SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR01815

Identifier
BACEFAMILY  [View Relations]  [View Alignment]  
Accession
PR01815
No. of Motifs
7
Creation Date
17-DEC-2002  (UPDATE 12-APR-2009)
Title
Beta-site APP cleaving enzyme (BACE) family signature
Database References
PRINTS; PR00792 PEPSIN; PR01816 BACE1; PR01817 BACE2
Literature References
1. GLENNER, G. AND WONG, C.
Alzheimer's disease: initial report of the purification and characterization
of a novel cerebrovascular amyloid protein.
BIOCHEM.BIOPHYS.RES.COMMUN. 120 885-890 (1984).
 
2. KANG, J., LEMAIRE, H., UNTERBECK, A., SALBAUM, J., MASTERS, C., 
GRZESCHIK, K., MULTHAUP, G., BEYREUTHER, K. AND MULLER-HILL, B.
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-
surface receptor.
NATURE 325 733-736 (1987).
 
3. VASSAR, R., BENNETT, B., BABU-KAHN, S., KAHN, S., MENDIAZ, E., DENIS, P.,
TEPLOW, D., ROSS, S., AMARANTE, P., LOELOFF, R., LUO, Y., FISHER, S., 
FULLER, J., EDENSON, S., LILE, J., JAROSINSKI, M., BIERE, A., CURRAN, E., 
BURGESS, T., LOUIS, J., COLLINS, F., TREANOR, J., ROGERS, G. AND CITRON, M.
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the 
transmembrane aspartic protease BACE.
SCIENCE 286 735-741 (1999).
 
4. HUSSAIN, I., POWELL, D., HOWLETT, D., TEW, D., MEEK, T., CHAPMAN, C., 
GLOGER, I., MURPHY, K., SOUTHAN C., RYAN, D., SMITH, T., SIMMONS, D., 
WALSH, F., DINGWALL, C. AND CHRISTIE, G.
Identification of a novel aspartic protease (Asp 2) as beta-secretase.
MOL.CELL.NEUROSCI. 14 419-427 (1999).
 
5. YAN, R., BIENKOWSKI, M., SHUCK, M., MIAO, H., TORY, M., PAULEY, A., 
BRASHIER, J., STRATMAN, N., MATHEWS, W., BUHL, A., CARTER, D.,
TOMASSELLI, A., PARODI, L., HEINRIKSON, R. AND GURNEY, M.
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase 
activity.
NATURE 402 533-537 (1999).
 
6. CITRON, M.
Beta-secretase as a target for the treatment of Alzheimer's disease.
J.NEUROSCI.RES. 70 373-379 (2002).

Documentation
One of the major neuropathological hallmarks of Alzheimer's disease (AD)
is the progressive formation in the brain of insoluble amyloid plaques and 
vascular deposits consisting of beta-amyloid protein (beta-APP) [1].
Production of beta-APP requires proteolytic cleavage of the large type-1 
transmembrane (TM) protein amyloid precursor protein (APP) [2]. This process
is performed by a variety of enzymes known as secretases. To initiate 
beta-APP formation, beta-secretase cleaves APP to release a soluble 
N-terminal fragment (APPsBeta) and a C-terminal fragment that remains 
membrane bound. This fragment is subsequently cleaved by gamma-secretase 
to liberate beta-APP.
 
Several independent studies identified a novel TM aspartic protease as the
major beta-secretase [3,4,5]. This protein, termed beta-site APP cleaving
enzyme 1 (BACE1), shares 64% amino acid sequence similarity with a second
enzyme, termed BACE2. Together, BACE1 and BACE2 define a novel family of 
aspartyl proteases [6]. Both enzymes share significant sequence similarity
with other members of the pepsin family of aspartyl proteases and contain 
the two characteristic D(T/S)G(T/S) motifs that form the catalytic site.
However, by contrast with other aspartyl proteases, BACE1 and BACE2 are
type I TM proteins. Each protein comprises a large lumenal domain containing
the active centre, a single TM domain and a small cytoplasmic tail.
 
