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PR01947

Identifier
INTLKN15MAML  [View Relations]  [View Alignment]  
Accession
PR01947
No. of Motifs
3
Creation Date
30-OCT-2008
Title
Mammalian interleukin-15 signature
Database References
PRINTS; PR01930 INTRLEUKIN15
BLOCKS; IPB003443
PFAM; PF02372 IL15
PRODOM; PD006156
INTERPRO; IPR003443
MIM; 600554
Literature References
1. LIU, C., PERUSSIA, B. AND YOUNG, J.
The emerging role of IL-15 in NK-cell development.
IMMUNOL.TODAY 21 113-116 (2000).
 
2. KU, C., MURAKAMI, M., SAKAMOTO, A., KAPPLER, J. AND MARRACK, P.
Control of homeostasis of CD8+ memory T cells by opposing cytokines.
SCIENCE 288 675-678 (2000).
 
3. DOHERTY, T., SEDER, R. AND SHER, A.
Induction and regulation of IL-15 expression in murine macrophages.
J.IMMUNOL. 156 735-741 (1996).

Documentation
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
 
Interleukin-15 (IL-15) has a variety of biological functions, including 
stimulation and maintenance of cellular immune responses [1]. It is 
required for division of CD8+ T cells of memory phenotype - a process that
is increased by inhibition of IL-2 [2]. The numbers of CD8+ memory T cells
in animals may, therefore, be controlled by a balance between IL-15 and -2.
 
IL-15 has been identified in mammals, birds and fish. Mammalian IL-15s are
expressed in a number of different tissues and cell types. Within the 
immune system, they are mainly produced by monocytes and macrophages [3].
 
INTLKN15MAML is a 3-element fingerprint that provides a signature for
mammalian interleukin-15. The fingerprint was derived from an initial
alignment of 18 sequences: the motifs were drawn from conserved regions
spanning the N-terminal half of the alignment. Two iterations on SPTR55_38f
were required to reach convergence, at which point a true set comprising
20 sequences was identified. A single partial match was also found,
Q1AHQ7_MOUSE, a mouse interleukin-15 isoform that fails to match motif 3.
Summary Information
  20 codes involving  3 elements
1 codes involving 2 elements
Composite Feature Index
3202020
2110
123
True Positives
A8WE60_PIG    IL15_BOVIN    IL15_BUBBU    IL15_CERAE    
IL15_FELCA IL15_HUMAN IL15_MACMU IL15_MACTH
IL15_MOUSE IL15_PIG IL15_RABIT IL15_RAT
IL15_SHEEP Q06F26_PIG Q1AHQ6_MOUSE Q2PUG6_RABIT
Q3U1Z6_MOUSE Q5EEK6_MARMO Q5WQV8_MARMO Q75SZ9_CAVPO
True Positive Partials
Codes involving 2 elements
Q1AHQ7_MOUSE
Sequence Titles
A8WE60_PIG  Interleukin 15 - Sus scrofa (Pig).            
IL15_BOVIN Interleukin-15 precursor (IL-15) - Bos taurus (Bovine).
IL15_BUBBU Interleukin-15 precursor (IL-15) - Bubalus bubalis (Domestic water buffalo).
IL15_CERAE Interleukin-15 precursor (IL-15) - Cercopithecus aethiops (Green monkey) (Grivet).
IL15_FELCA Interleukin-15 precursor (IL-15) - Felis silvestris catus (Cat).
IL15_HUMAN Interleukin-15 precursor (IL-15) - Homo sapiens (Human).
IL15_MACMU Interleukin-15 precursor (IL-15) - Macaca mulatta (Rhesus macaque).
IL15_MACTH Interleukin-15 precursor (IL-15) - Macaca thibetana (Pere David's macaque) (Tibetan macaque).
IL15_MOUSE Interleukin-15 precursor (IL-15) - Mus musculus (Mouse).
IL15_PIG Interleukin-15 precursor (IL-15) - Sus scrofa (Pig).
IL15_RABIT Interleukin-15 precursor (IL-15) - Oryctolagus cuniculus (Rabbit).
IL15_RAT Interleukin-15 precursor (IL-15) - Rattus norvegicus (Rat).
IL15_SHEEP Interleukin-15 precursor (IL-15) - Ovis aries (Sheep).
Q06F26_PIG Interleukin-15 - Sus scrofa (Pig).
Q1AHQ6_MOUSE Putative interleukin 15 isoform aE7 precursor - Mus musculus (Mouse).
Q2PUG6_RABIT Interleukin-15 - Oryctolagus cuniculus (Rabbit).
Q3U1Z6_MOUSE Interleukin-15 - Mus musculus (Mouse).
Q5EEK6_MARMO Interleukin-15 - Marmota monax (Woodchuck).
Q5WQV8_MARMO Interleukin 15 precursor - Marmota monax (Woodchuck).
Q75SZ9_CAVPO Interleukin-15 precursor - Cavia porcellus (Guinea pig).

