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PR01912

Identifier
BDNFACTOR  [View Relations]  [View Alignment]  
Accession
PR01912
No. of Motifs
5
Creation Date
29-AUG-2008
Title
Brain derived neurotrophic factor signature
Database References
PRINTS; PR00268 NGF
PRODOM; PD009320
PDB; 1BND; 1B8M
SCOP; 1BND; 1B8M
CATH; 1BND; 1B8M
MIM; 113505
Literature References
1. HOFER, M., PAGLIUSI, S.R., HOHN, A., LEIBROCK, J. AND BARDE, Y.A.
Regional distribution of brain-derived neurotrophic factor messenger RNA in
the adult mouse brain.
EMBO J. 9(8) 2459-2464 (1990).
 
2. KOYAMA, J.I., INOUE, S., IKEDA, K. AND HAYASHI, K.
Purification and amino acid sequence of a nerve growth factor from the
venom of Vipera russelli russelli.
BIOCHIM.BIOPHYS.ACTA 1160 287-292 (1992).
 
3. INOUE, S., ODA, T., KOYAMA, J., IKEDA, K. AND HAYASHI, K.
Amino acid sequences of nerve growth factors derived from cobra venoms.
FEBS LETT. 279(1) 38-40 (1991).
 
4. BARDE, Y., EDGAR, D. AND THOENEN, H.
Purification of a new neurotrophic factor from mammalian brain.
EMBO J. 1 549-553 (1982).
 
5. HIBBERT, A., KRAMER, B., MILLER, F. AND KAPLAN, D.
The localization, trafficking and retrograde transport of BDNF bound to 
p75NTR in sympathetic neurons.
MOL.CELL.NEUROSCI. 32 387-402 (2006).
 
6. LINNARSSON, S., BJORKLUND, A. AND ERNFORS, P.
Learning deficit in BDNF mutant mice.
EUR.J.NEUROSCI. 9 2581-2587 (1997).
 
7. LEBRUN, B., BARIOHAY, B., MOYSE, E. AND JEAN, A.
Brain-derived neurotrophic factor (BDNF) and food intake regulation: a 
minireview.
AUTON.NEUROSCI. 126-127 30-38 (2006).
 
8. KOZISEK, M., MIDDLEMAS, D. AND BYLUND, D.
Brain-derived neurotrophic factor and its receptor tropomyosin-related
kinase B in the mechanism of action of antidepressant therapies.
PHARMACOL.THER. 117 30-51 (2008).

Documentation
During the development of the vertebrate nervous system, many neurons
become redundant (because they have died, failed to connect to target
cells, etc.) and are eliminated. At the same time, developing neurons send
out axon outgrowths that contact their target cells [1]. Such cells control
their degree of innervation (the number of axon connections) by the
secretion of various specific neurotrophic factors that are essential for
neuron survival. One of these is nerve growth factor (NGF), which is
involved in the survival of some classes of embryonic neuron (e.g., peri-
pheral sympathetic neurons) [1]. NGF is mostly found outside the central
nervous system (CNS), but slight traces have been detected in adult CNS
tissues, although a physiological role for this is unknown [1]; it has also
been found in several snake venoms [2,3]. Proteins similar to NGF include
brain-derived neurotrophic factor (BDNF) and neurotrophins 3 to 7, all of
which demonstrate neuron survival and outgrowth activities.
 
Originally purified from pig brain [4], the neurotrophin BDNF is expressed 
in a range of tissues and cell types in the CNS and periphery. It exerts
its effects by binding to neurotrophic tyrosine kinase receptor type 2 
(NTRK2; also called TrkB) and the low affinity nerve growth factor receptor, 
p75NTR. While the former receptor mediates the neurotrophin's prosurvival 
functions, activation of p75NTR by BDNF has been shown to promote apoptosis
and to inhibit axonal growth [5].
 
BDNF is a key regulator of synaptic plasticity, and plays an important role
in learning and memory [6]. Several lines of evidence suggest that it is 
also involved in the control of food intake and body weight [7]. A number 
of clinical studies have demonstrated an association between aberrant BDNF
levels and disorders and disease states, such as depression, epilepsy, 
bipolar disorder, Parkinson's disease and Alzheimer's disease [8].
 
