SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR01930

Identifier
INTRLEUKIN15  [View Relations]  [View Alignment]  
Accession
PR01930
No. of Motifs
3
Creation Date
30-OCT-2008
Title
Interleukin-15 signature
Database References
PRINTS; PR01948 INTLKN15BIRD; PR01949 INTLKN15FISH; PR01947 INTLKN15MAML

BLOCKS; IPB003443
PFAM; PF02372 IL15
PRODOM; PD006156
INTERPRO; IPR003443
MIM; 600554
Literature References
1. LIU, C., PERUSSIA, B. AND YOUNG, J.
The emerging role of IL-15 in NK-cell development.
IMMUNOL.TODAY 21 113-116 (2000).
 
2. KU, C., MURAKAMI, M., SAKAMOTO, A., KAPPLER, J. AND MARRACK, P.
Control of homeostasis of CD8+ memory T cells by opposing cytokines.
SCIENCE 288 675-678 (2000).

Documentation
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
 
Interleukin-15 (IL-15) has a variety of biological functions, including 
stimulation and maintenance of cellular immune responses [1]. It is 
required for division of CD8+ T cells of memory phenotype, a process that
is increased by inhibition of IL-2 [2]. The numbers of CD8+ memory T cells
in animals may, therefore, be controlled by a balance between IL-15 and -2.
 
INTRLEUKIN15 is a 3-element fingerprint that provides a signature for 
interleukin-15. The fingerprint was derived from an initial alignment of 31
sequences: the motifs were drawn from conserved regions spanning the
C-terminal two thirds of the alignment. Two iterations on SPTR55_38f were
required to reach convergence, at which point a true set comprising 32
sequences was identified. Two partial matches were also found, Q1AHQ7_MOUSE
and Q1AHQ6_MOUSE, mouse interleukin-15 isoforms that fail to match motifs 1
and 2 respectively.
Summary Information
  32 codes involving  3 elements
2 codes involving 2 elements
Composite Feature Index
3323232
2112
123
True Positives
A7LLW4_CHICK  A8WE60_PIG    B0FLP3_CHICK  IL15_BOVIN    
IL15_BUBBU IL15_CERAE IL15_FELCA IL15_HUMAN
IL15_MACMU IL15_MACTH IL15_MOUSE IL15_PIG
IL15_RABIT IL15_RAT IL15_SHEEP Q06F26_PIG
Q15KG7_DANRE Q1AN26_TETNG Q1AN27_FUGRU Q1HFY0_ANAPL
Q2PUG6_RABIT Q3SCC6_DANRE Q3SCC8_FUGRU Q3SCC9_FUGRU
Q3U1Z6_MOUSE Q575Z3_ONCMY Q5EEK6_MARMO Q5WQV8_MARMO
Q6FGX7_HUMAN Q75SZ9_CAVPO Q9DEV5_CHICK Q9W756_CHICK
True Positive Partials
Codes involving 2 elements
Q1AHQ6_MOUSE Q1AHQ7_MOUSE
Sequence Titles
A7LLW4_CHICK Interleukin-15 - Gallus gallus (Chicken).     
A8WE60_PIG Interleukin 15 - Sus scrofa (Pig).
B0FLP3_CHICK Interleukin 15 - Gallus gallus (Chicken).
IL15_BOVIN Interleukin-15 precursor (IL-15) - Bos taurus (Bovine).
IL15_BUBBU Interleukin-15 precursor (IL-15) - Bubalus bubalis (Domestic water buffalo).
IL15_CERAE Interleukin-15 precursor (IL-15) - Cercopithecus aethiops (Green monkey) (Grivet).
IL15_FELCA Interleukin-15 precursor (IL-15) - Felis silvestris catus (Cat).
IL15_HUMAN Interleukin-15 precursor (IL-15) - Homo sapiens (Human).
IL15_MACMU Interleukin-15 precursor (IL-15) - Macaca mulatta (Rhesus macaque).
IL15_MACTH Interleukin-15 precursor (IL-15) - Macaca thibetana (Pere David's macaque) (Tibetan macaque).
IL15_MOUSE Interleukin-15 precursor (IL-15) - Mus musculus (Mouse).
IL15_PIG Interleukin-15 precursor (IL-15) - Sus scrofa (Pig).
IL15_RABIT Interleukin-15 precursor (IL-15) - Oryctolagus cuniculus (Rabbit).
IL15_RAT Interleukin-15 precursor (IL-15) - Rattus norvegicus (Rat).
IL15_SHEEP Interleukin-15 precursor (IL-15) - Ovis aries (Sheep).
Q06F26_PIG Interleukin-15 - Sus scrofa (Pig).
Q15KG7_DANRE Interleukin-15 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q1AN26_TETNG IL-15-like - Tetraodon nigroviridis (Green puffer).
Q1AN27_FUGRU IL-15-like - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
Q1HFY0_ANAPL Interleukin-15 precursor - Anas platyrhynchos (Domestic duck).
Q2PUG6_RABIT Interleukin-15 - Oryctolagus cuniculus (Rabbit).
Q3SCC6_DANRE Interleukin-15 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q3SCC8_FUGRU Interleukin 15 variant - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
Q3SCC9_FUGRU Interleukin 15 - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
Q3U1Z6_MOUSE Interleukin-15 - Mus musculus (Mouse).
Q575Z3_ONCMY Interleukin-15 precursor - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Q5EEK6_MARMO Interleukin-15 - Marmota monax (Woodchuck).
Q5WQV8_MARMO Interleukin 15 precursor - Marmota monax (Woodchuck).
Q6FGX7_HUMAN IL15 protein (Interleukin 15, isoform CRA_a) (cDNA FLJ77069, highly similar to Homo sapiens interleukin 15 (IL15), transcript variant 2, mRNA) (Interleukin-15) - Homo sapiens (Human).
Q75SZ9_CAVPO Interleukin-15 precursor - Cavia porcellus (Guinea pig).
Q9DEV5_CHICK Interleukin-15 - Gallus gallus (Chicken).
Q9W756_CHICK Interleukin-15 - Gallus gallus (Chicken).

