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PR01776

Identifier
HPOMPFAMILY  [View Relations]  [View Alignment]  
Accession
PR01776
No. of Motifs
4
Creation Date
31-JUL-2002  (UPDATE 07-MAR-2003)
Title
Helicobacter pylori outer membrane protein family signature
Database References

PFAM; PF01856 HP_OMP
INTERPRO; IPR002718
Literature References
1. DOIG, P. AND TRUST, T.J.
Identification of surface-exposed outer membrane antigens of Helicobacter
pylori.
INFECT.IMMUN. 62 4526-4533 (1994).
 
2. EXNER, M.M., DOIG, P., TRUST, T.J. AND HANCOCK, R.E.
Isolation and characterization of a family of porin proteins from
Helicobacter pylori.
INFECT.IMMUN. 63 1567-1572 (1995).
 
3. ILVER, D., ARNQVIST, A., OGREN, J., FRICK, I.M., KERSULYTE, D., INCECIK,
E.T., BERG, D.E., COVACCI, A., ENGSTRAND, L. AND BOREN T.
Helicobacter pylori adhesin binding fucosylated histo-blood group antigens
revealed by retagging.
SCIENCE 279 373-377 (1998).
 
4. JIANG, Z., TAO, X.H., HUANG, A.L. AND WANG, P.L.
A study of recombinant protective H.pylori antigens.
WORLD J.GASTROENTEROL. 8 308-311 (2002).

Documentation
Gram-negative bacterial outer membranes constitute a semi-permeable, size-
dependent permeability barrier, for example to hydrolytic enzymes, 
detergents, dyes and hydrophobic anti-microbials. The outer membrane
protein (OMP) profile of Helicobacter pylori (Hp) differs from that of other
Gram-negative bacteria, where the highly non-selective porins are absent and
a number of less abundant protein species are observed [1]. OMPs from Hp 
have been identified as porins, gastric epithelial cell adhesins and Lewis B
binding adhesins [2,3]. Extensive C-terminal sequence similarity between
these OMPs has been used to define a much larger paralogous family.
 
Helicobacter pylori is the causative agent of gastritis and peptic
ulceration in humans. Numerous subtypes of OMPs have been identified in
Hp. Attempts have been made to construct recombinant vectors that are able
to express these OMPs in order to develop a vaccine protecting against
Hp infection and a diagnostic reagent kit to quickly detect Hp infection
[4]. OMPs were chosen as possible targets of vaccine development as they are
Hp specific, surface exposed and highly antigenic.
 