BDNFACTOR is a 5-element fingerprint that provides a signature for brain-
derived neurotrophic factor. The fingerprint was derived from an initial 
alignment of 33 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length - motif 1 includes part of the
signal sequence. Three iterations on SPTR55_38f were required to reach 
convergence, at which point a true set comprising 47 sequences was 
identified. A single partial match was also found, Q6YNR1_HUMAN, a human
BDNF splice variant that fails to match motifs 4 and 5.
Summary Information
  47 codes involving  5 elements
0 codes involving 4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
54747474747
400000
311100
200000
12345
True Positives
A2AII2_MOUSE  A2ICR4_AMBME  A3FPG9_XENTR  A4L7M3_BOMOR  
A4L7M4_9SALA A4L7M5_SALSL A7LA85_HUMAN A7LA92_HUMAN
BDNF_AILFU BDNF_AILME BDNF_BOVIN BDNF_CANFA
BDNF_CHICK BDNF_CYPCA BDNF_FELCA BDNF_HORSE
BDNF_HUMAN BDNF_LIPVE BDNF_MOUSE BDNF_PANTR
BDNF_PIG BDNF_PROLO BDNF_RAT BDNF_SELTH
BDNF_SPECI BDNF_URSAR BDNF_URSML BDNF_XIPMA
O70183 Q06B76_DICLA Q4JHT7_POEGU Q541P3_MOUSE
Q598Q1_HUMAN Q63ZM5_XENLA Q6DN19_HUMAN Q6NZ01_DANRE
Q6YNR2_HUMAN Q6YNR3_HUMAN Q8AV78_NIPNI Q8CCH9_MOUSE
Q8JGW4_PAROL Q8QG74_9SAUR Q8QG75_9SAUR Q8QG76_9SAUR
Q8QG77_9SALA Q8VHH4_MOUSE Q9YH42_DANRE
True Positive Partials
Codes involving 3 elements
Q6YNR1_HUMAN
Sequence Titles
A2AII2_MOUSE Brain derived neurotrophic factor - Mus musculus (Mouse). 
A2ICR4_AMBME Brain-derived neurotrophic factor - Ambystoma mexicanum (Axolotl).
A3FPG9_XENTR Brain-derived neurotrophic factor - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
A4L7M3_BOMOR Brain-derived neurotrophic factor - Bombina orientalis (Oriental fire-bellied toad).
A4L7M4_9SALA Brain-derived neurotrophic factor - Pleurodeles poireti (Algerian ribbed newt).
A4L7M5_SALSL Brain-derived neurotrophic factor - Salamandra salamandra (European fire salamander).
A7LA85_HUMAN Brain derived neurotrophic factor variant - Homo sapiens (Human).
A7LA92_HUMAN Brain derived neurotrophic factor variant - Homo sapiens (Human).
BDNF_AILFU Brain-derived neurotrophic factor precursor (BDNF) - Ailurus fulgens (Lesser panda) (Red panda).
BDNF_AILME Brain-derived neurotrophic factor precursor (BDNF) - Ailuropoda melanoleuca (Giant panda).
BDNF_BOVIN Brain-derived neurotrophic factor precursor (BDNF) - Bos taurus (Bovine).
BDNF_CANFA Brain-derived neurotrophic factor precursor (BDNF) - Canis familiaris (Dog).
BDNF_CHICK Brain-derived neurotrophic factor precursor (BDNF) - Gallus gallus (Chicken).
BDNF_CYPCA Brain-derived neurotrophic factor precursor (BDNF) - Cyprinus carpio (Common carp).
BDNF_FELCA Brain-derived neurotrophic factor precursor (BDNF) - Felis silvestris catus (Cat).
BDNF_HORSE Brain-derived neurotrophic factor precursor (BDNF) - Equus caballus (Horse).
BDNF_HUMAN Brain-derived neurotrophic factor precursor (BDNF) (Abrineurin) - Homo sapiens (Human).
BDNF_LIPVE Brain-derived neurotrophic factor precursor (BDNF) - Lipotes vexillifer (Yangtze river dolphin).
BDNF_MOUSE Brain-derived neurotrophic factor precursor (BDNF) - Mus musculus (Mouse).
BDNF_PANTR Brain-derived neurotrophic factor precursor (BDNF) - Pan troglodytes (Chimpanzee).
BDNF_PIG Brain-derived neurotrophic factor precursor (BDNF) - Sus scrofa (Pig).
BDNF_PROLO Brain-derived neurotrophic factor precursor (BDNF) - Procyon lotor (Raccoon).
BDNF_RAT Brain-derived neurotrophic factor precursor (BDNF) - Rattus norvegicus (Rat).
BDNF_SELTH Brain-derived neurotrophic factor precursor (BDNF) - Selenarctos thibetanus (Asiatic black bear).
BDNF_SPECI Brain-derived neurotrophic factor precursor (BDNF) - Spermophilus citellus (European suslik) (Citellus citellus).
BDNF_URSAR Brain-derived neurotrophic factor precursor (BDNF) - Ursus arctos (Brown bear) (Grizzly bear).
BDNF_URSML Brain-derived neurotrophic factor precursor (BDNF) - Ursus malayanus (Malayan sun bear) (Helarctos malayanus).
BDNF_XIPMA Brain-derived neurotrophic factor precursor (BDNF) - Xiphophorus maculatus (Southern platyfish).
O70183 BRAIN-DERIVED NEUROTROPHIC FACTOR - CAVIA PORCELLUS (GUINEA PIG).
Q06B76_DICLA Brain-derived neurotrophic factor - Dicentrarchus labrax (European sea bass).
Q4JHT7_POEGU BDNF - Poephila guttata (Zebra finch) (Taeniopygia guttata).
Q541P3_MOUSE Brain-derived neurotrophic factor BDNF1 (Brain-derived neurotrophic factor transcript variant I) (Brain-derived neurotrophic factor transcript variant IIA) (Brain-derived neurotrophic factor transcript variant IIB) (Brain-derived neurotrophic factor transcript variant IIC) (Brain-derived neurotrophic factor transcript variant IV) (Brain- derived neurotrophic factor transcript variant VI) (Brain-derived neurotrophic factor transcript variant III) (Brain-derived neurotrophic factor transcript variant V) (Brain-derived neurotrophic factor transcript variant VII) (Brain-derived neurotrophic factor transcript variant VIII) (Brain-derived neurotrophic factor transcript variant IXA) (Brain derived neurotrophic factor) (Brain-derived neurotrophic factor BDNF6B) (Brain-derived neurotrophic factor BDNF6A) (Brain-derived neurotrophic factor BDNF5) (Brain-derived neurotrophic factor BDNF4) (Brain-derived neurotrophic factor BDNF3) (Brain-derived neurotrophic factor BDNF2C) (Brain-derived neurotrophic factor BDNF2B) (Brain-derived neurotrophic factor BDNF2A) - Mus musculus (Mouse).
Q598Q1_HUMAN Brain-derived neurotrophic factor BDNF2B (Brain-derived neurotrophic factor, isoform CRA_a) (Brain derived neurotrophic factor transcript IIa) (Brain derived neurotrophic factor transcript IIb) (Brain derived neurotrophic factor transcript IIc) (Brain derived neurotrophic factor transcript III) (Brain derived neurotrophic factor transcript IV) (Brain derived neurotrophic factor variant) (cDNA FLJ77010, highly similar to Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 4, mRNA) (Brain-derived neurotrophic factor BDNF6A) (Brain-derived neurotrophic factor BDNF5) (Brain-derived neurotrophic factor BDNF4) (Brain-derived neurotrophic factor BDNF3) (Brain-derived neurotrophic factor BDNF2C) (Brain-derived neurotrophic factor BDNF2A) (Brain-derived neurotrophic factor) - Homo sapiens (Human).
Q63ZM5_XENLA Bdnf protein (Brain derived neurotrophic factor) - Xenopus laevis (African clawed frog).
Q6DN19_HUMAN Brain-derived neurotrophic factor transcript variant 5 - Homo sapiens (Human).
Q6NZ01_DANRE Brain-derived neurotrophic factor (Bdnf protein) - Danio rerio (Zebrafish) (Brachydanio rerio).
Q6YNR2_HUMAN Brain-derived neurotrophic factor BDNF6B (Brain-derived neurotrophic factor, isoform CRA_b) (Brain derived neurotrophic factor variant) - Homo sapiens (Human).
Q6YNR3_HUMAN Brain-derived neurotrophic factor BDNF1 (Brain-derived neurotrophic factor, isoform CRA_c) (Brain derived neurotrophic factor variant) (cDNA FLJ77015, highly similar to Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 3, mRNA) - Homo sapiens (Human).
Q8AV78_NIPNI Brain-derived neurotrophic factor - Nipponia nippon (Crested ibis).
Q8CCH9_MOUSE 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030442P22 product:brain derived neurotrophic factor, full insert sequence - Mus musculus (Mouse).
Q8JGW4_PAROL Brain-derived neurotrophic factor BDNF - Paralichthys olivaceus (Japanese flounder).
Q8QG74_9SAUR Brain derived neurotrophic factor - Cyclophiops major.
Q8QG75_9SAUR Brain derived neurotrophic factor - Phrynocephalus hongyuanensis.
Q8QG76_9SAUR Brain derived neurotrophic factor - Japalura splendida.
Q8QG77_9SALA Brain derived neurotrophic factor - Tylototriton taliangensis (Taliang knobby newt).
Q8VHH4_MOUSE Anorexia BDNF - Mus musculus (Mouse).
Q9YH42_DANRE Brain-derived neurotrophic factor - Danio rerio (Zebrafish) (Brachydanio rerio).

