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PR01933

Identifier
INTRLEUKIN18  [View Relations]  [View Alignment]  
Accession
PR01933
No. of Motifs
4
Creation Date
29-JUL-2008
Title
Interleukin-18 signature
Database References

PRODOM; PD016861
INTERPRO; IPR015529
PDB; 1J0S
SCOP; 1J0S
CATH; 1J0S
MIM; 600953
Literature References
1. KATO, Z., JEE, J., SHIKANO, H., MISHIMA, M., OHKI, I., OHNISHI, H.,
LI, A., HASHIMOTO, K., MATSUKUMA, E., OMOYA, K., YAMAMOTO, Y., YONEDA, T., 
HARA, T., KONDO, N. AND SHIRAKAWA, M. 
The structure and binding mode of interleukin-18. 
NAT.STRUCT.BIOL. 10 966-71 (2003).
 
2. BIET, F., LOCHT, C. AND KREMER, L.
Immunoregulatory functions of interleukin 18 and its role in defense 
against bacterial pathogens.
J.MOL.MED. 80 147-162 (2002).

Documentation
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
 
Interleukin-18 (IL-18) is a potent proinflammatory cytokine that has 
pleiotropic immunoregulatory functions, including augmentation of IFN-gamma
production, Fas-mediated cytotoxicity, and developmental regulation of 
T-lymphocyte helper type I [1]. The cytokine plays a critical role in the 
defense against intracellular bacteria, including Listeria, Shigella, 
Salmonella and Mycobacterium tuberculosis [2].
 
