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PR01928

Identifier
INTRLEUKN12B  [View Relations]  [View Alignment]  
Accession
PR01928
No. of Motifs
3
Creation Date
29-JUL-2008
Title
Interleukin-12 beta subunit signature
Database References

PRODOM; PD720907; PD005906
INTERPRO; IPR015528
PDB; 1F42; 1F45
SCOP; 1F42; 1F45
CATH; 1F42; 1F45
MIM; 161561
Literature References
1. BRIGHTBILL, H., LIBRATY, D., KRUTZIK, S., YANG, R., BELLSIE, J.,
BIEHARSKI, J., MAITLAND, M., NORGARD, M., PLEVYl, S., SMALE, S.,
BRENNAN, P., BLOOM, B., GODOWSKI, P. AND MODLIN, R.
Host defense mechanisms triggered by microbial lipoproteins through toll-
like receptors. 
SCIENCE 285 732-736 (1999). 
 
2. OPPMANN, B., LESLEY, R., BLOM, B., TIMANS, J., XU, Y., HUNTE, B.,
VEGA, F., YU, N., WANG, J., SINGH, K., ZONIN, F., VAISBERG, E., CHURAKOVA, T.,
LIU, M., GORMAN, D., WAGNER, J., ZURAWSKI, S., LIU, Y., ABRAMS, J.S., 
MOORE, K.W., RENNICK, D., DE WAAL-MALEFYT, R., HANNUM, C., BAZAN, J.F.
AND KASTELEIN, R.A.
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
biological activities similar as well as distinct from IL-12.
IMMUNITY 13 715-725 (2000).
 
3. SHIME, H., YABU, M., AKAZAWA, T., KODAMA, K., MATSUMOTO, M., SEYA, T. 
AND INOUE, N.
Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway.
J.IMMUNOL. 180 7175-7183 (2008).

Documentation
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
 
Interleukin-12 (IL-12, also known as natural killer cell stimulatory 
factor and cytotoxic lymphocyte maturation factor) is a 75 kDa heterodimer
composed of two genetically unrelated subunits - an alpha chain (p35 
subunit) and a beta chain (p40 subunit). Production of the cytokine plays 
an important role in the generation of cell-mediated immunity against many
infectious pathogens [1]. The IL-12 beta chain also associates with 
IL-23 alpha to form IL-23 [2], a proinflammatory cytokine that is 
over-expressed in and around tumour tissues, where it induces local
inflammation and promotes tumour development [3].
 