Q6YNR1_HUMAN Brain-derived neurotrophic factor BDNF7 - Homo sapiens (Human).
Scan History
SPTR55_38f 3  300  NSINGLE    
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
ISYFGCMKAAPMK BDNF_FELCA 10 10 -
ISYFGCMKAAPMK Q8CCH9_MOUSE 10 10 -
ISYFGCMKAAPMK Q6YNR3_HUMAN 18 18 -
ISYFGCMKAAPMK Q6YNR2_HUMAN 25 25 -
ISYFGCMKAAPMK Q598Q1_HUMAN 10 10 -
ISYFGCMKAAPMK Q541P3_MOUSE 10 10 -
ISYFGCMKAAPMK BDNF_URSML 10 10 -
ISYFGCMKAAPMK BDNF_URSAR 10 10 -
ISYFGCMKAAPMK BDNF_SPECI 10 10 -
ISYFGCMKAAPMK BDNF_SELTH 10 10 -
ISYFGCMKAAPMK BDNF_RAT 10 10 -
ISYFGCMKAAPMK BDNF_PROLO 10 10 -
ISYFGCMKAAPMK BDNF_PIG 10 10 -
ISYFGCMKAAPMK BDNF_PANTR 10 10 -
ISYFGCMKAAPMK BDNF_MOUSE 10 10 -
ISYFGCMKAAPMK BDNF_HUMAN 10 10 -
ISYFGCMKAAPMK BDNF_CANFA 10 10 -
ISYFGCMKAAPMK BDNF_BOVIN 10 10 -
ISYFGCMKAAPMK BDNF_AILME 10 10 -
ISYFGCMKAAPMK BDNF_AILFU 10 10 -
ISYFGCMKAAPMK A7LA92_HUMAN 92 92 -
ISYFGCMKAAPMK A7LA85_HUMAN 39 39 -
ISYFGCMKAAPMK O70183 10 10 -
ISYFGCMKAAPMK BDNF_HORSE 10 10 -
ISYFGCMKAAPMK Q8VHH4_MOUSE 10 10 -
ISYFGCMKAAPMK Q6DN19_HUMAN 10 10 -
ISYFGCMKAAPMK A2AII2_MOUSE 18 18 -
ISYFSCMKAAPMK BDNF_LIPVE 10 10 -
ISYFSCMKAAPMK BDNF_CHICK 10 10 -
ISYFSCMKAAPMK Q8AV78_NIPNI 10 10 -
ISYFTCMKAAPMK Q4JHT7_POEGU 10 10 -
ISYFSCMRAAPMR BDNF_CYPCA 10 10 -
ISYFSCMRAAPLR BDNF_XIPMA 10 10 -

