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PR01833

Identifier
VEGFRECEPTR1  [View Relations]  [View Alignment]  
Accession
PR01833
No. of Motifs
7
Creation Date
13-FEB-2003
Title
Vascular endothelial growth factor receptor type 1 signature
Database References
PRINTS; PR01832 VEGFRECEPTOR
PDB; 1QSV
SCOP; 1QSV
CATH; 1QSV
Literature References
1. CONNOLLY, D.T., HEUVELMAN, D.M., NELSON, R., OLANDER, J.V., EPPLEY, B.L.,
DELFINO, J.J., SIEGEL, N.R., LEIMGRUBER, R.M. AND FEDER, J.
Tumor vascular permeability factor stimulates endothelial cell growth and
angiogenesis.
J.CLIN.INVEST. 84 1470-1478 (1989).
 
2. AIELLO, L.P., AVERY, R.L., ARRIGG, P.G., KEYT, B.A., JAMPEL, H.D., 
SHAH, S.T., PASQUALE, L.R.,THIEME, H., IWAMOTO, M.A. AND  PARK, J.E.
Vascular endothelial growth factor in ocular fluid of patients with diabetic
retinopathy and other retinal disorders.
N.ENGL.J.MED. 331 1480-1487 (1994).
 
3. MUSTONEN, T. AND ALITALO, K.
Endothelial receptor tyrosine kinases involved in angiogenesis.
J.CELL.BIOL. 129 895-898 (1995).

Documentation
Vascular endothelial growth factor (VEGF) is a potent and specific
endothelial cell mitogen [1]. Through binding with its receptor, VEGFR, VEGF
has critical roles in the growth and maintenance of vascular endothelial
cells and in the development of new blood- and lymphatic-vessels in
physiological and pathological states [2]. The vessel systems are important 
for the supply of oxygen and nutrients to all tissues of the body, as well
as for the drainage of excess fluids with waste metabolites from peripheral
tissues. VEGF receptors have a characteristic structure, with 7 Ig-like
domains in the extracellular domain and a cytoplasmic tyrosine kinase domain
with a long kinase insert region.
 
The VEGF receptor family consists of three members, VEGFR-1 (Flt-1), VEGFR-2
(KDR/Flk-1) and VEGFR-3 (Flt-4), all of which belong to the receptor type
tyrosine kinase superfamily [3]. Among these receptors, VEGFR-1 binds
strongest to VEGF, VEGF-2 binds more weakly, and VEGFR-3 shows essentially
no binding, although it does bind to other members of the VEGF family.
 
The tyrosine kinase domain of VEGFR-1, although much weaker than that of
VEGFR-2, tranduces signals for endothelial cells. A null mutation of VEGFR-1
in mice results in lethality in early embryogenesis, owing to a
disorganisation of blood vessels and an overgrowth of endothelial-like cells.
 
VEGFRECEPTR1 is a 7-element fingerprint that provides a signature for the
type 1 vascular endothelial growth factor receptors. The fingerprint was
derived from an initial alignment of 3 sequences: the motifs were drawn from
conserved regions spanning the N-terminal half of the extracellular domain,
focusing on those sections that characterise the VEGFR1 subtypes, but 
distinguish them from the rest of the VEGFR family - motif 2 lies in the 
first Ig domain; motif 3 spans beta-strands 1 and 2; motif 5 residues in the
third Ig domain; and motif 7 lies in the fourth Ig domain. Two iterations on
SPTR40_20f were required to reach convergence, at which point a true set 
comprising 7 sequences was identified.
Summary Information
7 codes involving  7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
77777777
60000000
50000000
40000000
30000000
20000000
1234567
True Positives
O55095        Q12954        Q9DAV2        Q9JJ08        
VEGR_RAT VGR1_HUMAN VGR1_MOUSE
Sequence Titles
O55095      SFLT-1 (FLT-1 PROTEIN) - Mus musculus (Mouse). 
Q12954 SOLUBLE VASCULAR ENDOTHELIAL CELL GROWTH FACTOR RECEPTOR - Homo sapiens (Human).
Q9DAV2 FMS-LIKE TYROSINE KINASE 1 - Mus musculus (Mouse).
Q9JJ08 SOLUBLE FLT-1 - Rattus norvegicus (Rat).
VEGR_RAT VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 PRECURSOR (EC 2.7.1.112) (VEGFR-1) (TYROSINE-PROTEIN KINASE RECEPTOR FLT) (FLT-1) - RATTUS NORVEGICUS (RAT).
VGR1_HUMAN Vascular endothelial growth factor receptor 1 precursor (EC 2.7.1.112) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Tyrosine- protein kinase FRT) - Homo sapiens (Human).
VGR1_MOUSE Vascular endothelial growth factor receptor 1 precursor (EC 2.7.1.112) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2) - Mus musculus (Mouse).
Scan History
SPTR40_20f 2  150  NSINGLE    
Initial Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
GSKLKVPELSLKGTQH VGR1_MOUSE 26 26 -
GSKLKGPELSLKGTQH VEGR_RAT 26 26 -
GSKLKDPELSLKGTQH VGR1_HUMAN 26 26 -

Motif 2 width=15
Element Seqn Id St Int Rpt
SACGRDNRQFCSTLT VGR1_MOUSE 80 38 -
SACGRNNRQFCSTLT VEGR_RAT 79 37 -
SACGRNGKQFCSTLT VGR1_HUMAN 79 37 -

Motif 3 width=26
Element Seqn Id St Int Rpt
DAGSPFIEMHTDIPKLVHMTEGRQLI VGR1_MOUSE 131 36 -
DAGSPFIEMHSDIPKLVHMTEGRELI VEGR_RAT 130 36 -
DTGRPFVEMYSEIPEIIHMTEGRELV VGR1_HUMAN 130 36 -

