
receptor superfamily.
ADV.PROTEIN CHEM. 68 225-279 (2004).
4. LOCKSLEY, R., KILLEEN, N. AND LENARDO, M.
The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology.
CELL 104 487-501 (2001).
5. GRAVESTEIN, L. AND BORST, J.
Tumor necrosis factor receptor family members in the immune system.
SEMIN.IMMUNOL. 10 423-434 (1998).
6. LOENEN, W.
D27 and (TNFR) relatives in the immune system: their role in health and
disease.
SEMIN.IMMUNOL. 10 417-422 (1998).
7. MONTGOMERY, R., WARNER, M., LUM, B. AND SPEAR, P.
Herpes simplex virus-1 entry into cells mediated by a novel member of the
TNF/NGF receptor family.
CELL 87 427-436 (1996).
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| Documentation | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more
than 20 type-I transmembrane proteins. Family members are defined based on
similarity in their extracellular domain - a region that contains many
cysteine residues arranged in a specific repetitive pattern [1]. The
cysteines allow formation of an extended rod-like structure, responsible for
ligand binding [2].
Upon receptor activation, different intracellular signalling complexes are
assembled for different members of the TNFR superfamily, depending on their
intracellular domains and sequences [3]. Activation of TNFRs can therefore
induce a range of disparate effects, including cell proliferation,
differentiation, survival, or apoptotic cell death, depending upon the
receptor involved [4,5].
TNFRs are widely distributed and play important roles in many crucial
biological processes, such as lymphoid and neuronal development, innate and
adaptive immunity, and maintenance of cellular homeostasis [3]. Drugs that
manipulate their signalling have potential roles in the prevention and
treatment of many diseases, such as viral infections, coronary heart
disease, transplant rejection, and immune disease [6].
TNF receptor 14 is also known as herpesvirus entry mediator (HVEM). It plays
an important role in the entry of herpes simplex virus into cells, and hence
pathogenesis of the virus [7].
TNFACTORR14 is a 3-element fingerprint that provides a signature for tumour
necrosis factor receptor 14. The fingerprint was derived from an initial
alignment of 6 sequences: the motifs were drawn from conserved regions in
the N-terminal half of the alignment, focusing on those sections that
characterise TNF receptor 14 but distinguish it from other TNF receptor
subtypes - all motifs lie in the extracellular N-terminal region. Two
iterations on SPTR57_40f were required to reach convergence, at which point
a true set comprising 11 sequences was identified. Two partial matches were
also found, B4DU65_HUMAN and B4E0P6_HUMAN, both which are translated human
cDNA sequences that fail to match motif 4.
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| Sequence Titles | B8LFF5_HORSE ELR1-insert - Equus caballus (Horse).
B9A034_HUMAN Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) - Homo sapiens (Human).
B9DI89_HUMAN Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) - Homo sapiens (Human).
Q0MSE4_MACMU Herpesvirus entry mediator - Macaca mulatta (Rhesus macaque).
Q3SXX1_MOUSE Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) - Mus musculus (Mouse).
Q4G265_HORSE ELR1 - Equus caballus (Horse).
Q5BK53_RAT Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) - Rattus norvegicus (Rat).
Q71F55_MOUSE Herpes virus entry mediator - Mus musculus (Mouse).
Q80WM9_MOUSE Tumor necrosis factor receptor superfamily member 14 - Mus musculus (Mouse).
Q9XSZ8_CERAE HveAs - Cercopithecus aethiops (Green monkey) (Grivet).
TNR14_HUMAN Tumor necrosis factor receptor superfamily member 14 - Homo sapiens (Human).
B4DU65_HUMAN cDNA FLJ57170, highly similar to Tumor necrosis factor receptor superfamily member 14 - Homo sapiens (Human).
B4E0P6_HUMAN cDNA FLJ56728, highly similar to Tumor necrosis factor receptor superfamily member 14 - Homo sapiens (Human).
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