Motif 2 width=16
Element Seqn Id St Int Rpt
WLTDTFEQVIEELLEV BDNF_CYPCA 65 42 -
SLADTFEHVIEELLDE A2AII2_MOUSE 68 37 -
SLADTFEHVIEELLDE Q8CCH9_MOUSE 60 37 -
SLADTFEHVIEELLDE Q6YNR3_HUMAN 66 35 -
SLADTFEHVIEELLDE Q6YNR2_HUMAN 73 35 -
SLADTFEHVIEELLDE Q598Q1_HUMAN 58 35 -
SLADTFEHVIEELLDE Q541P3_MOUSE 60 37 -
SLADTFEHVIEELLDE BDNF_URSML 58 35 -
SLADTFEHVIEELLDE BDNF_URSAR 58 35 -
SLADTFEHVIEELLDE BDNF_SPECI 58 35 -
SLADTFEHVIEELLDE BDNF_SELTH 58 35 -
SLADTFEHVIEELLDE BDNF_RAT 60 37 -
SLADTFEHVIEELLDE BDNF_PROLO 58 35 -
SLADTFEHVIEELLDE BDNF_PIG 63 40 -
SLADTFEHVIEELLDE BDNF_PANTR 58 35 -
SLADTFEHVIEELLDE BDNF_MOUSE 60 37 -
SLTDTFEQVIEELLEV BDNF_XIPMA 63 40 -
SLADTFEHVIEELLDE BDNF_HUMAN 58 35 -
SLADTFEHVIEELLDE BDNF_FELCA 58 35 -
SLADTFEHVIEELLDE BDNF_CANFA 58 35 -
SLADTFEHVIEELLDE BDNF_BOVIN 61 38 -
SLADTFEHVIEELLDE BDNF_AILME 58 35 -
SLADTFEHVIEELLDE BDNF_AILFU 58 35 -
SLADTFEHVIEELLDE A7LA92_HUMAN 140 35 -
SLADTFEHVIEELLDE A7LA85_HUMAN 87 35 -
SLADTFEHVIEELLVE O70183 66 43 -
SLADTFEHVIEDLLDE BDNF_HORSE 58 35 -
SLADTFDHVIEELLDE Q8VHH4_MOUSE 60 37 -
SLADTFEHMIEELLDE Q6DN19_HUMAN 58 35 -
SLADTVEHVIEELLDE BDNF_LIPVE 59 36 -
SLADTFEHVIEELLDE BDNF_CHICK 58 35 -
SLADTFEHVIEELLDE Q8AV78_NIPNI 58 35 -
SLADTFEHVIEELLDE Q4JHT7_POEGU 58 35 -

Motif 3 width=17
Element Seqn Id St Int Rpt
PLLFLLEEYKNYLDAAN BDNF_HUMAN 105 31 -
PLLFLLEEYKNYLDAAN A2AII2_MOUSE 115 31 -
PLLFLLEEYKNYLDAAN Q8CCH9_MOUSE 107 31 -
PLLFLLEEYKNYLDAAN Q6YNR3_HUMAN 113 31 -
PLLFLLEEYKNYLDAAN Q6YNR2_HUMAN 120 31 -
PLLFLLEEYKNYLDAAN Q598Q1_HUMAN 105 31 -
PLLFLLEEYKNYLDAAN Q541P3_MOUSE 107 31 -
PLLFLLEEYKNYLDAAN BDNF_URSML 105 31 -
PLLFLLEEYKNYLDAAN BDNF_URSAR 105 31 -
PLLFLLEEYKNYLDAAN BDNF_SPECI 105 31 -
PLLFLLEEYKNYLDAAN BDNF_SELTH 105 31 -
PLLFLLEEYKNYLDAAN BDNF_RAT 107 31 -
PLLFLLEEYKNYLDAAN BDNF_PROLO 105 31 -
PLLFLLEEYKNYLDAAN BDNF_PIG 110 31 -
PLLFLLEEYKNYLDAAN BDNF_PANTR 105 31 -
PLLFLLEEYKNYLDAAN BDNF_MOUSE 107 31 -
PLLFLLEEYKNYLDAAN BDNF_FELCA 105 31 -
PLLFLLEEYKNYLDAAN BDNF_CANFA 105 31 -
PLLFLLEEYKNYLDAAN BDNF_BOVIN 108 31 -
PLLFLLEEYKNYLDAAN BDNF_AILME 105 31 -
PLLFLLEEYKNYLDAAN BDNF_AILFU 105 31 -
PLLFLLEEYKNYLDAAN A7LA92_HUMAN 187 31 -
PLLFLLEEYKNYLDAAN A7LA85_HUMAN 134 31 -
PLLFLLEEYKNYLDAAN O70183 113 31 -
PLLFLLEEYKNYLDAAN BDNF_HORSE 105 31 -
PLLFLLEEYKNYLDAAN Q8VHH4_MOUSE 107 31 -
PLLFLLEEYKNYLDAAN Q6DN19_HUMAN 105 31 -
PLLFLLEEYKNYLDAAN BDNF_LIPVE 106 31 -
PLLFLLEEYKNYLDAAN BDNF_CHICK 104 30 -
PLLFLLEEYKNYLDAAN Q8AV78_NIPNI 104 30 -
PLLFLLEEYKNYLDAAN Q4JHT7_POEGU 104 30 -
PLLFLLEEYKNYLDAAN BDNF_CYPCA 128 47 -
PLLFLLEEYKNYLDAAN BDNF_XIPMA 127 48 -