INTRLEUKN12B is a 3-element fingerprint that provides a signature for the
interleukin-12 beta subunit. The fingerprint was derived from an initial 
alignment of 13 sequences: the motifs were drawn from conserved regions 
spanning the C-terminal two thirds of the alignment - motifs 1 and 2
encompass short regions of beta strand, and motif 3 spans a beta turn. Two
iterations on SPTR55_38f were required to reach convergence, at which point
a true set comprising 43 sequences was identified.
Summary Information
43 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3434343
2000
123
True Positives
A3RL77_BUBBU  A8WH99_DANRE  A9QWR4_BOVIN  IL12B_BOVIN   
IL12B_BUBBU IL12B_BUBCA IL12B_CANFA IL12B_CAPHI
IL12B_CAVPO IL12B_CEREL IL12B_CERTO IL12B_FELCA
IL12B_HORSE IL12B_HUMAN IL12B_LAMGL IL12B_MACMU
IL12B_MARMO IL12B_MESAU IL12B_MOUSE IL12B_PAPAN
IL12B_PIG IL12B_SHEEP IL12B_SIGHI Q0V941_DANRE
Q1KX13_DICLA Q2MH16_9CETA Q2PCT1_CYPCA Q2PD23_CYPCA
Q2PE54_BUBBU Q3ZAX5_MOUSE Q5DVP6_ONCMY Q5DVP7_ONCMY
Q6E218_CAPHI Q6F3Q9_DANRE Q6UAP1_TETNG Q6X0K9_CHICK
Q70M89_CHICK Q70M90_CHICK Q7SX69_FUGRU Q800F2_FUGRU
Q924K7_MERUN Q9ET05_MARMO Q9R278_RAT
Sequence Titles
A3RL77_BUBBU Interleukin-12p40 - Bubalus bubalis (Domestic water buffalo). 
A8WH99_DANRE Interleukin 12 p40.b - Danio rerio (Zebrafish) (Brachydanio rerio).
A9QWR4_BOVIN Interleukin 12 40kDa subunit - Bos taurus (Bovine).
IL12B_BOVIN Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Bos taurus (Bovine).
IL12B_BUBBU Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Bubalus bubalis (Domestic water buffalo).
IL12B_BUBCA Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Bubalus carabanensis (Swamp type water buffalo).
IL12B_CANFA Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Canis familiaris (Dog).
IL12B_CAPHI Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Capra hircus (Goat).
IL12B_CAVPO Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Cavia porcellus (Guinea pig).
IL12B_CEREL Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Cervus elaphus (Red deer).
IL12B_CERTO Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Cercocebus torquatus atys (Red-crowned mangabey) (Sooty mangabey).
IL12B_FELCA Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Felis silvestris catus (Cat).
IL12B_HORSE Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Equus caballus (Horse).
IL12B_HUMAN Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (NK cell stimulatory factor chain 2) (NKSF2) - Homo sapiens (Human).
IL12B_LAMGL Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Lama glama (Llama).
IL12B_MACMU Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Macaca mulatta (Rhesus macaque).
IL12B_MARMO Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Marmota monax (Woodchuck).
IL12B_MESAU Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Mesocricetus auratus (Golden hamster).
IL12B_MOUSE Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Mus musculus (Mouse).
IL12B_PAPAN Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Papio anubis (Olive baboon).
IL12B_PIG Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Sus scrofa (Pig).
IL12B_SHEEP Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Ovis aries (Sheep).
IL12B_SIGHI Interleukin-12 subunit beta precursor (IL-12B) (IL-12 subunit p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) - Sigmodon hispidus (Hispid cotton rat).
Q0V941_DANRE Zgc:152789 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q1KX13_DICLA Interleukin-12 p40 chain - Dicentrarchus labrax (European sea bass).
Q2MH16_9CETA Interleukin-12p40 - Bubalus bubalis x Bubalus carabanensis.
Q2PCT1_CYPCA Interleukin-12 p40b subunit - Cyprinus carpio (Common carp).
Q2PD23_CYPCA Interleukin-12 p40a subunit - Cyprinus carpio (Common carp).
Q2PE54_BUBBU Interleukin-12p40 - Bubalus bubalis (Domestic water buffalo).
Q3ZAX5_MOUSE Il12b protein (Interleukin 12b) (0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430014H12 product:interleukin 12b, full insert sequence) - Mus musculus (Mouse).
Q5DVP6_ONCMY Interleukin-12 beta chain precursor - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Q5DVP7_ONCMY Interleukin-12 beta chain precursor - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Q6E218_CAPHI Interleukin 12 p40 subunit - Capra hircus (Goat).
Q6F3Q9_DANRE Interleukin-12 p40 subunit - Danio rerio (Zebrafish) (Brachydanio rerio).
Q6UAP1_TETNG Class I helical cytokine receptor number 15 - Tetraodon nigroviridis (Green puffer).
Q6X0K9_CHICK IL-12p40 subunit - Gallus gallus (Chicken).
Q70M89_CHICK Interleukin-12 beta chain precursor - Gallus gallus (Chicken).
Q70M90_CHICK Interleukin-12 beta chain precursor - Gallus gallus (Chicken).
Q7SX69_FUGRU Interleukin-12 p40 - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
Q800F2_FUGRU Interleukin 12 beta chain - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
Q924K7_MERUN Interleukin-12 p40 subunit - Meriones unguiculatus (Mongolian jird) (Mongolian gerbil).
Q9ET05_MARMO Interleukin-12 p40 subunit - Marmota monax (Woodchuck).
Q9R278_RAT Interleukin-12 p40 - Rattus norvegicus (Rat).
Scan History
SPTR55_38f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
LRCEAKNYSGRFTCWW IL12B_HUMAN 129 129 -
LKCEAKDYSGHFTCSW IL12B_CAPHI 129 129 -
LKCEAKDYSGHFTCWW IL12B_BUBCA 129 129 -
LKCEAANYSGRFTCWW IL12B_SIGHI 129 129 -
VTCEAKNYSGRFTCWW Q9ET05_MARMO 128 128 -
LKCEAANYSGRFTCSW Q924K7_MERUN 128 128 -
LKCEAKNYSGIFTCSW Q70M89_CHICK 128 128 -
LSCSANNFNGDFRCSW Q7SX69_FUGRU 135 135 -
LSCSANNFNGDFRCSW Q800F2_FUGRU 123 123 -
LSCSAKNFDGEFVCSW Q6UAP1_TETNG 126 126 -
IHCATNNYGGLFQCSW Q6F3Q9_DANRE 124 124 -
ISCRAKSYGCTFNCSW Q5DVP6_ONCMY 108 108 -
ISCRAKSYGCTFNCSW Q5DVP7_ONCMY 108 108 -