INTRLEUKIN18 is a 4-element fingerprint that provides a signature for 
interleukin-18. The fingerprint was derived from an initial alignment of 7
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length. Three iterations on SPTR55_38f were required to
reach convergence, at which point a true set comprising 38 sequences was 
identified. A single partial match was also found, A0PJ18_MOUSE, a murine
translated cDNA sequence that fails to match motif 3.
Summary Information
  38 codes involving  4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
438383838
31101
20000
1234
True Positives
A2I7W4_ANSCY  A2IBW1_PIG    A2IRI7_FELCA  A5A360_PIG    
A5JV27_VULVU A7Y426_PIG A8W970_NYCPR A9QWR6_BOVIN
IL18_BOSTR IL18_BOVIN IL18_CANFA IL18_CAPHI
IL18_CHICK IL18_FELCA IL18_HORSE IL18_HUMAN
IL18_MOUSE IL18_PIG IL18_RAT Q19KR6_ANAPL
Q1HFX9_ANAPL Q2PMY2_MOUSE Q5S4P2_CHICK Q6FGY3_HUMAN
Q6IT44_CHICK Q6STL7_PIG Q6T573_BUBBU Q6TLW4_BUBBU
Q6USQ6_MOUSE Q6WWJ7_HUMAN Q80SS8_MOUSE Q80Y07_MERUN
Q91Z66_SIGHI Q96KJ8_HUMAN Q9BGI5_MACMU Q9GL09_SHEEP
Q9I8D2_CHICK Q9N1P7_PIG
True Positive Partials
Codes involving 3 elements
A0PJ18_MOUSE
Sequence Titles
A2I7W4_ANSCY Interleukin-18 - Anser cygnoides (Chinese goose). 
A2IBW1_PIG IL-18 - Sus scrofa (Pig).
A2IRI7_FELCA Interferon gamma inducing factor - Felis silvestris catus (Cat).
A5A360_PIG Interleukin 18 - Sus scrofa (Pig).
A5JV27_VULVU IL-18 - Vulpes vulpes (Red fox).
A7Y426_PIG IL-18 - Sus scrofa (Pig).
A8W970_NYCPR IL-18 - Nyctereutes procyonoides (Raccoon dog) (Canis procyonoides).
A9QWR6_BOVIN Interleukin 18 - Bos taurus (Bovine).
IL18_BOSTR Interleukin-18 precursor (IL-18) (Interferon-gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) - Boselaphus tragocamelus (Nilgai).
IL18_BOVIN Interleukin-18 precursor (IL-18) (Interferon-gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) - Bos taurus (Bovine).
IL18_CANFA Interleukin-18 precursor (IL-18) (Interferon-gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) - Canis familiaris (Dog).
IL18_CAPHI Interleukin-18 precursor (IL-18) (Interferon-gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) - Capra hircus (Goat).
IL18_CHICK Interleukin-18 precursor (IL-18) - Gallus gallus (Chicken).
IL18_FELCA Interleukin-18 precursor (IL-18) (Interferon-gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) - Felis silvestris catus (Cat).
IL18_HORSE Interleukin-18 precursor (IL-18) (Interferon-gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) - Equus caballus (Horse).
IL18_HUMAN Interleukin-18 precursor (IL-18) (Interferon-gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) (Iboctadekin) - Homo sapiens (Human).
IL18_MOUSE Interleukin-18 precursor (IL-18) (Interferon-gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) - Mus musculus (Mouse).
IL18_PIG Interleukin-18 precursor (IL-18) (Interferon-gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) - Sus scrofa (Pig).
IL18_RAT Interleukin-18 precursor (IL-18) (Interferon-gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) - Rattus norvegicus (Rat).
Q19KR6_ANAPL Interleukin-18 - Anas platyrhynchos (Domestic duck).
Q1HFX9_ANAPL Interleukin-18 precursor - Anas platyrhynchos (Domestic duck).
Q2PMY2_MOUSE Interleukin-18 - Mus musculus (Mouse).
Q5S4P2_CHICK Interleukin-18 - Gallus gallus (Chicken).
Q6FGY3_HUMAN IL18 protein - Homo sapiens (Human).
Q6IT44_CHICK Interleukin 18 - Gallus gallus (Chicken).
Q6STL7_PIG Interleukin 18 - Sus scrofa (Pig).
Q6T573_BUBBU Interleukin-18 - Bubalus bubalis (Domestic water buffalo).
Q6TLW4_BUBBU Interleukin 18 - Bubalus bubalis (Domestic water buffalo).
Q6USQ6_MOUSE Interleukin 18 - Mus musculus (Mouse).
Q6WWJ7_HUMAN DELTA3PRO-IL-18 (Interleukin 18 (Interferon-gamma-inducing factor), isoform CRA_a) - Homo sapiens (Human).
Q80SS8_MOUSE Interleukin 18 - Mus musculus (Mouse).
Q80Y07_MERUN Interleukin 18 - Meriones unguiculatus (Mongolian jird) (Mongolian gerbil).
Q91Z66_SIGHI Interleukin 18 - Sigmodon hispidus (Hispid cotton rat).
Q96KJ8_HUMAN Interleukin 18 - Homo sapiens (Human).
Q9BGI5_MACMU Interleukin-18 - Macaca mulatta (Rhesus macaque).
Q9GL09_SHEEP Interleukin-18 (IGIF) - Ovis aries (Sheep).
Q9I8D2_CHICK Interleukin 18 - Gallus gallus (Chicken).
Q9N1P7_PIG Interleukin-18 - Sus scrofa (Pig).

A0PJ18_MOUSE Interleukin-18 - Mus musculus (Mouse).
Scan History
SPTR55_38f 3  300  NSINGLE    
Initial Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
LESDHFGKLEPKLSIIR Q6T573_BUBBU 33 33 -
LESDHFGKLEPKLSIIR IL18_BOSTR 33 33 -
LESDYFGRLEPKLSIIR IL18_HORSE 33 33 -
LESDYFGKLESKLSVIR IL18_HUMAN 33 33 -
LESDYFGKLEPKLSIIR IL18_CANFA 33 33 -
LECDAFCKDKTIKRFFR IL18_CHICK 24 24 -
LECDAFSKEKTLHRFLR A2I7W4_ANSCY 27 27 -

Motif 2 width=12
Element Seqn Id St Int Rpt
SVQCKKMSTLSC Q6T573_BUBBU 101 51 -
SVQCKKMSTLSC IL18_BOSTR 101 51 -
SVKCEKTSTLSC IL18_HORSE 101 51 -
SVKCEKISTLSC IL18_HUMAN 101 51 -
SVKYKTMSTLSC IL18_CANFA 101 51 -
SVQVEDKSYYMC IL18_CHICK 93 52 -
SVQVEDKSYYMC A2I7W4_ANSCY 96 52 -