Q1AHQ7_MOUSE Putative interleukin 15 isoform aE6 precursor - Mus musculus (Mouse).
Scan History
SPTR55_38f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
MRILKPYLRSTSIQCYLC IL15_BUBBU 1 1 -
MRISKPHLRSISIQCYLC IL15_CERAE 1 1 -
MRISKPHLRSVSIQCYLC IL15_MACTH 1 1 -
MRISKPHLRSVSIQCYLC IL15_MACMU 1 1 -
MRISKPHLRSISIQCYLC IL15_HUMAN 1 1 -
MRILKPYLRSTSIQCYLC IL15_BOVIN 1 1 -
MRILKPYLRSTSIQCYLC IL15_SHEEP 1 1 -
MRISKPYLRSTSIQCYLC IL15_RABIT 1 1 -
MRISKPYLRSTSIQCYLC Q2PUG6_RABIT 1 1 -
MRILKPCLRSTCIQCYLC IL15_PIG 1 1 -
MKILKPYMRNTSISCYLC IL15_MOUSE 1 1 -
MKILKPYMRNTSISCYLC Q3U1Z6_MOUSE 1 1 -
MKILKPYMRNTSISCYLC Q1AHQ6_MOUSE 1 1 -
MRISKPHLRITSIQCYVC Q5WQV8_MARMO 1 1 -
MRISKPSLRSTSIQCYLC Q75SZ9_CAVPO 1 1 -
MRISKPHLRITSIQCYVC Q5EEK6_MARMO 1 1 -
MKILKPYMRNTSILYYLC IL15_RAT 1 1 -
MRILKPYLRSTSIQCYLC IL15_FELCA 1 1 -

Motif 2 width=26
Element Seqn Id St Int Rpt
HFLTEAGIHVFILGCISAGLPKTEAN IL15_BUBBU 24 5 -
HFLTEAGIHVFILGCFSAGLPKTEAN IL15_CERAE 24 5 -
HFLTEAGIHVFILGCFSAGLPKTEAN IL15_MACTH 24 5 -
HFLTEAGIHVFILGCFSAGLPKTEAN IL15_MACMU 24 5 -
HFLTEAGIHVFILGCFSAGLPKTEAN IL15_HUMAN 24 5 -
HFLTEAGIHVFILGCISASLPKTEAN IL15_BOVIN 24 5 -
HFLTEAGIHVFILGCISAGLPKTEAN IL15_SHEEP 24 5 -
HFLAEAGIHVFIFGCISAGLPKTEAN IL15_RABIT 24 5 -
HFLAEAGIHVFIFGCISAGLPKTEAN Q2PUG6_RABIT 24 5 -
HFLTEDGIHVFILGCISAGLPKTEAT IL15_PIG 24 5 -
HFLTEAGIHVFILGCVSVGLPKTEAN IL15_MOUSE 24 5 -
HFLTEAGIHVFILGCVSVGLPKTEAN Q3U1Z6_MOUSE 24 5 -
HFLTEAGIHVFILGCVSVGLPKTEAN Q1AHQ6_MOUSE 24 5 -
HFLTEAGIRVFILGCISAGIPKTEAN Q5WQV8_MARMO 24 5 -
HLITEAGIHVFVWGCISAGLPKTEAS Q75SZ9_CAVPO 24 5 -
HFLTEAGIRVFILGCISASIPKTEAN Q5EEK6_MARMO 24 5 -
HFLTEAGIHVFILGCVSVGLPKTEAN IL15_RAT 24 5 -
HFLTEACIPVFILSCINAGLPKTEAN IL15_FELCA 24 5 -

Motif 3 width=12
Element Seqn Id St Int Rpt
TIEHLIQSIHMD IL15_BUBBU 59 9 -
KIEDLIQSMHID IL15_CERAE 59 9 -
KIEDLIQSMHID IL15_MACTH 59 9 -
KIEDLIQSMHID IL15_MACMU 59 9 -
KIEDLIQSMHID IL15_HUMAN 59 9 -
TIEHLIQSIHMD IL15_BOVIN 59 9 -
TIEHLIQSMHMD IL15_SHEEP 59 9 -
RIEDLIKSIHID IL15_RABIT 59 9 -
RIEDLIKSIHID Q2PUG6_RABIT 59 9 -
KIEDLIRSIHMD IL15_PIG 59 9 -
KIESLIQSIHID IL15_MOUSE 59 9 -
KIESLIQSIHID Q3U1Z6_MOUSE 59 9 -
KIESLIQSIHID Q1AHQ6_MOUSE 59 9 -
KIENLIQSLHMD Q5WQV8_MARMO 59 9 -
RIENLIQSIHID Q75SZ9_CAVPO 59 9 -
KIENLIQSLHMD Q5EEK6_MARMO 59 9 -
KIESLIQFIHID IL15_RAT 59 9 -
IIDKIIQSLHID IL15_FELCA 59 9 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
MRILKPYLRSTSIQCYLC IL15_BUBBU 1 1 -
MRISKPHLRSISIQCYLC IL15_CERAE 1 1 -
MRISKPHLRSVSIQCYLC IL15_MACTH 1 1 -
MRISKPHLRSVSIQCYLC IL15_MACMU 1 1 -
MRISKPHLRSISIQCYLC IL15_HUMAN 1 1 -
MRILKPYLRSTSIQCYLC IL15_BOVIN 1 1 -
MRILKPYLRSTSIQCYLC IL15_SHEEP 1 1 -
MRILKPCLRSTCIQCYLC Q06F26_PIG 1 1 -
MRISKPYLRSTSIQCYLC IL15_RABIT 1 1 -
MRISKPYLRSTSIQCYLC Q2PUG6_RABIT 1 1 -
MRILKPCLRSTCIQCYLC A8WE60_PIG 1 1 -
MRILKPCLRSTCIQCYLC IL15_PIG 1 1 -
MKILKPYMRNTSISCYLC IL15_MOUSE 1 1 -
MKILKPYMRNTSISCYLC Q3U1Z6_MOUSE 1 1 -
MKILKPYMRNTSISCYLC Q1AHQ6_MOUSE 1 1 -
MRISKPHLRITSIQCYVC Q5WQV8_MARMO 1 1 -
MRISKPSLRSTSIQCYLC Q75SZ9_CAVPO 1 1 -
MRISKPHLRITSIQCYVC Q5EEK6_MARMO 1 1 -
MKILKPYMRNTSILYYLC IL15_RAT 1 1 -
MRILKPYLRSTSIQCYLC IL15_FELCA 1 1 -