HPOMPFAMILY is a 4-element fingerprint that provides a signature for the
Helicobacter pylori outer membrane protein family. The fingerprint was 
derived from an initial alignment of 6 sequences: the motifs were drawn from
conserved regions spanning the C-terminal portion of the alignment. Six
iterations on SPTR40_20f were required to reach convergence, at which point
a true set comprising 67 sequences was identified. Several partial matches
were also found, all of which are H.pylori hypothetical and putative OMPs
that fail to make significant matches with one or more motifs.
Summary Information
  67 codes involving  4 elements
2 codes involving 3 elements
4 codes involving 2 elements
Composite Feature Index
467676767
32022
20404
1234
True Positives
O24870        O24908        O24941        O25015        
O25034 O25036 O25086 O25222
O25382 O25410 O25481 O25556
O25570 O25571 O25580 O25740
O25771 O25772 O25791 O25840
O25945 O26005 O26031 O32641
O32642 O34523 O51811 O52269
Q93HU0 Q93HU1 Q93HU2 Q9R7I4
Q9S3I7 Q9X745 Q9X746 Q9X747
Q9X748 Q9X749 Q9X750 Q9X751
Q9X752 Q9Z390 Q9ZJ82 Q9ZJB9
Q9ZJF0 Q9ZJY3 Q9ZK39 Q9ZK57
Q9ZK58 Q9ZKA1 Q9ZKS8 Q9ZKT6
Q9ZKT7 Q9ZKV2 Q9ZL48 Q9ZLB8
Q9ZLC1 Q9ZLD5 Q9ZLG6 Q9ZLZ6
Q9ZMI2 Q9ZMI3 Q9ZMK5 Q9ZMV0
Q9ZMY9 Q9ZN38 Q9ZN51
True Positive Partials
Codes involving 3 elements
O25091 Q9ZMB4
Codes involving 2 elements
O25355 O25735 Q9ZKA5 Q9ZLJ8
Sequence Titles
O24870      HYPOTHETICAL PROTEIN HP0025 - Helicobacter pylori (Campylobacter pylori). 
O24908 HYPOTHETICAL PROTEIN HP0079 - Helicobacter pylori (Campylobacter pylori).
O24941 HYPOTHETICAL PROTEIN HP0127 - Helicobacter pylori (Campylobacter pylori).
O25015 OUTER MEMBRANE PROTEIN (OMP6) - (Campylobacter pylori).
O25034 OUTER MEMBRANE PROTEIN (OMP7) - Helicobacter pylori (Campylobacter pylori).
O25036 OUTER MEMBRANE PROTEIN (OMP8) - Helicobacter pylori (Campylobacter pylori).
O25086 OUTER MEMBRANE PROTEIN (OMP9) - Helicobacter pylori (Campylobacter pylori).
O25222 HYPOTHETICAL PROTEIN HP0477 - Helicobacter pylori (Campylobacter pylori).
O25382 OUTER MEMBRANE PROTEIN (OMP14) - Helicobacter pylori (Campylobacter pylori).
O25410 OUTER MEMBRANE PROTEIN (OMP15) - Helicobacter pylori (Campylobacter pylori).
O25481 HYPOTHETICAL PROTEIN HP0796 - Helicobacter pylori (Campylobacter pylori).
O25556 OUTER MEMBRANE PROTEIN (OMP19) - Helicobacter pylori (Campylobacter pylori).
O25570 HYPOTHETICAL PROTEIN HP0912 - Helicobacter pylori (Campylobacter pylori).
O25571 OUTER MEMBRANE PROTEIN (OMP21) - Helicobacter pylori (Campylobacter pylori).
O25580 HYPOTHETICAL PROTEIN HP0923 - Helicobacter pylori (Campylobacter pylori).
O25740 OUTER MEMBRANE PROTEIN (OMP24) - Helicobacter pylori (Campylobacter pylori).
O25771 HYPOTHETICAL PROTEIN HP1156 - Helicobacter pylori (Campylobacter pylori).
O25772 HYPOTHETICAL PROTEIN HP1157 - Helicobacter pylori (Campylobacter pylori).
O25791 OUTER MEMBRANE PROTEIN (OMP27) - Helicobacter pylori (Campylobacter pylori).
O25840 HYPOTHETICAL PROTEIN HP1243 - Helicobacter pylori (Campylobacter pylori).
O25945 HYPOTHETICAL PROTEIN HP1395 - Helicobacter pylori (Campylobacter pylori).
O26005 HYPOTHETICAL PROTEIN HP1469 - Helicobacter pylori (Campylobacter pylori).