BACEFAMILY is a 7-element fingerprint that provides a signature for the 
beta-site APP cleaving enzyme (BACE) family. The fingerprint was derived 
from an initial alignment of 19 sequences: the motifs were drawn from 
conserved regions spanning virtually the full alignment length, focusing on
those regions that characterise the BACE family but distinguish it from
closely related proteases. Three iterations on SPTR55_38f were required to
reach convergence, at which point a true set comprising 22 sequences was
identified. Five partial matches were also found, all of which are BACE
family homologues that fail to make signficant matches with one or more
motifs.
Summary Information
  22 codes involving  7 elements
1 codes involving 6 elements
3 codes involving 5 elements
1 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
722222222222222
61101111
52232222
41111000
30000000
20000000
1234567
True Positives
A0M8W7_HUMAN  A8K7P1_HUMAN  BACE1_BOVIN   BACE1_CAVPO   
BACE_HUMAN BACE_MOUSE BACE_RAT BAE2_HUMAN
Q0P4T5_XENTR Q3TNS7_MOUSE Q6IE75_RAT Q6NZT7_DANRE
Q6PB20_XENLA Q7T0Y2_XENLA Q8BQY4_MOUSE Q8C5E9_MOUSE
Q8C793_MOUSE Q8C7R1_MOUSE Q8IYC8_HUMAN Q8N2D4_HUMAN
Q9H2V8 Q9JL18
True Positive Partials
Codes involving 6 elements
Q8C4F4_MOUSE
Codes involving 5 elements
Q9CUU5_MOUSE Q9NZL1 Q9NZL2
Codes involving 4 elements
Q5XJ89_DANRE
Sequence Titles
A0M8W7_HUMAN Beta-site APP-cleaving enzyme 1 (Beta-site APP-cleaving enzyme 1, isoform CRA_d) - Homo sapiens (Human). 
A8K7P1_HUMAN cDNA FLJ77581, highly similar to Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA (Beta-site APP-cleaving enzyme 2, isoform CRA_c) - Homo sapiens (Human).
BACE1_BOVIN Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) - Bos taurus (Bovine).
BACE1_CAVPO Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) - Cavia porcellus (Guinea pig).
BACE_HUMAN Beta-secretase precursor (EC 3.4.23.-) (Beta-site APP cleaving enzyme) (Beta-site amyloid precursor protein cleaving enzyme) (Aspartyl protease 2) (Asp 2) (ASP2) (Membrane-associated aspartic protease 2) (Memapsin-2) - Homo sapiens (Human).
BACE_MOUSE Beta-secretase precursor (EC 3.4.23.-) (Beta-site APP cleaving enzyme) (Beta-site amyloid precursor protein cleaving enzyme) (Aspartyl protease 2) (Asp 2) (ASP2) (Membrane-associated aspartic protease 2) (Memapsin-2) - Mus musculus (Mouse).
BACE_RAT Beta-secretase precursor (EC 3.4.23.-) (Beta-site APP cleaving enzyme) (Beta-site amyloid precursor protein cleaving enzyme) (Aspartyl protease 2) (Asp 2) (ASP2) (Membrane-associated aspartic protease 2) (Memapsin-2) - Rattus norvegicus (Rat).
BAE2_HUMAN Beta secretase 2 precursor (EC 3.4.23.-) (Beta-site APP-cleaving enzyme 2) (Aspartyl protease 1) (Asp 1) (ASP1) (Membrane-associated aspartic protease 1) (Memapsin-1) - Homo sapiens (Human).
Q0P4T5_XENTR Beta-site APP-cleaving enzyme 1 - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Q3TNS7_MOUSE 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130311K05 product:beta-site APP-cleaving enzyme 2, full insert sequence - Mus musculus (Mouse).
Q6IE75_RAT Beta-site APP-cleaving enzyme 2 (EC 3.4.23.45) - Rattus norvegicus (Rat).
Q6NZT7_DANRE Zgc:77409 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q6PB20_XENLA MGC68482 protein - Xenopus laevis (African clawed frog).
Q7T0Y2_XENLA Bace2-prov protein - Xenopus laevis (African clawed frog).
Q8BQY4_MOUSE Adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230346M13 product:beta-site APP cleaving enzyme, full insert sequence - Mus musculus (Mouse).
Q8C5E9_MOUSE 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030470O09 product:beta-site APP-cleaving enzyme 2, full insert sequence - Mus musculus (Mouse).
Q8C793_MOUSE 13 days embryo heart cDNA, RIKEN full-length enriched library, clone:D330025D14 product:beta-site APP-cleaving enzyme 2, full insert sequence - Mus musculus (Mouse).
Q8C7R1_MOUSE 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530008K17 product:beta-site APP cleaving enzyme, full insert sequence - Mus musculus (Mouse).
Q8IYC8_HUMAN Beta-site APP-cleaving enzyme 1 - Homo sapiens (Human).
Q8N2D4_HUMAN cDNA PSEC0239 fis, clone OVARC1000363, highly similar to Homo sapiens aspartyl protease mRNA - Homo sapiens (Human).
Q9H2V8 CDA13 - Homo sapiens (Human).
Q9JL18 ASPARTYL PROTEASE 1 - Mus musculus (Mouse).

Q8C4F4_MOUSE 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230037E16 product:beta-site APP cleaving enzyme, full insert sequence - Mus musculus (Mouse).

