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PR01940

Identifier
NTKRECEPTOR1  [View Relations]  [View Alignment]  
Accession
PR01940
No. of Motifs
3
Creation Date
03-APR-2008
Title
Neurotrophic tyrosine kinase receptor type 1 signature
Database References
PRINTS; PR00109 TYRKINASE; PR01939 NTKRECEPTOR
PRODOM; PD032078
PDB; 1HE7; 1WWA; 1WWW; 2IFG
SCOP; 1HE7; 1WWA; 1WWW; 2IFG
CATH; 1HE7; 1WWA; 1WWW; 2IFG
MIM; 191315
Literature References
1. BOTHWELL, M.
Functional interactions of neurotrophins and neurotrophin receptors.
ANNU.REV.NEUROSCI. 18 223-253 (1995).
 
2. HUANG, E. AND REICHARDT, L.
Neurotrophins: roles in neuronal development and function.
ANNU.REV.NEUROSCI. 24 677-736 (2001).
 
3. LEI, L. AND PARADA, L.
Transcriptional regulation of Trk family neurotrophin receptors.
CELL.MOL.LIFE SCI. 64 522-532 (2007).
 
4. ADLY, M., ASSAF, H., NADA, E., SOLIMAN, M. AND HUSSEIN, M.
Expression of nerve growth factor and its high-affinity receptor, tyrosine
kinase A proteins, in the human scalp skin.
J.CUTAN.PATHOL. 33 559-568 (2006).
 
5. YOON, S., CASACCIA-BONNEFIL, P., CARTER, B. AND CHAO, M.
Competitive signaling between TrkA and p75 nerve growth factor receptors 
determines cell survival.
J.NEUROSCI. 18 3273-3281 (1998).

Documentation
Neurotrophins are a family of secreted proteins that regulate development, 
maintenance and function of vertebrate nervous systems. They act via two 
different classes of receptor: p75NTR (a member of the TNF receptor 
superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also 
known as tropomyosin-related kinases (Trks) [1].
 
NTRKs are multi-domain, transmembrane proteins - in addition to their
cytoplasmic kinase domains, members of the family possess a number of
extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand
binding induces them to dimerise, resulting in activation of their
cytoplasmic tyrosine kinase domains. The activated receptors couple to a
variety of intracellular signalling cascades, including the Ras,
phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP)
kinase, and phospholipase C (PLC)-gamma pathways [2].
 
NTRK1 (also termed TrkA) is a high-affinity receptor for nerve growth 
factor (NGF). The receptor is expressed in the dorsal root ganglia,
trigeminal ganglia and sympathetic neurons of the peripheral nervous
system, and in basal forebrain cholinergic neurons [3]. It is also
expressed in peripheral sites, such as scalp skin [4]. Whereas p75NTR 
activation by NGF induces apoptosis, NTRK1 mediates the growth factor's 
cell survival-promoting effects [5].
 
NTKRECEPTOR1 is a 3-element fingerprint that provides a signature for 
neurotrophic tyrosine kinase receptor type 1. The fingerprint was derived
from an initial alignment of 2 sequences: the motifs were drawn from 
conserved regions spanning the central portion of the alignment, focusing on 
those sections that characterise NTRK1 but distinguish it from other members
of the NTRK family: motif 1 lies within the N-terminal extracellular region; 
and motifs 2 and 3 reside in the cytoplasmic portion of the receptor. Two
iterations on SPTR55_38f were required to reach convergence, at which point
a true set comprising 6 sequences was identified.
Summary Information
6 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3666
2000
123
True Positives
A6NF12_HUMAN  A8K3Z4_HUMAN  NTRK1_MOUSE   Q90699        
TRKA_HUMAN TRKA_RAT
Sequence Titles
A6NF12_HUMAN Tyrosine-protein kinase receptor (EC 2.7.10.1) - Homo sapiens (Human). 
A8K3Z4_HUMAN cDNA FLJ75372, highly similar to Human trk proto-oncogene insert of pLM6 - Homo sapiens (Human).
NTRK1_MOUSE High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) - Mus musculus (Mouse).
Q90699 TROPOMYOSIN RECEPTOR KINASE - GALLUS GALLUS (CHICKEN).
TRKA_HUMAN HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (TRK1 TRANSFORMING TYROSINE KINASE PROTEIN) (P140-TRKA) (TRK-A) - HOMO SAPIENS (HUMAN).
TRKA_RAT HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (P140-TRKA) (SLOW NERVE GROWTH FACTOR RECEPTOR) (TRK-A) - RATTUS NORVEGICUS (RAT).
Scan History
SPTR55_38f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
DNPFEFNPEDPIPVSFSPVD TRKA_HUMAN 380 380 -
DNPFSFSPEEPIPVSISPLG Q90699 373 373 -

Motif 2 width=16
Element Seqn Id St Int Rpt
LNKCGRRNKFGINRPA TRKA_HUMAN 439 39 -
LNKCGHRSKFGINRSA Q90699 433 40 -

Motif 3 width=16
Element Seqn Id St Int Rpt
APEDGLAMSLHFMTLG TRKA_HUMAN 457 2 -
AQEDDLAMSLHFMNLG Q90699 451 2 -
Final Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
DNPFEFNPEDPIPVSFSPVD TRKA_HUMAN 380 380 -
DNPFEFNPEDPIPVSFSPVD NTRK1_MOUSE 383 383 -
DNPFEFNPEDPIPVSFSPVD TRKA_RAT 383 383 -
DNPFSFSPEEPIPVSISPLG Q90699 373 373 -
DNPFEFNPEDPIPDTNSTSG A6NF12_HUMAN 350 350 -
DNPFEFNPEDPIPDTNSTSG A8K3Z4_HUMAN 380 380 -

Motif 2 width=16
Element Seqn Id St Int Rpt
LNKCGRRNKFGINRPA TRKA_HUMAN 439 39 -
LNKCGQRSKFGINRPA NTRK1_MOUSE 442 39 -
LNKCGQRSKFGINRPA TRKA_RAT 442 39 -
LNKCGHRSKFGINRSA Q90699 433 40 -
LNKCGRRNKFGINRPA A6NF12_HUMAN 403 33 -
LNKCGRRNKFGINRPA A8K3Z4_HUMAN 433 33 -

Motif 3 width=16
Element Seqn Id St Int Rpt
APEDGLAMSLHFMTLG TRKA_HUMAN 457 2 -
APEDGLAMSLHFMTLG NTRK1_MOUSE 460 2 -
APEDGLAMSLHFMTLG TRKA_RAT 460 2 -
AQEDDLAMSLHFMNLG Q90699 451 2 -
APEDGLAMSLHFMTLG A6NF12_HUMAN 421 2 -
APEDGLAMSLHFMTLG A8K3Z4_HUMAN 451 2 -