Q1AHQ6_MOUSE Putative interleukin 15 isoform aE7 precursor - Mus musculus (Mouse).
Q1AHQ7_MOUSE Putative interleukin 15 isoform aE6 precursor - Mus musculus (Mouse).
Scan History
SPTR55_38f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
DATLYTESDAHP IL15_RABIT 70 70 -
DATLYTESDAHP Q2PUG6_RABIT 70 70 -
DATLYTESDVHP IL15_CERAE 70 70 -
DATLYTESDVHP IL15_MACTH 70 70 -
DATLYTESDVHP IL15_MACMU 70 70 -
DATLYTESDVHP IL15_HUMAN 70 70 -
DATLYTESDAHP IL15_PIG 70 70 -
DATLYTESDAHP Q06F26_PIG 70 70 -
DATLYTESDVHP IL15_FELCA 70 70 -
DATLYTESDAHP A8WE60_PIG 70 70 -
DATLYTESDVHP Q5EEK6_MARMO 70 70 -
DATLYTESDVHP Q5WQV8_MARMO 70 70 -
DATLYTESDAHP IL15_BOVIN 70 70 -
DATLYTESDVHP Q75SZ9_CAVPO 70 70 -
DATLYTEGDAHP IL15_BUBBU 70 70 -
DATLYTESDAHP IL15_SHEEP 70 70 -
DTTLYTDSDFHP IL15_RAT 70 70 -
DTTLYTDSDFHP IL15_MOUSE 70 70 -
DTTLYTDSDFHP Q3U1Z6_MOUSE 70 70 -
DVSLYTANTYED A7LLW4_CHICK 88 88 -
DVSLYTANTYED Q9W756_CHICK 88 88 -
DVSLYTANTYED Q9DEV5_CHICK 88 88 -
DVSLYTANTYED B0FLP3_CHICK 88 88 -
DVSLYTANTDED Q1HFY0_ANAPL 88 88 -
DAMLYAPSANSV Q3SCC8_FUGRU 66 66 -
DAMLYAPSANSV Q3SCC9_FUGRU 77 77 -
DAMLYAPSANSV Q1AN27_FUGRU 77 77 -
DAMLYTPSANYV Q1AN26_TETNG 76 76 -
DACLYAPTNDDI Q575Z3_ONCMY 94 94 -
TAHLYTPKTDDI Q3SCC6_DANRE 95 95 -
TAHLYTPKIDDI Q15KG7_DANRE 95 95 -

