| Literature References | 1. CRUIKSHANK, W., CENTER, D., NISAR, N., WU, M., NATKE, B., THEODORE, A.
AND KORNFELD, H.
Molecular and functional analysis of a lymphocyte chemoattractant factor:
association of biologic function with CD4 expression.
PROC.NATL.ACAD.SCI.U.S.A. 91 5109-5113 (1994).
2. GLASS, W., SARISKY, R. AND VECCHIO, A.
Not-so-sweet sixteen: the role of IL-16 in infectious and immune-mediated
inflammatory diseases.
J.INTERFERON CYTOKINE RES. 26 511-520 (2006).
|
| Documentation | Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
Interleukin-16 (IL-16, also known as lymphocyte chemoattractant factor) is
a proinflammatory cytokine that signals via CD4, inducing chemotactic and
immunomodulatory responses of CD4+ lymphocytes, monocytes and eosinophils
[1]. The cytokine has been implicated in the exacerbation of a number of
infectious, immune-mediated and autoimmune inflammatory disorders,
including atopic dermatitis, irritable bowel syndrome, systemic lupus
erythematosus, neurodegenerative disorders, and viral infections [2].
INTRLEUKIN16 is a 3-element fingerprint that provides a signature for
interleukin-16. The fingerprint was derived from an initial alignment of 5
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length, motifs 2 and 3 encompassing short regions of beta
strand. Two iterations on SPTR55_38f were required to reach convergence,
at which point a true set comprising 28 sequences was identified.
|
| Sequence Titles | A6NM20_HUMAN Uncharacterized protein IL16 - Homo sapiens (Human).
A8MU65_HUMAN Uncharacterized protein IL16 (Interleukin 16 (Lymphocyte chemoattractant factor), isoform CRA_d) - Homo sapiens (Human).
IL16_AOTTR Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Aotus trivirgatus (Night monkey) (Douroucouli).
IL16_BOVIN Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Bos taurus (Bovine).
IL16_CERAE Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Cercopithecus aethiops (Green monkey) (Grivet).
IL16_HUMAN Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Homo sapiens (Human).
IL16_MACFA Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
IL16_MACMU Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Macaca mulatta (Rhesus macaque).
IL16_MOUSE Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Mus musculus (Mouse).
IL16_PANTR Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Pan troglodytes (Chimpanzee).
IL16_SAISC Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF) - Saimiri sciureus (Common squirrel monkey).
Q2HYY2_TETNG Interleukin-16 - Tetraodon nigroviridis (Green puffer).
Q3UZ81_MOUSE Adult male thymus cDNA, RIKEN full-length enriched library, clone:5830405J22 product:interleukin 16, full insert sequence - Mus musculus (Mouse).
Q58IE0_TETNG Interleukin 16 - Tetraodon nigroviridis (Green puffer).
Q6VVE6_HUMAN Neural interleukin 16 protein - Homo sapiens (Human).
Q6ZMQ7_HUMAN cDNA FLJ16759 fis, clone BRACE3046450, highly similar to Interleukin- 16 - Homo sapiens (Human).
Q6ZTT5_HUMAN cDNA FLJ44234 fis, clone THYMU3007137, highly similar to Interleukin- 16 - Homo sapiens (Human).
Q6ZVH3_HUMAN cDNA FLJ42574 fis, clone BRACE3008137, highly similar to Interleukin- 16 - Homo sapiens (Human).
Q70XC4_CHICK Interleukin-16 - Gallus gallus (Chicken).
Q76EI9_PIG Interleukin 16 - Sus scrofa (Pig).
Q76KI6_PIG Interleukin-16 - Sus scrofa (Pig).
Q76KI7_PIG Interleukin-16 - Sus scrofa (Pig).
Q804H4_CHICK Interleukin 16 - Gallus gallus (Chicken).
Q804Z8_CHICK Interleukin-16 - Gallus gallus (Chicken).
Q8JID9_ANAPL Interleukin-16 - Anas platyrhynchos (Domestic duck).
Q8JIE0_ANAPL Interleukin-16 - Anas platyrhynchos (Domestic duck).
Q9QZP6_MOUSE Neuronal IL-16 (Interleukin 16) - Mus musculus (Mouse).
Q9UME6_HUMAN Interleukin-16 - Homo sapiens (Human).
|