O26031 HYPOTHETICAL PROTEIN HP1501 - Helicobacter pylori (Campylobacter pylori).
O32641 ADHESIN - Helicobacter pylori (Campylobacter pylori).
O32642 HYPOTHETICAL 55.4 KDA PROTEIN - Helicobacter pylori (Campylobacter pylori).
O34523 HYPOTHETICAL PROTEIN HP1342 - Helicobacter pylori (Campylobacter pylori).
O51811 ADHESIN-BINDING FUCOSYLATED HISTO-BLOOD GROUP ANTIGEN - Helicobacter pylori (Campylobacter pylori).
O52269 ADHESIN BINDING FUCOSYLATED HISTO-BLOOD GROUP ANTIGEN - Helicobacter pylori (Campylobacter pylori).
Q93HU0 OMU116 PROTEIN - Helicobacter pylori (Campylobacter pylori).
Q93HU1 HPOMP29(SS1) PROTEIN - Helicobacter pylori (Campylobacter pylori).
Q93HU2 HPOMP29(43504) PROTEIN - Helicobacter pylori (Campylobacter pylori).
Q9R7I4 ADHESIN-BINDING FUCOSYLATED HISTO-BLOOD GROUP ANTIGEN - Helicobacter pylori (Campylobacter pylori).
Q9S3I7 HOPZ PROTEIN PRECURSOR - Helicobacter pylori (Campylobacter pylori).
Q9X745 HOPZ PROTEIN PRECURSOR - Helicobacter pylori (Campylobacter pylori).
Q9X746 HOPZ PROTEIN PRECURSOR - Helicobacter pylori (Campylobacter pylori).
Q9X747 HOPZ PROTEIN PRECURSOR - Helicobacter pylori (Campylobacter pylori).
Q9X748 HOPZ PROTEIN PRECURSOR - Helicobacter pylori (Campylobacter pylori).
Q9X749 HOPV PROTEIN PRECURSOR - Helicobacter pylori (Campylobacter pylori).
Q9X750 HOPW PROTEIN PRECURSOR - Helicobacter pylori (Campylobacter pylori).
Q9X751 HOPX PROTEIN PRECURSOR - Helicobacter pylori (Campylobacter pylori).
Q9X752 HOPZ PROTEIN PRECURSOR - Helicobacter pylori (Campylobacter pylori).
Q9Z390 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZJ82 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZJB9 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZJF0 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZJY3 OUTER MEMBRANE PROTEIN-ADHESIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZK39 PUTATIVE OUTER MEMBRANE FUNCTION - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZK57 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZK58 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZKA1 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZKS8 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZKT6 OUTER MEMBRANE PROTEIN/PORIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZKT7 OUTER MEMBRANE PROTEIN/PORIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZKV2 OUTER MEMBRANE PROTEIN-ADHESIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZL48 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZLB8 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZLC1 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZLD5 OUTER MEMBRANE PROTEIN/PORIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZLG6 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZLZ6 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZMI2 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZMI3 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZMK5 OUTER MEMBRANE PROTEIN/PORIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZMV0 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZMY9 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZN38 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZN51 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).