Q9CUU5_MOUSE Adult male brain cDNA, RIKEN full-length enriched library, clone:3526402A15 product:beta-site APP cleaving enzyme, full insert sequence - Mus musculus (Mouse).
Q9NZL1 ASPARTYL PROTEASE - Homo sapiens (Human).
Q9NZL2 ASPARTYL PROTEASE - Homo sapiens (Human).

Q5XJ89_DANRE Zgc:103530 - Danio rerio (Zebrafish) (Brachydanio rerio).
Scan History
SPTR55_38f 3  100  NSINGLE    
Initial Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
FAVGAAPHPFLHRYYQRQLSSTY A0M8W7_HUMAN 99 99 -
FAVGAAPHPFLHRYYQRQLSSTY Q8C7R1_MOUSE 99 99 -
FAVGAAPHPFLHRYYQRQLSSTY Q8BQY4_MOUSE 99 99 -
FAVGAAPHPFLHRYYQRQLSSTY BACE_RAT 99 99 -
FAVGAAPHPFLHRYYQRQLSSTY BACE_MOUSE 99 99 -
FAVGAAPHPFLHRYYQRQLSSTY BACE_HUMAN 99 99 -
FAVGAAPHPFLHRYYQRQLSSTY BACE1_BOVIN 99 99 -
FAVGAAPHPFLHRYYQRQLFSTY Q8IYC8_HUMAN 99 99 -
FAVAGAPHSYIDTYFDSESSSTY Q6IE75_RAT 112 112 -
FAVAGAPHSYIDTYFDSESSSTY Q3TNS7_MOUSE 112 112 -
FAVAGAPHSYIDTYFDSESSSTY Q9JL18 112 112 -
FAVAGAPHSYIDTYFDSESSSTY Q8C5E9_MOUSE 112 112 -
FAVAGAPHSYIDTYFDSESSSTY Q8C793_MOUSE 112 112 -
FAVAGTPHSYIDTYFDTERSSTY A8K7P1_HUMAN 116 116 -
FAVAGTPHSYIDTYFDTERSSTY BAE2_HUMAN 116 116 -
FAVGAAPHPFLKRYYHRQHSRTY Q0P4T5_XENTR 100 100 -
FAVGAAAHPFLHRYYHRSLSSSY Q6NZT7_DANRE 104 104 -
FAVAGSPNPDVNTFFDSKLSTSY Q7T0Y2_XENLA 100 100 -
FAVAGSPNPDVKTFYDSKLSTSY Q6PB20_XENLA 99 99 -

Motif 2 width=24
Element Seqn Id St Int Rpt
SIPHGPNVTVRANIAAITESDKFF A0M8W7_HUMAN 147 25 -
SIPHGPNVTVRANIAAITESDKFF Q8C7R1_MOUSE 147 25 -
SIPHGPNVTVRANIAAITESDKFF Q8BQY4_MOUSE 147 25 -
SIPHGPNVTVRANIAAITESDKFF BACE_RAT 147 25 -
SIPHGPNVTVRANIAAITESDKFF BACE_MOUSE 147 25 -
SIPHGPNVTVRANIAAITESDKFF BACE_HUMAN 147 25 -
SIPHGPNVTVRANIAAITESDKFF BACE1_BOVIN 147 25 -
SIPHGPNVTVRANIAAITESDKFF Q8IYC8_HUMAN 147 25 -
TIPKGFNSSFLVNIATIFESENFF Q6IE75_RAT 160 25 -
TIPKGFNSSFLVNIATIFESENFF Q3TNS7_MOUSE 160 25 -
TIPKGFNSSFLVNIATIFESENFF Q9JL18 160 25 -
TIPKGFNSSFLVNIATIFESENFF Q8C5E9_MOUSE 160 25 -
TIPKGFNSSFLVNIATIFESENFF Q8C793_MOUSE 160 25 -
TIPKGFNTSFLVNIATIFESENFF A8K7P1_HUMAN 164 25 -
TIPKGFNTSFLVNIATIFESENFF BAE2_HUMAN 164 25 -
TIPHGPNVTVTANIAAITDSDKFF Q0P4T5_XENTR 148 25 -
SVPCGPNVSLRANIAAITQSDRFF Q6NZT7_DANRE 152 25 -
SIPKGVNGTFLINIASIFQSESFF Q7T0Y2_XENLA 148 25 -
SMPKGVNGTFLINIASILQSDNFF Q6PB20_XENLA 147 25 -