Motif 2 width=19
Element Seqn Id St Int Rpt
CKVTAMKCFLLELRVISHE IL15_RABIT 83 1 -
CKVTAMKCFLLELRVISHE Q2PUG6_RABIT 83 1 -
CKVTAMKCFLLELQVISHE IL15_CERAE 83 1 -
CKVTAMKCFLLELQVISHE IL15_MACTH 83 1 -
CKVTAMKCFLLELQVISHE IL15_MACMU 83 1 -
CKVTAMKCFLLELQVISLE IL15_HUMAN 83 1 -
CKVTAMKCFLLELRVILQE IL15_PIG 83 1 -
CKVTAMKCFLLELRVILQE Q06F26_PIG 83 1 -
CKVTAMKCFLLELHVISLE IL15_FELCA 83 1 -
CKVTAMKCFLLELHVILQE A8WE60_PIG 83 1 -
CKVTAMNCFLLELEVISHE Q5EEK6_MARMO 83 1 -
CKVTAMNCFLLELEVISHE Q5WQV8_MARMO 83 1 -
CKVTAMQCFLLELRVILHE IL15_BOVIN 83 1 -
CKITAMKCFLLELRVILHE Q75SZ9_CAVPO 83 1 -
CKVTAMQCFLLELRVILHE IL15_BUBBU 83 1 -
CKVTALQCFLLELRVILHE IL15_SHEEP 83 1 -
CKVTAMNCFLLELQVILHE IL15_RAT 83 1 -
CKVTAMNCFLLELQVILHE IL15_MOUSE 83 1 -
CKVTAMNCFLLELQVILHE Q3U1Z6_MOUSE 83 1 -
CQEPVMRCFFLEMKVILHE A7LLW4_CHICK 102 2 -
CQEPVMRCFFLEMKVILHE Q9W756_CHICK 102 2 -
CQEPVMRCFFLEMKVILHE Q9DEV5_CHICK 102 2 -
CQEPVMRCFFLEMKVILHE B0FLP3_CHICK 102 2 -
CQEPIMRCFFLEMNVILHE Q1HFY0_ANAPL 102 2 -
CKNMSLRCYMLELIMVINE Q3SCC8_FUGRU 81 3 -
CKNMSLRCYMLELIMVINE Q3SCC9_FUGRU 92 3 -
CKNMSLRCYMLELIMVINE Q1AN27_FUGRU 92 3 -
CKNKSLKCYMLELLMVIDE Q1AN26_TETNG 97 9 -
CIFKFMHCYLLELEVVLFE Q575Z3_ONCMY 110 4 -
CTFRFFDCFLLEMKVVLYE Q3SCC6_DANRE 109 2 -
CTFRFFDCFLLEMKVVLYE Q15KG7_DANRE 109 2 -