O25091 HYPOTHETICAL PROTEIN HP0324 - Helicobacter pylori (Campylobacter pylori).
Q9ZMB4 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).

O25355 HYPOTHETICAL PROTEIN HP0638 - Helicobacter pylori (Campylobacter pylori).
O25735 HYPOTHETICAL PROTEIN HP1107 - Helicobacter pylori (Campylobacter pylori).
Q9ZKA5 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Q9ZLJ8 PUTATIVE OUTER MEMBRANE PROTEIN - Helicobacter pylori J99 (Campylobacter pylori J99).
Scan History
SPTR40_20f 6  100  NSINGLE    
Initial Motifs
Motif 1  width=22
Element Seqn Id St Int Rpt
SQTNNGAMNGIGIQVGYKQFFG O52269 557 557 -
SQTNNGAMNGIGIQVGYKQFFG Q9R7I4 519 519 -
SQTNNGAMNGIGIQVGYKQFFG Q9ZKV2 560 560 -
SQTNNGAMNGLGVQAGYKQFFG Q9ZK39 459 459 -
SQNNNGALNGLGVQVGYKQFFG Q9ZLB8 470 470 -
SQNNNGALNGLGVQVGYKQFFG Q9ZLC1 457 457 -

Motif 2 width=21
Element Seqn Id St Int Rpt
WGARYYGFFDYNHAFIKSSFF O52269 583 4 -
WGARYYGFFDYNHAFIKSSFF Q9R7I4 545 4 -
WGARYYGFFDYNHAFIKSSFF Q9ZKV2 586 4 -
WGLRYYGFFDYNHTYIKSSFF Q9ZK39 485 4 -
WGLRYYGFFDYNHGYIKSSFF Q9ZLB8 496 4 -
WGLRYYGFFDYNHGYIKSSFF Q9ZLC1 483 4 -

Motif 3 width=22
Element Seqn Id St Int Rpt
NSASDVWTYGFGADALYNFIND O52269 604 0 -
NSASDVWTYGFGADALYNFIND Q9R7I4 566 0 -
NSASDVWTYGFGADALYNFIND Q9ZKV2 607 0 -
NSSSDVLTYGVGSDLLFNFIND Q9ZK39 506 0 -
NSSSDIWTYGGGSDLLVNFIND Q9ZLB8 517 0 -
NSSSDIWTYGGGSDLLVNFIND Q9ZLC1 504 0 -