Motif 3 width=12
Element Seqn Id St Int Rpt
VSFKEMNPPDNI Q6T573_BUBBU 117 4 -
VSFKEMNPPDNI IL18_BOSTR 117 4 -
ISFKEMSPPENI IL18_HORSE 117 4 -
ISFKEMNPPDNI IL18_HUMAN 117 4 -
ISFQKMSPPDSI IL18_CANFA 117 4 -
VRFREGEVPKDI IL18_CHICK 114 9 -
VRFREGEVPKDI A2I7W4_ANSCY 117 9 -

Motif 4 width=10
Element Seqn Id St Int Rpt
SLYKGYFLAC Q6T573_BUBBU 154 25 -
SLYKGYFLAC IL18_BOSTR 154 25 -
SLYKGYFLAC IL18_HORSE 154 25 -
SSYEGYFLAC IL18_HUMAN 154 25 -
SLYKGHFLAC IL18_CANFA 154 25 -
SLEQGMFLAF IL18_CHICK 151 25 -
SLERGMFLAF A2I7W4_ANSCY 154 25 -
Final Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
LESDHFGKLEPKLSIIR IL18_CAPHI 32 32 -
LESDHFGKLEPKLSIIR Q9GL09_SHEEP 33 33 -
LESDHFGKLEPKLSIIR A9QWR6_BOVIN 33 33 -
LESDHFGKLEPKLSIIR Q6TLW4_BUBBU 33 33 -
LESDHFGKLEPKLSIIR Q6T573_BUBBU 33 33 -
LESDHFGKLEPKLSIIR IL18_BOVIN 33 33 -
LESDHFGKLEPKLSIIR IL18_BOSTR 33 33 -
LESDYFGKLEPKLSIIR A5A360_PIG 32 32 -
LESDYFGKLEPKLSIIR Q9N1P7_PIG 32 32 -
LESDYFGKLEPKLSIIR Q6STL7_PIG 32 32 -
LESDYFGKLEPKLSIIR IL18_PIG 32 32 -
LESDYFGKLEPKLSIIR A7Y426_PIG 32 32 -
LESDYFGKLEPKLSIIR A2IBW1_PIG 32 32 -
LESDYFGRLEPKLSIIR IL18_HORSE 33 33 -
LESDYFGKLESKLSIIR Q9BGI5_MACMU 33 33 -
LESDYFGKLESKLSVIR IL18_HUMAN 33 33 -
LESDYFGKLESKLSVIR Q6WWJ7_HUMAN 29 29 -
LESDYFGKLESKLSVIR Q6FGY3_HUMAN 33 33 -
LESDYFGKLEPKLSIIR IL18_CANFA 33 33 -
LETDYFGKLEHKLSILR A2IRI7_FELCA 32 32 -
LETDYFGKLEHKLSILR IL18_FELCA 32 32 -
LESDYFGKLEPKLSIIR A8W970_NYCPR 33 33 -
LESDYFGKLESKLSVIR Q96KJ8_HUMAN 33 33 -
LESDYFGKLEPKLSIIR A5JV27_VULVU 33 33 -
LESDNFGRLHCTTAVIR IL18_MOUSE 32 32 -
LESDNFGRLHCTTAVIR Q80SS8_MOUSE 29 29 -
LESDNFGRLHCTTAVIR Q6USQ6_MOUSE 32 32 -
LESDNFGRLHCTTAVIR Q2PMY2_MOUSE 32 32 -
LESDHFGRLHCTTAVIR IL18_RAT 33 33 -
LESDSFGRLSSTATVIR Q80Y07_MERUN 34 34 -
LESDNFFKESSTTAVIR Q91Z66_SIGHI 34 34 -
LECDAFCKDKTIKRFFR IL18_CHICK 24 24 -
LECDAFCKDKTIKRFFR Q9I8D2_CHICK 26 26 -
LECDAFCKDKTIKRFFR Q6IT44_CHICK 24 24 -
LECDAFCKDKTIKRFFR Q5S4P2_CHICK 26 26 -
LECDAFSKEKTLHRFLR A2I7W4_ANSCY 27 27 -
LECDAFSKEKTLHRFLR Q1HFX9_ANAPL 27 27 -
LECDAFSKEKILHRFLR Q19KR6_ANAPL 27 27 -