Motif 3 width=14
Element Seqn Id St Int Rpt
ECEELEEKNITEFL IL15_RABIT 135 33 -
ECEELEEKNITEFL Q2PUG6_RABIT 136 34 -
ECEELEEKNIKEFL IL15_CERAE 135 33 -
ECEELEEKNIKEFL IL15_MACTH 135 33 -
ECEELEEKNIKEFL IL15_MACMU 135 33 -
ECEELEEKNIKEFL IL15_HUMAN 135 33 -
ECEELEEKNINEFL IL15_PIG 135 33 -
ECEELEEKNINEFL Q06F26_PIG 135 33 -
ECEELEEKNIKEFL IL15_FELCA 135 33 -
ECEELEEKNINEFL A8WE60_PIG 135 33 -
VCEELEEKNITEFL Q5EEK6_MARMO 135 33 -
VCEELEEKNITEFL Q5WQV8_MARMO 135 33 -
ECEELEEKSIKEFL IL15_BOVIN 135 33 -
ECEELEEKSIAEFL Q75SZ9_CAVPO 135 33 -
ECEELEEKSIKEFL IL15_BUBBU 135 33 -
ECEELEKKSIKEFL IL15_SHEEP 135 33 -
ECEELEERNFTEFL IL15_RAT 135 33 -
ECEELEEKTFTEFL IL15_MOUSE 135 33 -
ECEELEEKTFTEFL Q3U1Z6_MOUSE 135 33 -
ECEEYEEKNFTEFI A7LLW4_CHICK 158 37 -
ECEEYEEKNFTEFI Q9W756_CHICK 158 37 -
ECEEYEEKNFTEFI Q9DEV5_CHICK 158 37 -
ECEEYEEKNFTEFI B0FLP3_CHICK 158 37 -
ECEEYEEKSFTEFI Q1HFY0_ANAPL 157 36 -
PCEEYAIRNITIFL Q3SCC8_FUGRU 127 27 -
PCEEYAIRNITIFL Q3SCC9_FUGRU 138 27 -
PCEEYAIRNITMFL Q1AN27_FUGRU 138 27 -
PCEVYPQNNITIFL Q1AN26_TETNG 143 27 -
PCEAQRVANSTIFL Q575Z3_ONCMY 165 36 -
PCELQELTNSTLFF Q3SCC6_DANRE 157 29 -
PCELQELTNSTLFF Q15KG7_DANRE 157 29 -
Final Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
DATLYTESDAHP IL15_RABIT 70 70 -
DATLYTESDAHP Q2PUG6_RABIT 70 70 -
DATLYTESDVHP IL15_CERAE 70 70 -
DATLYTESDVHP IL15_MACTH 70 70 -
DATLYTESDVHP IL15_MACMU 70 70 -
DATLYTESDVHP IL15_HUMAN 70 70 -
DATLYTESDVHP Q6FGX7_HUMAN 43 43 -
DATLYTESDAHP IL15_PIG 70 70 -
DATLYTESDAHP Q06F26_PIG 70 70 -
DATLYTESDVHP IL15_FELCA 70 70 -
DATLYTESDAHP A8WE60_PIG 70 70 -
DATLYTESDVHP Q5EEK6_MARMO 70 70 -
DATLYTESDVHP Q5WQV8_MARMO 70 70 -
DATLYTESDAHP IL15_BOVIN 70 70 -
DATLYTESDVHP Q75SZ9_CAVPO 70 70 -
DATLYTEGDAHP IL15_BUBBU 70 70 -
DATLYTESDAHP IL15_SHEEP 70 70 -
DTTLYTDSDFHP IL15_RAT 70 70 -
DTTLYTDSDFHP IL15_MOUSE 70 70 -
DTTLYTDSDFHP Q3U1Z6_MOUSE 70 70 -
DVSLYTANTYED A7LLW4_CHICK 88 88 -
DVSLYTANTYED Q9W756_CHICK 88 88 -
DVSLYTANTYED Q9DEV5_CHICK 88 88 -
DVSLYTANTYED B0FLP3_CHICK 88 88 -
DVSLYTANTDED Q1HFY0_ANAPL 88 88 -
DAMLYAPSANSV Q3SCC8_FUGRU 66 66 -
DAMLYAPSANSV Q3SCC9_FUGRU 77 77 -
DAMLYAPSANSV Q1AN27_FUGRU 77 77 -
DAMLYTPSANYV Q1AN26_TETNG 76 76 -
DACLYAPTNDDI Q575Z3_ONCMY 94 94 -
TAHLYTPKTDDI Q3SCC6_DANRE 95 95 -
TAHLYTPKIDDI Q15KG7_DANRE 95 95 -

