| Literature References | 1. BITO, H., DEISSEROTH, K. AND TSIEN, R.
Ca2+-dependent regulation in neuronal gene expression.
CURR.OPIN.NEUROBIOL. 7 419-429 (1997).
2. DUNLAP, K., LEUBKE, J. AND TURNER, T.
Exocytotic calcium channels in mammalian central neurons.
TRENDS NEUROSCI. 18 89-98 (1995).
3. AHLIJANIAN, M., WESTENBROEK, R. AND CATTERALL, W.
Subunit structure and localization of dihydropyridine-sensitive calcium
channels in mammalian brain, spinal cord, and retina.
NEURON 4 819-832 (1990).
4. WITCHER, D., DE WAARD, M., SAKAMOTO, J., FRANZINI-ARMSTRONG, C.,
PRAGNELL, M., KAHL, S. AND CAMPBELL, K.
Subunit identification and reconstitution of the N-type Ca2+ channel complex
purified from brain.
SCIENCE 261 486-489 (1993).
5. BURGESS, D., GEFRIDES, L., FOREMAN, P. AND NOEBELS, J.
A cluster of three novel Ca2+ channel gamma subunit genes on chromosome
19q13.4: evolution and expression profile of the gamma subunit gene family.
GENOMICS 71 339-350 (2001).
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| Documentation | Voltage-dependent calcium channels are a diverse family of proteins that
encompass a variety of biological functions, including presynaptic
neurotransmitter release and protein signalling within the cell [1,2]. The
high voltage-activated (L-, N-, P-, Q- and R-type) channels comprise the
alpha-1 subunit, which creates the pore for the import of extracellular
calcium ions [2]. The activity of this pore is modulated by 4 tightly-
coupled subunits: an intracellular beta subunit; a transmembrane (TM) gamma
subunit; and a disulphide-linked complex of alpha-2 and delta subunits,
which are proteolytically cleaved from the same gene product [3,4].
The voltage-dependent calcium channel gamma (VDCCG) subunit family consists
of at least 8 members, which share a number of common structural features
[5]. Each member is predicted to possess 4 TM domains, with intracellular
N- and C-termini. The first extracellular loop contains a highly conserved
N-glycosylation site and a pair of conserved cysteine residues. The
C-terminal 7 residues of VDCCG-2, -3, -4 and -8 are also conserved and
contain a consensus site for phosphorylation by cAMP and cGMP-dependent
protein kinases, and a target site for binding by PDZ domain proteins [5].
VDCCGAMMA is a 3-element fingerprint that provides a signature for the
voltage-dependent calcium channel gamma subunit proteins. The fingerprint
was derived from an initial alignment of 3 sequences: the motifs were drawn
from conserved regions spanning virtually the full alignment length - motif
1 spans the C-terminus of TM domain 1 and the N-terminus of the first
extracellular loop; motif 2 encodes the C-terminus of TM domain 3 and the N-
terminus of the second extracellular loop; and motif 3 lies partly within
the second extracellular loop and partly within TM domain 4. Three
iterations on SPTR40_20f were required to reach convergence, at which point
a true set comprising 28 sequences was identified. A single partial match
was also found, Q9D563, an uncharacterised translated mouse cDNA that
matches motifs 1 and 3.
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| Sequence Titles | CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit (Dihydropyridine- sensitive L-type, skeletal muscle calcium channel gamma subunit) - Homo sapiens (Human).
CCG1_MOUSE Voltage-dependent calcium channel gamma-1 subunit (Dihydropyridine- sensitive L-type, skeletal muscle calcium channel gamma subunit) - Mus musculus (Mouse).
CCG1_RABIT Voltage-dependent calcium channel gamma-1 subunit (Dihydropyridine- sensitive L-type, skeletal muscle calcium channel gamma subunit) - Oryctolagus cuniculus (Rabbit).
CCG1_RAT Voltage-dependent calcium channel gamma-1 subunit (Dihydropyridine- sensitive L-type, skeletal muscle calcium channel gamma subunit) - Rattus norvegicus (Rat).
CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage- gated calcium channel gamma-2 subunit) - Homo sapiens (Human).
CCG2_MOUSE Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage- gated calcium channel gamma-2 subunit) (Stargazin) - Mus musculus (Mouse).
CCG3_HUMAN Voltage-dependent calcium channel gamma-3 subunit (Neuronal voltage- gated calcium channel gamma-3 subunit) - Homo sapiens (Human).
CCG4_HUMAN Voltage-dependent calcium channel gamma-4 subunit (Neuronal voltage- gated calcium channel gamma-4 subunit) - Homo sapiens (Human).
CCG4_MOUSE Voltage-dependent calcium channel gamma-4 subunit (Neuronal voltage- gated calcium channel gamma-4 subunit) - Mus musculus (Mouse).
CCG5_HUMAN Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage- gated calcium channel gamma-5 subunit) - Homo sapiens (Human).
Q8VBX3 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-7 SUBUNIT - Mus musculus (Mouse), and Rattus norvegicus (Rat).
Q8VHW2 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-8 SUBUNIT - Mus musculus (Mouse).
Q8VHW3 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-6 SUBUNIT - Mus musculus (Mouse).
Q8VHW4 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-5 SUBUNIT - Mus musculus (Mouse).
Q8VHW5 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-8 SUBUNIT - Rattus norvegicus (Rat).
Q8VHW6 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-6 SUBUNIT SHORT ISOFORM - Rattus norvegicus (Rat).
Q8VHW7 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-6 SUBUNIT LONG ISOFORM - Rattus norvegicus (Rat).
Q8VHW8 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-5 SUBUNIT - Rattus norvegicus (Rat).
Q8VHW9 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-4 SUBUNIT - Rattus norvegicus (Rat).
Q8VHX0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-3 SUBUNIT - Rattus norvegicus (Rat).
Q8WXS5 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-8 SUBUNIT - Homo sapiens (Human).
Q8WXS6 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-7 SUBUNIT - Homo sapiens (Human).
Q8WXS7 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-5 SUBUNIT - Homo sapiens (Human).
Q90X18 CALCIUM CHANNEL GAMMA 4 SUBUNIT - Gallus gallus (Chicken).
Q98UH4 IPR328-LIKE PROTEIN - Gallus gallus (Chicken).
Q99PR9 IPR328 PROTEIN - Rattus norvegicus (Rat).
Q9BXT2 CALCIUM CHANNEL GAMMA SUBUNIT 6 (VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-6 SUBUNIT) - Homo sapiens (Human).
Q9JJV5 CALCIUM CHANNEL GAMMA 3 SUBUNIT - Mus musculus (Mouse).
Q9D563 4930511J11RIK PROTEIN - Mus musculus (Mouse).
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