Motif 4 width=12
Element Seqn Id St Int Rpt
LEKVPVSKGQLK A2AII2_MOUSE 177 45 -
LEKVPVSKGQLK Q6YNR3_HUMAN 175 45 -
LEKVPVSKGQLK Q6YNR2_HUMAN 182 45 -
LEKVPVSKGQLK Q598Q1_HUMAN 167 45 -
LEKVPVSKGQLK Q541P3_MOUSE 169 45 -
LEKVPVSKGQLK BDNF_URSML 167 45 -
LEKVPVSKGQLK BDNF_URSAR 167 45 -
LEKVPVSKGQLK BDNF_SPECI 167 45 -
LEKVPVSKGQLK BDNF_SELTH 167 45 -
LEKVPVSKGQLK BDNF_RAT 169 45 -
LEKVPVSKGQLK BDNF_PROLO 167 45 -
LEKVPVSKGQLK BDNF_PIG 172 45 -
LEKVPVSKGQLK BDNF_PANTR 167 45 -
LEKVPVSKGQLK BDNF_MOUSE 169 45 -
LEKVPVSKGQLK BDNF_HUMAN 167 45 -
LEKVPVSKGQLK BDNF_FELCA 167 45 -
LEKVPVSKGQLK Q8CCH9_MOUSE 169 45 -
LEKVPVSKGQLK BDNF_CANFA 167 45 -
LEKVPVSKGQLK BDNF_BOVIN 170 45 -
LEKVPVSKGQLK BDNF_AILME 167 45 -
LEKVPVSKGQLK BDNF_AILFU 167 45 -
LEKVPVSKGQLK A7LA92_HUMAN 249 45 -
LEKVPVSKGQLK A7LA85_HUMAN 196 45 -
LEKVPVSKGQLK O70183 175 45 -
LEKVPVSKGQLK BDNF_HORSE 167 45 -
LEKVPVSKGQLK Q8VHH4_MOUSE 169 45 -
LEKVPVSKGQLK Q6DN19_HUMAN 167 45 -
LEKVPVSKGQLK BDNF_LIPVE 168 45 -
LEKVPVPKGQLK BDNF_CHICK 166 45 -
LEKVPVPKGQLK Q8AV78_NIPNI 166 45 -
LEKVPVPKGQLK Q4JHT7_POEGU 166 45 -
LEKVPVTNGQLK BDNF_CYPCA 190 45 -
MEKVPVPNGQLK BDNF_XIPMA 189 45 -

Motif 5 width=10
Element Seqn Id St Int Rpt
CNPLGYTKEG BDNF_CYPCA 209 7 -
CNPMGYTKEG A2AII2_MOUSE 196 7 -
CNPMGYTKEG Q8CCH9_MOUSE 188 7 -
CNPMGYTKEG Q6YNR3_HUMAN 194 7 -
CNPMGYTKEG Q6YNR2_HUMAN 201 7 -
CNPMGYTKEG Q598Q1_HUMAN 186 7 -
CNPMGYTKEG Q541P3_MOUSE 188 7 -
CNPMGYTKEG BDNF_URSML 186 7 -
CNPMGYTKEG BDNF_URSAR 186 7 -
CNPMGYTKEG BDNF_SPECI 186 7 -
CNPMGYTKEG BDNF_SELTH 186 7 -
CNPMGYTKEG BDNF_RAT 188 7 -
CNPMGYTKEG BDNF_PROLO 186 7 -
CNPMGYTKEG BDNF_PIG 191 7 -
CNPMGYTKEG BDNF_PANTR 186 7 -
CNPMGYTKEG BDNF_MOUSE 188 7 -
CNPMGYTKEG BDNF_HUMAN 186 7 -
CNPMGYTKEG BDNF_FELCA 186 7 -
CNPMGYTKEG BDNF_CANFA 186 7 -
CNPMGYTKEG BDNF_BOVIN 189 7 -
CNPMGYTKEG BDNF_AILME 186 7 -
CNPMGYTKEG BDNF_AILFU 186 7 -
CNPMGYTKEG A7LA92_HUMAN 268 7 -
CNPMGYTKEG A7LA85_HUMAN 215 7 -
CNPMGYTKEG O70183 194 7 -
CNPMGYTKEG BDNF_HORSE 186 7 -
CNPMGYTKEG Q8VHH4_MOUSE 188 7 -
CNPMGYTKEG Q6DN19_HUMAN 186 7 -
CNPMGYTKEG BDNF_LIPVE 187 7 -
CNPKGYTKEG BDNF_CHICK 185 7 -
CNPKGYTKEG Q8AV78_NIPNI 185 7 -
CNPKGYTKEG Q4JHT7_POEGU 185 7 -
CNPMGYTKDG BDNF_XIPMA 208 7 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
ISYFGCMKAAPMK A7LA85_HUMAN 39 39 -
ISYFGCMKAAPMK Q8CCH9_MOUSE 10 10 -
ISYFGCMKAAPMK Q6YNR3_HUMAN 18 18 -
ISYFGCMKAAPMK Q6YNR2_HUMAN 25 25 -
ISYFGCMKAAPMK Q598Q1_HUMAN 10 10 -
ISYFGCMKAAPMK Q541P3_MOUSE 10 10 -
ISYFGCMKAAPMK BDNF_URSML 10 10 -
ISYFGCMKAAPMK BDNF_URSAR 10 10 -
ISYFGCMKAAPMK BDNF_SPECI 10 10 -
ISYFGCMKAAPMK BDNF_SELTH 10 10 -
ISYFGCMKAAPMK BDNF_RAT 10 10 -
ISYFGCMKAAPMK BDNF_PROLO 10 10 -
ISYFGCMKAAPMK BDNF_PIG 10 10 -
ISYFGCMKAAPMK BDNF_PANTR 10 10 -
ISYFGCMKAAPMK BDNF_MOUSE 10 10 -
ISYFGCMKAAPMK BDNF_HUMAN 10 10 -
ISYFGCMKAAPMK BDNF_FELCA 10 10 -
ISYFGCMKAAPMK BDNF_CANFA 10 10 -
ISYFGCMKAAPMK BDNF_BOVIN 10 10 -
ISYFGCMKAAPMK BDNF_AILME 10 10 -
ISYFGCMKAAPMK BDNF_AILFU 10 10 -
ISYFGCMKAAPMK A7LA92_HUMAN 92 92 -
ISYFGCMKAAPMK O70183 10 10 -
ISYFGCMKAAPMK BDNF_HORSE 10 10 -
ISYFGCMKAAPMK Q8VHH4_MOUSE 10 10 -
ISYFGCMKAAPMK Q6DN19_HUMAN 10 10 -
ISYFGCMKAAPMK A2AII2_MOUSE 18 18 -
ISYFSCMKAAPMK BDNF_LIPVE 10 10 -
ISYFSCMKAAPMK BDNF_CHICK 10 10 -
ISYFSCMKAAPMK Q8AV78_NIPNI 10 10 -
ISYFTCMKAAPMK Q4JHT7_POEGU 10 10 -
ISYFSCMKAAPMK A4L7M3_BOMOR 10 10 -
ISYFSCMKAAPMK Q63ZM5_XENLA 10 10 -
ISYFSCMKAAPMK A3FPG9_XENTR 10 10 -
ISYFSCMKAAPMK Q8QG75_9SAUR 10 10 -
ISYFSCMKAAPMK Q8QG76_9SAUR 10 10 -
ISYFSCMKAAPMK A4L7M4_9SALA 10 10 -
ISYFSCMKAAPMK A4L7M5_SALSL 10 10 -
ISYFSCLKAAPMK A2ICR4_AMBME 10 10 -
ISYFSCMKAAPMK Q8QG77_9SALA 10 10 -
ISYFSCMRAAPMR Q6NZ01_DANRE 10 10 -
ISYFSCMRAAPMR Q9YH42_DANRE 10 10 -
ISYFSCMRAAPLR Q8JGW4_PAROL 10 10 -
ISYFSCMRAAPLR Q06B76_DICLA 10 10 -
ISYFSCMRAAPMR BDNF_CYPCA 10 10 -
ISYLSCMKATPMK Q8QG74_9SAUR 10 10 -
ISYFSCMRAAPLR BDNF_XIPMA 10 10 -