Motif 3 width=20
Element Seqn Id St Int Rpt
EINGQDLKMDCKEYNYDKSI A0M8W7_HUMAN 268 97 -
EINGQDLKMDCKEYNYDKSI Q8C7R1_MOUSE 268 97 -
EINGQDLKMDCKEYNYDKSI Q8BQY4_MOUSE 268 97 -
EINGQDLKMDCKEYNYDKSI BACE_RAT 268 97 -
EINGQDLKMDCKEYNYDKSI BACE_MOUSE 268 97 -
EINGQDLKMDCKEYNYDKSI BACE_HUMAN 268 97 -
EINGQDLKMDCKEYNYDKSI BACE1_BOVIN 268 97 -
EINGQDLKMDCKEYNYDKSI Q8IYC8_HUMAN 268 97 -
EIGGQSLNLDCREYNADKAI Q6IE75_RAT 278 94 -
EIGGQNLNLDCREYNADKAI Q3TNS7_MOUSE 278 94 -
EIGGQNLNLDCREYNADKAI Q9JL18 278 94 -
EIGGQNLNLDCREYNADKAI Q8C5E9_MOUSE 278 94 -
EIGGQNLNLDCREYNADKAI Q8C793_MOUSE 278 94 -
EIGGQSLNLDCREYNADKAI A8K7P1_HUMAN 282 94 -
EIGGQSLNLDCREYNADKAI BAE2_HUMAN 282 94 -
EINGQDLHMDCKEYNYDKSI Q0P4T5_XENTR 269 97 -
EVNGQDLNMDCKEYNYDKSI Q6NZT7_DANRE 274 98 -
EVGGQRLNLDCTVYNSDKAI Q7T0Y2_XENLA 266 94 -
EVGGQNLNLDCTVYNSDKAI Q6PB20_XENLA 265 94 -

Motif 4 width=24
Element Seqn Id St Int Rpt
FPDGFWLGEQLVCWQAGTTPWNIF A0M8W7_HUMAN 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF Q8C7R1_MOUSE 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF Q8BQY4_MOUSE 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF BACE_RAT 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF BACE_MOUSE 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF BACE_HUMAN 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF BACE1_BOVIN 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF Q8IYC8_HUMAN 318 30 -
FSDGFWTGAQLACWTNSETPWAYF Q6IE75_RAT 328 30 -
FSDGFWTGAQLACWTNSETPWAYF Q3TNS7_MOUSE 328 30 -
FSDGFWTGAQLACWTNSETPWAYF Q9JL18 328 30 -
FSDGFWTGAQLACWTNSETPWAYF Q8C5E9_MOUSE 328 30 -
FSDGFWTGAQLACWTNSETPWAYF Q8C793_MOUSE 328 30 -
FSDGFWTGSQLACWTNSETPWSYF A8K7P1_HUMAN 332 30 -
FSDGFWTGSQLACWTNSETPWSYF BAE2_HUMAN 332 30 -
FPDGFWLGEQLVCWQEGTTPWHIF Q0P4T5_XENTR 319 30 -
FPSGFWLGEQLVCWQAGTTPWHIF Q6NZT7_DANRE 324 30 -
FNAEFWAGLQLACWDKTQQPWNYF Q7T0Y2_XENLA 316 30 -
FNAEFWAGLQLACWDKTQQPWNYF Q6PB20_XENLA 315 30 -

Motif 5 width=15
Element Seqn Id St Int Rpt
SFRITILPQQYLRPV A0M8W7_HUMAN 356 14 -
SFRITILPQQYLRPV Q8C7R1_MOUSE 356 14 -
SFRITILPQQYLRPV Q8BQY4_MOUSE 356 14 -
SFRITILPQQYLRPV BACE_RAT 356 14 -
SFRITILPQQYLRPV BACE_MOUSE 356 14 -
SFRITILPQQYLRPV BACE_HUMAN 356 14 -
SFRITILPQQYLRPV BACE1_BOVIN 356 14 -
SFRITILPQQYLRPV Q8IYC8_HUMAN 356 14 -
SFRITILPQLYIQPM Q6IE75_RAT 366 14 -
SFRITILPQLYIQPM Q3TNS7_MOUSE 366 14 -
SFRITILPQLYIQPM Q9JL18 366 14 -
SFRITILPQLYIQPM Q8C5E9_MOUSE 366 14 -
SFRTTILPQLYIQPM Q8C793_MOUSE 366 14 -
SFRITILPQLYIQPM A8K7P1_HUMAN 370 14 -
SFRITILPQLYIQPM BAE2_HUMAN 370 14 -
SFKITILPQQYLRPV Q0P4T5_XENTR 357 14 -
SFRISILPQQYLRPV Q6NZT7_DANRE 362 14 -
SFRLTLKPQLYIQSV Q7T0Y2_XENLA 354 14 -
SFRLTLKPQLYIQSV Q6PB20_XENLA 353 14 -