Motif 2 width=12
Element Seqn Id St Int Rpt
SVQCKKMSTLSC IL18_CAPHI 100 51 -
SVQCKKMSTLSC Q9GL09_SHEEP 101 51 -
SVQCKKMSTLSC A9QWR6_BOVIN 101 51 -
SVQCKKMSTLSC Q6TLW4_BUBBU 101 51 -
SVQCKKMSTLSC Q6T573_BUBBU 101 51 -
SVQCKKMSTLSC IL18_BOVIN 101 51 -
SVQCKKMSTLSC IL18_BOSTR 101 51 -
SVQCKKMSTLSC A5A360_PIG 100 51 -
SVQCKKMSTLSC Q9N1P7_PIG 100 51 -
SVQCKKMSTLSC Q6STL7_PIG 100 51 -
SVQCKKMSTLSC IL18_PIG 100 51 -
SVQCKKMSTLSC A7Y426_PIG 100 51 -
SVQCKKMSTLSC A2IBW1_PIG 100 51 -
SVKCEKTSTLSC IL18_HORSE 101 51 -
SVKCEKISTLSC Q9BGI5_MACMU 101 51 -
SVKCEKISTLSC IL18_HUMAN 101 51 -
SVKCEKISTLSC Q6WWJ7_HUMAN 97 51 -
SVKCEKISTLSC Q6FGY3_HUMAN 101 51 -
SVKYKTMSTLSC IL18_CANFA 101 51 -
SVNYKTMSTLSC A2IRI7_FELCA 100 51 -
SVNYKTMSTLSC IL18_FELCA 100 51 -
SVKYKTMSTLPC A8W970_NYCPR 101 51 -
SVKCEKISTLSC Q96KJ8_HUMAN 101 51 -
SVKYKTMSTLPC A5JV27_VULVU 101 51 -
SVKDSKMSTLSC IL18_MOUSE 99 50 -
SVKDSKMSTLSC Q80SS8_MOUSE 96 50 -
SVKDSKMSTLSC Q6USQ6_MOUSE 99 50 -
SVKDSKMSTLSC Q2PMY2_MOUSE 99 50 -
SVKDGRMSTLSC IL18_RAT 101 51 -
SVKDTTMATLSC Q80Y07_MERUN 102 51 -
SVRDRTMRTLSC Q91Z66_SIGHI 103 52 -
SVQVEDKSYYMC IL18_CHICK 93 52 -
SVQVEDKSYYMC Q9I8D2_CHICK 95 52 -
SVQVEDKSYYMC Q6IT44_CHICK 93 52 -
SVQVEDKSYYMC Q5S4P2_CHICK 95 52 -
SVQVEDKSYYMC A2I7W4_ANSCY 96 52 -
SVRVEDKSYYMC Q1HFX9_ANAPL 96 52 -
SVRVEDKSYYMC Q19KR6_ANAPL 96 52 -