Motif 2 width=16
Element Seqn Id St Int Rpt
SLADTFEHVIEELLDE Q8QG74_9SAUR 58 35 -
SLADTFEHVIEELLDE A2AII2_MOUSE 68 37 -
SLADTFEHVIEELLDE Q8CCH9_MOUSE 60 37 -
SLADTFEHVIEELLDE Q6YNR3_HUMAN 66 35 -
SLADTFEHVIEELLDE Q6YNR2_HUMAN 73 35 -
SLADTFEHVIEELLDE Q598Q1_HUMAN 58 35 -
SLADTFEHVIEELLDE Q541P3_MOUSE 60 37 -
SLADTFEHVIEELLDE BDNF_URSML 58 35 -
SLADTFEHVIEELLDE BDNF_URSAR 58 35 -
SLADTFEHVIEELLDE BDNF_SPECI 58 35 -
SLADTFEHVIEELLDE BDNF_SELTH 58 35 -
SLADTFEHVIEELLDE BDNF_RAT 60 37 -
SLADTFEHVIEELLDE BDNF_PROLO 58 35 -
SLADTFEHVIEELLDE BDNF_PIG 63 40 -
SLADTFEHVIEELLDE BDNF_PANTR 58 35 -
SLADTFEHVIEELLDE BDNF_MOUSE 60 37 -
SLADTFEHVIEELLDE BDNF_HUMAN 58 35 -
SLADTFEHVIEELLDE BDNF_FELCA 58 35 -
SLADTFEHVIEELLDE BDNF_CANFA 58 35 -
SLADTFEHVIEELLDE BDNF_BOVIN 61 38 -
SLADTFEHVIEELLDE BDNF_AILME 58 35 -
SLADTFEHVIEELLDE BDNF_AILFU 58 35 -
SLTDTFEQVIEELLEV BDNF_XIPMA 63 40 -
SLADTFEHVIEELLDE A7LA92_HUMAN 140 35 -
SLADTFEHVIEELLDE A7LA85_HUMAN 87 35 -
SLADTFEHVIEELLVE O70183 66 43 -
SLADTFEHVIEDLLDE BDNF_HORSE 58 35 -
SLADTFDHVIEELLDE Q8VHH4_MOUSE 60 37 -
SLADTFEHMIEELLDE Q6DN19_HUMAN 58 35 -
SLADTVEHVIEELLDE BDNF_LIPVE 59 36 -
SLADTFEHVIEELLDE BDNF_CHICK 58 35 -
SLADTFEHVIEELLDE Q8AV78_NIPNI 58 35 -
SLADTFEHVIEELLDE Q4JHT7_POEGU 58 35 -
SLTDTFEQVIEELLEE A4L7M3_BOMOR 59 36 -
SLTDTFEQVIEELLEE Q63ZM5_XENLA 59 36 -
SLTDTFEHVIEELMEE A3FPG9_XENTR 59 36 -
SLADTFEQVIEELLDE Q8QG75_9SAUR 58 35 -
SLADTFEHVLEELLDE Q8QG76_9SAUR 58 35 -
SLADTFEQVIEEMLED A4L7M4_9SALA 59 36 -
SLADTFEQVIEEMLED A4L7M5_SALSL 59 36 -
SLADTFEQVIEEMLED A2ICR4_AMBME 59 36 -
SLADTFEQVIEEMLED Q8QG77_9SALA 59 36 -
SLTDTFEQVIEELLEV Q6NZ01_DANRE 65 42 -
SLTDTFEQVIEELLEV Q9YH42_DANRE 65 42 -
SLADTFEQVIEELLEV Q8JGW4_PAROL 63 40 -
SLTDTFEQVIEELLEV Q06B76_DICLA 63 40 -
WLTDTFEQVIEELLEV BDNF_CYPCA 65 42 -