Motif 6 width=24
Element Seqn Id St Int Rpt
AVSACHVHDEFRTAAVEGPFVTLD A0M8W7_HUMAN 416 45 -
AVSACHVHDEFRTAAVEGPFVTAD Q8C7R1_MOUSE 416 45 -
AVSACHVHDEFRTAAVEGPFVTAD Q8BQY4_MOUSE 416 45 -
AVSACHVHDEFRTAAVEGPFVTAD BACE_RAT 416 45 -
AVSACHVHDEFRTAAVEGPFVTAD BACE_MOUSE 416 45 -
AVSACHVHDEFRTAAVEGPFVTLD BACE_HUMAN 416 45 -
AVSACHVHDEFRTAAVEGPFVTPD BACE1_BOVIN 416 45 -
AVSACHVHDEFRTAAVEGPFVTLD Q8IYC8_HUMAN 416 45 -
AVSPCAEIAGTTVSEISGPFSTED Q6IE75_RAT 425 44 -
AVSPCAEIEGTTVSEISGPFSTED Q3TNS7_MOUSE 425 44 -
AVSPCAEIEGTTVSEISGPFSTED Q9JL18 425 44 -
AVSPCAEIEGTTVSEISGPFSTED Q8C5E9_MOUSE 425 44 -
AVSPCAEIEGTTVSEISGPFSTED Q8C793_MOUSE 425 44 -
AASPCAEIAGAAVSEISGPFSTED A8K7P1_HUMAN 429 44 -
AASPCAEIAGAAVSEISGPFSTED BAE2_HUMAN 429 44 -
AVSTCHVHDYFRTASVEGPFFASD Q0P4T5_XENTR 417 45 -
AVSTCHVHDEFRTAAVEGPFHGLD Q6NZT7_DANRE 422 45 -
AVSSCAEVSGITVSEIAGPFGTSD Q7T0Y2_XENLA 413 44 -
AVSSCAEVSGITVSEIAGPFGTSD Q6PB20_XENLA 412 44 -

Motif 7 width=22
Element Seqn Id St Int Rpt
ESTLMTIAYVMAAICALFMLPL A0M8W7_HUMAN 452 12 -
ESTLMTIAYVMAAICALFMLPL Q8C7R1_MOUSE 452 12 -
ESTLMTIAYVMAAICALFMLPL Q8BQY4_MOUSE 452 12 -
ESTLMTIAYVMAAICALFMLPL BACE_RAT 452 12 -
ESTLMTIAYVMAAICALFMLPL BACE_MOUSE 452 12 -
ESTLMTIAYVMAAICALFMLPL BACE_HUMAN 452 12 -
ESTLMTIAYVMAAICALFMLPL BACE1_BOVIN 452 12 -
ESTLMTIAYVMAAICALFMLPL Q8IYC8_HUMAN 452 12 -
EPILWIVSYALMSVCGAILLVL Q6IE75_RAT 461 12 -
EPILWIVSYALMSVCGAILLVL Q3TNS7_MOUSE 461 12 -
EPILWIVSYALMSVCGAILLVL Q9JL18 461 12 -
EPILWIVSYALMSVCGAILLVL Q8C5E9_MOUSE 461 12 -
EPILWIVSYALMSVCGAILLVL Q8C793_MOUSE 461 12 -
EPILWIVSYALMSVCGAILLVL A8K7P1_HUMAN 465 12 -
EPILWIVSYALMSVCGAILLVL BAE2_HUMAN 465 12 -
ESALMTTAYVMAGVCALFMLPL Q0P4T5_XENTR 453 12 -
ESTLMTIAYIMAGICALFMLPL Q6NZT7_DANRE 458 12 -
EPIMWIISYSLMSLCGMILLVL Q7T0Y2_XENLA 449 12 -
EPIMWIISYSLMSLCGIILLVL Q6PB20_XENLA 448 12 -
Final Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
FAVGAAPHPFLHRYYQRQLSSTY A0M8W7_HUMAN 99 99 -
FAVGAAPHPFLHRYYQRQLSSTY Q8C7R1_MOUSE 99 99 -
FAVGAAPHPFLHRYYQRQLSSTY Q8BQY4_MOUSE 99 99 -
FAVGAAPHPFLHRYYQRQLSSTY BACE_RAT 99 99 -
FAVGAAPHPFLHRYYQRQLSSTY BACE_MOUSE 99 99 -
FAVGAAPHPFLHRYYQRQLSSTY BACE_HUMAN 99 99 -
FAVGAAPHPFLHRYYQRQLSSTY BACE1_BOVIN 99 99 -
FAVGAAPHPFLHRYYQRQRSSTY BACE1_CAVPO 96 96 -
FAVGAAPHPFLHRYYQRQLFSTY Q8IYC8_HUMAN 99 99 -
FAVAGAPHSYIDTYFDSESSSTY Q6IE75_RAT 112 112 -
FAVAGAPHSYIDTYFDSESSSTY Q3TNS7_MOUSE 112 112 -
FAVAGAPHSYIDTYFDSESSSTY Q9JL18 112 112 -
FAVAGAPHSYIDTYFDSESSSTY Q8C5E9_MOUSE 112 112 -
FAVAGAPHSYIDTYFDSESSSTY Q8C793_MOUSE 112 112 -
FAVAGTPHSYIDTYFDTERSSTY A8K7P1_HUMAN 116 116 -
FAVAGTPHSYIDTYFDTERSSTY Q9H2V8 37 37 -
FAVAGTPHSYIDTYFDTERSSTY BAE2_HUMAN 116 116 -
FAVAGTPHSYIDTYFDTERSSTY Q8N2D4_HUMAN 21 21 -
FAVGAAPHPFLKRYYHRQHSRTY Q0P4T5_XENTR 100 100 -
FAVGAAAHPFLHRYYHRSLSSSY Q6NZT7_DANRE 104 104 -
FAVAGSPNPDVNTFFDSKLSTSY Q7T0Y2_XENLA 100 100 -
FAVAGSPNPDVKTFYDSKLSTSY Q6PB20_XENLA 99 99 -