Motif 3 width=12
Element Seqn Id St Int Rpt
ISFKEMNPPDNI IL18_CAPHI 116 4 -
ISFKEMNPPDNI Q9GL09_SHEEP 117 4 -
VSFKEMNPPDNI A9QWR6_BOVIN 117 4 -
VSFKEMNPPDNI Q6TLW4_BUBBU 117 4 -
VSFKEMNPPDNI Q6T573_BUBBU 117 4 -
VSFKEMNPPDNI IL18_BOVIN 117 4 -
VSFKEMNPPDNI IL18_BOSTR 117 4 -
LSFKEMSPPDNI A5A360_PIG 116 4 -
LSFKEMSPPDNI Q9N1P7_PIG 116 4 -
LSFKEMSPPDNI Q6STL7_PIG 116 4 -
LSFKEMSPPDNI IL18_PIG 116 4 -
LSFKEMSPPDNI A7Y426_PIG 116 4 -
LSFKEMSPPDNI A2IBW1_PIG 116 4 -
ISFKEMSPPENI IL18_HORSE 117 4 -
ISFKEMNPPDNI Q9BGI5_MACMU 117 4 -
ISFKEMNPPDNI IL18_HUMAN 117 4 -
ISFKEMNPPDNI Q6WWJ7_HUMAN 113 4 -
ISFKEMNPPDNI Q6FGY3_HUMAN 117 4 -
ISFQKMSPPDSI IL18_CANFA 117 4 -
ISFKEMSPPESI A2IRI7_FELCA 116 4 -
ISFKEMSPPESI IL18_FELCA 116 4 -
ISFQKMSPPDNI A8W970_NYCPR 117 4 -
ISFKEVNPPDNI Q96KJ8_HUMAN 117 4 -
ISFQKMSPPDSI A5JV27_VULVU 117 4 -
ISFEEMDPPENI IL18_MOUSE 115 4 -
ISFEEMDPPENI Q80SS8_MOUSE 112 4 -
ISFEEMDPPENI Q6USQ6_MOUSE 115 4 -
ISFEEMDPPENI Q2PMY2_MOUSE 115 4 -
ISFEEMNPPENI IL18_RAT 117 4 -
ISFEEMNPPENI Q80Y07_MERUN 118 4 -
ISFEEMDPPLEI Q91Z66_SIGHI 119 4 -
VRFREGEVPKDI IL18_CHICK 114 9 -
VRFREGEVPKDI Q9I8D2_CHICK 116 9 -
VRFREGEVPKDI Q6IT44_CHICK 114 9 -
VRFREGEVPKDI Q5S4P2_CHICK 116 9 -
VRFREGEVPKDI A2I7W4_ANSCY 117 9 -
VRFREGEVPKDI Q1HFX9_ANAPL 117 9 -
VRFREGEVPKDI Q19KR6_ANAPL 117 9 -

Motif 4 width=10
Element Seqn Id St Int Rpt
SLYKGYFLAC IL18_CAPHI 153 25 -
SLYKGYFLAC Q9GL09_SHEEP 154 25 -
SLYKGYFLAC A9QWR6_BOVIN 154 25 -
SLYKGYFLAC Q6TLW4_BUBBU 154 25 -
SLYKGYFLAC Q6T573_BUBBU 154 25 -
SLYKGYFLAC IL18_BOVIN 154 25 -
SLYKGYFLAC IL18_BOSTR 154 25 -
SLYKGYFLAC A5A360_PIG 153 25 -
SLYKGYFLAC Q9N1P7_PIG 153 25 -
SLYKGYFLAC Q6STL7_PIG 153 25 -
SLYKGYFLAC IL18_PIG 153 25 -
SLYKGYFLAC A7Y426_PIG 153 25 -
SLYKGYLLAC A2IBW1_PIG 153 25 -
SLYKGYFLAC IL18_HORSE 154 25 -
SSYEGYFLAC Q9BGI5_MACMU 154 25 -
SSYEGYFLAC IL18_HUMAN 154 25 -
SSYEGYFLAC Q6WWJ7_HUMAN 150 25 -
SSYEGYFLAC Q6FGY3_HUMAN 154 25 -
SLYKGHFLAC IL18_CANFA 154 25 -
SLYKGYFLAC A2IRI7_FELCA 153 25 -
SLYKGYFLAC IL18_FELCA 153 25 -
SLYKGRFLAC A8W970_NYCPR 154 25 -
SSYEGYFLTC Q96KJ8_HUMAN 154 25 -
SLYKGRFLAC A5JV27_VULVU 154 25 -
SLYEGHFLAC IL18_MOUSE 151 24 -
SLYEGHFLAC Q80SS8_MOUSE 148 24 -
SLYEGHFLAC Q6USQ6_MOUSE 151 24 -
SLYEGHFLAC Q2PMY2_MOUSE 151 24 -
SLYEGHFLAC IL18_RAT 153 24 -
SLYKGHFLAC Q80Y07_MERUN 154 24 -
SLHEGHFLAC Q91Z66_SIGHI 155 24 -
SLEQGMFLAF IL18_CHICK 151 25 -
SLEQGMFLAF Q9I8D2_CHICK 153 25 -
SLEQGMFLAF Q6IT44_CHICK 151 25 -
SLEQGMFLAF Q5S4P2_CHICK 153 25 -
SLERGMFLAF A2I7W4_ANSCY 154 25 -
SLERGMFLAF Q1HFX9_ANAPL 154 25 -
SLERGMFLAF Q19KR6_ANAPL 154 25 -