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PR01941

Identifier
NTKRECEPTOR2  [View Relations]  [View Alignment]  
Accession
PR01941
No. of Motifs
4
Creation Date
03-APR-2008
Title
Neurotrophic tyrosine kinase receptor type 2 signature
Database References
PRINTS; PR00109 TYRKINASE; PR01939 NTKRECEPTOR
PDB; 1HCF; 1WWB
SCOP; 1HCF; 1WWB
CATH; 1HCF; 1WWB
MIM; 600456
Literature References
1. BOTHWELL, M.
Functional interactions of neurotrophins and neurotrophin receptors.
ANNU.REV.NEUROSCI. 18 223-253 (1995).
 
2. HUANG, E. AND REICHARDT, L.
Neurotrophins: roles in neuronal development and function.
ANNU.REV.NEUROSCI. 24 677-736 (2001).
 
3. LEI, L. AND PARADA, L.
Transcriptional regulation of Trk family neurotrophin receptors.
CELL.MOL.LIFE SCI. 64 522-532 (2007).
 
4. RICO, B., XU, B. AND REICHARDT, L.
TrkB receptor signaling is required for establishment of GABAergic synapses
in the cerebellum.
NAT.NEUROSCI. 5 225-233 (2002).
 
5. YAMADA, K. AND NABESHIMA, T.
Brain-derived neurotrophic factor/TrkB signaling in memory processes.
J.PHARMACOL.SCI. 91 267-270 (2003).

Documentation
Neurotrophins are a family of secreted proteins that regulate development, 
maintenance and function of vertebrate nervous systems. They act via two 
different classes of receptor: p75NTR (a member of the TNF receptor 
superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also 
known as tropomyosin-related kinases (Trks) [1]. 
 
NTRKs are multi-domain, transmembrane proteins - in addition to their
cytoplasmic kinase domains, members of the family possess a number of
extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand
binding induces them to dimerise, resulting in activation of their
cytoplasmic tyrosine kinase domains. The activated receptors couple to a
variety of intracellular signalling cascades, including the Ras,
phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP)
kinase, and phospholipase C (PLC)-gamma pathways [2].
 
NTRK2 (also termed TrkB) is a high-affinity receptor for brain-derived 
neurotrophic factor (BDNF) and neurotrophin (NT-4). It is broadly expressed
in the nervous system, and is also found in some non-neural tissues [3]. 
The receptor is involved in synaptogenesis and neuronal development [4]. It
plays a crucial role in learning and memory [5].
 
NTKRECEPTOR2 is a 4-element fingerprint that provides a signature for 
neurotrophic tyrosine kinase receptor type 2. The fingerprint was derived
from an initial alignment of 2 sequences: the motifs were drawn from 
conserved regions spanning the N-terminal extracellular domain, focusing on
those sections that characterise NTRK2 but distinguish it from other members
of the NTRK family - motif 1 lies in the signal sequence, and motifs 3 and 4
each encompass short beta strands. Two iterations on SPTR55_38f were
required to reach convergence, at which point a true set comprising 10 
sequences was identified. A single partial match was also found,
Q95K65_MACFA, a translated macaque cDNA that fails to match motifs 3 and 4.
Summary Information
  10 codes involving  4 elements
0 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
410101010
30000
21100
1234
True Positives
Q0VCN4_BOVIN  Q3UHE3_MOUSE  Q548C2_HUMAN  Q5VWE5_HUMAN  
Q8WXJ5_HUMAN Q8WXJ7_HUMAN TRKB_CHICK TRKB_HUMAN
TRKB_MOUSE TRKB_RAT
True Positive Partials
Codes involving 2 elements
Q95K65_MACFA
Sequence Titles
Q0VCN4_BOVIN Neurotrophic tyrosine kinase, receptor, type 2 - Bos taurus (Bovine). 
Q3UHE3_MOUSE CDNA, RIKEN full-length enriched library, clone:M5C1042H21 product:neurotrophic tyrosine kinase, receptor, type 2, full insert sequence - Mus musculus (Mouse).
Q548C2_HUMAN Neurotrophic tyrosine kinase receptor type 2 - Homo sapiens (Human).
Q5VWE5_HUMAN Neurotrophic tyrosine kinase, receptor, type 2 (Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a) (cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA) - Homo sapiens (Human).
Q8WXJ5_HUMAN Neurotrophin receptor tyrosine kinase type 2 truncated isoform - Homo sapiens (Human).
Q8WXJ7_HUMAN Tyrosine-protein kinase receptor (EC 2.7.10.1) - Homo sapiens (Human).
TRKB_CHICK BDNF/NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKB TYROSINE KINASE) (TRK-B) - GALLUS GALLUS (CHICKEN).
TRKB_HUMAN BDNF/NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKB TYROSINE KINASE) (GP145-TRKB) (TRK-B) - HOMO SAPIENS (HUMAN).
TRKB_MOUSE BDNF/NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKB TYROSINE KINASE) (GP145-TRKB/GP95-TRKB) (TRK-B) - MUS MUSCULUS (MOUSE).
TRKB_RAT BDNF/NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (EC 2.7.1.112) (TRKB TYROSINE KINASE) (GP145-TRKB/GP95-TRKB) (TRK-B) - RATTUS NORVEGICUS (RAT).