Motif 4 width=22
Element Seqn Id St Int Rpt
QHGIELGLKIPTINTNYYSFMG O52269 701 75 -
QHGIELGLKIPTINTNYYSFMG Q9R7I4 663 75 -
QHGIELGLKIPTINTNYYSFMG Q9ZKV2 704 75 -
QHGMELGVKIPTINTNYYSYLG Q9ZK39 603 75 -
QHGVELGIKIPTINTNYYSFLG Q9ZLB8 611 72 -
QHGVELGIKIPTINTNYYSFLG Q9ZLC1 598 72 -
Final Motifs
Motif 1  width=22
Element Seqn Id St Int Rpt
SQTNNGAMNGIGVQVGYKQFFG Q9X745 488 488 -
SQTNNGAMNGIGVQVGYKQFFG Q9X747 489 489 -
SQTNNGAMNGIGVQVGYKQFFG Q9X748 487 487 -
SQTNNGAMNGIGVQVGYKQFFG Q9ZN51 488 488 -
SQTNNGAMNGIGVQIGYKQFFG Q9S3I7 486 486 -
SQTNNGAMNGIGVQIGYKQFFG Q9X746 519 519 -
FQNNNGAMNGIGVQVGYKQFFG O34523 507 507 -
SQTNNGAMNGIGIQVGYKQFFG O25086 561 561 -
SQTNNGAMNGIGIQVGYKQFFG O25556 524 524 -
SQTNNGAMNGIGIQVGYKQFFG O25840 549 549 -
SQTNNGAMNGIGIQVGYKQFFG O51811 523 523 -
SQTNNGAMNGIGIQVGYKQFFG O52269 557 557 -
SQTNNGAMNGIGIQVGYKQFFG Q9R7I4 519 519 -
SQTNNGAMNGIGIQVGYKQFFG Q9ZJY3 519 519 -
SQTNNGAMNGIGIQVGYKQFFG Q9ZKV2 560 560 -
YQNNNGAMNGIGVQAGYKQFFG Q9Z390 512 512 -
SQTNNGAMNGLGVQAGYKQFFG Q9ZK39 459 459 -
STTNNGALNGLGVQVGYKQFFG O25791 457 457 -
SQSNNGAMNGVGVQLGYKQFFG Q9ZMK5 314 314 -
SQNNNGALNGLGVQVGYKQFFG Q9ZLB8 470 470 -
SQNNNGALNGLGVQVGYKQFFG Q9ZLC1 457 457 -
SQSNNGAMNGVGVQLGYKQFFG O25015 314 314 -
STTNNGAMNGIGFQVGYKQFFG O24870 531 531 -
STTNNGAMNGIGFQVGYKQFFG Q9ZN38 510 510 -
KSSQHGVINGFGIQVGYKQFFG Q9X751 293 293 -
TSSQHGVINGFGIQVGYKQFFG Q9ZMI2 292 292 -
TSSQHGVINGFGIQVGYKQFFG O25036 252 252 -
NSSQVNAFNGFITKIGYKQFFG O25571 356 356 -
NSSQVNAFNGFITKIGYKQFFG O32642 345 345 -
NSSQVNAFNGFITKIGYKQFFG Q9ZKT6 354 354 -
KDYQSASMNGFGAKMGYKQFFT Q9X752 312 312 -
KDYQSASMNGFGAKMGYKQFFT Q9ZMI3 306 306 -
KDYQSASMNGFGAKMGYKQFFT O25034 314 314 -
KTDYLAVMQGLGLTVGYKQFFG O25382 82 82 -
NSRATNILNGFYTKVGYKQFFG Q9ZKT7 345 345 -
KTDYLAVMQGLGLTVGYKQFFG Q9ZLG6 82 82 -
NSRSTNILNGFYTKIGYKQFFG O25570 340 340 -
NSRSTNILNGFYTKIGYKQFFG O32641 343 343 -
HNSNSNNMNGFGVKMGYKQFFG O25771 522 522 -
HNSNSNNMNGFGVKMGYKQFFG Q9ZK58 523 523 -
IPGRNQPMYGLGVMTGYKHFVG Q9ZJB9 146 146 -
IPGRNQPMYGLGVMTGYKHFIG O26031 146 146 -
IPGRNQPMYGLGVMTGYKHFIG Q9X750 145 145 -
NTNNYGQMYGVDAMAGYKWFFG O24908 411 411 -
NTNNYGQMYGVDAMAGYKWFFG Q93HU1 76 76 -
NTNNYGQMYGVDAMAGYKWFFG Q93HU2 71 71 -
NTNNYGQMYGVDAMAGYKWFFG Q9ZMY9 71 71 -
NTNNYGQMYGVDAMAGYKWFFG Q93HU0 76 76 -
PLIKFPPYAGAGFEVGYKQFFG Q9X749 48 48 -
PLIKFPPYAGAGFEVGYKQFFG O26005 48 48 -
PLIKFPPYAGPGFEVGYKQFFG Q9ZJF0 48 48 -
KSTQHGMSNGLGVGIGYKYFFG Q9ZK57 1054 1054 -
KSTQHGMSNGLGVGLGYKYFFG O25772 1047 1047 -
YSKNISSMYGVSLSVGYKHFFT O25222 185 185 -
YSKNISSMYGVSLSVGYKHFFT O25580 187 187 -
YSKNVSSMYGVGLSVGYKHFFT Q9ZKS8 184 184 -
YSKNVSSMYGVGLSVGYKHFFT Q9ZLZ6 189 189 -
LSNQQYAINGFGFVVGYKHFFK O24941 103 103 -
LSNQQYAINGFGFVVGYKHFFK Q9ZMV0 103 103 -
SKYANGALNGFGLNVGYKKFFQ Q9ZLD5 75 75 -
AKYANGALNGLGLNVGYKKFFQ O25410 78 78 -
KQATSATIKGFDALLGYQFFFG O25945 48 48 -
KQATNATIKGFDALLGYQFFFE Q9ZJ82 48 48 -
VFKNSYVSNGLGVQVGYKWVGK Q9ZKA1 87 87 -
VFKNSYVSNGLGVQVGYKWVGK O25740 87 87 -
SKYRNIPFAEVSLIYGYKQFFP Q9ZL48 94 94 -
SKYRDIPFAEVSLIYGYKQFFP O25481 94 94 -