Motif 2 width=24
Element Seqn Id St Int Rpt
SIPHGPNVTVRANIAAITESDKFF A0M8W7_HUMAN 147 25 -
SIPHGPNVTVRANIAAITESDKFF Q8C7R1_MOUSE 147 25 -
SIPHGPNVTVRANIAAITESDKFF Q8BQY4_MOUSE 147 25 -
SIPHGPNVTVRANIAAITESDKFF BACE_RAT 147 25 -
SIPHGPNVTVRANIAAITESDKFF BACE_MOUSE 147 25 -
SIPHGPNVTVRANIAAITESDKFF BACE_HUMAN 147 25 -
SIPHGPNVTVRANIAAITESDKFF BACE1_BOVIN 147 25 -
SIPHGPNVTVRANIAAITESDKFF BACE1_CAVPO 144 25 -
SIPHGPNVTVRANIAAITESDKFF Q8IYC8_HUMAN 147 25 -
TIPKGFNSSFLVNIATIFESENFF Q6IE75_RAT 160 25 -
TIPKGFNSSFLVNIATIFESENFF Q3TNS7_MOUSE 160 25 -
TIPKGFNSSFLVNIATIFESENFF Q9JL18 160 25 -
TIPKGFNSSFLVNIATIFESENFF Q8C5E9_MOUSE 160 25 -
TIPKGFNSSFLVNIATIFESENFF Q8C793_MOUSE 160 25 -
TIPKGFNTSFLVNIATIFESENFF A8K7P1_HUMAN 164 25 -
TIPKGFNTSFLVNIATIFESENFF Q9H2V8 85 25 -
TIPKGFNTSFLVNIATIFESENFF BAE2_HUMAN 164 25 -
TIPKGFNTSFLVNIATIFESGNFF Q8N2D4_HUMAN 69 25 -
TIPHGPNVTVTANIAAITDSDKFF Q0P4T5_XENTR 148 25 -
SVPCGPNVSLRANIAAITQSDRFF Q6NZT7_DANRE 152 25 -
SIPKGVNGTFLINIASIFQSESFF Q7T0Y2_XENLA 148 25 -
SMPKGVNGTFLINIASILQSDNFF Q6PB20_XENLA 147 25 -