Motif 2 width=12
Element Seqn Id St Int Rpt
CPAAEESLPIEV IL12B_HUMAN 199 54 -
CPAAEESLPIEV IL12B_CAPHI 200 55 -
CPAAEESLLIEV IL12B_BUBCA 200 55 -
CPTAEETLPIEL IL12B_SIGHI 200 55 -
CPTAEETLPITV Q9ET05_MARMO 199 55 -
CPTAEETVPIGL Q924K7_MERUN 200 56 -
CPFAEEHQPTEM Q70M89_CHICK 192 48 -
CPYAEESQPIHI Q7SX69_FUGRU 213 62 -
CPYAEESQPIHI Q800F2_FUGRU 195 56 -
CPYAEESQPVQI Q6UAP1_TETNG 204 62 -
CPYAEELERINL Q6F3Q9_DANRE 182 42 -
SPYTEEAAPLVV Q5DVP6_ONCMY 169 45 -
SPYTEEAAPLVV Q5DVP7_ONCMY 169 45 -

Motif 3 width=11
Element Seqn Id St Int Rpt
TWSTPHSYFSL IL12B_HUMAN 261 50 -
TWSTPHSYFSL IL12B_CAPHI 262 50 -
TWSTPHSYFSL IL12B_BUBCA 262 50 -
SWSTPHSYFSL IL12B_SIGHI 261 49 -
SWSTPHSYFSL Q9ET05_MARMO 261 50 -
SWSTPHSYFAL Q924K7_MERUN 261 49 -
TWSTPKSYFPL Q70M89_CHICK 248 44 -
SWNTPFSYFPL Q7SX69_FUGRU 270 45 -
SWNTPFSYFPL Q800F2_FUGRU 259 52 -
SWNSPSSYFPL Q6UAP1_TETNG 261 45 -
SWNTPSSYFPL Q6F3Q9_DANRE 238 44 -
TWNCPPSYFPL Q5DVP6_ONCMY 229 48 -
TWNCPPSYFPL Q5DVP7_ONCMY 229 48 -
Final Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
LKCEAKNYSGRFTCWW IL12B_FELCA 129 129 -
LKCEAKNYSGRFTCWW IL12B_PIG 129 129 -
LKCEAKNYSGHFTCWW IL12B_LAMGL 130 130 -
LKCEAKDYSGHFTCWW IL12B_CEREL 129 129 -
LRCEAKNYSGRFTCWW IL12B_HUMAN 129 129 -
LKCEAKNYSGRFTCWW IL12B_CANFA 129 129 -
LKCEAKNYSGRFTCWW IL12B_HORSE 129 129 -
LKCEAKDYSGHFTCSW IL12B_CAPHI 129 129 -
LKCEAKDYSGHFTCSW Q6E218_CAPHI 129 129 -
LKCEAKDYSGHFTCSW IL12B_SHEEP 129 129 -
LRCEAKNYSGRFTCWW IL12B_MACMU 129 129 -
LRCEAKNYSGRFTCWW IL12B_PAPAN 129 129 -
LKCEAKDYSGHFTCWW A3RL77_BUBBU 129 129 -
LKCEAKDYSGHFTCWW Q2PE54_BUBBU 129 129 -
LKCEAKDYSGHFTCWW IL12B_BUBCA 129 129 -
LKCEAKDYSGHFTCWW IL12B_BUBBU 129 129 -
LKCEAKDYSGHFTCWW IL12B_BOVIN 129 129 -
LKCEAKDYSGHFTCWW A9QWR4_BOVIN 129 129 -
LKCEARSYSGRFTCWW IL12B_CAVPO 129 129 -
LKCEAANYSGRFTCWW IL12B_SIGHI 129 129 -
LKCEAPNYSGRFTCSW IL12B_MOUSE 126 126 -
LKCEAPNYSGRFTCSW Q9R278_RAT 126 126 -
LKCEAPNYSGRFTCSW Q3ZAX5_MOUSE 126 126 -
LRCEAKNYSGRITCWW IL12B_CERTO 129 129 -
LKCEAANYSGRFTCWW IL12B_MESAU 129 129 -
LKCEAKDYSEHFTGWW Q2MH16_9CETA 129 129 -
VTCEAKNYSGRFTCWW IL12B_MARMO 128 128 -
VTCEAKNYSGRFTCWW Q9ET05_MARMO 128 128 -
LKCEAANYSGRFTCSW Q924K7_MERUN 128 128 -
LKCEAKNYSGIFTCSW Q6X0K9_CHICK 128 128 -
LKCEAKNYSGIFTCSW Q70M90_CHICK 128 128 -
LKCEAKNYSGIFTCSW Q70M89_CHICK 128 128 -
LSCSANNFNGDFRCSW Q7SX69_FUGRU 135 135 -
LSCSANNFNGDFRCSW Q800F2_FUGRU 123 123 -
LKCSTRNYNGEFHCSW Q1KX13_DICLA 127 127 -
LSCSAKNFDGEFVCSW Q6UAP1_TETNG 126 126 -
IHCATNNYGGLFQCSW A8WH99_DANRE 124 124 -
IHCATNNYGGLFQCSW Q6F3Q9_DANRE 124 124 -
IHCATNNYGGFFQCSW Q0V941_DANRE 124 124 -
ISCTARNYDGQFHCSW Q2PCT1_CYPCA 119 119 -
IDCSTNNYGGSFKCKW Q2PD23_CYPCA 124 124 -
ISCRAKSYGCTFNCSW Q5DVP6_ONCMY 108 108 -
ISCRAKSYGCTFNCSW Q5DVP7_ONCMY 108 108 -