Motif 2 width=21
Element Seqn Id St Int Rpt
WGLRYYGFFDYNHAYIKSSFF Q9X745 514 4 -
WGLRYYGFFDYNHAYIKSSFF Q9X747 515 4 -
WGLRYYGFFDYNHAYIKSSFF Q9X748 513 4 -
WGLRYYGFFDYNHAYIKSSFF Q9ZN51 514 4 -
WGLRYYGFFDYNHAYIKSSFF Q9S3I7 512 4 -
WGARYYGFFDYNHAYIKSSFF Q9X746 545 4 -
WGLRYYGFFDYNHAYIKSNFF O34523 533 4 -
WGARYYGFFDYNHAFIKSSFF O25086 587 4 -
WGARYYGFFDYNHAFIKSSFF O25556 550 4 -
WGARYYGFFDYNHAFIKSSFF O25840 575 4 -
WGARYYGFFDYNHAFIKSSFF O51811 549 4 -
WGARYYGFFDYNHAFIKSSFF O52269 583 4 -
WGARYYGFFDYNHAFIKSSFF Q9R7I4 545 4 -
WGARYYGFFDYNHAFIKSSFF Q9ZJY3 545 4 -
WGARYYGFFDYNHAFIKSSFF Q9ZKV2 586 4 -
WGLRYYGFFDYNHAYIKSNFF Q9Z390 538 4 -
WGLRYYGFFDYNHTYIKSSFF Q9ZK39 485 4 -
WGLRYYGFFDYNHAYIKSNFF O25791 483 4 -
FGIRYYGFFDYNYAYIKSNFF Q9ZMK5 340 4 -
WGLRYYGFFDYNHGYIKSSFF Q9ZLB8 496 4 -
WGLRYYGFFDYNHGYIKSSFF Q9ZLC1 483 4 -
FGIRYYAFFDYNHAYIKSNFF O25015 340 4 -
WGARYYGFVDYNHTYNKSQFF O24870 557 4 -
WGARYYGFVDYNHTYNKSQFF Q9ZN38 536 4 -
IGLRYYAFFDYGFTQLGSLNS Q9X751 319 4 -
IGLRYYAFFDYGFTQLGSLNS Q9ZMI2 318 4 -
IGLRYYAFFDYGFTQLGSLSS O25036 278 4 -
VGLRYYGFFSYNGAGVGNGPT O25571 382 4 -
VGLRYYGFFSYNGAGVGNGPT O32642 371 4 -
VGLRYYGFFSYNGAGVGNGPT Q9ZKT6 380 4 -
IGLRYYGFLDYGYANFGDTNL Q9X752 338 4 -
IGLRYYGFLDYGYANFGDTNL Q9ZMI3 332 4 -
VGLRYYGFLDYGYANFGDTNL O25034 340 4 -
FGARYYGFMDYGHAVFGANAL O25382 108 4 -
IGLRYYGFFSYNGASVGFRST Q9ZKT7 371 4 -
FGARYYGFMDYGHAVFGANAL Q9ZLG6 108 4 -
IGLRYYGFFSYNGASVGFRST O25570 366 4 -
IGLRYYGFFSYNGASVGFRST O32641 369 4 -
FGLRYYGFYDFGYAQFGAESS O25771 548 4 -
FGLRYYGFYDFGYAQFGTESS Q9ZK58 549 4 -
FGLRYYGFFDYGHTNFSNSRA Q9ZJB9 172 4 -
FGLRYYGFFDYGHTNFSNSRA O26031 172 4 -
FGLRYYGFFDYGHTNFSNSRA Q9X750 171 4 -
FGFRSYGYYSYNHANLSFVGS O24908 437 4 -
FGFRSYGYYSYNHANLSFVGS Q93HU1 102 4 -
FGFRSYGYYSYNHANLSFVGS Q93HU2 97 4 -
FGFRTYGYYSYNHANLSFVGS Q9ZMY9 97 4 -
FGFRSYGYYSYNHANLSFVGS Q93HU0 102 4 -
FGARYYGFFDYAHNRFGVMKK Q9X749 74 4 -
FGMRYYGFFDYAHNRFGVMKK O26005 74 4 -
FGMRYYGFFDYAHNRFGVMKK Q9ZJF0 74 4 -
LGLRHYFFFDYGFSEIGLANQ Q9ZK57 1080 4 -
LGLRHYFFFDYGFSEIGLANQ O25772 1073 4 -
QGLRYYLFYDYGYTNFGFVGN O25222 211 4 -
QGLRYYLFYDYGYTNFGFVGN O25580 213 4 -
QGFRYYLFYDYGYTNFGFVGN Q9ZKS8 210 4 -
QGFRYYLFYDYGYTNFGFVGN Q9ZLZ6 215 4 -
FGMRYYGFFDFASSYYKYYTY O24941 129 4 -
FGMRYYGFFDFASSYYKYYTY Q9ZMV0 129 4 -
FGFRVYGLFDYGHADLGKQVY Q9ZLD5 107 10 -
FGFRVYGLFDYGHATLGKQVY O25410 110 10 -
FGLRLYGFFDYAHANSIRLKN O25945 72 2 -
FGLRLYGFFDYAHANSIKLKN Q9ZJ82 72 2 -
FGFRWGLFYDLSASLYGSQES Q9ZKA1 115 6 -
FGFRWGLFYDLSASLYGQKES O25740 115 6 -
YGFRFYVSLDYAYGFFLKNKG Q9ZL48 120 4 -
YGFRFYVSLDYAYGFFLKNKG O25481 120 4 -