Motif 3 width=17
Element Seqn Id St Int Rpt
PLLFLLEEYKNYLDAAN A7LA85_HUMAN 134 31 -
PLLFLLEEYKNYLDAAN A2AII2_MOUSE 115 31 -
PLLFLLEEYKNYLDAAN Q8CCH9_MOUSE 107 31 -
PLLFLLEEYKNYLDAAN Q6YNR3_HUMAN 113 31 -
PLLFLLEEYKNYLDAAN Q6YNR2_HUMAN 120 31 -
PLLFLLEEYKNYLDAAN Q598Q1_HUMAN 105 31 -
PLLFLLEEYKNYLDAAN Q541P3_MOUSE 107 31 -
PLLFLLEEYKNYLDAAN BDNF_URSML 105 31 -
PLLFLLEEYKNYLDAAN BDNF_URSAR 105 31 -
PLLFLLEEYKNYLDAAN BDNF_SPECI 105 31 -
PLLFLLEEYKNYLDAAN BDNF_SELTH 105 31 -
PLLFLLEEYKNYLDAAN BDNF_RAT 107 31 -
PLLFLLEEYKNYLDAAN BDNF_PROLO 105 31 -
PLLFLLEEYKNYLDAAN BDNF_PIG 110 31 -
PLLFLLEEYKNYLDAAN BDNF_PANTR 105 31 -
PLLFLLEEYKNYLDAAN BDNF_MOUSE 107 31 -
PLLFLLEEYKNYLDAAN BDNF_HUMAN 105 31 -
PLLFLLEEYKNYLDAAN BDNF_FELCA 105 31 -
PLLFLLEEYKNYLDAAN BDNF_CANFA 105 31 -
PLLFLLEEYKNYLDAAN BDNF_BOVIN 108 31 -
PLLFLLEEYKNYLDAAN BDNF_AILME 105 31 -
PLLFLLEEYKNYLDAAN BDNF_AILFU 105 31 -
PLLFLLEEYKNYLDAAN A7LA92_HUMAN 187 31 -
PLLFLLEEYKNYLDAAN O70183 113 31 -
PLLFLLEEYKNYLDAAN BDNF_HORSE 105 31 -
PLLFLLEEYKNYLDAAN Q8VHH4_MOUSE 107 31 -
PLLFLLEEYKNYLDAAN Q6DN19_HUMAN 105 31 -
PLLFLLEEYKNYLDAAN BDNF_LIPVE 106 31 -
PLLFLLEEYKNYLDAAN BDNF_CHICK 104 30 -
PLLFLLEEYKNYLDAAN Q8AV78_NIPNI 104 30 -
PLLFLLEEYKNYLDAAN Q4JHT7_POEGU 104 30 -
PLLFLLEEYKNYLDAAN A4L7M3_BOMOR 105 30 -
PLLFLLEEYKNYLDAAN Q63ZM5_XENLA 105 30 -
PLLFLLEEYKNYLDAAN A3FPG9_XENTR 105 30 -
PLLFLLEEYKNYLDAAN Q8QG75_9SAUR 104 30 -
PLLFLLEEYKNYLDAAN Q8QG76_9SAUR 104 30 -
PLLFLLEEYKNYLDAAN A4L7M4_9SALA 105 30 -
PLLFLLEEYKNYLDAAN A4L7M5_SALSL 105 30 -
PLLFLLEEYKNYLDAAN A2ICR4_AMBME 105 30 -
PLLFLLEEYKNYLDAAN Q8QG77_9SALA 105 30 -
PLLFLLEEYKNYLDAAN Q6NZ01_DANRE 128 47 -
PLLFLLEEYKNYLDAAN Q9YH42_DANRE 128 47 -
PLLFLLEEYKNYLDAAN Q8JGW4_PAROL 127 48 -
PLLFLLEEYKNYLDAAN Q06B76_DICLA 127 48 -
PLLFLLEEYKNYLDAAN BDNF_CYPCA 128 47 -
PLLFLLEEYKNYLDAAN Q8QG74_9SAUR 104 30 -
PLLFLLEEYKNYLDAAN BDNF_XIPMA 127 48 -