Q95K65_MACFA Putative uncharacterized protein - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
Scan History
SPTR55_38f 2  200  NSINGLE    
Initial Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
WGFCWLVVGFWRAA TRKB_HUMAN 16 16 -
WGLCCLVLGCWRGA TRKB_CHICK 16 16 -

Motif 2 width=11
Element Seqn Id St Int Rpt
RIWCSDPSPGI TRKB_HUMAN 42 12 -
RIWCSEPVPGI TRKB_CHICK 42 12 -

Motif 3 width=15
Element Seqn Id St Int Rpt
FAPTITFLESPTSDH TRKB_HUMAN 285 232 -
FAPNITFIESPTPDH TRKB_CHICK 284 231 -

Motif 4 width=14
Element Seqn Id St Int Rpt
ICTKIHVTNHTEYH TRKB_HUMAN 330 30 -
ICTKIHVINQSEYH TRKB_CHICK 329 30 -
Final Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
WGFCWLVVGFWRAA TRKB_HUMAN 16 16 -
WGFCWLVVGFWRAA Q8WXJ7_HUMAN 16 16 -
WGFCWLVVGFWRAA Q8WXJ5_HUMAN 16 16 -
WGFCWLVVGFWRAA Q5VWE5_HUMAN 16 16 -
WGFCWLVVGFWRAA Q548C2_HUMAN 16 16 -
WGFCWLIVGFWRAA Q0VCN4_BOVIN 16 16 -
WGLCLLVLGFWRAS TRKB_MOUSE 16 16 -
WGLCLLVLGFWRAS Q3UHE3_MOUSE 16 16 -
WGLCLLVLGFWRAS TRKB_RAT 16 16 -
WGLCCLVLGCWRGA TRKB_CHICK 16 16 -

Motif 2 width=11
Element Seqn Id St Int Rpt
RIWCSDPSPGI TRKB_HUMAN 42 12 -
RIWCSDPSPGI Q8WXJ7_HUMAN 42 12 -
RIWCSDPSPGI Q8WXJ5_HUMAN 42 12 -
RIWCSDPSPGI Q5VWE5_HUMAN 42 12 -
RIWCSDPSPGI Q548C2_HUMAN 42 12 -
RIWCGDPSPGI Q0VCN4_BOVIN 42 12 -
RIWCTEPSPGI TRKB_MOUSE 42 12 -
RIWCTEPSPGI Q3UHE3_MOUSE 42 12 -
RIWCTEPSPGI TRKB_RAT 42 12 -
RIWCSEPVPGI TRKB_CHICK 42 12 -

Motif 3 width=15
Element Seqn Id St Int Rpt
FAPTITFLESPTSDH TRKB_HUMAN 285 232 -
FAPTITFLESPTSDH Q8WXJ7_HUMAN 285 232 -
FAPTITFLESPTSDH Q8WXJ5_HUMAN 285 232 -
FAPTITFLESPTSDH Q5VWE5_HUMAN 285 232 -
FAPTITFLESPTSDH Q548C2_HUMAN 285 232 -
FAPTITFLESPTSDH Q0VCN4_BOVIN 285 232 -
FAPTITFLESPTSDH TRKB_MOUSE 285 232 -
FAPTITFLESPTSDH Q3UHE3_MOUSE 285 232 -
FAPTITFLESPTSDH TRKB_RAT 285 232 -
FAPNITFIESPTPDH TRKB_CHICK 284 231 -

Motif 4 width=14
Element Seqn Id St Int Rpt
ICTKIHVTNHTEYH TRKB_HUMAN 330 30 -
ICTKIHVTNHTEYH Q8WXJ7_HUMAN 330 30 -
ICTKIHVTNHTEYH Q8WXJ5_HUMAN 330 30 -
ICTKIHVTNHTEYH Q5VWE5_HUMAN 330 30 -
ICTKIHVTNHTEYH Q548C2_HUMAN 330 30 -
ICTKIHVTNHTEYH Q0VCN4_BOVIN 330 30 -
ICTKIHVTNHTEYH TRKB_MOUSE 330 30 -
ICTKIHVTNHTEYH Q3UHE3_MOUSE 330 30 -
ICTKIHVTNHTEYH TRKB_RAT 330 30 -
ICTKIHVINQSEYH TRKB_CHICK 329 30 -