Motif 4 width=24
Element Seqn Id St Int Rpt
RQTNTILDVQIRPPSPVRLLHGQT VGR1_MOUSE 225 68 -
RQTNTILDVQISPPSPVRFLRGQT VEGR_RAT 224 68 -
RQTNTIIDVQISTPRPVKLLRGHT VGR1_HUMAN 224 68 -

Motif 5 width=18
Element Seqn Id St Int Rpt
TKRASIRQRIDRSHSHNN VGR1_MOUSE 274 25 -
TKRASIRQRIDQSNPHSN VEGR_RAT 273 25 -
NKRASVRRRIDQSNSHAN VGR1_HUMAN 273 25 -

Motif 6 width=21
Element Seqn Id St Int Rpt
RRSYRLSMKVKAFPSPEIVWL VGR1_MOUSE 351 59 -
KRSHRLSMKVKAFPSPEVVWL VEGR_RAT 350 59 -
KRSYRLSMKVKAFPSPEVVWL VGR1_HUMAN 350 59 -

Motif 7 width=15
Element Seqn Id St Int Rpt
PATLKSARYLVHGYS VGR1_MOUSE 376 4 -
PATEKSARYSVHGYS VEGR_RAT 375 4 -
PATEKSARYLTRGYS VGR1_HUMAN 375 4 -
Final Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
GSKLKVPELSLKGTQH O55095 26 26 -
GSKLKVPELSLKGTQH Q9DAV2 26 26 -
GSKLKVPELSLKGTQH VGR1_MOUSE 26 26 -
GSKLKGPELSLKGTQH Q9JJ08 26 26 -
GSKLKGPELSLKGTQH VEGR_RAT 26 26 -
GSKLKDPELSLKGTQH Q12954 26 26 -
GSKLKDPELSLKGTQH VGR1_HUMAN 26 26 -

Motif 2 width=15
Element Seqn Id St Int Rpt
SACGRDNRQFCSTLT O55095 80 38 -
SACGRDNRQFCSTLT Q9DAV2 80 38 -
SACGRDNRQFCSTLT VGR1_MOUSE 80 38 -
SACGRNNRQFCSTLT Q9JJ08 79 37 -
SACGRNNRQFCSTLT VEGR_RAT 79 37 -
SACGRNGKQFCSTLT Q12954 79 37 -
SACGRNGKQFCSTLT VGR1_HUMAN 79 37 -

Motif 3 width=26
Element Seqn Id St Int Rpt
DAGSPFIEMHTDIPKLVHMTEGRQLI O55095 131 36 -
DAGSPFIEMHTDIPKLVHMTEGRQLI Q9DAV2 131 36 -
DAGSPFIEMHTDIPKLVHMTEGRQLI VGR1_MOUSE 131 36 -
DAGSPFIEMHSDIPKLVHMTEGRELI Q9JJ08 130 36 -
DAGSPFIEMHSDIPKLVHMTEGRELI VEGR_RAT 130 36 -
DTGRPFVEMYSEIPEIIHMTEGRELV Q12954 130 36 -
DTGRPFVEMYSEIPEIIHMTEGRELV VGR1_HUMAN 130 36 -

Motif 4 width=24
Element Seqn Id St Int Rpt
RQTNTILDVQIRPPSPVRLLHGQT O55095 225 68 -
RQTNTILDVQIRPPSPVRLLHGQT Q9DAV2 225 68 -
RQTNTILDVQIRPPSPVRLLHGQT VGR1_MOUSE 225 68 -
RQTNTILDVQISPPSPVRFLRGQT Q9JJ08 224 68 -
RQTNTILDVQISPPSPVRFLRGQT VEGR_RAT 224 68 -
RQTNTIIDVQISTPRPVKLLRGHT Q12954 224 68 -
RQTNTIIDVQISTPRPVKLLRGHT VGR1_HUMAN 224 68 -

Motif 5 width=18
Element Seqn Id St Int Rpt
TKRASIRQRIDRSHSHNN O55095 274 25 -
TKRASIRQRIDRSHSHNN Q9DAV2 274 25 -
TKRASIRQRIDRSHSHNN VGR1_MOUSE 274 25 -
TKRASIRQRIDQSNPHSN Q9JJ08 273 25 -
TKRASIRQRIDQSNPHSN VEGR_RAT 273 25 -
NKRASVRRRIDQSNSHAN Q12954 273 25 -
NKRASVRRRIDQSNSHAN VGR1_HUMAN 273 25 -

Motif 6 width=21
Element Seqn Id St Int Rpt
RRSYRLSMKVKAFPSPEIVWL O55095 351 59 -
RRSYRLSMKVKAFPSPEIVWL Q9DAV2 351 59 -
RRSYRLSMKVKAFPSPEIVWL VGR1_MOUSE 351 59 -
KRSHRLSMKVKAFPSPEVVWL Q9JJ08 350 59 -
KRSHRLSMKVKAFPSPEVVWL VEGR_RAT 350 59 -
KRSYRLSMKVKAFPSPEVVWL Q12954 350 59 -
KRSYRLSMKVKAFPSPEVVWL VGR1_HUMAN 350 59 -

Motif 7 width=15
Element Seqn Id St Int Rpt
PATLKSARYLVHGYS O55095 376 4 -
PATLKSARYLVHGYS Q9DAV2 376 4 -
PATLKSARYLVHGYS VGR1_MOUSE 376 4 -
PATEKSARYSVHGYS Q9JJ08 375 4 -
PATEKSARYSVHGYS VEGR_RAT 375 4 -
PATEKSARYLTRGYS Q12954 375 4 -
PATEKSARYLTRGYS VGR1_HUMAN 375 4 -