Motif 2 width=26
Element Seqn Id St Int Rpt
HFLTEAGIHVFILGCISAGLPKTEAN IL15_BUBBU 24 5 -
HFLTEAGIHVFILGCFSAGLPKTEAN IL15_CERAE 24 5 -
HFLTEAGIHVFILGCFSAGLPKTEAN IL15_MACTH 24 5 -
HFLTEAGIHVFILGCFSAGLPKTEAN IL15_MACMU 24 5 -
HFLTEAGIHVFILGCFSAGLPKTEAN IL15_HUMAN 24 5 -
HFLTEAGIHVFILGCISASLPKTEAN IL15_BOVIN 24 5 -
HFLTEAGIHVFILGCISAGLPKTEAN IL15_SHEEP 24 5 -
HFLTEAGIHVFILGCISAGLPKTEAT Q06F26_PIG 24 5 -
HFLAEAGIHVFIFGCISAGLPKTEAN IL15_RABIT 24 5 -
HFLAEAGIHVFIFGCISAGLPKTEAN Q2PUG6_RABIT 24 5 -
HFLTEAGIHVFILGCITAGLPKTEAT A8WE60_PIG 24 5 -
HFLTEDGIHVFILGCISAGLPKTEAT IL15_PIG 24 5 -
HFLTEAGIHVFILGCVSVGLPKTEAN IL15_MOUSE 24 5 -
HFLTEAGIHVFILGCVSVGLPKTEAN Q3U1Z6_MOUSE 24 5 -
HFLTEAGIHVFILGCVSVGLPKTEAN Q1AHQ6_MOUSE 24 5 -
HFLTEAGIRVFILGCISAGIPKTEAN Q5WQV8_MARMO 24 5 -
HLITEAGIHVFVWGCISAGLPKTEAS Q75SZ9_CAVPO 24 5 -
HFLTEAGIRVFILGCISASIPKTEAN Q5EEK6_MARMO 24 5 -
HFLTEAGIHVFILGCVSVGLPKTEAN IL15_RAT 24 5 -
HFLTEACIPVFILSCINAGLPKTEAN IL15_FELCA 24 5 -

Motif 3 width=12
Element Seqn Id St Int Rpt
TIEHLIQSIHMD IL15_BUBBU 59 9 -
KIEDLIQSMHID IL15_CERAE 59 9 -
KIEDLIQSMHID IL15_MACTH 59 9 -
KIEDLIQSMHID IL15_MACMU 59 9 -
KIEDLIQSMHID IL15_HUMAN 59 9 -
TIEHLIQSIHMD IL15_BOVIN 59 9 -
TIEHLIQSMHMD IL15_SHEEP 59 9 -
KIEDLIRSIHMD Q06F26_PIG 59 9 -
RIEDLIKSIHID IL15_RABIT 59 9 -
RIEDLIKSIHID Q2PUG6_RABIT 59 9 -
KIEDLIRSIHMD A8WE60_PIG 59 9 -
KIEDLIRSIHMD IL15_PIG 59 9 -
KIESLIQSIHID IL15_MOUSE 59 9 -
KIESLIQSIHID Q3U1Z6_MOUSE 59 9 -
KIESLIQSIHID Q1AHQ6_MOUSE 59 9 -
KIENLIQSLHMD Q5WQV8_MARMO 59 9 -
RIENLIQSIHID Q75SZ9_CAVPO 59 9 -
KIENLIQSLHMD Q5EEK6_MARMO 59 9 -
KIESLIQFIHID IL15_RAT 59 9 -
IIDKIIQSLHID IL15_FELCA 59 9 -