Motif 2 width=12
Element Seqn Id St Int Rpt
CPAAEESLPIEV IL12B_FELCA 200 55 -
CPAAEESLPIEV IL12B_PIG 195 50 -
CPAAEESLPIEL IL12B_LAMGL 201 55 -
CPAAEESLPIEV IL12B_CEREL 200 55 -
CPAAEESLPIEV IL12B_HUMAN 199 54 -
CPSAEESLPIEV IL12B_CANFA 200 55 -
CPAAEESLPIEI IL12B_HORSE 200 55 -
CPAAEESLPIEV IL12B_CAPHI 200 55 -
CPAAEESLPIEV Q6E218_CAPHI 200 55 -
CPAAEESLPIEV IL12B_SHEEP 200 55 -
CPAAEERLPIEV IL12B_MACMU 199 54 -
CPAAEERLPIEV IL12B_PAPAN 199 54 -
CPAAEESLLIEV A3RL77_BUBBU 200 55 -
CPAAEESLLIEV Q2PE54_BUBBU 200 55 -
CPAAEESLLIEV IL12B_BUBCA 200 55 -
CPAAEESLLIEV IL12B_BUBBU 200 55 -
CPAAEESLLIEV IL12B_BOVIN 200 55 -
CPAAEESLLIEV A9QWR4_BOVIN 200 55 -
CPTAEESLPIEV IL12B_CAVPO 195 50 -
CPTAEETLPIEL IL12B_SIGHI 200 55 -
CPTAEETLPIEL IL12B_MOUSE 197 55 -
CPTAEETLPIEL Q9R278_RAT 197 55 -
CPTAEETLPIEL Q3ZAX5_MOUSE 197 55 -
CPAAEERLPIEV IL12B_CERTO 199 54 -
CPTAEETLPIGL IL12B_MESAU 200 55 -
CPAAEESLLIEV Q2MH16_9CETA 200 55 -
CPTAEETLPITV IL12B_MARMO 199 55 -
CPTAEETLPITV Q9ET05_MARMO 199 55 -
CPTAEETVPIGL Q924K7_MERUN 200 56 -
CPFAEEHQPTEM Q6X0K9_CHICK 192 48 -
CPFAEEHQPTEM Q70M90_CHICK 192 48 -
CPFAEEHQPTEM Q70M89_CHICK 192 48 -
CPYAEESQPIHI Q7SX69_FUGRU 213 62 -
CPYAEESQPIHI Q800F2_FUGRU 195 56 -
CPYAEENQKIHI Q1KX13_DICLA 205 62 -
CPYAEESQPVQI Q6UAP1_TETNG 204 62 -
CPYAEELERINL A8WH99_DANRE 182 42 -
CPYAEELERINL Q6F3Q9_DANRE 182 42 -
CPYAEELGRINL Q0V941_DANRE 182 42 -
CPYSEESRSINL Q2PCT1_CYPCA 176 41 -
CPYAEEVERINL Q2PD23_CYPCA 182 42 -
SPYTEEAAPLVV Q5DVP6_ONCMY 169 45 -
SPYTEEAAPLVV Q5DVP7_ONCMY 169 45 -