Motif 3 width=20
Element Seqn Id St Int Rpt
EINGQDLKMDCKEYNYDKSI A0M8W7_HUMAN 268 97 -
EINGQDLKMDCKEYNYDKSI Q8C7R1_MOUSE 268 97 -
EINGQDLKMDCKEYNYDKSI Q8BQY4_MOUSE 268 97 -
EINGQDLKMDCKEYNYDKSI BACE_RAT 268 97 -
EINGQDLKMDCKEYNYDKSI BACE_MOUSE 268 97 -
EINGQDLKMDCKEYNYDKSI BACE_HUMAN 268 97 -
EINGQDLKMDCKEYNYDKSI BACE1_BOVIN 268 97 -
EINGQDLKMDCKEYNYDKSI BACE1_CAVPO 240 72 -
EINGQDLKMDCKEYNYDKSI Q8IYC8_HUMAN 268 97 -
EIGGQSLNLDCREYNADKAI Q6IE75_RAT 278 94 -
EIGGQNLNLDCREYNADKAI Q3TNS7_MOUSE 278 94 -
EIGGQNLNLDCREYNADKAI Q9JL18 278 94 -
EIGGQNLNLDCREYNADKAI Q8C5E9_MOUSE 278 94 -
EIGGQNLNLDCREYNADKAI Q8C793_MOUSE 278 94 -
EIGGQSLNLDCREYNADKAI A8K7P1_HUMAN 282 94 -
EIGGQSLNLDCREYNADKAI Q9H2V8 203 94 -
EIGGQSLNLDCREYNADKAI BAE2_HUMAN 282 94 -
EIGGQSLNLDCREYNADKAI Q8N2D4_HUMAN 187 94 -
EINGQDLHMDCKEYNYDKSI Q0P4T5_XENTR 269 97 -
EVNGQDLNMDCKEYNYDKSI Q6NZT7_DANRE 274 98 -
EVGGQRLNLDCTVYNSDKAI Q7T0Y2_XENLA 266 94 -
EVGGQNLNLDCTVYNSDKAI Q6PB20_XENLA 265 94 -

Motif 4 width=24
Element Seqn Id St Int Rpt
FPDGFWLGEQLVCWQAGTTPWNIF A0M8W7_HUMAN 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF Q8C7R1_MOUSE 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF Q8BQY4_MOUSE 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF BACE_RAT 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF BACE_MOUSE 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF BACE_HUMAN 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF BACE1_BOVIN 318 30 -
FPDGFWLGEQLVCWQAGTTPWNIF BACE1_CAVPO 290 30 -
FPDGFWLGEQLVCWQAGTTPWNIF Q8IYC8_HUMAN 318 30 -
FSDGFWTGAQLACWTNSETPWAYF Q6IE75_RAT 328 30 -
FSDGFWTGAQLACWTNSETPWAYF Q3TNS7_MOUSE 328 30 -
FSDGFWTGAQLACWTNSETPWAYF Q9JL18 328 30 -
FSDGFWTGAQLACWTNSETPWAYF Q8C5E9_MOUSE 328 30 -
FSDGFWTGAQLACWTNSETPWAYF Q8C793_MOUSE 328 30 -
FSDGFWTGSQLACWTNSETPWSYF A8K7P1_HUMAN 332 30 -
FSDGFWTGSQLACWTNSETPWSYF Q9H2V8 253 30 -
FSDGFWTGSQLACWTNSETPWSYF BAE2_HUMAN 332 30 -
FSDGFWTGSQLACWTNSETPWSYF Q8N2D4_HUMAN 237 30 -
FPDGFWLGEQLVCWQEGTTPWHIF Q0P4T5_XENTR 319 30 -
FPSGFWLGEQLVCWQAGTTPWHIF Q6NZT7_DANRE 324 30 -
FNAEFWAGLQLACWDKTQQPWNYF Q7T0Y2_XENLA 316 30 -
FNAEFWAGLQLACWDKTQQPWNYF Q6PB20_XENLA 315 30 -

Motif 5 width=15
Element Seqn Id St Int Rpt
SFRITILPQQYLRPV A0M8W7_HUMAN 356 14 -
SFRITILPQQYLRPV Q8C7R1_MOUSE 356 14 -
SFRITILPQQYLRPV Q8BQY4_MOUSE 356 14 -
SFRITILPQQYLRPV BACE_RAT 356 14 -
SFRITILPQQYLRPV BACE_MOUSE 356 14 -
SFRITILPQQYLRPV BACE_HUMAN 356 14 -
SFRITILPQQYLRPV BACE1_BOVIN 356 14 -
SFRITILPQQYLRPV BACE1_CAVPO 328 14 -
SFRITILPQQYLRPV Q8IYC8_HUMAN 356 14 -
SFRITILPQLYIQPM Q6IE75_RAT 366 14 -
SFRITILPQLYIQPM Q3TNS7_MOUSE 366 14 -
SFRITILPQLYIQPM Q9JL18 366 14 -
SFRITILPQLYIQPM Q8C5E9_MOUSE 366 14 -
SFRTTILPQLYIQPM Q8C793_MOUSE 366 14 -
SFRITILPQLYIQPM A8K7P1_HUMAN 370 14 -
SFRITILPQLYIQPM Q9H2V8 291 14 -
SFRITILPQLYIQPM BAE2_HUMAN 370 14 -
SFRITILPQLYIQPM Q8N2D4_HUMAN 275 14 -
SFKITILPQQYLRPV Q0P4T5_XENTR 357 14 -
SFRISILPQQYLRPV Q6NZT7_DANRE 362 14 -
SFRLTLKPQLYIQSV Q7T0Y2_XENLA 354 14 -
SFRLTLKPQLYIQSV Q6PB20_XENLA 353 14 -