Motif 2 width=19
Element Seqn Id St Int Rpt
CKVTAMKCFLLELRVISHE IL15_RABIT 83 1 -
CKVTAMKCFLLELRVISHE Q2PUG6_RABIT 83 1 -
CKVTAMKCFLLELQVISHE IL15_CERAE 83 1 -
CKVTAMKCFLLELQVISHE IL15_MACTH 83 1 -
CKVTAMKCFLLELQVISHE IL15_MACMU 83 1 -
CKVTAMKCFLLELQVISLE IL15_HUMAN 83 1 -
CKVTAMKCFLLELQVISLE Q6FGX7_HUMAN 56 1 -
CKVTAMKCFLLELRVILQE IL15_PIG 83 1 -
CKVTAMKCFLLELRVILQE Q06F26_PIG 83 1 -
CKVTAMKCFLLELHVISLE IL15_FELCA 83 1 -
CKVTAMKCFLLELHVILQE A8WE60_PIG 83 1 -
CKVTAMNCFLLELEVISHE Q5EEK6_MARMO 83 1 -
CKVTAMNCFLLELEVISHE Q5WQV8_MARMO 83 1 -
CKVTAMQCFLLELRVILHE IL15_BOVIN 83 1 -
CKITAMKCFLLELRVILHE Q75SZ9_CAVPO 83 1 -
CKVTAMQCFLLELRVILHE IL15_BUBBU 83 1 -
CKVTALQCFLLELRVILHE IL15_SHEEP 83 1 -
CKVTAMNCFLLELQVILHE IL15_RAT 83 1 -
CKVTAMNCFLLELQVILHE IL15_MOUSE 83 1 -
CKVTAMNCFLLELQVILHE Q3U1Z6_MOUSE 83 1 -
CQEPVMRCFFLEMKVILHE A7LLW4_CHICK 102 2 -
CQEPVMRCFFLEMKVILHE Q9W756_CHICK 102 2 -
CQEPVMRCFFLEMKVILHE Q9DEV5_CHICK 102 2 -
CQEPVMRCFFLEMKVILHE B0FLP3_CHICK 102 2 -
CQEPIMRCFFLEMNVILHE Q1HFY0_ANAPL 102 2 -
CKNMSLRCYMLELIMVINE Q3SCC8_FUGRU 81 3 -
CKNMSLRCYMLELIMVINE Q3SCC9_FUGRU 92 3 -
CKNMSLRCYMLELIMVINE Q1AN27_FUGRU 92 3 -
CKNKSLKCYMLELLMVIDE Q1AN26_TETNG 97 9 -
CIFKFMHCYLLELEVVLFE Q575Z3_ONCMY 110 4 -
CTFRFFDCFLLEMKVVLYE Q3SCC6_DANRE 109 2 -
CTFRFFDCFLLEMKVVLYE Q15KG7_DANRE 109 2 -

Motif 3 width=14
Element Seqn Id St Int Rpt
ECEELEEKNITEFL IL15_RABIT 135 33 -
ECEELEEKNITEFL Q2PUG6_RABIT 136 34 -
ECEELEEKNIKEFL IL15_CERAE 135 33 -
ECEELEEKNIKEFL IL15_MACTH 135 33 -
ECEELEEKNIKEFL IL15_MACMU 135 33 -
ECEELEEKNIKEFL IL15_HUMAN 135 33 -
ECEELEEKNIKEFL Q6FGX7_HUMAN 108 33 -
ECEELEEKNINEFL IL15_PIG 135 33 -
ECEELEEKNINEFL Q06F26_PIG 135 33 -
ECEELEEKNIKEFL IL15_FELCA 135 33 -
ECEELEEKNINEFL A8WE60_PIG 135 33 -
VCEELEEKNITEFL Q5EEK6_MARMO 135 33 -
VCEELEEKNITEFL Q5WQV8_MARMO 135 33 -
ECEELEEKSIKEFL IL15_BOVIN 135 33 -
ECEELEEKSIAEFL Q75SZ9_CAVPO 135 33 -
ECEELEEKSIKEFL IL15_BUBBU 135 33 -
ECEELEKKSIKEFL IL15_SHEEP 135 33 -
ECEELEERNFTEFL IL15_RAT 135 33 -
ECEELEEKTFTEFL IL15_MOUSE 135 33 -
ECEELEEKTFTEFL Q3U1Z6_MOUSE 135 33 -
ECEEYEEKNFTEFI A7LLW4_CHICK 158 37 -
ECEEYEEKNFTEFI Q9W756_CHICK 158 37 -
ECEEYEEKNFTEFI Q9DEV5_CHICK 158 37 -
ECEEYEEKNFTEFI B0FLP3_CHICK 158 37 -
ECEEYEEKSFTEFI Q1HFY0_ANAPL 157 36 -
PCEEYAIRNITIFL Q3SCC8_FUGRU 127 27 -
PCEEYAIRNITIFL Q3SCC9_FUGRU 138 27 -
PCEEYAIRNITMFL Q1AN27_FUGRU 138 27 -
PCEVYPQNNITIFL Q1AN26_TETNG 143 27 -
PCEAQRVANSTIFL Q575Z3_ONCMY 165 36 -
PCELQELTNSTLFF Q3SCC6_DANRE 157 29 -
PCELQELTNSTLFF Q15KG7_DANRE 157 29 -