Motif 4 width=12
Element Seqn Id St Int Rpt
LEKVPVSKGQLK A2AII2_MOUSE 177 45 -
LEKVPVSKGQLK Q6YNR3_HUMAN 175 45 -
LEKVPVSKGQLK Q6YNR2_HUMAN 182 45 -
LEKVPVSKGQLK Q598Q1_HUMAN 167 45 -
LEKVPVSKGQLK Q541P3_MOUSE 169 45 -
LEKVPVSKGQLK BDNF_URSML 167 45 -
LEKVPVSKGQLK BDNF_URSAR 167 45 -
LEKVPVSKGQLK BDNF_SPECI 167 45 -
LEKVPVSKGQLK BDNF_SELTH 167 45 -
LEKVPVSKGQLK BDNF_RAT 169 45 -
LEKVPVSKGQLK BDNF_PROLO 167 45 -
LEKVPVSKGQLK BDNF_PIG 172 45 -
LEKVPVSKGQLK BDNF_PANTR 167 45 -
LEKVPVSKGQLK BDNF_MOUSE 169 45 -
LEKVPVSKGQLK BDNF_HUMAN 167 45 -
LEKVPVSKGQLK BDNF_FELCA 167 45 -
LEKVPVSKGQLK BDNF_CANFA 167 45 -
LEKVPVSKGQLK BDNF_BOVIN 170 45 -
LEKVPVSKGQLK BDNF_AILME 167 45 -
LEKVPVSKGQLK BDNF_AILFU 167 45 -
LEKVPVSKGQLK A7LA92_HUMAN 249 45 -
LEKVPVSKGQLK A7LA85_HUMAN 196 45 -
LEKVPVSKGQLK O70183 175 45 -
LEKVPVSKGQLK Q8CCH9_MOUSE 169 45 -
LEKVPVSKGQLK BDNF_HORSE 167 45 -
LEKVPVSKGQLK Q8VHH4_MOUSE 169 45 -
LEKVPVSKGQLK Q6DN19_HUMAN 167 45 -
LEKVPVSKGQLK BDNF_LIPVE 168 45 -
LEKVPVPKGQLK BDNF_CHICK 166 45 -
LEKVPVPKGQLK Q8AV78_NIPNI 166 45 -
LEKVPVPKGQLK Q4JHT7_POEGU 166 45 -
LEKVPVSKGQLK A4L7M3_BOMOR 167 45 -
LEKVPVSKGQLK Q63ZM5_XENLA 167 45 -
LEKVPVSKGQLK A3FPG9_XENTR 167 45 -
LEKVPVPKGQLK Q8QG75_9SAUR 166 45 -
LEKVPVPKGQLK Q8QG76_9SAUR 166 45 -
LEKVPVPKGQLK A4L7M4_9SALA 167 45 -
LEKVPVPKGQLK A4L7M5_SALSL 167 45 -
LEKVPVPKGQLK A2ICR4_AMBME 167 45 -
LEKVPVPEGQLK Q8QG77_9SALA 167 45 -
LEKVPVTNGQLK Q6NZ01_DANRE 190 45 -
LEKVPVTNGQLK Q9YH42_DANRE 190 45 -
MEKVPVPNGQLK Q8JGW4_PAROL 189 45 -
MEKVPVPNGQLK Q06B76_DICLA 189 45 -
LEKVPVTNGQLK BDNF_CYPCA 190 45 -
LEKVPVPKGQLK Q8QG74_9SAUR 166 45 -
MEKVPVPNGQLK BDNF_XIPMA 189 45 -

Motif 5 width=10
Element Seqn Id St Int Rpt
CSTKGYAKEG Q8QG74_9SAUR 185 7 -
CNPMGYTKEG A2AII2_MOUSE 196 7 -
CNPMGYTKEG Q8CCH9_MOUSE 188 7 -
CNPMGYTKEG Q6YNR3_HUMAN 194 7 -
CNPMGYTKEG Q6YNR2_HUMAN 201 7 -
CNPMGYTKEG Q598Q1_HUMAN 186 7 -
CNPMGYTKEG Q541P3_MOUSE 188 7 -
CNPMGYTKEG BDNF_URSML 186 7 -
CNPMGYTKEG BDNF_URSAR 186 7 -
CNPMGYTKEG BDNF_SPECI 186 7 -
CNPMGYTKEG BDNF_SELTH 186 7 -
CNPMGYTKEG BDNF_RAT 188 7 -
CNPMGYTKEG BDNF_PROLO 186 7 -
CNPMGYTKEG BDNF_PIG 191 7 -
CNPMGYTKEG BDNF_PANTR 186 7 -
CNPMGYTKEG BDNF_MOUSE 188 7 -
CNPMGYTKEG BDNF_HUMAN 186 7 -
CNPMGYTKEG BDNF_FELCA 186 7 -
CNPMGYTKEG BDNF_CANFA 186 7 -
CNPMGYTKEG BDNF_BOVIN 189 7 -
CNPMGYTKEG BDNF_AILME 186 7 -
CNPMGYTKEG BDNF_AILFU 186 7 -
CNPMGYTKEG A7LA92_HUMAN 268 7 -
CNPMGYTKEG A7LA85_HUMAN 215 7 -
CNPMGYTKEG O70183 194 7 -
CNPMGYTKEG BDNF_HORSE 186 7 -
CNPMGYTKEG Q8VHH4_MOUSE 188 7 -
CNPMGYTKEG Q6DN19_HUMAN 186 7 -
CNPMGYTKEG BDNF_LIPVE 187 7 -
CNPKGYTKEG BDNF_CHICK 185 7 -
CNPKGYTKEG Q8AV78_NIPNI 185 7 -
CNPKGYTKEG Q4JHT7_POEGU 185 7 -
CNPMGYMKEG A4L7M3_BOMOR 186 7 -
CNPMGYMKEG Q63ZM5_XENLA 186 7 -
CNPMGYMKEG A3FPG9_XENTR 186 7 -
CNSKGYTKEG Q8QG75_9SAUR 185 7 -
CNSKGYTKEG Q8QG76_9SAUR 185 7 -
CNPMGYMKEG A4L7M4_9SALA 186 7 -
CNPMGYMKEG A4L7M5_SALSL 186 7 -
CNPMGYMKEG A2ICR4_AMBME 186 7 -
RNPMGYMKEG Q8QG77_9SALA 186 7 -
CNPLGYTKEG Q6NZ01_DANRE 209 7 -
CNPLGYTKEG Q9YH42_DANRE 209 7 -
CNPMGYTKEG Q8JGW4_PAROL 208 7 -
CNPMGYTKEG Q06B76_DICLA 208 7 -
CNPLGYTKEG BDNF_CYPCA 209 7 -
CNPMGYTKDG BDNF_XIPMA 208 7 -