Motif 6 width=24
Element Seqn Id St Int Rpt
AVSACHVHDEFRTAAVEGPFVTLD A0M8W7_HUMAN 416 45 -
AVSACHVHDEFRTAAVEGPFVTAD Q8C7R1_MOUSE 416 45 -
AVSACHVHDEFRTAAVEGPFVTAD Q8BQY4_MOUSE 416 45 -
AVSACHVHDEFRTAAVEGPFVTAD BACE_RAT 416 45 -
AVSACHVHDEFRTAAVEGPFVTAD BACE_MOUSE 416 45 -
AVSACHVHDEFRTAAVEGPFVTLD BACE_HUMAN 416 45 -
AVSACHVHDEFRTAAVEGPFVTPD BACE1_BOVIN 416 45 -
AVSACHVHDEFRTATVEGPFVTPD BACE1_CAVPO 388 45 -
AVSACHVHDEFRTAAVEGPFVTLD Q8IYC8_HUMAN 416 45 -
AVSPCAEIAGTTVSEISGPFSTED Q6IE75_RAT 425 44 -
AVSPCAEIEGTTVSEISGPFSTED Q3TNS7_MOUSE 425 44 -
AVSPCAEIEGTTVSEISGPFSTED Q9JL18 425 44 -
AVSPCAEIEGTTVSEISGPFSTED Q8C5E9_MOUSE 425 44 -
AVSPCAEIEGTTVSEISGPFSTED Q8C793_MOUSE 425 44 -
AASPCAEIAGAAVSEISGPFSTED A8K7P1_HUMAN 429 44 -
AASPCAEIAGAAVSEISGPFSTED Q9H2V8 350 44 -
AASPCAEIAGAAVSEISGPFSTED BAE2_HUMAN 429 44 -
AASPCAEIAGAAVSEISGPFSTED Q8N2D4_HUMAN 334 44 -
AVSTCHVHDYFRTASVEGPFFASD Q0P4T5_XENTR 417 45 -
AVSTCHVHDEFRTAAVEGPFHGLD Q6NZT7_DANRE 422 45 -
AVSSCAEVSGITVSEIAGPFGTSD Q7T0Y2_XENLA 413 44 -
AVSSCAEVSGITVSEIAGPFGTSD Q6PB20_XENLA 412 44 -

Motif 7 width=22
Element Seqn Id St Int Rpt
ESTLMTIAYVMAAICALFMLPL A0M8W7_HUMAN 452 12 -
ESTLMTIAYVMAAICALFMLPL Q8C7R1_MOUSE 452 12 -
ESTLMTIAYVMAAICALFMLPL Q8BQY4_MOUSE 452 12 -
ESTLMTIAYVMAAICALFMLPL BACE_RAT 452 12 -
ESTLMTIAYVMAAICALFMLPL BACE_MOUSE 452 12 -
ESTLMTIAYVMAAICALFMLPL BACE_HUMAN 452 12 -
ESTLMTIAYVMAAICALFMLPL BACE1_BOVIN 452 12 -
ESTLMTIAYVMAAICALFMLPL BACE1_CAVPO 424 12 -
ESTLMTIAYVMAAICALFMLPL Q8IYC8_HUMAN 452 12 -
EPILWIVSYALMSVCGAILLVL Q6IE75_RAT 461 12 -
EPILWIVSYALMSVCGAILLVL Q3TNS7_MOUSE 461 12 -
EPILWIVSYALMSVCGAILLVL Q9JL18 461 12 -
EPILWIVSYALMSVCGAILLVL Q8C5E9_MOUSE 461 12 -
EPILWIVSYALMSVCGAILLVL Q8C793_MOUSE 461 12 -
EPILWIVSYALMSVCGAILLVL A8K7P1_HUMAN 465 12 -
EPILWIVSYALMSVCGAILLVL Q9H2V8 386 12 -
EPILWIVSYALMSVCGAILLVL BAE2_HUMAN 465 12 -
EPILWIVSYALMSVCGAILLVL Q8N2D4_HUMAN 370 12 -
ESALMTTAYVMAGVCALFMLPL Q0P4T5_XENTR 453 12 -
ESTLMTIAYIMAGICALFMLPL Q6NZT7_DANRE 458 12 -
EPIMWIISYSLMSLCGMILLVL Q7T0Y2_XENLA 449 12 -
EPIMWIISYSLMSLCGIILLVL Q6PB20_XENLA 448 12 -