Motif 3 width=11
Element Seqn Id St Int Rpt
TWSTPHSYFSL IL12B_FELCA 262 50 -
TWSTPHSYFSL IL12B_PIG 257 50 -
TWSTPHSYFSL IL12B_LAMGL 263 50 -
TWSTPHSYFSL IL12B_CEREL 262 50 -
TWSTPHSYFSL IL12B_HUMAN 261 50 -
TWSTPHSYFSL IL12B_CANFA 262 50 -
TWSTPHSYFSL IL12B_HORSE 262 50 -
TWSTPHSYFSL IL12B_CAPHI 262 50 -
TWSTPHSYFSL Q6E218_CAPHI 262 50 -
TWSTPHSYFSL IL12B_SHEEP 262 50 -
TWSTPHSYFSL IL12B_MACMU 261 50 -
TWSTPHSYFSL IL12B_PAPAN 261 50 -
TWSTPHSYFSL A3RL77_BUBBU 262 50 -
TWSTPHSYFSL Q2PE54_BUBBU 262 50 -
TWSTPHSYFSL IL12B_BUBCA 262 50 -
TWSTPHSYFSL IL12B_BUBBU 262 50 -
TWSTPHSYFSL IL12B_BOVIN 262 50 -
TWSTPHSYFSL A9QWR4_BOVIN 262 50 -
TWSTPHSYFSL IL12B_CAVPO 257 50 -
SWSTPHSYFSL IL12B_SIGHI 261 49 -
SWSTPHSYFSL IL12B_MOUSE 258 49 -
SWSTPHSYFSL Q9R278_RAT 258 49 -
SWSTPHSYFSL Q3ZAX5_MOUSE 258 49 -
TWSTPHSYFSL IL12B_CERTO 261 50 -
SWSTPHSYFSL IL12B_MESAU 261 49 -
TWSTPHSYFSL Q2MH16_9CETA 262 50 -
SWSTPHSYFSL IL12B_MARMO 261 50 -
SWSTPHSYFSL Q9ET05_MARMO 261 50 -
SWSTPHSYFAL Q924K7_MERUN 261 49 -
TWSTPKSYFPL Q6X0K9_CHICK 249 45 -
TWSTPKSYFPL Q70M90_CHICK 248 44 -
TWSTPKSYFPL Q70M89_CHICK 248 44 -
SWNTPFSYFPL Q7SX69_FUGRU 270 45 -
SWNTPFSYFPL Q800F2_FUGRU 259 52 -
SWSSPFSYFPL Q1KX13_DICLA 262 45 -
SWNSPSSYFPL Q6UAP1_TETNG 261 45 -
SWNTPSSYFPL A8WH99_DANRE 238 44 -
SWNTPSSYFPL Q6F3Q9_DANRE 238 44 -
SWNTPSSYFPL Q0V941_DANRE 238 44 -
TWSFPCSFFPL Q2PCT1_CYPCA 232 44 -
SWNAPSSYFPL Q2PD23_CYPCA 238 44 -
TWNCPPSYFPL Q5DVP6_ONCMY 229 48 -
TWNCPPSYFPL Q5DVP7_ONCMY 229 48 -