Motif 3 width=22
Element Seqn Id St Int Rpt
NSASDVFTYGVGTDVLYNFIND Q9X745 535 0 -
NSASDVFTYGVGTDVLYNFIND Q9X747 536 0 -
NSASDVFTYGVGTDVLYNFIND Q9X748 534 0 -
NSASDVFTYGVGTDVLYNFIND Q9ZN51 535 0 -
NSASDVFTYGVGTDVLYNFIND Q9S3I7 533 0 -
NSASDVFTYGVGTDVLYNFIND Q9X746 566 0 -
NSASDVWTYGVGMDALYNFIND O34523 554 0 -
NSASDVWTYGFGADALYNFIND O25086 608 0 -
NSASDVWTYGFGADALYNFIND O25556 571 0 -
NSASDVWTYGFGADALYNFIND O25840 596 0 -
NSASDVWTYGFGADALYNFIND O51811 570 0 -
NSASDVWTYGFGADALYNFIND O52269 604 0 -
NSASDVWTYGFGADALYNFIND Q9R7I4 566 0 -
NSASDVWTYGFGADALYNFIND Q9ZJY3 566 0 -
NSASDVWTYGFGADALYNFIND Q9ZKV2 607 0 -
NSASDVWTYGVGMDALYNFIND Q9Z390 559 0 -
NSSSDVLTYGVGSDLLFNFIND Q9ZK39 506 0 -
NSASDVWTYGVGSDLLFNFIND O25791 504 0 -
NSASNVFTYGAGSDLLLNFING Q9ZMK5 361 0 -
NSSSDIWTYGGGSDLLVNFIND Q9ZLB8 517 0 -
NSSSDIWTYGGGSDLLVNFIND Q9ZLC1 504 0 -
NSASNVFTYGAGSDLLLNFING O25015 361 0 -
NSDSDVWTYGVGSDLLVNFIND O24870 578 0 -
NASSDVWTYGVGSDLLVNFIND Q9ZN38 557 0 -
AVKANIFTYGAGTDFLWNIFRR Q9X751 340 0 -
AVKANIFTYGAGTDFLWNIFRR Q9ZMI2 339 0 -
AVKANIFTYGAGTDFLWNIFRR O25036 299 0 -
YNQVNLLTYGVGTDVLYNVFSR O25571 403 0 -
YNQVNLLTYGVGTDVLYNVFSR O32642 392 0 -
YNQVNLLTYGVGTDVLYNVFSR Q9ZKT6 401 0 -
KVGANLVTYGVGTDFLYNVYER Q9X752 359 0 -
KVGANLVTYGVGTDFLYNVYER Q9ZMI3 353 0 -
KVGANLVTYGVGTDFLYNVYER O25034 361 0 -
GNLSDMFTYGVGIDTLYNVINK O25382 150 21 -
QNNVGLYTYGVGTDVLYNIFSR Q9ZKT7 392 0 -
GNLSDMFTYGVGIDTLYNVINK Q9ZLG6 150 21 -
QNNVGLYTYGVGTDVLYNIFSR O25570 387 0 -
QNNVGLYTYGVGTDVLYNIFSR O32641 390 0 -
LVKATLSSYGAGTDFLYNVFTR O25771 569 0 -
LVKATLSSYGAGTDFLYNVFTR Q9ZK58 570 0 -
DQKADMYTYGFGTDMLFNVIDK Q9ZJB9 203 10 -
DQKADMYTYGFGTDMLFNIIDK O26031 203 10 -
DQKADMYTYGFGTDMLFNIIDK Q9X750 202 10 -
ASQVNNFTYGVGFDVLYNFYES O24908 465 7 -
ASQVNNFTYGVGFDALYNFYES Q93HU1 130 7 -
ASQVNDFTYGVGFDVLYNFYES Q93HU2 125 7 -
ASQVNNFTYGVGFDALYNFYES Q9ZMY9 125 7 -
ASQVNNFTYGVGFDALYNFYES Q93HU0 130 7 -
QYYVNLFTYGVGLDTLWNFVNK Q9X749 124 29 -
QYYVNLFTYGVGLDTLWNFVNK O26005 124 29 -
QYYINLFTYGVGLDTLWNFVNK Q9ZJF0 124 29 -
SVKANIFAYGVGTDFLWNLFRR Q9ZK57 1101 0 -
SVKANIFAYGVGTDFLWNLFRR O25772 1094 0 -
LGKMNNHLYGLGIDYLYNFIDN O25222 236 4 -
LGKMNNHLYGLGIDYLYNFIDN O25580 238 4 -
LGKMNNHLYGLGIDYLFNFIDN Q9ZKS8 235 4 -
LGKMNNHLYGLGIDYLFNFIDN Q9ZLZ6 240 4 -
GSQSFMFGYGAGTDVLFNPAIF O24941 160 10 -
GSQSFMFGYGAGTDVLFNPAIF Q9ZMV0 160 10 -
KIQLDMVSWGVGSDLLADIIDK Q9ZLD5 131 3 -
KIQLDMVSWGVGSDLLADIIDN O25410 134 3 -
TFEPNMLTYGGAMDVMVNVINN O25945 123 30 -
TFEPNMLTYGGAMDVMVNVINN Q9ZJ82 123 30 -
SQSIIISTYGTYMDLLLNAYNG Q9ZKA1 135 -1 -
SQSVIISTYGTYMDLLLNAYNG O25740 135 -1 -
ETFINAIFYGVGADFLYKRAFG Q9ZL48 164 23 -
ETFINAIFYGAGADFLYKRAFG O25481 164 23 -

Motif 4 width=22
Element Seqn Id St Int Rpt
QHGVELGVKIPTINTNYYSLLG Q9X745 628 71 -
QHGVELGVKIPTINTNYYSLLG Q9X747 629 71 -
QHGVELGVKIPTINTNYYSLLG Q9X748 627 71 -
QHGVELGVKIPTINTNYYSLLG Q9ZN51 628 71 -
QHGVELGVKIPTINTNYYSLLG Q9S3I7 626 71 -
QHGVELGVKIPTINTNYYSLLG Q9X746 659 71 -
QHGIELGFKIPTINTNYYSFMG O34523 651 75 -
QHGIELGLKIPTINTNYYSFMG O25086 705 75 -
QHGIELGLKIPTINTNYYSFMG O25556 668 75 -
QHGIELGLKIPTINTNYYSFMG O25840 693 75 -
QHGIELGLKIPTINTNYYSFMG O51811 667 75 -
QHGIELGLKIPTINTNYYSFMG O52269 701 75 -
QHGIELGLKIPTINTNYYSFMG Q9R7I4 663 75 -
QHGIELGLKIPTINTNYYSFMG Q9ZJY3 663 75 -
QHGIELGLKIPTINTNYYSFMG Q9ZKV2 704 75 -
QHGMELGVKIPTINTDYYSFMG Q9Z390 656 75 -
QHGMELGVKIPTINTNYYSYLG Q9ZK39 603 75 -
QHGMELGVKIPTINTNYYSFLD O25791 601 75 -
HHGIELGVKIPTINTNYYSFMG Q9ZMK5 443 60 -
QHGVELGIKIPTINTNYYSFLG Q9ZLB8 611 72 -
QHGVELGIKIPTINTNYYSFLG Q9ZLC1 598 72 -
HHGVELGVKIPTINTNYYSFMG O25015 443 60 -
QHGMELGVKIPTINTNYYSLLG O24870 671 71 -
QHGIELGTKIPTINTNYYSLLG Q9ZN38 650 71 -
QHGMEFGVKIPAINQRYLKANG Q9X751 432 70 -
QHGMEFGVKIPAINQRYLKANG Q9ZMI2 431 70 -
QHGMEFGVKIPAINQRYLRANG O25036 391 70 -
QHSIEIGVQIPTIYNTYYKAGG O25571 489 64 -
QHSIEIGVQIPTIYNTYYKAGG O32642 478 64 -
QHSIEIGVQIPTIYNTYYKAGG Q9ZKT6 487 64 -
DQGIEFGVKIPVIAHKYFATQG Q9X752 445 64 -
DQGIEFGVKIPVIAHKYFATQG Q9ZMI3 439 64 -
DQGIEFGVKIPVIAHKYFATQG O25034 447 64 -
HQEFDFGVKIPTINVYYFNHGN O25382 230 58 -
QHTVEFGVVVPTIYNTYYKSAG Q9ZKT7 480 66 -
HQEFDFGVKIPTINVYYFNHGN Q9ZLG6 230 58 -
QHTVEFGVVVPTIYNTYYKSAG O25570 475 66 -
QHTVEFGVVVPTIYNTYYKSAG O32641 478 66 -
SQGIEFGLKIPVLYHTYYQSEG O25771 656 65 -
SQGIEFGLKIPVLYHTYYQSEG Q9ZK58 657 65 -
HHGIEFGIKIPTLPNYFFKGST Q9ZJB9 322 97 -
HHGIEFGIKIPTLPNYFFKGST O26031 322 97 -
HHGIEFGIKIPTLPNYFFKGST Q9X750 321 97 -
HSGIEVGFKLPLFTNQFYKERG O24908 551 64 -
HSGIEVGFKLPLFTNQFYKERG Q93HU1 216 64 -
HSGIEVGFKLPLFTNQFYKERG Q93HU2 211 64 -
HSGIEVGFKLPLFTNQFYKERG Q9ZMY9 211 64 -
HSGIEVGFKLPLFTNQFYEERG Q93HU0 216 64 -
HNSLELGIKVPTITHRLFSLTN Q9X749 203 57 -
HNSLELGIKVPTITHQLFSLTN O26005 203 57 -
HNSLELGIKVPTITHRLFFITN Q9ZJF0 203 57 -
QKSVEFGIKVPLINQAYLNSAG Q9ZK57 1197 74 -
QKSVEFGIKVPLINQAYLNSAG O25772 1190 74 -
HNGFEMGLKIPLAMNSFYETHG O25222 323 65 -
HNGFEMGLKIPLAMNSFYETHG O25580 325 65 -
HNGFEMGLKIPLAVNSFYETHG Q9ZKS8 322 65 -
HNGFEMGLKIPLAVNSFYETHG Q9ZLZ6 327 65 -
HQGFEIGLKIQTIRNNYYTASA O24941 238 56 -
HQGFEIGLKIQTIRNNYYTASA Q9ZMV0 238 56 -
HNGVEFGVRVPLLINKFLSAGP Q9ZLD5 226 73 -
HNGVEFGVRVPLLINKFLSAGP O25410 229 73 -
HSSIEAGVKFPMLKKNPYITAK O25945 201 56 -
HSSIEAGVKFPMLKKNPYITAK Q9ZJ82 201 56 -
HNQFGFGIKIPTYYFNHYYSMN Q9ZKA1 213 56 -
HNQFGFGIKIPTYYFNHYYSMN O25740 213 56 -
NWAIEFGARIPFLINDYFKTPL Q9ZL48 238 52 -
NWAIELGARIPFLTNDYFKTPL O25481 238 52 -